Study of the establishment and function of the habenulo-interpeduncular tract
Project/Area Number |
19300115
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
OKAMOTO Hitoshi The Institute of Physical and Chemical Research, 発生遺伝子制御研究チーム, シニア・チームリーダー (40183769)
|
Co-Investigator(Kenkyū-buntansha) |
AIZAWA Hidenori 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 副チームリーダー (80391837)
AOKI Tazu 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 研究員 (10425605)
AGETSUMA Masakazu 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 研究員 (30425607)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
Keywords | 発生 / 発達 / 再生神経科学 / ゼブラフィッシュ / カルシウム感受性蛍光タンパク / トランスジェニック / 能動的回避学習 / 終脳 / 恐怖学習 / すくみ行動 / 手綱核 / 基底核 / 行動解析 / 左右差 / Cre / loxP / カルシウムイメージング / 細胞平面極性 |
Research Abstract |
The habenula is a part of the neural circuit connecting the telencephalic limbic system with the monoaminergic neurons in the brain stem. Taking advantage of the high degree of evolutionary conservation of this neural circuit from fish to human, we have carried out genetic manipulation to inactivate specific subnuclei of the habenula in zebrafish and obtained a clue suggesting that the habenula plays an important role for experience-dependent decision in response to fear by animals.
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Report
(4 results)
Research Products
(97 results)
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[Journal Article]2009
Author(s)
浅島誠, 他編
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Journal Title
遺伝子と経験が作る神経回路現代生物科学入門第4巻(岩波書店)
Pages: 1-67
Related Report
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[Journal Article]2009
Author(s)
吉川寛, 他編
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Journal Title
研究をささえるモデル生物:実験室いきものガイド(化学同人)
Pages: 86-87
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