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Chemical biological approach for regulation of gene expression

Research Project

Project/Area Number 19201044
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KAGECHIKA Hiroyuki  東京医科歯科大学, 大学院・疾患生命科学研究部, 教授 (20177348)

Co-Investigator(Kenkyū-buntansha) HIRANO Tomoya  東京医科歯科大学, 生体材料工学研究所, 准教授 (20396980)
YAMAMOTO Keiko  昭和薬科大学, 薬学部, 教授 (90147017)
SHUDO Koichi  (財)乙卯研究所, 所長 (50012612)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2008: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywords遺伝子転写制御 / 核内受容体 / ケミカルバイオロジー / レチノイド / ビタミンD / アンドロゲン / プロゲステロン / 蛍光性リガンド / 疎水性ファーマコフォア / カルボラン / 蛍光プローブ / 不飽和脂肪酸 / 化合物ライブラリー
Research Abstract

Nuclear receptors are ligand-inducible transcription factors that regulate the expression of their target genes. Nuclear receptors have become one of the most significant molecular targets for drug discovery in the fields of cancer, metabolic syndrome, autoimmune diseases, and so on. We have developed various nuclear receptors ligands useful for regulation of each nuclear receptor or for elucidation of the functions.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (127 results)

All 2011 2010 2009 2008 2007

All Journal Article (55 results) (of which Peer Reviewed: 50 results) Presentation (58 results) Book (9 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Retinoid X receptorgamma signaling accelerates CNSremyelination2011

    • Author(s)
      Huang, J. K.; Jarjour, A. A.; Nait-Oumesmar, B.; Kerninon, C.; Williams, A. Krezel, W.; Kagechika, H.; Bauer, J.; Zhao, C.; Baron-Van Evercooren, A.; Chambon, P.; ffrench-Constant, C.; Franklin, R. J. M.
    • Journal Title

      Nature Neurosci

      Volume: 14 Pages: 45-53

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tributyltin chlorideinduces ABCA1 expression andapolipoprotein A-I-mediated cellularcholesterol efflux by activatingLXRalpha/RXR2011

    • Author(s)
      Cui, H.; Okuhira, K.; Ohoka, N.; Naito, M.; Kagechika, H.; Hirose, A, ; Nishimaki-Mogami, T.
    • Journal Title

      Biochem. Pharmacol

      Volume: 81 Pages: 819-824

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calix[3]amide-based anion receptors : High afinity for fluoride ion and a twisted binding model2011

    • Author(s)
      Katagiri, K.
    • Journal Title

      Supramol.Chem.

      Volume: 23 Pages: 125-130

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol eflux by activating LXRalpha/RXR2011

    • Author(s)
      Cui, H.
    • Journal Title

      Biochem.Pharmacol.

      Volume: 23 Pages: 819-824

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinoid X receptor gamma signaling accelerates CNS remyelination2011

    • Author(s)
      Huang, J.K.
    • Journal Title

      Nature Neurosci.

      Volume: 14 Pages: 45-53

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of intramolecularheterodimer-induced fluorescencequenching of tricarbocyanine dye for thedevelopment of fluorescent sensors2010

    • Author(s)
      Hirano, T.; Akiyama, J.; Mori, S.; Kagechika, H.
    • Journal Title

      Org. Biomol. Chem

      Volume: 8 Pages: 5568-5575

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis ofNovel Retinoid Synergists having aDibenzodiazepine Skeleton2010

    • Author(s)
      Ohta, K.; Kawachi, E.; Shudo, K.; Kagechika, H.
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 2465-2470

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmentof novel bisubstrate-type inhibitors ofhistone methyltransferase SET7/92010

    • Author(s)
      Mori, S.; Iwase, K.; Iwanami, N.; Tanaka, Y.; Kagechika, H.; Hirano, T.
    • Journal Title

      Bioorg. Med. Chem

      Volume: 18 Pages: 8158-8168

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Induction of CCR9 onT Cells Requires Coactivation of RetinoicAcid Receptors and Retinoid X Receptors (RXRs): Exaggerated T Cell Homing to theIntestine by RXR Activation withOrganotins2010

    • Author(s)
      Takeuchi, H.; Yokota, A.; Ohoka, Y.; Kagechika, H.; kato, C.; Song, S.-Y.; Iwata, M.
    • Journal Title

      J. Immunol

      Volume: 185 Pages: 5289-5299

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic Acid Induces Expression of theThyroid Hormone Transporter, Monocarboxylate Transporter 8(Mct8)2010

    • Author(s)
      Kogai, T.; Liu, Y.-Y.; Richter, L. L.; Mody, K.; Kagechika, H.; Bent, G. A.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 27279-27288

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Mammary Carcinoma CellGrowth by RXR is Mediated by the Receptor's Oligomeric Switch2010

    • Author(s)
      Yasmin, R.; Kannan-Thulasiraman, P.; Kagechika, H.; Dawson, M. I.; Noy, N.
    • Journal Title

      J. Mol. Biol.

      Volume: 397 Pages: 1121-1131

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synegistic activation of the mitochondrial apoptoic pathway2010

    • Author(s)
      Kurosu, T
    • Journal Title

      Apoptosis

      Volume: 15 Pages: 608-620

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Mammary Carcinoma Cell Growth by RXR is Mediated by the Receptor's Oligomeric Switch2010

    • Author(s)
      Yasmin, R.
    • Journal Title

      J.Mol.Biol

      Volume: 397 Pages: 1121-1131

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Latent Enamine Functionality of 5-Methyl-2,3-dihydropyradines2010

    • Author(s)
      Ito, S.
    • Journal Title

      Chem.Pharm.Bull.

      Volume: 58 Pages: 885-1002

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] InV itro Murine Spermatogenesis in an Ogan Culture System2010

    • Author(s)
      Gohbara, A.
    • Journal Title

      Biol.Reprod

      Volume: 83 Pages: 261-267

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic Acid Induces Expression of the Thyroid Hormone Transporter, Monocarboxylate Transporter 8 (Mct8)2010

    • Author(s)
      Kogai, T
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 27279-27288

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic-tri (N-methyl-meta-benzamide)s : substituent efects on the bowl-shaped conformation in the crystal and solution states2010

    • Author(s)
      Kakuta, H.
    • Journal Title

      Tetrahedron

      Volume: 66 Pages: 8254-8260

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eficient Induction of CCR9 on TCells Requires Coactivation of Retinoic Acid Receptors and Retinoid X Receptors (RXRs) : Exaggerated TCell Homing to the Intestine by RXR Activation with Oganotins2010

    • Author(s)
      Takeuchi, H.
    • Journal Title

      J.Immunol.

      Volume: 185 Pages: 5289-5299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/92010

    • Author(s)
      Mori, S.
    • Journal Title

      Bioog.Med.Chem.

      Volume: 18 Pages: 8158-8168

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis of Novel Retinoid Synegists having a Dibenzodiazepine Skeleton2010

    • Author(s)
      Ohta, K.
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 2465-2470

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of intramolecular heterodimerinduced fluorescence quenching of tricarbocyanine dye for the development of fluorescent sensors2010

    • Author(s)
      Hirano, T
    • Journal Title

      Og.Biomol.Chem.

      Volume: 8 Pages: 5568-5575

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Testicular Orphan Receptor4 by Fatty Acids2009

    • Author(s)
      Tsai, N.-P.; Huq, M.; Gupta, P.; Yamamoto, K.; Kagechika, H.; Wei, L.-N.
    • Journal Title

      Biochim. Biophys. Acta-Gene Regul. Mech

      Volume: 1789 Pages: 734-740

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Encapsulation of thesynthetic retinoids Am80 and LE540 intopolymeric micelles and the retinoids' rerease control2009

    • Author(s)
      Satoh, T.; Higuchi, Y.; Kawakami, S.; Hashida, M.; Kagechika, H.; Shudo, K.; Yokoyama, M.
    • Journal Title

      J. Controlled Release

      Volume: 136 Pages: 187-195

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the PI3 Kinase Pathway By Retinoic Acid Mediates Sodium/Iodide Symporter Induction and Iodide Transport in MCF-7 Breast CancerCells2009

    • Author(s)
      Ohashi, E.; Kogai, T.; Kagechika, H.; Brent, G. A.
    • Journal Title

      Cancer Res

      Volume: 69 Pages: 3443-3450

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thetranscriotion factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities2009

    • Author(s)
      Bourhis, E.; Maheux, J.; Paquet, B.; Kagechika, H.; Shudo, K.; Rompre, P.; Rouillard, C.; Levesque, D.
    • Journal Title

      Psychopharmacol

      Volume: 202 Pages: 635-648

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ApoC-III gene expression issharply increased during adipogenesis andis augmented by retinoid X receptor(RXR) agonists2009

    • Author(s)
      Takahashi, Y.; Inoue, J.; Kagechika, H.; Sato, R.
    • Journal Title

      FEBS Lett

      Volume: 583 Pages: 493-497

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of AP-1 interference induced by TAC-101 totumor growth suppression in ahepatocellular carcinoma model2009

    • Author(s)
      Eshima, K.; Fukaya S.; Sugimoto, A.; Mori, T.; Yokoi, H.; Yamamoto, Y.; Sugiura, S.; Honda, S.; Masuko, N.; Murakami, K.; Yamasaki, Y.; Kagechika, H.
    • Journal Title

      TumorBiol

      Volume: 30 Pages: 1-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acidicheterocycles as novel hydrophilicpharmacophore of androgen receptorligands with a carborane core structure. Bioorg2009

    • Author(s)
      Fujii, S.; Ohta, K.; Goto, T.; Kagechika, H.; Endo, Y.
    • Journal Title

      Med. Chem

      Volume: 17 Pages: 344-350

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Testicular Orphan Receptor 4 by Fatty Acids2009

    • Author(s)
      Tsai, N.-P., Huq, M., Gupta, P., Yamamoto, K., Kagechika, H., Wei, L.-N.
    • Journal Title

      Biochim.Biophys.Acta-Gene Regul.Mech. 1789

      Pages: 734-740

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model2009

    • Author(s)
      Eshima, K., Fukaya S., Sugimoto, A., Mori, T., Yokoi, H., Yamamoto, Y., Sugiura, S., Honda, S., Masuko, N., Murakami, K., Yamasaki, Y., Kagechika, H.
    • Journal Title

      Tumor Biol. 30

      Pages: 1-7

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Fluorescent visualization of the conformational change of aromatic amide or urea induced by N-methylation2009

    • Author(s)
      Hirano, T., Osaki, T., Fujii, S., Komatsu, D., Azumaya, I., Tanatani, A., Kagachika, H.
    • Journal Title

      Tetrahedron Lett 50

      Pages: 488-491

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure2009

    • Author(s)
      Fujii, S., Ohta, K., Goto, T., Kagechika, H., Endo, Y.
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 344-350

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] The transcriotion factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities.2009

    • Author(s)
      Bourhis, E.
    • Journal Title

      Psychopharmacol 202

      Pages: 635-648

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the PI3 Kinase Pathway By Retinoic Acid Mediates Sodium/Iodide Symporter Induction and Iodide Transport in MCF-7 Breast Cancer Cells.2009

    • Author(s)
      Ohashi, E.
    • Journal Title

      Cancer Res. 69

      Pages: 3443-3450

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.2009

    • Author(s)
      Kurosu, T.
    • Journal Title

      Cancer Res. 69

      Pages: 3927-3936

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' rerease control.2009

    • Author(s)
      Satoh, T.
    • Journal Title

      J.Controlled Release 136

      Pages: 187-195

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells.2009

    • Author(s)
      Suzuki, K.
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 1177-1182

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-Inducible Factor-3α Functions as an Accelerator of 3T3-L1 Adipose Differentiation.2009

    • Author(s)
      Hatanaka, M.
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 1166-1172

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Testicular Orphan Receptor 4 by Fatty Acids.2009

    • Author(s)
      Tsai, N.-P.
    • Journal Title

      Biochim.Biophys.Acta- Gene Regul.Mech. 1789

      Pages: 734-740

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure2009

    • Author(s)
      Shinya Fujii
    • Journal Title

      Bioorg. Med. Chem. 17

      Pages: 344-350

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure2009

    • Author(s)
      Kokoro Eshima
    • Journal Title

      Tumor Biology 30

      Pages: 1-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists2009

    • Author(s)
      Yu Takahashi
    • Journal Title

      FEBS Lett. 583

      Pages: 493-497

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of retinoic acids on the dendritic morphology of cultured hippocampal meurons2008

    • Author(s)
      Liu, Y.; Kagechika, H.; Ishikawa, J.; Hirano, H.; Matsukuma, S.; Tanaka, K.; Nakamura, S.
    • Journal Title

      J. Neurochem

      Volume: 106 Pages: 1104-1116

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The RXRagonists PA024 and HX630 have different abilities to activate LXR/RXR and toinduce ABCA1 expression in macrophage cellline2008

    • Author(s)
      Nishimaki-Mogami, T.; Tamehiro, N.; Sato, Y.; Okuhira, K.; Sai, K.; Kagechika, H.; Shudo, K.; Abe-Dohmae, S.; Yokoyama, S.; Ohno, Y.; Inoue, K.; Sawada, J.
    • Journal Title

      Biochem. Pharmacol

      Volume: 76 Pages: 1006-1013

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of An Intermediate in the Deboronation of or tho-Carborane : An Adduct of ortho-Carborane with Two Nucleophiles on One Boron Atom2008

    • Author(s)
      Taoda, Y.; Sawabe, T.; Endo, Y. Yamaguchi, K.; Fujii, S.; Kagechika, H.
    • Journal Title

      Chem. Commun

      Pages: 2049-2051

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell line2008

    • Author(s)
      Nishimaki-Mogami, T., Tamehiro, N., Sato, Y., Okuhira, K., Sai, K., Kagechika, H., Shudo, K., Abe-Dohmae, S., Yokoyama, S., Ohno, Y., Inoue, K., Sawada, J.
    • Journal Title

      Biochem.Pharmacol. 76

      Pages: 1006-1013

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Identification of An Intermediate in the Deboronation of ortho-Carborane : An Adduct of ortho-Carborane with Two Nucleophiles on One Boron Atom2008

    • Author(s)
      Yoshiyuki Taoda
    • Journal Title

      Chem. Commun.

      Pages: 2049-2051

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The RXR agonists PAO24 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell line2008

    • Author(s)
      Tomoko Nishimaki-Mogami
    • Journal Title

      Biochem. Pharmacol. 76

      Pages: 1006-1013

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 13-cis-Retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat2008

    • Author(s)
      Junko Ishikawa
    • Journal Title

      Eur. J. Neurosci. 27

      Pages: 2363-2372

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of retinoic acids on the dendritic morphology of cultured hippocampal meurons2008

    • Author(s)
      Ying Liu
    • Journal Title

      J. Neurochem. 106

      Pages: 1104-1116

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] b-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters inmacrophages2007

    • Author(s)
      Matsumoto, A.; Mizukami, H.; Mizuno, S.; Umegaki, K.; Nishikawa, J.; Shudo, K.; Kagechika, H.; Inoue, M.
    • Journal Title

      Biochem. Pharmacol

      Volume: 74 Pages: 256-264

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] STAT5a/PPARg Pathway Regulates Involucrin Expression in Keratinocyte Differentiation2007

    • Author(s)
      Dai, X.; Sayama, K.; Shirakata, Y.; Hanakawa, Y.; Yamasaki, K.; Tokumaru, S.; Yang, L.; Wang, X.; Hirakawa, S.; Tohyama, M.; Yamauchi, T.; Kadowaki, T.; Kagechika, H.; Hashimoto, K.
    • Journal Title

      J. Invest. Dermatol

      Volume: 127 Pages: 1728-1735

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] STAT5α/PPARγ Pathway Regulates Involucrin Expression in Keratinocyte Differentiation2007

    • Author(s)
      Dai, X.
    • Journal Title

      J. Invest. Dermatol. 127

      Pages: 1728-1735

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages2007

    • Author(s)
      Matsumoto, A.
    • Journal Title

      Biochem. Pharmacol 74

      Pages: 256-264

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tamibarotene2007

    • Author(s)
      Miwako, I.
    • Journal Title

      Drugs of Today 43

      Pages: 563-568

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of Novel Non-seco-Stroid-type Vitamin D Derivatives2010

    • Author(s)
      影近弘之
    • Organizer
      ICE2010 Official Satellite Symposium
    • Place of Presentation
      京都
    • Year and Date
      2010-03-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Novel Nonsteroidal Androgen Receptor Ligands Based on Hydrophobic Boron Clusters2010

    • Author(s)
      藤井晋也
    • Organizer
      ICE2010 Official Satellite Symposium
    • Place of Presentation
      京都
    • Year and Date
      2010-03-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Novel Progesterone Antagonists Bearing A6-Arylcoumarin Skeleton2010

    • Author(s)
      Aya Tanatani
    • Organizer
      ICE2010 Official Satellite Symposium
    • Place of Presentation
      京都
    • Year and Date
      2010-03-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Novel Synthetic Ligands for Nuclear Receptors2010

    • Author(s)
      Kagechika, H.
    • Organizer
      The 14^<th> International Congress of Endocrinology (ICE2010)
    • Place of Presentation
      京都
    • Year and Date
      2010-03-30
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Development of Novel Synthetic Ligands for Nuclear Receptors2010

    • Author(s)
      影近弘之
    • Organizer
      The 14^<th> International Congress of Endocrinology
    • Place of Presentation
      京都
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 変異受容体にも有効な新規アンドロゲンアンタゴニストの創製2010

    • Author(s)
      山田歩
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] カルボランを基盤としたチオエーテル構造を有する新規VDRリガンドの創製2010

    • Author(s)
      関根良太
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 6-アリールクマリン環を母核とした新規プロゲステロンアンタゴニストの創製2010

    • Author(s)
      酒井悠
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ホウ素クラスターを疎水性骨格とする新規非セコステロイド型ビタミンD誘導体:受容体結合様式と構造展開2010

    • Author(s)
      藤井晋也,増野弘幸,垰田善之,加納敦,中林誠,伊藤暢聡,河内恵美子,清水正人,棚谷綾,平野智也,影近弘之
    • Organizer
      日本レチノイド研究会第21回学術集会
    • Place of Presentation
      高槻
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] クマリン骨格を基盤とした蛍光センサーの効率的開発法の構築と、蛍光性プロゲステロン受容体リガンド開発への応用2010

    • Author(s)
      平野智也,酒井悠,白石拓也,森修一,藤井晋也,棚谷綾,影近弘之
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Development of NovelAndrogen Antagonists Based on Hydrophobic Boron Clusters2010

    • Author(s)
      Fujii, S., Yamada, A., Ohta, K., Endo, Y., Kagechika, H.
    • Organizer
      EFMC-ISMC2010 21^<st> International Symposium on MedicinalChemistry
    • Place of Presentation
      Brussels, Bergium
    • Related Report
      2010 Final Research Report
  • [Presentation] カルボランを疎水性骨格とするビタミンD誘導体とその核内受容体結合様式2010

    • Author(s)
      影近弘之,藤井晋也,増野弘幸,平野智也,伊藤暢聡,伊倉貞吉,棚谷綾
    • Organizer
      第7回中性子捕獲療法学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] カルボランを疎水性骨格とする新規アンドロゲン受容体リガンドの創製2010

    • Author(s)
      藤井晋也,山田歩,太田公規,遠藤泰之,影近弘之
    • Organizer
      第7回中性子捕獲療法学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] VDR活性をもつLCA誘導体の合成とVDR結合構造の解析2010

    • Author(s)
      増野弘幸,数井優子,伊倉貞吉,中林誠,伊藤暢聡,藤井晋也,河内恵美子,棚谷綾,影近弘之
    • Organizer
      ビタミン学会第62回大会
    • Place of Presentation
      岩手
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 変異ARを有するLNCaP細胞に対して有効な新規ARアンタゴニストの創製2010

    • Author(s)
      山田歩,富田景子,長野麻央,藤井晋也,原山尚,太田公規,遠藤泰之,影近弘之
    • Organizer
      ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Development of Novel Synthetic Ligands for Nuclear Receptors2010

    • Author(s)
      Kagechika, H.
    • Organizer
      The 14th International Congress ofEndocrinology(ICE2010)
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Novel Non-seco-Stroid-type Vitamin DDerivatives2010

    • Author(s)
      Kagechika, H.
    • Organizer
      ICE2010 Official Satellite Symposium-Nuclear Receptor and its Frontier-
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Novel Nonsteroidal AndrogenReceptor Ligands Based on Hydrophobic BoronClusters2010

    • Author(s)
      Fujii, S., Ohta, K., Endo, Y., Kagechika, H.
    • Organizer
      ICE2010 Official Satellite Symposium-Nuclear Receptor and its Frontier-
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] 核内受容体を分子標的とした医薬化学研究-レチノイドを中心に2010

    • Author(s)
      影近弘之
    • Organizer
      Metabolic Syndrome Seminar
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Novel Porphyrin Derivatives Based on Steric Properties of Amide Bond2010

    • Author(s)
      Matsumura, M.
    • Organizer
      ISCD-22
    • Place of Presentation
      奈良
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis and Conformational Analysis of Helical Aromatic Multilayered Ureas2010

    • Author(s)
      Kudo, M.
    • Organizer
      ISCD-22
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Novel Androgen Antagonists Based on Hydrophobic Boron Clusters2010

    • Author(s)
      Fujii, S.
    • Organizer
      International Symposium on Medicinal Chemistry
    • Place of Presentation
      Brussels, Begium
    • Related Report
      2010 Annual Research Report
  • [Presentation] 五員環の複素環構造を基盤とした芳香族アミドの立体特性2010

    • Author(s)
      山本紗をり
    • Organizer
      第21回基礎有機化学討論会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 環状トリアミドの二量体形成と結晶多形2010

    • Author(s)
      藤本慎子
    • Organizer
      第21回基礎有機化学討論会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] ビタミンA 新しい構造、機能、そして医薬へ2009

    • Author(s)
      影近弘之
    • Organizer
      第326回脂溶性ビタミン総合研究委員会
    • Place of Presentation
      静岡
    • Year and Date
      2009-12-04
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] ビタミンA新しい構造、機能、そして医薬へ2009

    • Author(s)
      影近弘之
    • Organizer
      第326回脂溶性ビタミン総合研究委員会
    • Place of Presentation
      静岡
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 変異を有するARに対して有効な新規ARアンタゴニストの創製2009

    • Author(s)
      藤井晋也
    • Organizer
      日本レチノイド研究会第20回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Novel Nuclear Receptor Ligands for Cancer Therapy2009

    • Author(s)
      影近弘之
    • Organizer
      TMD-CMU International Symposium
    • Place of Presentation
      東京
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Novel Non-secosteroidal Vitamin D Receptor Ligands Based on Carborane as A Hydrophobic Core Structure2009

    • Author(s)
      Fujii, A., Kano, A., Sekine, R., Kawachi, E., Masuno, H., Hirano, T., Tanatani, A., Kagechika, H.
    • Organizer
      14^<th> Vitamin D Workshop
    • Place of Presentation
      Brugge, Belgium
    • Year and Date
      2009-10-04
    • Related Report
      2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] Crystal Structures of Non-secosteroid Ligands Bound to Vitamin D Nuclear Receptor2009

    • Author(s)
      Hiroyuki Masuno
    • Organizer
      14^<th> Vitamin D Workshop
    • Place of Presentation
      Brugge, Belgium
    • Year and Date
      2009-10-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] カルボランを疎水性骨格とする新規核内受容体リガンドの創製2009

    • Author(s)
      藤井晋也
    • Organizer
      第120回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] リガンド分子への蛍光ラベル化を志向した、近赤外光励起が可能な蛍光団の開発2009

    • Author(s)
      平野智也
    • Organizer
      ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ビタミンD活性を有するリトコール酸誘導体の創製2009

    • Author(s)
      数井優子
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] IO-Vertex カルボランを用いたアンドロゲン受容体リガンドの創製2009

    • Author(s)
      藤井晋也
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多様な誘導体展開を志向した Riccardin C の全合成2009

    • Author(s)
      岩下真純
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変異ARに対して有効なカルボラン含有新規ARアンタゴニストの創製2009

    • Author(s)
      山田歩,富田景子,長野麻央,藤井晋也,原山尚,太田公規,遠藤泰之,影近弘之
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] カルボランを疎水性骨格とする新規非ステロイド型VDRリガンドの構造展開2009

    • Author(s)
      藤井晋也,加納敦,平野智也,河内恵美子,増野弘幸,棚谷綾,中林誠,伊倉貞吉,伊藤暢聡,清水正人,影近弘之
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Development ofNovel Non-secosteroidal Vitamin DReceptor Ligands Based on Carborane as AHydrophobic Core Structure2009

    • Author(s)
      Fujii, S., Kano, A., Sekine, R., Kawachi, E., Masuno, H., Hirano, T., Tanatani, A., Kagechika, H.
    • Organizer
      14th Vitamin D Workshop
    • Place of Presentation
      Brugge, Belgium
    • Related Report
      2010 Final Research Report
  • [Presentation] Crystal Structures of Non-secosteroidLigands Bound to Vitamin D NuclearReceptor2009

    • Author(s)
      Masuno, H., Fujii, S., Nakabayashi, M., Ikura, T., Ito, N., Shimizu, M., Kagechika, H.
    • Organizer
      14th Vitamin D Workshop
    • Place of Presentation
      Brugge, Belgium
    • Related Report
      2010 Final Research Report
  • [Presentation] Tricarbocyanine系蛍光物質の会合現象制御による蛍光センサーの開発2009

    • Author(s)
      平野智也,秋山淳,影近弘之
    • Organizer
      第24回生体機能関連化学シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Development of a novel "functional" fluorescent labeling reagents for variousligand molecules2009

    • Author(s)
      Hirano, T., Akiyama, J., Kagechika, H.
    • Organizer
      World Molecular ImagingCongress
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規非セコステロイド型VDRリガンドの構造展開と受容体結合様式の解析2009

    • Author(s)
      藤井晋也,加納敦,平野智也,河内恵美子,増野弘幸,棚谷綾,中林誠,伊倉貞吉,伊藤暢聡,清水正人,影近弘之
    • Organizer
      ビタミン学会第61回大会
    • Place of Presentation
      亀岡
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Development of a novel"functional"fluorescent labeling reagents for various ligand molecules2009

    • Author(s)
      平野智也
    • Organizer
      World Molecular Imaging Congress
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多様な誘導体展開を志向したRiccardin Cの全合成と誘導体創製2008

    • Author(s)
      岩下真純
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Androgen receptor antagonists based on boron cluster as a hydrophobic core structure2008

    • Author(s)
      Shinya Fujii
    • Organizer
      XIII IMEBORON
    • Place of Presentation
      Spain
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel non-seco-steroidal VDR ligands bearing a carborane as a hydrophobic pharmacophore2008

    • Author(s)
      Hiroyuki Kagechika
    • Organizer
      XIII IMEBORON
    • Place of Presentation
      Spain
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] レチノイド : 活性ビタミンAの医薬展開2008

    • Author(s)
      影近弘之
    • Organizer
      第386回国際治療談話会例会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-18
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 近赤外光で励起可能な新規環境応答型蛍光センサーの開発2008

    • Author(s)
      秋山淳
    • Organizer
      日本分析化学会第57年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of Riccardin C analogs as novel LXR ligands2008

    • Author(s)
      Masazumi Iwashita
    • Organizer
      236^<th> ACS National Meeting
    • Place of Presentation
      Pjiladelphia, USA
    • Year and Date
      2008-08-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] カルボラン含有ビタミンD誘導体の創製とVDR結合様式2008

    • Author(s)
      影近弘之
    • Organizer
      第320回脂溶性ビタミン総合研究委員会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel synthetic RAR- and RXR-selective agonists bearing a unique structure in the hydrophobic part2008

    • Author(s)
      Hiroyuki Kagechika
    • Organizer
      FASEB meeting on Retinoid
    • Place of Presentation
      New Haven, CT, USA
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel synthetic RAR- and RXR-selective agonists bearing a unique structure in the hydrophobic part2008

    • Author(s)
      Kagechika, H., Muratake, H., Amano, Y., Noguchi, M., Shudo. K.
    • Organizer
      FASEB meeting on Retinoid
    • Year and Date
      2008-06-15
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] カルボランを疎水性ファーマコフォアとする新規non-seco型VDRリガンドの創製と受容体結合様式の解析2008

    • Author(s)
      藤井晋也
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novelnon-seco-steroidal VDR ligands bearing acarborane as a hydrophobic pharmacophore2008

    • Author(s)
      Kagechika H, Kano A, Fujii S, Hirano T, Kawachi E, Tanatani A
    • Organizer
      XIII IMEBORON
    • Place of Presentation
      Spain
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Novel Inhibitors of Histone Methyltransferase2008

    • Author(s)
      Hirano T, Hoshino K, Iwanami N, TanakaY, Kagechika H
    • Organizer
      236th ACS National Meeting
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel synthetic RAR and RXR-selective agonists bearing aunique structure in the hydrophobic part2008

    • Author(s)
      Kagechika H, Muratake H, Amano Y, Noguchi M, Shudo K
    • Organizer
      FASEB meeting on Retinoid
    • Place of Presentation
      New Haven, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel VDR agonists bearing carborane : Synthesis, biological activity and VDR binding structure2008

    • Author(s)
      Hiroyuki Masuno
    • Organizer
      CBI Annual Meeting 2008
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synthetic Retinoids: Biological Functions and Clinical Utilities2007

    • Author(s)
      影近 弘之
    • Organizer
      第4回武田科学振興財団薬科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Book] Expert Opinion(Thyromimetics : a review of recent reports and patents (2004-2009))2010

    • Author(s)
      Hirano, T., Kagechika, H.
    • Related Report
      2009 Self-evaluation Report
  • [Book] Constructionof Coumarin Library for Development of Fluorescent Sensors, In' Combinatorialmethodologies for development of chemicaland biological sensors' Ed2009

    • Author(s)
      Hirano, T.; Kagechika, H.
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] フォルダマー、In超分子サイエンス & テクノロジー基礎からイノベーションまで(国武豊喜監修)第3章、第1節2009

    • Author(s)
      影近弘之、棚谷綾
    • Publisher
      NTS
    • Related Report
      2010 Final Research Report
  • [Book] Combinatorial methodologies for development of chemical and biological sensors(Ed. by Potyrailo, R. A. ; Mirsky, V. M., Construction of Coumarin Library for Development of Fluorescent Sensors, Chapter 18)2009

    • Author(s)
      Hirano, T., Kagechika, H.
    • Publisher
      Springer
    • Related Report
      2009 Self-evaluation Report
  • [Book] フォルダマー、In超分子サイエンス&テクノロジー-基礎からイノベーションまで(国武豊喜監修)第3章、第1節、pp 467-4762009

    • Author(s)
      影近弘之
    • Total Pages
      10
    • Publisher
      NTS
    • Related Report
      2009 Annual Research Report
  • [Book] Construction of Coumarin Library for Development of Fluorescent Sensors, In'Combinatorial methodologies for development of chemical and biological sensors'Ed. by Potyrailo, R.A.; Mirsky, V.M. Chapter 18, pp 441-4512009

    • Author(s)
      Hirano, T.
    • Total Pages
      11
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] NuclearReceptor Drug Discovery in Gene Family Based Molecular Design, Edited by KarenLackey2008

    • Author(s)
      Kagechika, H.; Tanatani, A.
    • Publisher
      Wiley-Interscience
    • Related Report
      2010 Final Research Report
  • [Book] Gene Family Based Molecular Design(Edited by Karen Lackey., Nuclear Receptor Drug Discovery, Chapter 9)2008

    • Author(s)
      Kagechika, H., Tanatani, A.
    • Publisher
      Wiley-Interscience
    • Related Report
      2009 Self-evaluation Report
  • [Book] Nuclear Receptor Drug Discovery in Gene Family Based Molecular Design, Edited by Karen Lackey. Chapter 92008

    • Author(s)
      Hiroyuki Kagechika
    • Total Pages
      40
    • Publisher
      Wiley-Interscience
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] PRアンタゴニスト活性を有するクマリン誘導体2010

    • Inventor(s)
      棚谷綾、酒井悠、影近弘之、平野智也
    • Industrial Property Rights Holder
      お茶の水女子大学、東京医科歯科大学
    • Filing Date
      2010-02-26
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] PRアンタゴニスト活性を有するクマリン誘導体2010

    • Inventor(s)
      棚谷綾, 酒井悠, 影近弘之, 平野智也
    • Industrial Property Rights Holder
      お茶の水女子大学、東京医科歯科大学
    • Industrial Property Number
      2010-043034
    • Filing Date
      2010-02-26
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] レチノイドXレセプター機能調節剤2010

    • Inventor(s)
      棚谷綾, 他3名
    • Industrial Property Rights Holder
      お茶の水女子大学・東京医科歯科大学
    • Industrial Property Number
      2010-043034
    • Filing Date
      2010-02-26
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] レチノイドXレセプター機能調節剤2009

    • Inventor(s)
      影近弘之
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2009-03-03
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] レチノイドXレセプター機能調節剤2009

    • Inventor(s)
      影近弘之
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2009-004977
    • Filing Date
      2009-03-03
    • Related Report
      2009 Self-evaluation Report

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Published: 2007-04-01   Modified: 2016-04-21  

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