|Budget Amount *help
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2010: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2009: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2007: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
We investigated bioaccumulation levels of environmental chemicals, e.g., carcinogens and pro-carcinogens, in wildlife and elucidated the effects of these environmental toxic compounds. We cloned cytochrome P450 1 subfamilies, arylhydrocarbon receptors and phase II enzymes, which contribute to activation or detoxification of carcinogens and procarcinogens, from bird and mammalian species including rare wildlife, and characterized these molecules. We also reported the molecular evolution of these enzymes and regulation receptors in wildlife.