Study of the establishment and function of the habenulo-interpeduncular tract

• Project/Area Number: 19300115
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: OKAMOTO Hitoshi The Institute of Physical and Chemical Research, 発生遺伝子制御研究チーム, シニア・チームリーダー (40183769)
• Co-Investigator(Kenkyū-buntansha): AIZAWA Hidenori 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 副チームリーダー (80391837) ; AOKI Tazu 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 研究員 (10425605) ; AGETSUMA Masakazu 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 研究員 (30425607)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 発生 / 発達 / 再生神経科学 / ゼブラフィッシュ / カルシウム感受性蛍光タンパク / トランスジェニック / 能動的回避学習 / 終脳 / 恐怖学習 / すくみ行動 / 手綱核 / 基底核 / 行動解析 / 左右差 / Cre / loxP / カルシウムイメージング / 細胞平面極性

Research Abstract

The habenula is a part of the neural circuit connecting the telencephalic limbic system with the monoaminergic neurons in the brain stem. Taking advantage of the high degree of evolutionary conservation of this neural circuit from fish to human, we have carried out genetic manipulation to inactivate specific subnuclei of the habenula in zebrafish and obtained a clue suggesting that the habenula plays an important role for experience-dependent decision in response to fear by animals.

Research Products

• [Journal Article] Identification of the zebrafish ventral habenula as a homologue of the mammalian lateral habenula. (2010)
  • Author(s): Amo R, Aizawa H, Takahoko M, Kobayashi M, Takahashi R, Aoki T, Okamoto H
  • Journal Title: J. Neuroscience 30 Pages: 1566-1574
  • Peer Reviewed
• [Journal Article] Identification of the zebrafish ventral habenula as a homologue of the mammalian lateral habenula (2010)
  • Author(s): Amo, R., et al.
  • Journal Title: J.Neuroscience 30 Pages: 1556-1574
  • Peer Reviewed
• [Journal Article] Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain (2009)
  • Author(s): Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H
  • Journal Title: Development 136(10) Pages: 1653-1663
  • Peer Reviewed
• [Journal Article] From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish. (2009)
  • Author(s): Miyasaka N, Morimoto K, Tsubokawa T, Higashijima S, Okamoto H, Yoshihara Y
  • Journal Title: J Neurosci 29 Pages: 4756-4767
  • Peer Reviewed
• [Journal Article] From the olfactory bulb to higher brain centers : genetic visualization of secondary olfactory pathways in zebrafish (2009)
  • Author(s): Miyasaka N., et al.
  • Journal Title: J Neurosci. 29 Pages: 4756-4767
  • Peer Reviewed
• [Journal Article] Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hind brain (2009)
  • Author(s): Ohata S., et al.
  • Journal Title: Development 136(10) Pages: 1653-1663
  • Peer Reviewed
• [Journal Article] Roles of planar cell polarity pathway genes for neural migration and differentiation (2009)
  • Author(s): Wada H., et al.
  • Journal Title: Dev Growth Differ 51 Pages: 233-240
  • Peer Reviewed
• [Journal Article] Roles of noncanonical Wnt/PCP pathway genes in neuronal migration and neurulation in zebrafish (2009)
  • Author(s): Wada H., et al.
  • Journal Title: Zebrafish 6 Pages: 3-8
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 浅島誠, 他編
  • Journal Title: 遺伝子と経験が作る神経回路現代生物科学入門第4巻(岩波書店) Pages: 1-67
• [Journal Article] (2009)
  • Author(s): 吉川寛, 他編
  • Journal Title: 研究をささえるモデル生物:実験室いきものガイド(化学同人) Pages: 86-87
• [Journal Article] Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation (2009)
  • Author(s): Carreira-Barbosa F, et al.
  • Journal Title: Development 136 Pages: 383-392
  • Peer Reviewed
• [Journal Article] Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish (2008)
  • Author(s): Okamoto H, Sato T, Aizawa H
  • Journal Title: Develop. Growth Differ 50Suppl1
  • NAID: 10024399828
  • Peer Reviewed
• [Journal Article] An interview with Hitoshi Okamoto (2008)
  • Author(s): Okamoto H
  • Journal Title: M.D., Ph. D. Interview by Stephen C. Ekker. Zebrafish 5 Pages: 155-158
  • Peer Reviewed
• [Journal Article] ゼブラフィッシュを使った情動系神経回路網の可視化と操作, ～手綱核神経投射の左右差の成り立ちとその意味を求めて～ (2008)
  • Author(s): 岡本仁、相沢秀紀、揚妻正和、青木田鶴
  • Journal Title: 蛋白質・核酸・酵素 53(4) Pages: 475-481
• [Journal Article] シリーズ“気になる脳の部位" (2008)
  • Author(s): 岡本仁、相澤秀紀
  • Journal Title: 手綱核先端医学 8(2) Pages: 134-141
• [Journal Article] Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53 (2008)
  • Author(s): Yamaguchi, M., et al.
  • Journal Title: Development 135 Pages: 1247-57
  • Peer Reviewed
• [Journal Article] Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish (2008)
  • Author(s): Okamoto, H., et al.
  • Journal Title: Develop. Growth Differ 50 Pages: 167-75
  • NAID: 10024399828
  • Peer Reviewed
• [Journal Article] Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish (2008)
  • Author(s): Nishiwaki Y, et al.
  • Journal Title: Mech Dev. 125 Pages: 932-946
  • Peer Reviewed
• [Journal Article] An interview with Hitoshi Okamoto, M. D., Ph. D. (2008)
  • Author(s): Okamoto H.
  • Journal Title: Zebrafish 5 Pages: 155-158
• [Journal Article] ゼブラフィッシュを使った情動系神経回路網の可視化と操作,〜手綱核神経投射の左右差の成り立ちとその意味を求めて〜 (2008)
  • Author(s): 岡本 仁
  • Journal Title: 蛋白質・核酸・酵素 (In press)
• [Journal Article] シリーズ"気になる脳の部位":手綱核 (2008)
  • Author(s): 岡本 仁
  • Journal Title: 先端医学 (In press)
• [Journal Article] R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patteming in mouse limb develepment. (2008)
  • Author(s): Aoki, M.,
  • Journal Title: Develop.Growth Differ 50 Pages: 85-95
  • Peer Reviewed
• [Journal Article] Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish (2008)
  • Author(s): Okamoto, H.
  • Journal Title: Develop, Growth Differ. (in press)
  • NAID: 10024399828
  • Peer Reviewed
• [Journal Article] Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53 (2008)
  • Author(s): Yamaguchi, M.,
  • Journal Title: Development (In press)
  • Peer Reviewed
• [Journal Article] emporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures (2007)
  • Author(s): Aizawa H, Goto M, Okamoto H
  • Journal Title: Developmental Cell 12 Pages: 87-98
  • Peer Reviewed
• [Journal Article] Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafish. (2007)
  • Author(s): Sato T, Hamaoka T, Aizawa H, Hosoya T, Okamoto H
  • Journal Title: J Neurosci 27 Pages: 5271-9
  • Peer Reviewed
• [Journal Article] Novel mutations affecting axon guidance in zebrafish and a role for plexin signaling in the guidance of trigeminal and facial nerve axons. (2007)
  • Author(s): Tanaka H, Maeda R, Shoji W, Wada H, Masai I, Shiraki T, Kobayashi M, Nakayama R, Okamoto H
  • Journal Title: Development 134 Pages: 3259-3269
  • Peer Reviewed
• [Journal Article] Yin-yang ways of controlling gene expression are now in our hands. (2007)
  • Author(s): Okamoto H
  • Journal Title: ACS Chem Biol 2 Pages: 646-648
  • Peer Reviewed
• [Journal Article] ゼブラフィッシュを使って明らかになってきた脳の神経回路の左右差 (2007)
  • Author(s): 相澤秀紀、岡本仁
  • Journal Title: Medical Bio 9月号 Pages: 82-88
• [Journal Article] ゼブラフィッシュを使って明らかになってきた脳の神経回路の左右差 (2007)
  • Author(s): 相澤 秀紀、岡本 仁
  • Journal Title: Medical Bio 9 Pages: 82-88
• [Journal Article] Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling inprojections from the posterior tectum to the hindbrain in zebrafish. (2007)
  • Author(s): Sato T
  • Journal Title: J Neurosci. 27 Pages: 5271-9
  • Peer Reviewed
• [Journal Article] Novel mutations affecting axon guidance in zebrafish and a role for plexin signaling in the guidance of trigeminal and facial nerve axons. (2007)
  • Author(s): Tanaka, H
  • Journal Title: Development 134 Pages: 3259-3269
  • Peer Reviewed
• [Journal Article] Yin-yang ways of controlling gene expression are now in our hands. (2007)
  • Author(s): Okamoto H
  • Journal Title: ACS Chem Biol. 2 Pages: 646-648
  • Peer Reviewed
• [Journal Article] Role of Bone morphogenetic protein 4 in zebrafish semicircular canal development. (2007)
  • Author(s): Omata Y
  • Journal Title: Dev Growth Differ. 49 Pages: 711-719
  • Peer Reviewed
• [Presentation] Functional analysis of the habenula in control of fear (2010)
  • Author(s): 岡本仁
  • Organizer: 11th Australian and New Zealand zebrafish workshop
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2010-02-04
• [Presentation] Functional analysis of the habenula in control of fear (2010)
  • Author(s): 岡本仁
  • Organizer: 14th IBRO-APRC associate school of neuroscience "Synaptic plasticity : From basics to clinical applications"
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2010-01-27
• [Presentation] Emotion (2010)
  • Author(s): 岡本仁
  • Organizer: 14th IBRO-APRC associate school of neuroscience "Synaptic plasticity : From basics to clinical applications"
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2010-01-27
• [Presentation] ゼブラフィッシュ研究から見たヒトの心の成り立ち (2010)
  • Author(s): 岡本仁
  • Organizer: 大阪バイオサイエンス研究所 Monthly Lecture
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2010-01-08
• [Presentation] A fish's-eye view of human emotion (2010)
  • Author(s): 岡本仁
  • Organizer: 人間知性研究センター第5回シンポジウム:ヒト以外の知性について話そう
  • Place of Presentation: 東京
• [Presentation] Functional analysis of the habenula in control of fear (2010)
  • Author(s): Okamoto H
  • Organizer: 11th Australian and New Zealand zebrafish workshop Sydney
  • Place of Presentation: Australia
• [Presentation] Functional analysis of the habenula in control of fear (2010)
  • Author(s): Okamoto H
  • Organizer: 14th IBRO-APRC associate school of neuroscience "Synaptic plasticity : From basics to clinical applications"
  • Place of Presentation: Bangkok Thailand
• [Presentation] Emotion (2010)
  • Author(s): Okamoto H
  • Organizer: 14th IBRO-APRC associate school of neuroscience "Synaptic plasticity : From basics to clinical applications"
  • Place of Presentation: Bangkok Thailand
• [Presentation] ゼブラフィッシュ研究から見たヒトの心の成り立ち (2010)
  • Author(s): 岡本仁
  • Organizer: 大阪バイオサイエンス研究所Monthly Lecture
  • Place of Presentation: 吹田
• [Presentation] Zebrafish as a model animal to study neural circuits against fear (2009)
  • Author(s): 岡本仁
  • Organizer: NCF Topical Workshop -Roles of neuroinformatics in the process of building, evaluating and using genetic animal models for brain diseases
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2009-12-13
• [Presentation] 恐怖研究の新しいモデル実験動物としてのゼブラフィッシュ (2009)
  • Author(s): 岡本仁
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2009-12-10
• [Presentation] Zebrafish as a model system for study of fear (2009)
  • Author(s): 岡本仁
  • Organizer: IBRO-APRC Neuroscience associate school : Hormones, Brain and Behaviour
  • Place of Presentation: Bandar Sunway, Malaysia
  • Year and Date: 2009-11-30
• [Presentation] 手綱核:行動と記憶のスイッチボードを求めて (2009)
  • Author(s): 岡本仁
  • Organizer: 千里ライフサイエンスセミナー「次世代の脳研究」
  • Place of Presentation: 千里ライフサイエンスセンタービル5階ライフホール(大阪府)
  • Year and Date: 2009-11-06
• [Presentation] Roles of Mosaic eyes/Crumbs complex in coordination of proliferation with the a pico-basal polarity of the neuroepithelial cells (2009)
  • Author(s): 岡本仁
  • Organizer: Construction and Reconstruction of the Brain
  • Place of Presentation: 淡路(兵庫県)
  • Year and Date: 2009-10-09
• [Presentation] Functional analysis of the habenula in control of fear (2009)
  • Author(s): 岡本仁
  • Organizer: 4th Asia-Oceania zebrafish meeting
  • Place of Presentation: Jeju island, Korea
  • Year and Date: 2009-09-01
• [Presentation] Zebrafish as a model animal to study neural circuits against fear (2009)
  • Author(s): kamoto H
  • Organizer: INCF Topical Workshop on Roles of neuroinformatics in the process of building, evaluating and using genetic animal models for brain diseases Stockholm Sweden
• [Presentation] 恐怖研究の新しいモデル実験動物としてのゼブラフィッシュ (2009)
  • Author(s): 岡本仁
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜日本
• [Presentation] Zebrafish as a model system for study of fear (2009)
  • Author(s): Okamoto H
  • Organizer: IBRO-APRC Neuroscience associate school: Hormones, Brain and Behaviour Bandar Sunway Malaysia
• [Presentation] Roles of Mosaic eyes/Crumbs complex in coordination of proliferation with the apico-basal polarity of the neuroepithelial cells (2009)
  • Author(s): Okamoto H
  • Organizer: Construction and Reconstruction of the Brain Awaji Japan
• [Presentation] 手綱核:行動と記憶のスイッチボードを求めて (2009)
  • Author(s): 岡本仁
  • Organizer: 千里ライフサイエンスセミナー「次世代の脳研究」
  • Place of Presentation: 豊中
• [Presentation] Functional analysis of the habenula in control of fear (2009)
  • Author(s): Okamoto H
  • Organizer: 4th Asia-Oceania zebrafish meeting Jeju island Korea
• [Presentation] Past, present and future of RIKEN BSI (2009)
  • Author(s): Okamoto H
  • Organizer: International Symposium on Brain Science Institute Incheon Korea
• [Presentation] ゼブラフィッシュから分かる, ヒト脳の発生と機能 (2009)
  • Author(s): 岡本仁
  • Organizer: 日本動物学会関東支部第61回大会シンポジウム「モデル動物を使った脳科学の新展開」
  • Place of Presentation: さいたま
• [Presentation] ゼブラフィッシュ脳のイメージングから分かる脳の成り立ちと働き (2009)
  • Author(s): 岡本仁
  • Organizer: 生命科学を翔るイメージング-東京大学新領域創成科学研究科附属バイオイメージングセンター(仮称)設立記念シンポジウム
  • Place of Presentation: 東京
• [Presentation] Functional analysis of the habenular nuclei in fear response based on the evolutionary conservation of the neural circuits (2009)
  • Author(s): Okamoto H
  • Organizer: 3rd strategic conference of zebrafish investigators
  • Place of Presentation: Asilomar USA
• [Presentation] The neuroepithelial guidance of the migrating cranial motoneuron precursors (2008)
  • Author(s): 岡本仁, 大畑慎也, 和田浩則, 木下滋晴
  • Organizer: 第31回日本神経科学大会(Neuroscience 2008)
  • Place of Presentation: 東京
• [Presentation] Development and Functions of the lateralized neural circuits for the emotional control of memory and behavior (2008)
  • Author(s): Okamoto H
  • Organizer: CDB Symposium 2008: Turning Neurons Into a Nervous System
  • Place of Presentation: Kobe Japan
• [Presentation] 手綱核神経回路の左右差の成立機構と機能解析 (2008)
  • Author(s): 岡本仁
  • Organizer: 文部科学省科学研究費特定領域研究「性分化機構の解明」第3回冬のワークショップ
  • Place of Presentation: 御殿場
• [Presentation] Genetic dissection of migration of the vagus motor neuron precursors (2008)
  • Author(s): Okamoto H
  • Organizer: Asia pacific zebrafish network meeting Auckland
  • Place of Presentation: New Zealand
• [Presentation] What does comparative genomics tell us about the evolutionary conservation and dynamic changes of the regulatory mechanisms for tissue specific gene expression? (2008)
  • Author(s): Okamoto H
  • Organizer: 54th NIBB conference New frontiers for the Medaka model Genome
  • Place of Presentation: bioresources and Biology Okazaki
• [Presentation] Practical guides for using zebrafish in neuroscience (2007)
  • Author(s): Okamoto Hitoshi
  • Organizer: RIKEN BSI-Picower Workshop 2007 at RIKEN
  • Place of Presentation: Wako Japan
  • Year and Date: 2007-11-29
• [Presentation] ゼブラフィッシュの神経パターニングにおける神経上皮細胞の前後平面極性 (2007)
  • Author(s): 栗栖 修作
  • Organizer: 科学技術振興機構(JST)戦略的創造研究推進事業(CREST)研究領域「生物の発生・分化・再生」第6回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Which causes left-right difference in the zebrafish habenula:proliferation,timing of neurogenesis or cell death? (2007)
  • Author(s): 相澤 秀紀
  • Organizer: 科学技術振興機構(JST)戦略的創造研究推進事業(CREST)研究領域「生物の発生・分化・再生」第6回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] ゼブラフィッシュDNMT1 associated proteinl(Dmap1)変異体による神経分化機構の解析 (2007)
  • Author(s): 田中 英臣
  • Organizer: 科学技術振興機構(JST)戦略的創造研究推進事業(CREST)研究領域「生物の発生・分化・再生」第6回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] 網膜発生における細胞死の制御メカニズム (2007)
  • Author(s): 山口 雅裕
  • Organizer: 科学技術振興機構(JST)戦略的創造研究推進事業(CREST)研究領域「生物の発生・分化・再生」第6回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Roles of fucosylated glycans and neuroepithelium polarity genes in the migration of vagus motor neuron precursors in zebrafish (2007)
  • Author(s): 大畑 慎也
  • Organizer: 科学技術振興機構(JST)戦略的創造研究推進事業(CREST)研究領域「生物の発生・分化・再生」第6回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] The left-right asymmetry of the neural circuit in the zebrafish limbic brain (2007)
  • Author(s): Okamoto Hitoshi
  • Organizer: Riken Brain Science Institute and Queensland brain institute joint symposium
  • Place of Presentation: Wako Japan
  • Year and Date: 2007-09-06
• [Presentation] 迷走運動神経細胞移動の遺伝学的解析 (2007)
  • Author(s): 岡本仁木下滋晴, 大畑慎也, 和田浩則
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会(BMB2007)
  • Place of Presentation: 横浜
• [Presentation] Practical guides for using zebrafish in neuroscience (2007)
  • Author(s): Okamoto H
  • Organizer: RIKEN BSI - Picower Workshop 2007 at RIKEN
  • Place of Presentation: Wako Japan
• [Presentation] Asymmetry of the emotion controlling neural circuits in the zebrafish brain (2007)
  • Author(s): Okamoto H
  • Organizer: Karolinska Institutet - RIKEN BSI 1st Joint Symposium: The Mysteries of the Brain- New Frontiers in Neuroscience Stockholm Sweden
• [Presentation] The left-right asymmetry of the neural circuit in the zebrafish limbic brain (2007)
  • Author(s): Okamoto H
  • Organizer: Riken Brain Science Institute and Queensland brain institute joint symposium Wako
• [Presentation] 心の基盤となる精神回路の成り立ちを究める (2007)
  • Author(s): 岡本仁
  • Organizer: 東洋紡バイオ財団設立25周年記念シンポジウム「次世代へのメッセージ:生命科学-世界に羽ばたいた若手の歩み」
  • Place of Presentation: 大阪
• [Presentation] Establishment of the asymmetry in the habenulo-interpeduncular projection (2007)
  • Author(s): Okamoto H
  • Organizer: Zebrafish meeting of From sensory perception to motor output: genetic bases behaviour in the zebrafish embryo Minerve France
• [Presentation] ゼブラフィッシュによって明らかになる神経細胞の分化の動態 (2007)
  • Author(s): 岡本仁
  • Organizer: 日本顕微鏡学会第63回学術講演会
  • Place of Presentation: 新潟
• [Presentation] Establishment of the asymmetry in the habenulo-interpeduncular projection (2007)
  • Author(s): Okamoto Hitoshi
  • Organizer: Zebrafish meeting of From sensory perception to motor output:genetic bases behaviour in the zebrafish embryo
  • Place of Presentation: Minerve,France
• [Presentation] Asymmetry of the emotion controlling neural circuits in the zebrafish brain (2007)
  • Author(s): Okamoto Hitoshi
  • Organizer: Karolinska Institutet-RIKEN BSI 1st Joint Symposium:The Mysteries of the Brain-New Frontiers in Neuroscience
  • Place of Presentation: Stockholm,Sweden
• [Presentation] Attenuation of ARF family GTPases as a potential general mechanism for chemo repulsion;a possible link between repulsion and cell adhesion (2007)
  • Author(s): 西谷 直之
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] R-spondin2 is required for maintenance of the apical ectodermal ridge in mouse limb development (2007)
  • Author(s): 青木 基子
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Planar Cell Polarity(PCP)遺伝子群の働きによって神経上皮細胞が運動神経細胞の侵入を阻害するメカニズム (2007)
  • Author(s): 和田 浩則
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] 脚間核を介した手綱核の左右非対称な神経伝導路 (2007)
  • Author(s): 相澤 秀紀
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会(Neuro2007)
  • Place of Presentation: 横浜
• [Presentation] DMAPlは神経細胞の移動と分化に関与する (2007)
  • Author(s): 田中 英臣
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会(Neuro2007)
  • Place of Presentation: 横浜
• [Presentation] 迷走運動神経前駆細胞の移動における糖鎖修飾と神経上皮極性因子の役割 (2007)
  • Author(s): 大畑 慎也
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京
• [Presentation] 遺伝的単一細胞モザイク解析を用いた視蓋から後脳への投射におけるEphrinB2逆行性シグナル伝達の役割 (2007)
  • Author(s): 佐藤 智美
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京
• [Presentation] ゼブラフィッシュ成魚視蓋に分布する分裂細胞群における神経幹細胞マーカー遺伝子の発現分布 (2007)
  • Author(s): 伊藤 容子
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京
• [Presentation] ゼブラフィッシュバイオリソースII (2007)
  • Author(s): 岡本 仁
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京
• [Presentation] ARF-GAP結合性膜受容体の同定と反発性ガイド機能へのARF-GAPの関与 (2007)
  • Author(s): 西谷 直之
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会(BMB2007)
  • Place of Presentation: 横浜
• [Presentation] ゼブラフィッシュ視蓋から後脳への投射におけるEphrinB2逆行性シグナル伝達の役割 (2007)
  • Author(s): 佐藤 智美
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会(BMB2007)
  • Place of Presentation: 横浜
• [Presentation] ゼブラフィッシュ成魚視蓋に分布する分裂細胞群における神経幹細胞マーカー遺伝子の発現分布 (2007)
  • Author(s): 伊藤 容子
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会(BMB2007)
  • Place of Presentation: 横浜
• [Presentation] NBRP「ゼブラフィッシュ」:ナショナルバイオリソース・ゼブラフィッシュ バージョン2 (2007)
  • Author(s): 岡本 仁
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会(BMB2007)
  • Place of Presentation: 横浜
• [Book] 遺伝子と経験が作る神経回路 (2009)
  • Author(s): 岡本仁
  • Publisher: 岩波書店
• [Book] 脳の基本設計図と心の進化、多様化、障害、シリーズ脳科学 (2008)
  • Author(s): 岡本仁
  • Publisher: 東京大学出版会
• [Book] 脳の進化と心の誕生、脳科学の最前線(上巻、脳と認知と進化) (2007)
  • Author(s): 岡本仁
  • Publisher: 講談社ブルーバックス
• [Book] 脳の進化と心の誕生、pp69-131, 脳科学の最前線(上巻、脳と認知と進化) (2007)
  • Author(s): 岡本 仁
  • Total Pages: 731
  • Publisher: 講談社ブルーバックス