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Effects of environmental pollutants on cancer in wildlife

Research Project

Project/Area Number 19208028
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Boundary agriculture
Research InstitutionHokkaido University

Principal Investigator

FUJITA Shoichi  Hokkaido University, 名誉教授 (10143314)

Co-Investigator(Kenkyū-buntansha) IKENAKA Yoshinori  北海道大学, 大学院・獣医学研究科, 講師 (40543509)
石塚 真由美  北海道大学, 大学院・獣医学研究科, 准教授 (50332474)
坂本 健太郎  北海道大学, 大学院・獣医学研究科, 講師 (80374627)
Co-Investigator(Renkei-kenkyūsha) ISHIZUKA Mayumi  北海道大学, 大学院・獣医学研究科, 教授 (50332474)
SAKAMOTO Kentaro  北海道大学, 大学院・獣医学研究科, 講師 (80374627)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2010: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2009: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2007: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywords環境汚染 / 野生動物 / プレデター / 化学発癌 / シトクロムP450
Research Abstract

We investigated bioaccumulation levels of environmental chemicals, e.g., carcinogens and pro-carcinogens, in wildlife and elucidated the effects of these environmental toxic compounds. We cloned cytochrome P450 1 subfamilies, arylhydrocarbon receptors and phase II enzymes, which contribute to activation or detoxification of carcinogens and procarcinogens, from bird and mammalian species including rare wildlife, and characterized these molecules. We also reported the molecular evolution of these enzymes and regulation receptors in wildlife.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (71 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (38 results) (of which Peer Reviewed: 38 results) Presentation (30 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens2011

    • Author(s)
      Sasaki N, Matsumoto T, Ikenaka Y, Kazusaka A, Ishizuka M, Fujita S
    • Journal Title

      Pestic Biochem Physiol. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens.2011

    • Author(s)
      Sasaki N., et al.
    • Journal Title

      Pestic Biochem Physiol.

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The CYP1D subfamily of genes in mammals and other vertebrates2010

    • Author(s)
      Kawai YK, Ikenaka Y, Fujita S, Ishizuka M
    • Journal Title

      Mamm Genome. 21(5-6)

      Pages: 320-9

    • NAID

      120003059573

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue2010

    • Author(s)
      Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M
    • Journal Title

      Toxicol.Sci. 116(1)

      Pages: 79-91

    • NAID

      120002834690

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 1A dependent activities in deer, cattle, and horses2010

    • Author(s)
      Darwish WS, Ikenaka Y, Eldaly EA, Ohno M, Sakamoto QK, Fujita S, Ishizuka M
    • Journal Title

      J Vet Med Sci. 72(5)

      Pages: 561-6

    • NAID

      130000149970

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The CYP1D subfamily of genes in mammals and other vertebrates.2010

    • Author(s)
      Kawai YK., et al.
    • Journal Title

      Mamm Genome.

      Volume: 21 Pages: 320-329

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 1A-dependent activities in deer, cattle and horses.2010

    • Author(s)
      Darwish WS., Et al.
    • Journal Title

      J Vet Med Sci.

      Volume: 72 Pages: 561-566

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and Sequence of CYP1A in Camel.2010

    • Author(s)
      Darwish WS, Morshdy AE, Ikenaka Y, Ibrahim ZS, Fujita S, Ishizuka M.
    • Journal Title

      J Vet Med Sci. 72

      Pages: 221-224

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic alkalosis due to feeding chicks in breeding Adelie penguins Pygoscelis adeliae under natural conditions.2010

    • Author(s)
      Sakamoto QK, Sato K, Kato A, Fukui D, Bando G, Naito Y, Habara Y, Ishizuka M, Fujita S.
    • Journal Title

      Physiol Biochem Zool. 83

      Pages: 232-238

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning of novel cytochrome P450 1A genes from nine Japanese amphibian species2009

    • Author(s)
      Nakayama SMM, Tanaka-Ueno T, Sakamoto QK, Fujita S, Ishizuka M
    • Journal Title

      J Vet Med Sci. 71(10)

      Pages: 1407-11

    • NAID

      130000134310

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological features and blood parameters of Weddell seal (Leptonychotes weddellii) mother and pup during breeding season2009

    • Author(s)
      Sakamoto QK, Sato K, Naito Y, Habara Y, Ishizuka M, Fujita S
    • Journal Title

      J Vet Med Sci. 71(3)

      Pages: 341-4

    • NAID

      110007131177

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning of novel cytochrome P450 1A genes from nine Japanese amphibian species2009

    • Author(s)
      Nakayama SMM, Tanaka-Ueno T, Sakamoto QK, Fujita S, Ishizuka M.
    • Journal Title

      J Vet Med Sci. 71(10)

      Pages: 1407-11

    • NAID

      130000134310

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Morphological features and blood parameters of Weddell seal (Leptonychotes weddellii) mother and pup during breeding season2009

    • Author(s)
      Sakamoto QK, Sato K, Naito Y, Habara Y, Ishizuka M, Fujita S.
    • Journal Title

      J Vet Med Sci. 71(3)

      Pages: 341-4

    • NAID

      110007131177

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning of novel cytochrome P450 1A genes from nine Japanese amphibian species.2009

    • Author(s)
      Nakayama SMM, Tanaka-Ueno T, Sakamoto QK, Fujita S, Ishizuka M.
    • Journal Title

      J Vet Med Sci. 71

      Pages: 1407-1411

    • NAID

      130000134310

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of Pleurotus cornucopiae mushroom on carbon tetrachloride-induced hepatotoxicity.2009

    • Author(s)
      El Bohi KM, Hashimoto Y, Muzandu K, Ikenaka Y, Ibrahim ZS, Kazusaka A, Fujita S, Ishizuka M.
    • Journal Title

      Jpn J Vet Res. 57

      Pages: 109-118

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crude cacao Theobroma cacao extract reduces mutagenicity induced by benzo[a]pyrene through inhibition of CYP1A activity in vitro.2009

    • Author(s)
      Ohno M, Sakamoto KQ, Ishizuka M, Fujita S.
    • Journal Title

      Phytother Res. 23

      Pages: 1134-1139

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic bases basis of inter-and intra-strain differences in diazepam p-hydroxylation in rats.2009

    • Author(s)
      Sakai N, Saito K, Sakamoto QK, Ishizuka M, Fujita S.
    • Journal Title

      rug Metab Dispos 37

      Pages: 268-271

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate.2009

    • Author(s)
      Nakano K, Ishizuka M, Sakamoto QK, Fujita S
    • Journal Title

      Biometals 22

      Pages: 345-351

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] dell seal(Leptonychotes weddellii)mother and pup during breeding season.2009

    • Author(s)
      Sakamoto QK, Sato K, Naito Y, Habara Y, Ishizuka M, Fujita S.
    • Journal Title

      J Vet Med Sci. 71

      Pages: 341-344

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological, features and blood parameters of Weddell seal (Leptony chotes weddellii) mothers and pups during the breeding season2009

    • Author(s)
      Sakamoto KQ, Sato K, Naito Y, Habara Y, Ishizuka M, Fujita S.
    • Journal Title

      J Vet Med Sci. 71

      Pages: 341-344

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic basis of inter-and intrastrain differences in diazepam p-hydr oxylation in rats2009

    • Author(s)
      Sakai N, Saito K, Sakamoto KQ, Ishizuka M, Fujita S.
    • Journal Title

      Drug Metab Dispos. 37

      Pages: 268-271

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The induction of cytochrome P450 1A1 by sudan dyes2008

    • Author(s)
      Refat NA, Ibrahim ZS, Moustafa GG, Sakamoto QK, Ishizuka M, Fujita S
    • Journal Title

      J Biochem Mol Toxicol 22(2)

      Pages: 77-84

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The induction of cytochrome P450 1A1 by sudan dyes2008

    • Author(s)
      Refat NA, Ibrahim ZS, Moustafa GG, Sakamoto KQ, Ishizuka M, Fujita S.
    • Journal Title

      J Biochem Mol Toxicol 22(2)

      Pages: 77-84

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Pesticide resistance in wild mammals-mechanisms of anticoagulant resistance in wild rodents2008

    • Author(s)
      Ishizuka M, Tanikawa T, Tanak a KD, Heewon M, Okajima F, Sakamoto KQ, Fujita S.
    • Journal Title

      J Toxicol Sci. 33

      Pages: 283-291

    • NAID

      110006862204

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of male-specific cytochrome P450 by profenofos2008

    • Author(s)
      Moustafa GG, Ibrahim ZS, Ahmed MM, Ghoneim MH, Sakamoto KQ, Ishizuka M, Fujita S.
    • Journal Title

      Jpn J Vet Res. 56

      Pages: 109-118

    • NAID

      120000947265

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of acrylamide in a complex matrix of polyacrylamide solutions treated by heat and ultraviolet light2008

    • Author(s)
      Ishizuka M, Fujioka K, Shibamo to T.
    • Journal Title

      J Agric Food Chem 56

      Pages: 6093-6096

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The induction of cytochrome P450 1A1 by sudan dyes2008

    • Author(s)
      Refat NA, Ibrahim ZS, Moustafa GG, Sakamoto KQ, Ishizuka M, Fujita S.
    • Journal Title

      J Biochem Mol Toxicol. 22

      Pages: 77-84

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adverse birth outcomes associated with maternal smoking and polymor phisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and C YP2E12008

    • Author(s)
      Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R.
    • Journal Title

      Am J Epidemiol. 167

      Pages: 719-726

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotic Furazolidone Induces CYP1A But Not CYP2E1 Subfamily in Rat Liver2008

    • Author(s)
      Sasaki N, Sakai N, Ikenaka Y, Kamiya T, Heewon M, Sakamoto KQ, Ishizuka M, Fujita S
    • Journal Title

      J Vet Med Sci 70

      Pages: 223-226

    • NAID

      110006633666

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Di-(2-ethylhexyl)phthalate suppresses tamoxifen-induced apoptosis in GH3 pituitary cells.2007

    • Author(s)
      Kim HS, Ishizuka M, Kazusaka A, Fujita S.
    • Journal Title

      Arch. Toxicol. 81

      Pages: 27-33

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Using Microarray Analysis to Evaluate Genetic Polymorphisms Involved in the Metabolism of Environmental Chemicals.2007

    • Author(s)
      Ban S, Kondo T, Ishizuka M, Sasaki S, Konishi K, Washino N, Fujita S, Kishi R.
    • Journal Title

      Fukuoka Acta Medica 89

      Pages: 208-214

    • NAID

      120000987163

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated warfarin metabolism in warfarin-resistant roof rats(Rattus rattus)in Tokyo.2007

    • Author(s)
      Ishizuka M, Okajima F, Tanikawa T, Min H, Tanaka KD, Sakamoto KQ, Fujita S.
    • Journal Title

      Drug Metab Dispos 35

      Pages: 62-66

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma pharmacokinetics and CYP3A12-dependent metabolism of c-kit inhibitor imatinib in dogs2007

    • Author(s)
      Ishizuka M, Nagai S, Sakamoto KQ, Fujita S
    • Journal Title

      Xenobiotica 37

      Pages: 503-513

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Testicular toxicity of profenofos in matured male rats2007

    • Author(s)
      Moustafa GG, Ibrahim ZS, Hashimoto Y, Alkelch AM, Sakamoto KQ, Ishizuka M, Fujita S
    • Journal Title

      Arch Toxicol 81

      Pages: 875-881

    • NAID

      120000951584

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue

    • Author(s)
      Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M.
    • Journal Title

      Toxicol. Sci. (in press)

    • NAID

      120002834690

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 1A dependent activities in deer, cattle, and horses

    • Author(s)
      Darwish WS, Ikenaka Y, Eldaly EA, Ohno M, Sakamoto KQ, Fujita S, Ishizuka M.
    • Journal Title

      J Vet Med Sci. (in press)

    • NAID

      130000149970

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue.

    • Author(s)
      Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M.
    • Journal Title

      Toxicol.Sci. (in press)

    • NAID

      120002834690

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 1A dependent activities in deer, cattle, and horses.

    • Author(s)
      Darwish WS, Ikenaka Y, Eldaly EA, Ohno M, Sakamoto KQ, Fujita S, Ishizuka M.
    • Journal Title

      J Vet Med Sci. (in press)

    • NAID

      130000149970

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 野生げっ歯類におけるワルファリン抵抗性機構と遺伝的背景について2010

    • Author(s)
      田中和之, 他8名
    • Organizer
      日本公衆衛生学会(北海道)
    • Place of Presentation
      花びしホテル(函館市)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Environmental Pollution in Zambia : Current status of POPs and heavy metals pollution in wildlife and domestic animals in Zambia2010

    • Author(s)
      Ikenaka Y, Muroya T, Nakayama S, Saentienchai A, Muzaundu K, Choongo K, John Y, Ishizuka M
    • Organizer
      31st Annual Meeting in North America of the Society of Environmental Toxicology and Chemistry (SETAC)
    • Place of Presentation
      Oregon Convention Center, Portland, Oregon, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] 舌に発現する薬物代謝酵素群と変異原物質の代謝機構.2009

    • Author(s)
      滝口真美、Wageh Sobhy、池中良徳、藤田正一、石塚真由美
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      とりぎん文化会館(鳥取県民文化会館)、鳥取市、鳥取県
    • Year and Date
      2009-09-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 鳥類ビタミンKエポキシド還元酵素のワルファリン感受性2009

    • Author(s)
      渡邉研右、田中和之、池中良徳、藤田正一、石塚真由美
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      とりぎん文化会館(鳥取県民文化会館)、鳥取市、鳥取県
    • Year and Date
      2009-09-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ワルファリン抵抗性ドブネズミ及びクマネズミにおける新規抵抗性機構の解明2009

    • Author(s)
      田中和之、春成常仁、谷川力、川上泰、坂本健太郎、藤田正一、石塚真由美
    • Organizer
      第36回日本トキシコロジー学会
    • Place of Presentation
      アイーナ(岩手県民情報交流センター)(盛岡市、岩手県)
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] A possible cause for the inter-species difference in CYP1A expression and activity in ungulates and rat.2009

    • Author(s)
      Wageh Sobhy Abdelrahem, Yoshinori Ikenaka, Kentaro Q Sakamoto, Shoichi Fujita, Mayumi Ishizuka.
    • Organizer
      16^<th> International Conference on Cytochrome P450
    • Place of Presentation
      万国津梁館(名護市、沖縄県)
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of astaxanthin of CYP1A expression and dependent metabolism2009

    • Author(s)
      Marumi Ohno, Wataru Miki, Kentaro Q Sakamoto, Shoichi Fujita, Mayumi Ishizuka
    • Organizer
      16^<th> International Conference on Cytochrome P450
    • Place of Presentation
      万国津梁館(名護市、沖縄県)
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] cDNA cloning and characterization of cytochrome P450 1As form mammalian species.2009

    • Author(s)
      Yusuke Kawai, Hideaki Yamamoto, Kentaro Q Sakamoto, Mami Takiguchi, Shoichi Fujita, Mayumi Ishizuka
    • Organizer
      16^<th> International Conference on Cytochrome P450
    • Place of Presentation
      万国津梁館(名護市、沖縄県)
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Arylhydrocarbon receptor(AhR)の分子生物学的解析によるハヤブサの環境汚染物質の感受性評価2009

    • Author(s)
      藤澤希望、山本秀明、川合佑典、坂本健太郎、藤田正一、石塚真由美
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木県総合文化センター、栃木県自治会館、栃木県
    • Year and Date
      2009-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Arylhydrocarbon receptor (AhR) の分子生物学的解析によるハヤブサの環境汚染物質の感受性評価2009

    • Author(s)
      藤澤希望, 山本秀明, 川合佑典, 坂本健太郎, 藤田正一, 石塚真由美
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木県総合文化センター、栃木県自治会館、栃木県
    • Year and Date
      2009-04-04
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Arylhydrocarbon receptor(AhR)の分子生物学的解析によるハヤブサの環境汚染物質の感受性評価.2009

    • Author(s)
      藤澤希望、山本秀明、川合佑典、坂本健太郎、藤田正一、石塚真由美
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木県総合文化センター、栃木県自治会館(宇都宮市、栃木県)
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 舌に発現するシトクロムP4502009

    • Author(s)
      滝口真美、安東志麻、Wageh Sobhy、大野円実、坂本健太郎、藤田正一、石塚真由美
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木県総合文化センター、栃木県自治会館(宇都宮市、栃木県)
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2つの異なる遺伝子変異がもたらすラットCYP2D依存の薬物代謝活性の系統差及び個体差2008

    • Author(s)
      井紀彰、斎藤愛、坂本健太郎、石塚真由美、藤田正一
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県・熊本市民会館
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mutagenic activation and detoxification of Benzo[a]pyrene by liver of meat producing animals2008

    • Author(s)
      Wageh Sobhy, 石塚真由美, 坂本健太郎, 藤田正一
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      ワールドコンベンション・センター、宮崎県
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] ワルファリン耐性クマネズミにおける耐性機構の解明2008

    • Author(s)
      安東志麻、谷川力、田中和之、坂本健太郎、石塚真由美、藤田正一
    • Organizer
      日本獣医学会
    • Place of Presentation
      宮崎県・ワールドコンベンションセンター・サミット(シーガイア)
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mutagenic activation and detoxification of Benzo[a]pyrene by liver of meat producing animals2008

    • Author(s)
      ワギソブヒ、石塚真由美、坂本健太郎、藤田正一
    • Organizer
      日本獣医学会
    • Place of Presentation
      宮崎県・ワールドコンベンションセンター・サミット(シーガイア)
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mechanism of low expression of CYP2D2 mRNA in Dark Agouti rats2008

    • Author(s)
      酒井紀彰、坂本健太郎、石塚真由美、藤田正一
    • Organizer
      17^<th> International symposium on microsomes and drug oxidations
    • Place of Presentation
      Saratoga Spring, USA
    • Year and Date
      2008-07-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of phase II metabolizing enzymes in decreasing the mutagenic activity of Ungulates microsomes2008

    • Author(s)
      Wageh Sobhy, 石塚真由美, 坂本健太郎, 藤田正一
    • Organizer
      第35回日本トキシコロジー学会学術年会
    • Place of Presentation
      国立オリンピック記念青少年総合センター、東京都
    • Year and Date
      2008-06-27
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] Role of phase II metabolizing enzymes in decreasing the mutagenic activity of Ungulates microsomes2008

    • Author(s)
      ワギソブヒ、石塚真由美、坂本健太郎、藤田正一
    • Organizer
      日本トキシコロジー学会
    • Place of Presentation
      東京都・国立オリンピック記念青少年総合センター
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characterization of Cytochrome P450 CYP1A in Ungulates2008

    • Author(s)
      Wageh Sobhy, 石塚真由美, 坂本健太郎, 藤田正一
    • Organizer
      The First Egypt-Japan International Symposium on Science and Technology
    • Place of Presentation
      早稲田大学、東京都
    • Year and Date
      2008-06-08
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] ラットにおけるCYP2D2,2D3依存の薬物代謝酵素活性の系統差及び個体差〜2つの異なる遺伝子変異の影響〜2008

    • Author(s)
      酒井紀彰, 斉藤 愛, 坂本健太郎, 石塚真由美, 藤田正一
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      神奈川県相模原市(麻生大学)
    • Related Report
      2007 Annual Research Report
  • [Presentation] カカオマス製品の粗抽出液の抗変異原作用2008

    • Author(s)
      大野円実, 坂本健太郎, 石塚真由美, 藤田正一
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      神奈川県相模原市(麻生大学)
    • Related Report
      2007 Annual Research Report
  • [Presentation] ワルファリン耐性ドブネズミにおける耐性機構の解明2008

    • Author(s)
      田中和之, 谷川 力, 石塚真由美, 坂本健太郎, 藤田正一
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      神奈川県相模原市(麻生大学)
    • Related Report
      2007 Annual Research Report
  • [Presentation] Environmental impact of persistent toxic substances on wildlife2007

    • Author(s)
      藤田正一, 坂本健太郎, 石塚真由美
    • Organizer
      13th International Symposium on Toxicity Assessment
    • Place of Presentation
      富山県民会館、富山県
    • Year and Date
      2007-08-21
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] 両生類、特に有尾類アカハライモリを中心としたCYP 1Aのcharacterization2007

    • Author(s)
      中山翔太、石塚真由美、田中 上野寛子、坂本健太郎、藤田正一
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      北海道江別市(酪農学園大学)
    • Related Report
      2007 Annual Research Report
  • [Presentation] Characterization of cytochrome P450 1A in Ungulates2007

    • Author(s)
      Sobhy Wageh、石塚真由美、Zein Shaban Ibrahim、坂本健太郎、藤田正一
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      北海道江別市(酪農学園大学)
    • Related Report
      2007 Annual Research Report
  • [Presentation] Environmental impact of persistent toxic substances on wildlife2007

    • Author(s)
      Fujita S, Sakamoto K, Ishizu ka M
    • Organizer
      13th INTERNATIONAL SYMPOSIUM ON TOXICITYASSESSMENT
    • Place of Presentation
      Toyama city (Toyama Pre fectural Hall)
    • Related Report
      2007 Annual Research Report
  • [Presentation] ワルファリン耐性ドブネズミ及びクマネズミにおける新規耐性機構の解明2007

    • Author(s)
      田中 和之, 谷川 力, 石塚 真由美, 坂本 健太郎, 藤田 正一
    • Organizer
      第34回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京都江戸川区(タワーホール船堀)
    • Related Report
      2007 Annual Research Report
  • [Presentation] 野生動物のCYP1Aサブファミリーの種差とキャラクタライゼーション2007

    • Author(s)
      川合 佑典, 石塚 真由美, 山本 秀明, 坂本 健太郎, 藤田 正一
    • Organizer
      第34回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京都江戸川区(タワーホール船堀)
    • Related Report
      2007 Annual Research Report
  • [Presentation] 野生生物のシトクロムP450と汚染環境への適応機構に関する研究2007

    • Author(s)
      石塚真由美
    • Organizer
      第34回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京都江戸川区(タワーホール船堀)
    • Related Report
      2007 Annual Research Report
  • [Book] 魚類のP450酵素系、P450の分子生物学 第2版2009

    • Author(s)
      藤田正一, 他
    • Publisher
      講談社サイエンティフィク
    • Related Report
      2010 Final Research Report
  • [Book] P450の分子生物学(魚類のP450酵素系, 第2版、分担執筆)2009

    • Author(s)
      藤田正一, 他
    • Total Pages
      297
    • Publisher
      講談社サイエンティフィク
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 第二相解毒酵素誘導剤2006

    • Inventor(s)
      大和修外
    • Industrial Property Rights Holder
      国立大学法人鹿児島大学
    • Filing Date
      2006-11-01
    • Related Report
      2010 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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