|Budget Amount *help
¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000)
Fiscal Year 2010: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2009: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2008: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Eukaryotic cells maintain their life by using autophagy, an intracellular bulk degradation system in the diverse aspects. To understand autophagy as a cellular survival strategy, we achieved molecular dissection of autophagy. In results, we found that Atg16L complex anchors LC3 to the autophagic membrane structure and that LC3 is required for completion of the structure. Furthermore, formation of the structure occurs inside of the special "cradle" derived from the endoplasmic reticulum membranes.