2009 Fiscal Year Final Research Report
Development of probes for the systematic analysis of Alzheimer's disease : establishment of a new diagnostic imaging.
| Project/Area Number |
19209041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
SAJI Hideo Kyoto University, 薬学研究科, 教授 (40115853)
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| Co-Investigator(Kenkyū-buntansha) |
KUGE Yuji 北海道大学, 医学研究科, 教授 (70321958)
FUKUYAMA Hidenao 京都大学, 医学研究科, 教授 (90181297)
ONO Masahiro 京都大学, 薬学研究科, 准教授 (80336180)
KAWASHIMA Hidekazu 京都大学, 医学研究科, 助教 (70359438)
TEMMA Takashi 京都大学, 薬学研究科, 助教 (90378787)
UEDA Masashi 京都大学, 医学研究科, 助教 (40381967)
ISHIZU Koichi 京都大学, 医学研究科, 准教授 (50314224)
IRIE Toshiaki 独立行政法人放射線医学総合研究所, 分子認識研究グループ, 専門業務員 (40160072)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アルツハイマー病 / 分子イメージング / 放射線画像診断 / トランスレーショナルリサーチ |
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| Research Abstract |
In order to reveal the brain dysfunction of Alzheimer's disease in molecular level, we developed several radiolabeled imaging probes targeting biomolecules which is concerned in neuropathological events on this disease. In vitro and in vivo experiments showed that synthesized probes were available for the early detection, staging and determination of the medication effects of Alzheimer's disease. An innovative clinical diagnostic imaging method for Alzheimer's disease would be established by the utilization of developed molecular imaging probes.
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