Molecular basis of autophagy as a cellular survival strategy

• Project/Area Number: 19207015
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: YOSHIMORI Tamotsu Osaka University, 大学院・生命機能研究科, 教授 (60191649)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000); Fiscal Year 2010: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2009: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000); Fiscal Year 2008: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000); Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: オートファゴソーム / 隔離膜 / 生存維持 / Atg16L / LC3 / 膜の起源 / オートファジー / 生存戦略 / Atgタンパク質 / Atg9 / ゴルジ体 / リソソーム / 膜損傷 / インタラクトーム / 細胞構造・機能 / メンブレントラフィック / 小胞体 / 電子線トモグラフィー / エンドソーム・リソソーム / 膜の損傷 / フォスファチジルエタノールアミン / 脂質化 / Atg4B / SNARE / rab / 病原細菌 / ベクリン複合体

Research Abstract

Eukaryotic cells maintain their life by using autophagy, an intracellular bulk degradation system in the diverse aspects. To understand autophagy as a cellular survival strategy, we achieved molecular dissection of autophagy. In results, we found that Atg16L complex anchors LC3 to the autophagic membrane structure and that LC3 is required for completion of the structure. Furthermore, formation of the structure occurs inside of the special "cradle" derived from the endoplasmic reticulum membranes.

Research Products

• [Journal Article] Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain. (2010)
  • Author(s): Tabata K, Matsunaga K, Sakane A, Sasaki T, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell. 21 Pages: 4162-4172
  • Peer Reviewed
• [Journal Article] Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. (2010)
  • Author(s): Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda T, Yoshimori T.
  • Journal Title: J Cell Biol. 190 Pages: 511-521
  • Peer Reviewed
• [Journal Article] Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy. (2010)
  • Author(s): Taguchi-Atarashi N, Hamasaki M, Matsunaga K, Omori H, Ktistakis NT, Yoshimori T, Noda T.
  • Journal Title: Traffic. 11 Pages: 468-478
  • Peer Reviewed
• [Journal Article] Autophagy requires endoplasmic reticulum targeting of the P13-kinase complex via Atg14L. (2010)
  • Author(s): Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda T, Yoshimori T.
  • Journal Title: J Cell Biol. Volume: 190 Pages: 511-521
  • Peer Reviewed
• [Journal Article] Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain. (2010)
  • Author(s): Tabata K, Matsunaga K, Sakane A, Sasaki T, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell. Volume: 21 Pages: 4162-4172
  • Peer Reviewed
• [Journal Article] Artificial induction of autophagy around polystyrene beads in nonphagocytic cells. (2010)
  • Author(s): Kobayashi S, Kojidani T, Osakada H, Yamamoto A, Yoshimori T, Hiraoka Y, Haraguchi T*.
  • Journal Title: Autophagy. 6 Pages: 36-45
  • Peer Reviewed
• [Journal Article] Modulation of local PtdIns3P levels by the Pl phosphatase MTMR3 regulates constitutive autophagy. (2010)
  • Author(s): Taguchi-Atarashi N, Hamasaki M, Matsunaga K, Omori H, Ktistakis NT, Yoshimori T, Noda T*.
  • Journal Title: Traffic. 11(4) Pages: 468-478
  • Peer Reviewed
• [Journal Article] Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vtilb Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes. (2010)
  • Author(s): Furuta N, Fujita N, Noda T, Yoshimori T, Amano A*.
  • Journal Title: Mol Biol Cell. 21 Pages: 1001-1010
  • Peer Reviewed
• [Journal Article] Autophagosome can support Yersinia pseudotuberculosis replication in macrophages. (2010)
  • Author(s): Moreau K, Lacas-Gervais S, Fujita N, Sebbane F, Yoshimori T, Simonet M, Lafont F*.
  • Journal Title: Cell Microbiol. (Feb 23. [Epub ahead of print])
  • Peer Reviewed
• [Journal Article] An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. (2009)
  • Author(s): Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T.
  • Journal Title: PLoS Pathog. 5
  • Peer Reviewed
• [Journal Article] Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.(§These authors contributed equally to this work.) (2009)
  • Author(s): Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S
  • Journal Title: Proc Natl Acad Sci USA. 106 Pages: 20842-20846
  • Peer Reviewed
• [Journal Article] A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. (2009)
  • Author(s): Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, Yamamoto A.
  • Journal Title: Nat Cell Biol. 11 Pages: 1433-1437
  • Peer Reviewed
• [Journal Article] Differencial involvement of ATG16L1 in Crohn's disease and canonical autophagy : analysis of the organization of the ATG16L1 complex in fibroblasts. (2009)
  • Author(s): Fujita N, Saitoh T, Kageyama S, Akira S, Noda T, Yoshimori T.
  • Journal Title: J Biol Chem. 284 Pages: 32602-32609
  • Peer Reviewed
• [Journal Article] Two Beclin-1 binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. (2009)
  • Author(s): Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda, K, Ichimura I, Isobe T, Akira S, Noda T, Yoshimori T.
  • Journal Title: Nature Cell Biol. 11 Pages: 385-396
  • Peer Reviewed
• [Journal Article] An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7 (2009)
  • Author(s): Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T
  • Journal Title: PLoS Pathog. 5(11)
  • Peer Reviewed
• [Journal Article] A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation (2009)
  • Author(s): Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, Yamamoto A
  • Journal Title: Nat Cell Biol. 11 Pages: 1433-1437
  • Peer Reviewed
• [Journal Article] Two Beclin-1 binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages (2009)
  • Author(s): Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda, K, Ichimura I, Isobe T, Akira S, Noda T, Yoshimori T
  • Journal Title: Nature Cell Biol. 11 Pages: 385-396
  • Peer Reviewed
• [Journal Article] Two Beclin-1 binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. (2009)
  • Author(s): Matsunaga K, Saitoh T, Tahata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura I, Isobe T, Akira S, Noda T, Yoshimori T*.
  • Journal Title: Nature Cell Biol 11 Pages: 385-396
  • Peer Reviewed
• [Journal Article] Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection. (2009)
  • Author(s): Ishida Y, Yamamoto A, Kitamura A, Lamande S, Yoshimori T, Bateman J, Kubota H, Nagata K*.
  • Journal Title: Mol Biol Cell. 20 Pages: 2744-2754
  • Peer Reviewed
• [Journal Article] Differencial involvement of ATG 16Ll in Crohn's disease and canonical autophagy : analysis of the organization of the ATG 16Ll complex in fibroblasts. (2009)
  • Author(s): Fujita N, Saitoh T, Kageyama S, Akira S, Noda T, Yoshimori T*.
  • Journal Title: J Brol Chem. 284 Pages: 32602-21609
  • Peer Reviewed
• [Journal Article] Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway. (2009)
  • Author(s): Taguwa S, Kambara H, Omori H, Tani H, Abe T, Mori Y, Suzuki T, Yoshimori T, Moriishi K, Matsuura Y*.
  • Journal Title: J Virol. 83 Pages: 10427-10436
  • Peer Reviewed
• [Journal Article] Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartments. (2009)
  • Author(s): Furuta N, Tsuda K, Omori H, Yoshimori T, Yoshimura F, Amano A*.
  • Journal Title: Infect Immun. 77 Pages: 4187-4196
  • Peer Reviewed
• [Journal Article] The Stent-Eluting Drugs Sirolimus and Paclitaxel Suppress Healing of the Endothelium by Induction of Autophagy. (2009)
  • Author(s): Hayashi SI, Yamamoto A, You F, Yamashita K, Ikegame Y, Tawada M, Yoshimori T, Shimizu S, Nakashima S*.
  • Journal Title: Am J Pathol. 175 Pages: 2226-2234
  • Peer Reviewed
• [Journal Article] A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. (2009)
  • Author(s): Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimon T*, Yamamoto A*.
  • Journal Title: Nat Cell Biol. 11 Pages: 1433-1437
  • Peer Reviewed
• [Journal Article] Atg9a controls dsDNA-driven dynamic translocation of STING and the ornate immune response. (2009)
  • Author(s): Saitoh T§, Fujita N§, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S*. (§These authors contributed equ|ally to this work. )
  • Journal Title: Proc Natl Acad Sci USA. 106(49) Pages: 20842-20846
  • Peer Reviewed
• [Journal Article] An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. (2009)
  • Author(s): Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T*.
  • Journal Title: PLoS Puthog. 5
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Yoshimori T, Amano A.
  • Journal Title: Curr Top Microbiol Imnunol. 335(Springer) Pages: 217-226
• [Journal Article] Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. (2009)
  • Author(s): Terebiznik MR, Raju D, Vazquez CL, Torbricki K, Kulkarni R, Blanke SR, Yoshimori T, Colombo MI, Jones NL.
  • Journal Title: Autophagy. Apr 19;5(3)(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced L-1beta production.(§These authors contributed equally to this work.) (2008)
  • Author(s): Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, shimori T, Akira S.
  • Journal Title: Nature. 456 Pages: 264-268
  • Peer Reviewed
• [Journal Article] An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure. (2008)
  • Author(s): Fujita N, Hayashi M, Fukumoto H, Omori H, Yamamoto A, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell. 19 Pages: 4651-4659
  • Peer Reviewed
• [Journal Article] Autophagic control of listeria through intracellular innate immune recognition in drosophila. (2008)
  • Author(s): Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T, Kurata S.
  • Journal Title: Nat Immunol. 9 Pages: 908-916
  • Peer Reviewed
• [Journal Article] The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy. (2008)
  • Author(s): Fujita N, Itoh T, Fukuda M, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell. 19 Pages: 2092-2100
  • Peer Reviewed
• [Journal Article] The Atgl6L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy. (2008)
  • Author(s): Fujita N, Itoh T, Fukuda M, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell. 19 Pages: 2092-2100
  • Peer Reviewed
• [Journal Article] Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes. (2008)
  • Author(s): Kimura S, Noda T, Yoshimori T.
  • Journal Title: Cell Struct Funct. 33 Pages: 109-122
  • NAID: 130004137532
  • Peer Reviewed
• [Journal Article] Functional Analysis of α5β1 Integrin and Lipid Rafts in Invasion of Epithelial Cells by Porphyromonas gingivalis using Fluorescent Beads Coated with Bacterial Membrane Vesicle. (2008)
  • Author(s): Tsuda K, Furuta N, Inaba H, Kawai S, Hanada K, Yoshimori T, Amano A.
  • Journal Title: Cell Struct Funct. 33 Pages: 123-132
  • Peer Reviewed
• [Journal Article] Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. (2008)
  • Author(s): Itoh T, Fujita N, Kanno E, Yamamoto A, Yoshimori T, Fukuda M.
  • Journal Title: Mol Biol Cell. 19 Pages: 2916-2925
  • Peer Reviewed
• [Journal Article] Ubc4/5 and c-Cbl Continue to Ubiquitinate EGF Receptor after Internalization to Facilitate Polyubiquitination and Degradation. (2008)
  • Author(s): Umebayashi K, Stenmark H, Yoshimori T.
  • Journal Title: Mol Biol Cell. 19 Pages: 3454-3462
  • Peer Reviewed
• [Journal Article] DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. (2008)
  • Author(s): Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi A.
  • Journal Title: Cell Death Differ. 15 Pages: 1875-1886
  • Peer Reviewed
• [Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 beta production. (2008)
  • Author(s): Saitoh T^*, Fujita N^*, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S. (^*These authors contributed equally to this work. )
  • Journal Title: Nature. 456 Pages: 264-268
  • Peer Reviewed
• [Journal Article] Nucleotide-Dependent Conformational Changes and Assembly of the AAA ATPase SKD1/VPS4B. (2008)
  • Author(s): Inoue M, Kamikubo H, Kataoka M, Kato R, Yoshimori T, Wakatsuki S, Kawasaki M.
  • Journal Title: Traffic. 9 Pages: 2180-2189
  • Peer Reviewed
• [Journal Article] A single amino acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication. (2008)
  • Author(s): Okamoto T, Omori H, Kaname Y, Abe T, Nishimura Y, Suzuki T, Miyamura T, Yoshimori T, Moriishi K, Matsuura Y.
  • Journal Title: J Virol. Jan.23
  • Peer Reviewed
• [Journal Article] Human RME-8 Is Involved in Membrane Trafficking through Early Endosomes. (2008)
  • Author(s): Fujibayashi A, Taguchi T, Misa ki R, Ohtani M, Dohmae N, T akio K, Yamada M, Gu J, Yamakami M, Fukuda M, Waguri S, Uchiyama Y, Yoshimori T, Sekiguchi K.
  • Journal Title: Cell Struct Funct. Feb.6
  • NAID: 130004053865
  • Peer Reviewed
• [Journal Article] GFP-like Proteins Stably Accumulate in Lysosomes. (2008)
  • Author(s): Katayama H, Yamamoto A, Mizushima N, Yoshimori T, Miyawaki A.
  • Journal Title: Cell Struct Funct. Feb.6
  • NAID: 130004053862
  • Peer Reviewed
• [Journal Article] The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy. (2008)
  • Author(s): Fujita N, Itoh T, Fukuda M, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell. (In press)
  • Peer Reviewed
• [Journal Article] Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. (2007)
  • Author(s): Kimura S, Noda T, Yoshimori T.
  • Journal Title: Autophagy. 3 Pages: 452-460
  • Peer Reviewed
• [Journal Article] The anticancer drug imatinib induces cellular autophagy. (2007)
  • Author(s): Ertmer A, Huber V, Gilch S, Yoshimori T, Erfle V, Duyster J, Elsasser HP, Schatzl HM.
  • Journal Title: Leukemia. 21 Pages: 936-942
  • Peer Reviewed
• [Journal Article] Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. (2007)
  • Author(s): Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, Ron D, Yin XM.
  • Journal Title: Am J Pathol. 171 Pages: 513-524
  • Peer Reviewed
• [Journal Article] Role of Hrs in maturation of autophagosomes in mammalian cells. (2007)
  • Author(s): Tamai K, Tanaka N, Nara A, Yamamoto A, Nakagawa I, Yoshimori T, Ueno Y, Shimosegawa T, Sugamura K.
  • Journal Title: Biochem Biophys Res Commun. 360 Pages: 721-727
  • Peer Reviewed
• [Journal Article] The C/EBPbeta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. (2007)
  • Author(s): Uematsu S, Kaisho T, Tanaka T, Matsumoto M, Yamakami M, Omori H, Yamamoto M, Yoshimori T, Akira S.
  • Journal Title: J Immunol. 179 Pages: 5378-5386
  • Peer Reviewed
• [Journal Article] Maturation of fimbria precursor protein by exogenous gingipains in Porphyromonas gingivalis gingipain-null mutant. (2007)
  • Author(s): Kato T, Tsuda T, Omori H, Kato T, Yoshimori T, Amano A.
  • Journal Title: FEMS Microbiol Lett. 273 Pages: 96-102
  • Peer Reviewed
• [Presentation] Membrane Biogenesis in Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 2011 International Symposium on Cell Signaling and Gene Regulation
  • Place of Presentation: National Cheng Kung University, Taiwan, Taiwan(招待講演)
  • Year and Date: 2011-02-19
• [Presentation] 細胞の守護者・オートファジー:分子機構と疾患との関わり (2011)
  • Author(s): 吉森保
  • Organizer: 第20回癌ゲノムサイエンス研究会
  • Place of Presentation: 東京ガーデンパレス、東京(招待講演)
  • Year and Date: 2011-02-03
• [Presentation] オートファジーにおける膜創生:始まりは何処に (2011)
  • Author(s): 吉森保
  • Organizer: 第6回オートファジー研究会
  • Place of Presentation: ヤマハリゾート「つま恋」掛川、静岡県(招待講演)
  • Year and Date: 2011-01-12
• [Presentation] Mechanistic Insights into Membrane Dynamics in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会BMB2010, Symposium2PS12(大会長企画シンポジウム)"Expanding world of autophagy : from molecular mechanisms to pathophysiological roles"
  • Place of Presentation: 神戸ポートアイランド兵庫県(招待講演)
  • Year and Date: 2010-12-08
• [Presentation] Tuning of Membrane Dynamics in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 1st Sino-Japan Autophagy Symposium
  • Place of Presentation: Shanxi Normal University Xian, China(招待講演)
  • Year and Date: 2010-10-16
• [Presentation] Molecular Insights into Membrane Biogenesis in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 22nd Annual Meeting of the Korean Society for Molecular and Cellular Biology, Symposium 19"Autophagy and Cell Death"
  • Place of Presentation: COEX Center Seoul, Korea(招待講演)
  • Year and Date: 2010-10-08
• [Presentation] 細胞の守護者オートファジー:分子機構と疾患における役割 (2010)
  • Author(s): 吉森保
  • Organizer: 第11回北摂循環器研究会
  • Place of Presentation: 大阪大学医学部附属病院(招待講演)
  • Year and Date: 2010-10-05
• [Presentation] オートファジーの分子機構 (2010)
  • Author(s): 吉森保
  • Organizer: 第69回日本癌学会学術総会・シンポジウムS16"がんとオートファジー"
  • Place of Presentation: 大阪国際会議場(招待講演)
  • Year and Date: 2010-09-23
• [Presentation] Mechanistic Insights into Membrane Dynamics in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 68th Harden Conference "Autophagy : from molecules to disease" in Cirencester
  • Place of Presentation: UK
  • Year and Date: 2010-09-08
• [Presentation] Mechanistic Insights into Membrane Dynamics in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 68th Harden Conference "Autophagy : from molecules to disease"
  • Place of Presentation: Royal Agricultural College Cirencester, UK(招待講演)
  • Year and Date: 2010-09-08
• [Presentation] 細胞内世界を見る:細胞内物流システムを例に (2010)
  • Author(s): 吉森保
  • Organizer: 第13回画像の認識・理解シンポジウムMIRU2010サテライトワークショップ「細胞内画像処理」
  • Place of Presentation: 釧路市観光国際交流センター、北海道(招待講演)
  • Year and Date: 2010-07-26
• [Presentation] 細胞の守護者オートファジー:その分子機構と生理機能 (2010)
  • Author(s): 吉森保
  • Organizer: 日本がん分子標的治療学会第14回学術集会Year in Review
  • Place of Presentation: タワーホール船堀東京(招待講演)
  • Year and Date: 2010-07-07
• [Presentation] 疾患に対抗する細胞機能オートファジー:分子機構、制御、生理機能 (2010)
  • Author(s): 吉森保
  • Organizer: 第6回自己免疫疾患研究会
  • Place of Presentation: 東海大学校友会館、東京(招待講演)
  • Year and Date: 2010-07-03
• [Presentation] Mechanistic insight into membrane dynamics of mammalian autophagy, Gordon Research Conference (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Autophagy In Stress, Development And Disease in Lucca
  • Place of Presentation: Italy
  • Year and Date: 2010-04-27
• [Presentation] Mechanistic insight into membrane dynamics of mammalian autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference "Autophagy In Stress, Development And Disease"
  • Place of Presentation: Il Ciocco Hotel and Resort Lucca, Italy(招待講演)
  • Year and Date: 2010-04-27
• [Presentation] Autophagy : Intracellular Self-Degradation System Fighting with Diseases (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: International Symposium on Organelle Network : Interface among Infection-Immunity, Cell Biology and Glycobiology
  • Place of Presentation: Senri Life Science Center Osaka(招待講演)
  • Year and Date: 2010-04-12
• [Presentation] Binding Rubicon to Cross the Rubicon, EMBO Conference Series on Autophagy : Cell Biology (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Physiology & Pathology in Ascona
  • Place of Presentation: Switzerland
  • Year and Date: 2009-10-19
• [Presentation] Mechanistic Insight into Membrane Dynamics in Mammalian Autophagy, Gordon Research Conference (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Molecular Membrane Biology in Andover
  • Place of Presentation: NH, USA
  • Year and Date: 2009-07-08
• [Presentation] 分解系ロジスティクスの疾患における役割と作動機構 (2009)
  • Author(s): 吉森 保
  • Organizer: 特定領域研究「トラフィック」終了・新学術領域研究「ロジスティクス」発足合同シンポジウム
  • Place of Presentation: 航空会館(東京)
  • Year and Date: 2009-01-29
• [Presentation] Binding Rubicon to Cross the Rubicon EMBO Conference on : Autophagy, Cell Biology (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Physiology and Pathology Monte Verita
  • Place of Presentation: Ascona, Switzerland
• [Presentation] Tuning Autophagy and Heterophagy (2009)
  • Author(s): 吉森保
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Mechanistic Insight into Membrane Dynamics in Mammalian Autophagy (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference Molecular Membrane Biology
  • Place of Presentation: Proctor Academy, Andaver, NH, USA
• [Presentation] Autophagy : Molecular Machinery and Roles in Diseases (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 7th CBD (ARC Centre of Excellence in Biotechnology & Development) Scientific Meeting
  • Place of Presentation: The Country Place Retreat, Kalorama, Victoria, Australia
• [Presentation] Beclinl Complexes, Salmonella, and Atg16L (2009)
  • Author(s): 吉森保
  • Organizer: 5th International Symposium on Autophagy
  • Place of Presentation: 大津プリンスホテル
• [Presentation] Binding Rubicon to Cross the Rubicon (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference on : Autophagy, Cell Biology, Physiology and Pathology
  • Place of Presentation: Monte Verity, Ascona, Switzerland
• [Presentation] Membrane Biogenesis and Regulatory Mechanisms in Autophagy (2009)
  • Author(s): 吉森保
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 細胞内自己消化システム・オートファジーによる生体防御 (2008)
  • Author(s): 吉森 保
  • Organizer: 日本細菌学会関東支部総会特別講演
  • Place of Presentation: 生命の森リゾート(千葉)
  • Year and Date: 2008-10-24
• [Presentation] Where they come from?: Mechanistic insight into autophagosome formation in mammals, Gordon Research Conference (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Autophagy In Stress, Development And Disease in Ventura
  • Place of Presentation: CA, USA
  • Year and Date: 2008-01-06
• [Presentation] Where they come from? : Mechanistic insight into autophagosome formation in mammals (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference "Autophagy In Stress, Development And Disease" Ventura
  • Place of Presentation: CA, USA
• [Presentation] Autophagy : Molecular Machinery and Role in Cellular Defense (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Korean Society of Medical Biochemistry and Molecular Biology Annual International Conference : In Commemoration of the 60th KSMBMB Anniversary, Symposium SY17 : Autophagy and Human Diseases
  • Place of Presentation: Seoul, Korea
• [Presentation] Mechanistic Insight into Membrane Dynamics in Mammalian Autophagy (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Center for the Study of Inflammatory Bowel Disease 18th Annual Workshop on Autophagy in Immunity
  • Place of Presentation: Boston, USA
• [Presentation] Molecular Machinery of Autophagy and Its Role in Diseases (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 11th Western Pacific Cingress on Chemotherapy and Infectious Diseases, Symposium 9 : Invasive Group A Streptococcal Infections
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Autophagy as a Cellular Defense System against Pathogens and Unfolding Proteins (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: BMB2008 (第31回日本分子生物学会年会・第81回日本生化学会大会合同大会) Symposium 3S3 : Intracellular Logistics : Approach to Pathophysiology of Membrane Traffic
  • Place of Presentation: 神戸ポーピアホテル
• [Presentation] Where they come from?: Mechanistic insight into autophagosome formation in mammals (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference "Autophagy In Stress, Development And Disease"
  • Place of Presentation: Ventura, CA, USA
• [Presentation] Autophagy as A Cellular Defense System (2007)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 2007 International RIMD-CVRDC Joint Symposium
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2007-12-18
• [Presentation] たんぱく質と膜が造る細胞内物流システム (2007)
  • Author(s): 吉森 保
  • Organizer: 科学技術振興機構戦略的創造研究推進事業(CREST)研究領域「たんぱく質の構造・機能と発現メカニズム」平成14年度採択課題終了シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-11-15
• [Presentation] オートファジー:分子機構と疾患における役割 (2007)
  • Author(s): 吉森 保
  • Organizer: 大阪大学21世紀COE「疾患関連糖鎖・タンパク質の統合的機能解析」若手セミナー
  • Place of Presentation: 大阪大学医学部
  • Year and Date: 2007-10-24
• [Presentation] オートファジー:生体防御にも働く細胞内自己消化システム (2007)
  • Author(s): 吉森 保
  • Organizer: 家畜DNA西郷シンポジウム
  • Place of Presentation: 福島県西白河郡
  • Year and Date: 2007-10-02
• [Presentation] 生体防御機構としてのオートファジー:細菌感染とフォールディング病 (2007)
  • Author(s): 吉森 保
  • Organizer: 文科省科研費特定領域研究「タンパク質分解による細胞・個体機能の制御」公開シンポジウム「オートファジー:病態に迫る!」
  • Place of Presentation: 東京
  • Year and Date: 2007-09-22
• [Presentation] Autophagy: new insights into its molecular machinery and functions (2007)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The invited seminar in Institute of Molecular and Cell Biology
  • Place of Presentation: Singapore
  • Year and Date: 2007-09-12
• [Presentation] 生体防御とオートファジー (2007)
  • Author(s): 吉森 保
  • Organizer: 第18回日本生体防御学会学術総会特別講演
  • Place of Presentation: 福岡
  • Year and Date: 2007-07-26
• [Presentation] ベールを脱ぐオートファジー:生体防御にも働く細胞内自己消化システム (2007)
  • Author(s): 吉森 保
  • Organizer: 熊本大学大学院医学教育部セミナー
  • Place of Presentation: 熊本大学大学院医学教育部
  • Year and Date: 2007-07-04
• [Presentation] New insight into Molecular Mechanisms of the Canonical and Specialized Autophagy Keystone Symposia on (2007)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Autophagy in Health and Disease in Monterey
  • Place of Presentation: California, U.S.A.
  • Year and Date: 2007-04-15
• [Presentation] New insight into Molecular Mechanisms of the Canonical and Specialized Autophagy (2007)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Keystone Symposia on "Autophagy in Health and Disease"
  • Place of Presentation: Monterey, California, U.S.A.
• [Presentation] Autophagy as a cellular guardian against bacteria and aggregate-prone proteins (2007)
  • Author(s): Tamotsu Yoshimori
  • Organizer: ELSO conference 2007, Subgroup meeting one-Autophagy
  • Place of Presentation: Dresden, Germany
• [Presentation] Autophagy: Molecular Machinery and Role in Cellular Defense (2007)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 20th Naito Conference on "Innate Immunity in Medicine and Biology III"
  • Place of Presentation: Kanagawa, Japan
• [Presentation] Membrane Dynamics and Cellular Defense Function of Autophagy (2007)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Internatinal Symposium on Membrane Traffic
  • Place of Presentation: Awajishima, Japan
• [Book] Curr Top Microbiol Immunol.335(Group a streptococcus : a loser in the battle with autophagy.) (2009)
  • Author(s): Yoshimori T, Amano A.
  • Publisher: Springer
• [Book] Methods Enzymol. 452 (2009)
  • Author(s): Kimura S, Fujita N, Noda T, Yoshimori T.
  • Publisher: Academic Press
• [Book] 分子細胞生物学辞典(第2版) (2008)
  • Author(s): 吉森 保
  • Publisher: (株)東京化学同人
• [Book] 生化学辞典(第4版)リソソームへの輸送 (2007)
  • Author(s): 吉森 保
  • Total Pages: 1616
  • Publisher: (株)東京化学同人
• [Remarks] ホームページ等
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/jp/achievement/010/
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/jp/achievement/010/
• [Remarks] ホームページ
  • URL: http://www.saibouseigyo.com/jp/
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/act/act_yoshimori.php
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/act/act_yoshimori.php
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/act/act_yoshimori.php