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Regeneration of intestinal mucosa and molecular mechanism of the failure of intestinal epithelial cells under intestinal inflammation.

Research Project

Project/Area Number 19209027
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

WATANABE Mamoru  Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (10175127)

Co-Investigator(Kenkyū-buntansha) TAKEDA Kiyoshi  大阪大学, 医学系研究科, 教授 (20309446)
HANDA Hiroshi  東京工業大学, 生命理工学研究科, 教授 (80107432)
土屋 輝一郎  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40376786)
永石 宇治  東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教員 (60447464)
深尾 太郎  東京医科歯科大学, 大学院・医歯学総合研究科, メティカルフェロー (20401127)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥49,010,000 (Direct Cost: ¥37,700,000、Indirect Cost: ¥11,310,000)
Fiscal Year 2009: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2008: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2007: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Keywords腸管再生 / Wntシグナル / Notchシグナル / Atoh1 / 炎症性腸疾患 / Wnt / Notch
Research Abstract

Significant results were provided as we showed it in this study as follows.
1) We showed that the up-regulation of Notch signal in inflammatory bowel disease was necessary to promote cell proliferation to maintain mucosal barrier with a sacrifice of differentiation state.
2) We identified Hes1 as the critical gene to suppress the differentiation of intestinal mucosa under the Notch signal stimulation in inflammatory bowel disease, using microarray examination.
3) We showed that Hes1 protein is highly expressed on the chronic inflammation mucosa under the Notch signal up-regulation in inflammatory bowel disease.
4) Hes1 suppress goblet cell differentiation by the repression of Hath1 gene transcription.
5) Hes1 directly binds to the 5' promoter region of Hath1 resulting in the suppression of Hath1 gene expression, using ChIP assay.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (131 results)

All 2010 2009 2008 2007 Other

All Journal Article (101 results) (of which Peer Reviewed: 101 results) Presentation (30 results)

  • [Journal Article] Magneto-optical biosensing platform based on light scattering from self-assembled chains of functionalized rotating magnetic beads2010

    • Author(s)
      Park S.Y, Handa H, Sandhu A
    • Journal Title

      Nano Lett. 10

      Pages: 446-451

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates2010

    • Author(s)
      Masaike Y, Takagi T, Hirota M, Yamada J, Ishihara S, Yung T M C, Inoue T, Sawa C, Sagara H, Sakamoto S, Kabe Y, Takahashi Y, Yamaguchi Y, Handa H
    • Journal Title

      Mol.Pharmacol. 77

      Pages: 262-269

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.2010

    • Author(s)
      Akiyama J, Watanabe M, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia2009

    • Author(s)
      Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M
    • Journal Title

      Am J Physiol GI & Liver 296

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T Cells in chronic colitis2009

    • Author(s)
      Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M
    • Journal Title

      J Immunol. 182

      Pages: 6079-6087

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-Lived colitogenic CD4+ Memory T Cells residing outside the intestine participate in the perpetuation of chronic colitis2009

    • Author(s)
      Nemoto Y, Kanai T, Kameyama K, Shinohara T, Sakamoto N, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sudo T, Matsumoto S, Watanabe M
    • Journal Title

      J Immunol. 183

      Pages: 5059-5068

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Intestinal Th17 cells bysegmented filamentous bacteria2009

    • Author(s)
      Ivanov II, Atarashi K, Manel N, Brodie EL,Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch S V, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR
    • Journal Title

      Cell 139

      Pages: 485-498

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection2009

    • Author(s)
      Kayama H, Koga R, Atarashi K, Mak T W, Takayanagi H, Honda K, Yamamoto M., Takeda K
    • Journal Title

      PLoS Pathogens 5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanisms of immune responses to intestinal bacteria2009

    • Author(s)
      Honda K, Takeda K
    • Journal Title

      Mucosal Immunol 2

      Pages: 187-196

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repression of RNA Polymerase II elongation in vivo is critically dependent on the C-terminus of Spt-52009

    • Author(s)
      Chen H, Contreras X, Yamaguchi Y, Handa H, Peterlin B. M, Guo S
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel applications of affinity beads2009

    • Author(s)
      Kabe Y, Hatakeyama M, Sakamoto S, Nishio K, Handa H
    • Journal Title

      In Protein Targeting with Small Molecules : Chemical Biology Techniques and Applications(ed. Oasda, H)(John Wiley & Sons, Inc, New Jersey)

      Pages: 39-56

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of spherical and uniform-sized ferrite nanoparticles with diameters between 50-150 nm for biomedical applications2009

    • Author(s)
      Tanaka T, Shimazu R, Nagai H, Tada M, Nakagawa T, Sandhu A, Handa H, Abe M
    • Journal Title

      J.Magn.Magn.Mater. 321(10)

      Pages: 1417-1420

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of conophylline affinity nano-beads and identification of target preotein2009

    • Author(s)
      Suzuki E, Ogura H, Kato K, Takei I, Kabe, Y, Handa H, Umezawa K
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 6188-6195

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incorporation of 8-hydroxyguanosine 5'-triphosphate (8-oxo-7,8-dihydroguanosine5'-triphospha te) by bacterial and human RNA polymerases2009

    • Author(s)
      Kamiya H, Suzuki A, Yamaguchi Y, Handa H, Harashima H
    • Journal Title

      Free Radic.Biol.Med. 46

      Pages: 1703-1707

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and medical application of magnetic beads conjugated with bioactive molecules2009

    • Author(s)
      Abe M, Nishio K, Hatakeyama M, Hanyu N, Tanaka T, Tada M, Nakagawa T, Sandhu A, Handa H
    • Journal Title

      J.Magn.Magn.Mater. 321

      Pages: 645-649

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput bioscreening system utilizing high-performance affinity magnetic carriers exhibiting minimal non-specific protein binding2009

    • Author(s)
      Hanyu N, Nishio K, Hatakeyama M, Yasuno H, Tanaka T, Tada M, Nakagawa T, Sandhu A, Abe M, Handa H
    • Journal Title

      J.Magn.Magn.Mater. 321

      Pages: 1625-1627

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of hollow ferrite nanospheres for biomedical applications2009

    • Author(s)
      Tada M, Kanemaru T, Hara T, Nakagawa T, Handa H, Abe M
    • Journal Title

      J.Magn.Magn.Mater. 321

      Pages: 1414-1416

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitorcells : Therapeutic implications in tumor angiogenesis2009

    • Author(s)
      Zou G-M, Karikari C, Kabe Y, Handa H, Anders R. A, Maitra A
    • Journal Title

      J.Cell.Physiol. 219

      Pages: 209-218

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High speed magneto-optical valve : Rapid control of the optical transmittance of aqueous solutions by magnetically induced self-assembly of superparamagnetic particle chains2009

    • Author(s)
      Park S Y, Handa H, Sandhu A
    • Journal Title

      J.Appl.Phys. 105

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High sensitivity and multifunctional micro-Hall sensors fabricated using InAlSb/InAsSb/InAlSb heterostructures2009

    • Author(s)
      Bando M, Ohashi T, Dede M, Akram R, Oral A, Park S Y, Shibasaki I, Handa H, Sandhu A
    • Journal Title

      J.Appl.Phys 105

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Magnetic Nanobeads by Self-Assembly of Superparamagnetic Microbeads for Biosensing2009

    • Author(s)
      Morimoto Y, Abe M, Hatakeyama M, Handa H, Sandhu A
    • Journal Title

      IEEE Transactions on Magnetics 45

      Pages: 2871-2874

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and application of high-performance affinity beads : toward chemical biology and drug discovery2009

    • Author(s)
      Sakamoto S, Kabe Y, Hatakeyama M, Yamaguchi Y, Handa H
    • Journal Title

      Chem.Rec. 9

      Pages: 66-85

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Capsaicin binds to prohibitin 2 and displacesit from the mitochondria to the nuclus2009

    • Author(s)
      Kuramori C, Azuma M, Kume K, Kaneko Y, Inoue A, Yamaguchi Y, Kabe Y, Hosoya T, Kizak M, Suematsu M, Handa H
    • Journal Title

      Biochem.Biophys.Res.Commun. 379

      Pages: 519-525

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteization of a magnetic carrier encapsulating europium and ferrite nanoparticles for biomolecular recognition and imaging2009

    • Author(s)
      Hatakeyama M, Mochizuki Y, Kita H, Kishi K, Nishio S, Sakamoto M, Abe, M., Handa, H.
    • Journal Title

      J.Magn.Magn.Mater. 321

      Pages: 1364-1367

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis2009

    • Author(s)
      Komori K, Inukai N, Yamada T, Yamaguchi Y, Handa H
    • Journal Title

      Genes Cells. 14

      Pages: 343-354

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 17 β-hydroxysteeroid dehydrogenase type 12 in human breast carcinoma : a prognostic factor via potential regulation of fatty acids synthesis2009

    • Author(s)
      Nagasaki S, Suzuki T, Miki Y, Akahira J-I, Kitada K, Ishida T, Handa H, Ohuchi N, Sasano H
    • Journal Title

      Cancer Res. 69

      Pages: 1392-1399

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress2009

    • Author(s)
      Kang J, Gemberling M, Nakamura M, Whitby F G, Handa H, Fairbrother W, Tantin D
    • Journal Title

      Genes Dev. 23

      Pages: 208-222

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signaling pathway via TNFα/NFκB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009

    • Author(s)
      Onizawa M, Watanabe M, et al.
    • Journal Title

      Am J Physiol GI & Liver. 296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009

    • Author(s)
      Okamoto R, Watanabe M, et al.
    • Journal Title

      Am J Physiol GI & Liver. 296

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-Lived colitogenic CD4+ Memory T Cells residing outside the intestine participate in the perpetuation of chronic colitis.2009

    • Author(s)
      Nemoto Y, Watanabe M, et al.
    • Journal Title

      J Immunol. 183

      Pages: 5059-5068

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Musashi-1 suppresses expression of Paneth cell specific genes in human intestinal epithelial cells.2009

    • Author(s)
      Murayama M, Watanabe M, et al.
    • Journal Title

      J Gastroenterol. 44

      Pages: 173-182

    • NAID

      10025173646

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T Cells in chronic colitis.2009

    • Author(s)
      Totsuka T, Watanabe M, et al.
    • Journal Title

      J Immunol. 182

      Pages: 6079-3087

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4+ memory T cells in chronic colitis.2009

    • Author(s)
      Tomita T, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 39

      Pages: 2737-2747

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signaling pathway via TNFα/NFκB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009

    • Author(s)
      Onizawa M, Watanabe M, et al.
    • Journal Title

      Am J Physiol GI & Liver. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative feedback regulation of colitogenic CD4+ T cells by increased granulopolesis.2009

    • Author(s)
      Nemoto Y, Watanabe M, et al.
    • Journal Title

      Inflamm Bowel Dis. 14

      Pages: 1491-1503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion and survival of colitogenic CD4+ T cells in chronic colitis2008

    • Author(s)
      Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M
    • Journal Title

      J Immunol. 180

      Pages: 5291-5299

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis2008

    • Author(s)
      Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M
    • Journal Title

      J Immunol. 180

      Pages: 383-390

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATP drives lamina propria TH17 cell differentiation2008

    • Author(s)
      Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K
    • Journal Title

      Nature 455

      Pages: 808-812

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of nuclear IkB proteins in the regulation of host immune responses2008

    • Author(s)
      Yamamoto M, Takeda K
    • Journal Title

      J.Infect.Chemother 14

      Pages: 265-269

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkBz2008

    • Author(s)
      Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K
    • Journal Title

      J.Biol.Chem. 283

      Pages: 12468-12477

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids2008

    • Author(s)
      Nakanishi A, Chapellie B., Maekawa N, Hiramoto M, Kuge T, Takahashi R-H, Handa H,Imai T
    • Journal Title

      Virology 379

      Pages: 110-117

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presentation of functional foreign peptides on the surface of SV40 virus-like particles2008

    • Author(s)
      Takahashi R-H, Kanesashi S-N, Inoue T, Enomoto T, Kawano M-A, Tsukamoto H, Takeshita F, Imai T, Ochiya T, Kataoka K, Yamaguchi Y, Handa H
    • Journal Title

      J.Biotechnol. 135

      Pages: 385-392

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenine nucleotide translocator transports haem precursors into mitochondria2008

    • Author(s)
      Azuma M, Kabe Y, Kuramori C, Kondo M, Yamaguchi Y, Handa H
    • Journal Title

      PLoS ONE. 3

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissu-and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by HEXIM12008

    • Author(s)
      Shimizu N, Yoshikawa N, Wada T, Handa H, Sano M, Fukuda K, Suematsu M, Sawai T, Morimoto C, Tanaka H
    • Journal Title

      Mol.Endocrinol. 22

      Pages: 2609-2623

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new APE1/Ref-1-dependent pathway leading to reduction of NF-kB and AP-1, and activation of their DNA-binding activity2008

    • Author(s)
      Ando K, Hirao S, Kabe Y, Ogura Y, Sato I, Yamaguchi Y, Wada T, Handa H
    • Journal Title

      Nucleic Acid Res. 36

      Pages: 4327-4336

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm2008

    • Author(s)
      Hase Y, Tatsuno M, Nishi T, Kataoka K, Kabe Y, Yamaguchi Y, Ozawa N, Natori M, Handa H, Watanabe H
    • Journal Title

      Biochem.Biophys.Res.Commun. 366

      Pages: 66-72

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a chemical screening system using aqueorin-fused protein2008

    • Author(s)
      Suzuki M, Furukawa S, Kuramori C, Sawa, C, Kabe Y, Nakamura M, Sawada J, Yamaguchi Y, Sakamoto S, Inoue, S, Handa H
    • Journal Title

      Biochem.Biophys.Res.Commun. 368

      Pages: 600-605

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of novel magnetic nano-carriers for high-performance affinity purification2008

    • Author(s)
      Nishio K, Masaike Y, Ikeda M, Narimatsu H, Gokon N, Tsubouchi S, Hatakeyama M, Sakamoto S, Hanyu N, Sandhu A, Kawaguchi H, Abe M, Handa H
    • Journal Title

      Colloid and Surface B : Biointerfaces. 64

      Pages: 162-169

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads2008

    • Author(s)
      Yoshida M, Kabe Y, Wada T, Asai A, Handa H
    • Journal Title

      Mol.Pharmacol. 73

      Pages: 987-994

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with minor capsid proteins VP2/32008

    • Author(s)
      Inoue T, Kawano M, Takahashi R, Tsukamoto H, Enomoto T, Imai T, Kataoka K, Handa H
    • Journal Title

      J.Biotechnol. 134

      Pages: 181-192

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of XAB2 complex involved in pre-mRNA splicing, transcription and transcription-coupled repair2008

    • Author(s)
      Kuraoka I, Ito S, Wada T, Hayashida M, Lee L, Saijo M, Nakatsu Y, Matsumoto M, Matsunaga T, Handa H, Qin J, Nakatani Y,Tanaka K
    • Journal Title

      J.Biol.Chem. 283

      Pages: 940-950

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.2008

    • Author(s)
      Fujii F, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 38

      Pages: 3290-3303

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Colitogenic CD4^+ effector-memory T cells actively recirculate in chronic colitic mice.2008

    • Author(s)
      Tomita T, Watanabe M, et al.
    • Journal Title

      Inflamm Bowel Dis. 14

      Pages: 1630-1640

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells.2008

    • Author(s)
      Yoshioka A, Watanabe M, et al.
    • Journal Title

      Cytokine. 44

      Pages: 57-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous generation of colitogenic CD4+ T cells in persistent colitis.2008

    • Author(s)
      Tomita T, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 38

      Pages: 1264-1274

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inducible expression of microRNA-194 is regulated by HNF-1 during intestinal epithelial cell differentiation.2008

    • Author(s)
      Hino K, Watanabe M, et al.
    • Journal Title

      RNA. 14

      Pages: 1433-1442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion and survival of colitogenic CD4+ T cells in chronic colitis.2008

    • Author(s)
      Tomita T, Watanabe M, et al.
    • Journal Title

      J Immunol. 180

      Pages: 5291-5299

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunosenescent colitogenic CD4+ T cells convert to regulatory cells to suppress colitis.2008

    • Author(s)
      Totsuka T, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 38

      Pages: 1275-1286

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008

    • Author(s)
      Aragaki M, Watanabe M, et al.
    • Journal Title

      Biochem Biophys Res Commun. 368

      Pages: 923-929

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.2008

    • Author(s)
      Tomita T, Watanabe M, et al.
    • Journal Title

      J Immunol. 180

      Pages: 383-390

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.2008

    • Author(s)
      Ito Y, Watanabe M, et al.
    • Journal Title

      Am J Physiol GI & Liver. 394

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis.2008

    • Author(s)
      Totsuka T, Watanabe M, et. al.
    • Journal Title

      Eur J Immunol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MyD88-dependent pathway in T Cells directly modulates the expansion of colitogenic CD4+ T Cells in chronic colitisl.2008

    • Author(s)
      Tomita T, Watanabe M, et. al.
    • Journal Title

      J Immunol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteasomal degradation of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008

    • Author(s)
      Aragaki M, Watanabe M, et. al.
    • Journal Title

      Biochem Biophys Res Commun. 368

      Pages: 923-929

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chroniccolitis.2008

    • Author(s)
      Tomita T, Watanabe M, et. al.
    • Journal Title

      J Immunol. 180

      Pages: 383-390

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis2007

    • Author(s)
      Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Takeda K, Watanabe M
    • Journal Title

      Gastroenterology 132

      Pages: 176-189

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-7 is essential for the development and the persistence of chronic colitis2007

    • Author(s)
      Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M
    • Journal Title

      J Immunol. 178

      Pages: 4737-4748

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation2007

    • Author(s)
      Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M
    • Journal Title

      J Immunol. 178

      Pages: 4937-4946

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency2007

    • Author(s)
      Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S
    • Journal Title

      J.Exp.Med. 204

      Pages: 2233-2239

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-42007

    • Author(s)
      Saito Y, Imazeki H, Miura S, Yoshimura T, Okutsu H, Harada Y, Ohwaki T, Nagao O, Kamiya S,Hayashi R, Kodama H, Handa H, Yoshida T,Fukai F
    • Journal Title

      J.Biol.Chem. 282

      Pages: 34929-34937

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila Blimp-1 is a transient transcriptional respressor that controls timing of the ecdysone-induced developmenatal pathway2007

    • Author(s)
      Agawa Y, Sarhan M, Kageyama Y, Akagi K, Takai M, Hashiyama K, Wada T, Handa H, Iwamatsu A, Hirose S, Ueda S
    • Journal Title

      Mol.Cell.Biol. 27

      Pages: 8739-8747

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function2007

    • Author(s)
      Iizumi Y, Sagara H, Kabe Y, Azuma M, Kume K, Ogawa M, Nagai T, Gillespie P G, Sasakawa C, Handa H
    • Journal Title

      Cell Host & Microbe. 2

      Pages: 383-392

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles2007

    • Author(s)
      Tsukamoto H, Kawano M, Inoue T, Enomoto T, Takahashi R, Yokoyama N, Yamamoto N, Imai T, Kataoka K, Yamaguchi Y, Handa H
    • Journal Title

      Genes Cells. 12

      Pages: 1267-1279

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity2007

    • Author(s)
      Yamaguchi Y, Mura T, Chanarat S, Okamoto S, Handa H
    • Journal Title

      Genes Cells. 12

      Pages: 863-875

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation2007

    • Author(s)
      Zhu W, Wada T, Okabe S, Taneda T, Yamaguchi Y, Handa H
    • Journal Title

      Nucleic Acids Res. 35

      Pages: 4064-4075

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of NF-kappaB by elongation factors is determined by core promoter type2007

    • Author(s)
      Amir-Zilberstein L, Ainbinder E, Toube L, Yamaguchi Y, Handa H, Dikstein R
    • Journal Title

      Mol Cell Biol. 27

      Pages: 5246-5259

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS2007

    • Author(s)
      Kuraoka I, Suzuki K, Ito S, Hayashida M, Kwei JS, Ikegami T, Handa H, Nakabeppu Y, Tanaka K.
    • Journal Title

      DNA Repair. 6

      Pages: 841-851

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] NELF interacts with CBC and participates in 3'-end processing of replication-dependent histone mRNAs2007

    • Author(s)
      Narita T, Yung T M C, Yamamoto J Tsuboi Y, Tanabe H, Tanaka K, Yamaguchi Y, Handa H
    • Journal Title

      Mol Cell. 26

      Pages: 349-365

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules2007

    • Author(s)
      Sandhu A, Kumagai Y, Lapicki A,Sakamoto S, Abe A, Handa H
    • Journal Title

      Biosensors and Bioelectronics 22

      Pages: 2115-2120

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP12007

    • Author(s)
      Yokoyama N, Kawano M, Tsukamoto H, Enomoto T, Inoue T, Takahashi R, Nakanishi A, Imai T, Wada T, Handa H
    • Journal Title

      J.Biochem. 141

      Pages: 279-286

    • NAID

      10020101612

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Minor capsid proteins of SV40 are dispensable for nucleocapsid assembly and cell entry, but are required for nuclear entry of the viral genome2007

    • Author(s)
      Nakanishi A, Itoh N, Li P P, Handa H, Liddington R C, Kasamatsu H
    • Journal Title

      J.Virol. 81

      Pages: 3778-3785

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of size controlled (30-100 nm) magnetite nanoparticles for biomedical applications2007

    • Author(s)
      Nishio K, Ikeda M, Gokon N, Tsubouchi S, Narimatsu H, Mochizuki Y, Sakamoto S, Snadhu A, Abe M, Handa H
    • Journal Title

      J.Magn.Magn.Mater. 310

      Pages: 2408-2410

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a chemical substance that is immobilized to ferrite nanoparticles (FP)2007

    • Author(s)
      Nishio K, Gokon N, Hasegawa M, Ogura Y, Ikeda M, Narimatsu H, Tada M, Yamaguchi Y, Sakamoto S, Abe M, Handa H
    • Journal Title

      Colloid and Surface B : Biointerfaces 54

      Pages: 249-253

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adeno-associated virus site-specific integration is regulated by TRP-1852007

    • Author(s)
      Yamamoto N, Suzuki M, Kawano M, Inoue T, Takahashi R, Tsukamoto H, Enomoto T, Yamaguchi Y, Wada T, Handa H
    • Journal Title

      J.Virol. 81

      Pages: 1990-2001

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] hnRNP-U enhances the expression of specific genes by stabilizing mRNA2007

    • Author(s)
      Yugami M, Kabe Y, Yamaguchi Y, Wada T, Handa H
    • Journal Title

      FEBS Lett. 581

      Pages: 1-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.2007

    • Author(s)
      Nemoto Y, Watanabe M, et. al.
    • Journal Title

      Gastroenterology. 132

      Pages: 176-189

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3β in human colon cancer.2007

    • Author(s)
      Tsuchiya K, Watanabe M, et. al.
    • Journal Title

      Gastroenterology. 132

      Pages: 208-220

    • NAID

      40015644487

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracorporeal elimination of TNF-α-producing CD14^<dul>l CD16^+ monocytes in leukocytapheresis therapy for ulcerative colitis2007

    • Author(s)
      Kanai T, Watanabe M, et. al.
    • Journal Title

      Inflamm Bowel Dis. 13

      Pages: 284-290

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-7 is essential for the development and the persistence of chronic colitis.2007

    • Author(s)
      Totsuka T, Watanabe M, et. al.
    • Journal Title

      J Immunol. 178

      Pages: 4737-4748

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal lamina propria retaining CD4+CD25+regulatory T cells is a suppressive site of intestinal inflammation.2007

    • Author(s)
      Makita S, Watanabe M, et. al.
    • Journal Title

      J Immunol. 178

      Pages: 4937-4946

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fatedecision.2007

    • Author(s)
      Nakamura T, Watanabe M, et. al.
    • Journal Title

      J Gastroenterol. 42

      Pages: 705-710

    • NAID

      10019816553

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+T cell-mediated colitis.2007

    • Author(s)
      Ito Y, Watanabe M, et. al.
    • Journal Title

      Am J Physiol GI & Liver. 394

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis.2007

    • Author(s)
      Nakamura T, Watanabe M, et. al.
    • Journal Title

      Digestion. 77

      Pages: 36-41

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3

    • Author(s)
      Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Farve D, Takeda K
    • Journal Title

      J.Exp.Med. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a primary target of thalidomide teratogenicity

    • Author(s)
      Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H
    • Journal Title

      Science (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the testis-specific promoter region in the human pituitary adenylate cyclase-activating polypeptide (PACAP) gene

    • Author(s)
      Tominaga A, Sugawara H, Futagawa T, Inoue K, Sasaki K, Minamino N, Hatakeyama M, Handa H, Miyata A
    • Journal Title

      Genes Cells (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates

    • Author(s)
      Masaike Y, Takagi T, Hirota M, Yamada J, Ishihara S, Yung T.M.C., Inoue T, Sawa, C, Sagara H, Sakamoto S, Kabe Y, Takahashi Y, Yamaguchi Y,Handa H
    • Journal Title

      Mol.Pharmacol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium-bridge Triggers capsid Disassembly in the Cell Entry Process of Simian Virus 40

    • Author(s)
      Kawano M, Xing L, Tsukamoto H, Inoue T, Handa H, Holland R
    • Journal Title

      Biochem.Mol.Biol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DSIF, the Paf1 complex, and Tat-SF1 have non-redundant, cooperative roles in RNA polymerase II elongation

    • Author(s)
      Chen Y, Yamaguchi Y, Tsugeno Y, Yamamoto J, Yamada T, Nakamura M, Hisatake K, Handa H
    • Journal Title

      Genes Dev. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular dynamics of the negative transcription elongation factor NELF

    • Author(s)
      Yung T M.C., Narita T, Komori T, Yamaguchi Y, Handa H
    • Journal Title

      Exp.Cell Res. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis

    • Author(s)
      Kuramori C, Hase Y, Hoshikawa K, Watanabe K, Nishi T, Hishiki T, Soga T, Nashimoto A, Kabe Y, Yamaguchi Y, Watanabe H, Kataoka K, Suematsu M, Handa H
    • Journal Title

      Toxicological Sciences (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 炎症性腸疾患における Notch シグナル異常と分子標的の可能性2009

    • Author(s)
      渡辺守
    • Organizer
      第37回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Related Report
      2009 Final Research Report
  • [Presentation] 「消化器疾患のトピックス」IBD2009

    • Author(s)
      渡辺守
    • Organizer
      第51回日本消化器病学会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-17
    • Related Report
      2009 Final Research Report
  • [Presentation] GSK3 inhibitor induces the intestinal differentiation by the protein stabilization of Atoh12009

    • Author(s)
      Tsuchiya K, Okamoto R, Nakamura T, Watanabe M
    • Organizer
      DDW2009
    • Place of Presentation
      Chicago
    • Year and Date
      2009-06-02
    • Related Report
      2009 Final Research Report
  • [Presentation] GSK3 inhibitor induces the intestinal differentiation by the protein stabilization of Atohl.2009

    • Author(s)
      Tsuchiya K, Watanabe M, et al.
    • Organizer
      DDW2009
    • Place of Presentation
      Chicago
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Notch1 activation promptes goblet cell depletion and expression of PLA2G2A in the inflamed mucosa of ulcerative colitis2009

    • Author(s)
      Okamoto R
    • Organizer
      DDW2009
    • Place of Presentation
      Chicago
    • Year and Date
      2009-06-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Systemic, but not intersinal, IL-7 is essential for the development and persistence of Chronic Colitis2009

    • Author(s)
      Totsuka T
    • Organizer
      DDW2009
    • Place of Presentation
      Chicago
    • Year and Date
      2009-05-31
    • Related Report
      2009 Final Research Report
  • [Presentation] 炎症性腸疾患と発癌2009

    • Author(s)
      渡辺守
    • Organizer
      第106回日本内科学会総会・講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Pathogenesis of Inflammatory Bowel Disease : Current Understanding2009

    • Author(s)
      Watanabe M
    • Organizer
      Asia Pacific Working Group Inaugural Meeting on IBD
    • Place of Presentation
      Chaina
    • Year and Date
      2009-03-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Innate immune responses at the intestinal mucosa2009

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The first CSI/JSI/KAI Joint Symposium on Immunology
    • Place of Presentation
      Shanghai, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Innate immune responses at the intestinal mucosa2009

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The 2009 Fall Conference of the Korean Association of Immunologists
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] ATP from commensal bacteria induces Th17 cell development in the intestine2009

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      Regulation of innate immunity
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] 腸管粘膜に特有の自然免疫系細胞の機能2009

    • Author(s)
      竹田潔
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 自然免疫系の活性制御と免疫疾患(特別講演)2009

    • Author(s)
      竹田潔
    • Organizer
      第51回日本小児血液学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Commensal bacteria-derived ATP mediates development of intestinal Th17 cells2009

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      RCAI-JSI International Symposium on Immunology 2009
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 炎症性腸疾患における粘膜免疫異常と上皮分化・再生障害の接点2008

    • Author(s)
      渡辺守
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 自然免疫系と炎症性腸疾患2008

    • Author(s)
      竹田潔
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 腸内フローラと炎症性腸疾患2008

    • Author(s)
      竹田潔
    • Organizer
      第12回腸内細菌学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Notch signaling suppresses the transcriptional activity of Hath1 Gene, resulting in the undifferentiated form of human intestinal epithelial cells2008

    • Author(s)
      Tsuchiya K, Inoue K, Aragaki M, Okamoto R, Nakamura T, Kanai T, Watanabe M
    • Organizer
      DDW2008
    • Place of Presentation
      San Diego
    • Year and Date
      2008-05-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Notch signaling suppresses the transcriptional activity of Hath1 Gene, resulting in the undifferentiated form of human intestinal epithelial cells.2008

    • Author(s)
      Tsuchiya K, Watanabe M
    • Organizer
      DDW 2008
    • Place of Presentation
      San Diego
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] A mechanism for development of intestinal Th17 cells causing intestinal inflammation2008

    • Author(s)
      Kiyoshi Takeda, Koji Atarashi, Kenya Honda
    • Organizer
      The 7^<th> Sino-Japan Joint Conference for Cancer Research
    • Place of Presentation
      Guangzhou, China
    • Related Report
      2009 Final Research Report
  • [Presentation] NFAT is responsible for TLR-independent innate immune responses to a protozoan parasite2008

    • Author(s)
      Kiyoshi Takeda, Hisako Kayama, Masahiro Yamamoto
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Commensal bacteria-derived ATP mediates Th17 cell development in the intestinal lamina propria (Symposium)2008

    • Author(s)
      Kiyoshi Takeda, Koji Atarashi, Kenya Honda
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Regulation of innate immune responses2007

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The 9^<th> International Colooquium on Paratuberculosis
    • Place of Presentation
      Tsukuba
    • Year and Date
      2007-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Regulation of inflammatory responses by nuclear IkB proteins2007

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      Regulation of inflammatory responses by nuclear IkB proteins
    • Place of Presentation
      Sendai
    • Year and Date
      2007-10-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 自然免疫系による結核感染防御機構2007

    • Author(s)
      竹田潔
    • Organizer
      第60回日本細菌学会九州支部総会
    • Place of Presentation
      長崎
    • Year and Date
      2007-10-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 自然免疫シグナルの制御機構2007

    • Author(s)
      竹田潔
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2007-08-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Stabilization of Atoh1 protein induces Mucin2 gene expression in human coloncancer cells.2007

    • Author(s)
      Tsuchiya K, Watanabe M
    • Organizer
      DDW 2007.
    • Place of Presentation
      Washington, D.C
    • Year and Date
      2007-05-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ulcerative colitis : A disorder of epithelial cell differentiation?2007

    • Author(s)
      渡辺守
    • Organizer
      第93回日本消化器病学会 (4th Joint Meeting of the Japanese Society of Gastroenterology and the American Gastroenterological Association)
    • Place of Presentation
      青森
    • Year and Date
      2007-04-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Emerging issues in inflammatory bowel diseases2007

    • Author(s)
      渡辺守
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Emerging issues in inflammatory bowel diseases.2007

    • Author(s)
      Watanabe M
    • Organizer
      APDW 2007.
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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