Study on the prophylaxis effect of peptides on vascular-related diseases
| Project/Area Number |
19208012
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUI Toshiro Kyushu University, 農学研究院, 准教授 (20238942)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Kiyoshi 九州大学, 農学研究院, 教授 (80038322)
SATO Masao 九州大学, 農学研究院, 准教授 (90294909)
KIMOTO Koichi 東京家政大学, 家政学部, 教授 (60133378)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2007: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
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| Keywords | ペプチド / 高血圧 / 動脈硬化 / LC-MS / MS / 血管機能 / 生活習慣病 / MD |
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| Research Abstract |
The object of this study was to clarify the prophylaxis effect of small peptides on vascular-related diseases. As a result, peptides having basic amino acids could evoke a significant vasorelaxation effect in contracted rat aorta. The effect was closely associated with the reduction of intracellular Ca2+ through a Ca2+ channel. In addition, a 9-wk administration of WH to apo E deficient mice successfully improved a significant atherosclerosis area.
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Report
(4 results)
Research Products
(32 results)
