Development of probes for the systematic analysis of Alzheimer's disease : establishment of a new diagnostic imaging.
| Project/Area Number |
19209041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
SAJI Hideo Kyoto University, 薬学研究科, 教授 (40115853)
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| Co-Investigator(Kenkyū-buntansha) |
KUGE Yuji 北海道大学, 医学研究科, 教授 (70321958)
FUKUYAMA Hidenao 京都大学, 医学研究科, 教授 (90181297)
ONO Masahiro 京都大学, 薬学研究科, 准教授 (80336180)
KAWASHIMA Hidekazu 京都大学, 医学研究科, 助教 (70359438)
TEMMA Takashi 京都大学, 薬学研究科, 助教 (90378787)
UEDA Masashi 京都大学, 医学研究科, 助教 (40381967)
ISHIZU Koichi 京都大学, 医学研究科, 准教授 (50314224)
IRIE Toshiaki 独立行政法人放射線医学総合研究所, 分子認識研究グループ, 専門業務員 (40160072)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2009: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2008: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2007: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
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| Keywords | アルツハイマー病 / 分子イメージング / 放射線画像診断 / トランスレーショナルリサーチ / 痴呆 / 放射線 / 画像診断 |
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| Research Abstract |
In order to reveal the brain dysfunction of Alzheimer's disease in molecular level, we developed several radiolabeled imaging probes targeting biomolecules which is concerned in neuropathological events on this disease. In vitro and in vivo experiments showed that synthesized probes were available for the early detection, staging and determination of the medication effects of Alzheimer's disease. An innovative clinical diagnostic imaging method for Alzheimer's disease would be established by the utilization of developed molecular imaging probes.
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Report
(4 results)
Research Products
(34 results)
