| Project/Area Number |
19300133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyorin University |
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Principal Investigator |
AKAGAWA Kimio Kyorin University, 医学部, 教授 (80129303)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Tomonori 杏林大学, 医学部, 講師 (90255399)
SUGA Kei 杏林大学, 医学部, 助教 (30306675)
MISHIMA Tatsuya 杏林大学, 医学部, 助教
KOFUJI Takefumi 杏林大学, 医学部, 助教 (40365200)
SANADA Masumi 杏林大学, 医学部, 実験助手 (70424108)
SAITOU Ayako 杏林大学, 医学部, 実験助手 (80424109)
三嶋 竜弥 杏林大学, 医学部, 助教 (40317095)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | シナプス伝達 / シンタキシン1A / シンタキシン1B / ノックアウトマウス自閉性障害 / 疾患モデル動物 / シナプス機能分化 / シナプス伝達制御因子 / 遺伝子ノックアウトマウス / 行動異常 / 速い神経伝達 / 遅い神経伝達 / syntaxin1B / syntaxin1A / 致死 / 痙攣発作 / 運動障害 / シンタキシン1 / 自閉症 / 疾患モデル |
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| Research Abstract |
It was suggested by studying syntaxin1A (sy1A) or syntaxin1B (sy1B) gene knockout mice that sy1A and sy1B function in monoaminergic and mainly in glutamatergic fast transmission respectively. These findings overturned the usual thought that sy1a and sy1B played similar roles in synaptic function.
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