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Development of the fluorescence imaging system for medical applications based on the ultrasonic tagging technique

Research Project

Project/Area Number 19300162
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku Institute of Technology

Principal Investigator

KOBAYASHI Masaki  Tohoku Institute of Technology, 工学部, 教授 (90332981)

Co-Investigator(Kenkyū-buntansha) 榎本 幹  東北工業大学, 工学部, 教授 (10085392)
武田 元博  東北大学, 工学研究科, 准教授 (10333808)
Co-Investigator(Renkei-kenkyūsha) TAKEDA Motohiro  東北大学, 大学院・医学系研究科, 准教授 (10333808)
ENOMOTO Masaru  東北工業大学, 工学部, 教授 (10085392)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords蛍光 / 超音波 / 音響光学効果 / 診断装置 / 医用画像 / センチネルリンパ節 / 生体 / 断層画像 / 光CT
Research Abstract

Non-invasive imaging technique of fluorescent marker in living body for diagnosis of physiological and pathological condition has been studied. Ultrasonic tagging technique based on the acousto-optic effect has been examined and the tomographic imaging system to determine the localized fluorescent substances at the depth of 30mm has been developed.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (44 results)

All 2010 2009 2008 2007 Other

All Journal Article (14 results) (of which Peer Reviewed: 10 results) Presentation (23 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Nano-imaging of the lymph network structure with quantum dots2010

    • Author(s)
      M. Hikage, K. Gonda, M. Takeda, T. Kamei, M. Kobayashi, M. Kumasaka, M. Watanabe, S. Satomi, N. Ohuchi
    • Journal Title

      Nanotechnology Vol.21

      Pages: 185103-185103

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of Ultraweak Spontaneous Photon Emission from Human Body Displaying Diurnal Rhythm2009

    • Author(s)
      M. Kobayashi, D. Kikuchi, H. Okamura
    • Journal Title

      PLoS ONE Vol.4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 超音波変調による生体蛍光イメージング2009

    • Author(s)
      小林正樹
    • Journal Title

      光学 Vol.38

      Pages: 316-321

    • NAID

      10024750508

    • Related Report
      2009 Final Research Report
  • [Journal Article] Imaging of Ultraweak Spontaneous Photon Emission from Human Body Displaying Diurnal Rhythm2009

    • Author(s)
      M.Kobayashi, D.Kikuchi, H.Okamura
    • Journal Title

      PloS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超音波変調による生体蛍光イメージング2009

    • Author(s)
      小林正樹
    • Journal Title

      光学 38

      Pages: 316-321

    • NAID

      10024750508

    • Related Report
      2009 Annual Research Report
  • [Journal Article] In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine2008

    • Author(s)
      M. Takeda, H. Tada, H. Higuchi, Y. Kobayashi, M. Kobayashi, Y. Sakurai, T. Ishida, N. Ohuchi
    • Journal Title

      Breast Cancer Vol.15

      Pages: 145-152

    • NAID

      10025371809

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小林正樹2008

    • Author(s)
      生命科学・医学応用のための極微弱発光・蛍光イメージング技術
    • Journal Title

      顕微鏡 Vol.43

      Pages: 202-206

    • Related Report
      2009 Final Research Report
  • [Journal Article] In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine2008

    • Author(s)
      M. Takeda, H. Tada, H. Higuchi, Y. Kobayashi, M. Kobayashi, Y. Sakurai, T. Ishida, N. Ohuchi
    • Journal Title

      Breast Cancer 15

      Pages: 145-152

    • NAID

      10025371809

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence tomography of biological tissue based on ultrasound tagging technique, M. Kobayashi2007

    • Author(s)
      M. Kobayashi, T. Mizumoto, T.Q. Duc, M. Takeda
    • Journal Title

      Proc. SPIE 6633

    • Related Report
      2009 Final Research Report
  • [Journal Article] J. Kim, Y. Kim, Y.J. Lee, M. Kobayashi, Y. Tsutsumi, R. Kondo, S.K. Lee, K.S. Soh2007

    • Author(s)
      Spontaneous ultraweak photon emission during the growth of the cell population of cultured HeLa cell line
    • Journal Title

      J. Health Sci Vol.53

      Pages: 481-485

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] M. Kobayashi, K. Sasaki, M. Enomoto, Y. Ehara2007

    • Author(s)
      Highly sensitive determination of transient generation of biophotons during hypersensitive response to cucumber mosaic virus in cowpea
    • Journal Title

      J. Exp. Botany Vol.58

      Pages: 465-472

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence Tomography of Biological Tissue Based on Ultrasound Tagging Technique2007

    • Author(s)
      M. Kobayashi, T. Mizumoto, T. Q. Duc, M. Takeda
    • Journal Title

      Proc. SPIE 6633

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly sensitive determination of transient generation of biophotons during hypersensitive response to cucumber mosaic virus in cowpea2007

    • Author(s)
      M. Kobayashi, K Sasaki, M Enomoto, Y. Ehara
    • Journal Title

      J. Exp. Botany 58

      Pages: 465-472

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nano-imaging of the lymph network structure with quantum dots

    • Author(s)
      M.Hikage, K.Gonda, M.Takeda, T.Kamei, M.Kobayashi, M.Kumasaka, M.Watanabe, S.Satomim, N.Ohuchi
    • Journal Title

      Nanotechnology (掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 超音波タグ生体蛍光イメージングのための扇形走査超音波プローブの開発2010

    • Author(s)
      鈴木知佳, Trinh Quang Duc, 成瀬慧, 小林正樹
    • Organizer
      平成22年東北地区若手研究者研究発表会
    • Place of Presentation
      東北学院大学(宮城県)
    • Year and Date
      2010-02-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 担がんマウスを用いた悪性腫瘍由来生物フォトン発光による抗がん剤薬効評価手法の開発2009

    • Author(s)
      熊坂増高, 近彬光, 古積聖太, 武田元博, 大内憲明, 小林正樹
    • Organizer
      第43回日本生体医工学会東北支部大会
    • Place of Presentation
      福島大学(福島県)
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Imaging of ultraweak spontaneous photon emission from human body displaying diurnal rhythm2009

    • Author(s)
      M.Kobayashi, D.Kikuchi, H.Okamura
    • Organizer
      The 6^<th> congress of Asian Sleep Research Society
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-10-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 冷却CCDカメラによる悪性腫瘍由来生物フォトン発光の高感度長時間連続画像計測2009

    • Author(s)
      熊坂増高, 武田元博, 大内憲明, 小林正樹
    • Organizer
      電子情報通信学会2009年総合大会
    • Place of Presentation
      愛媛大学, 松山市
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 音響光学効果による光散乱媒質内蛍光変調メカニズムのモンテカルロ法によるシミュレーション2009

    • Author(s)
      高橋誠樹, 南部雄也, Trinh QuangDuc, 小林正樹
    • Organizer
      平成21年東北地区若手研究者研究発表会
    • Place of Presentation
      東北学院大学, 多賀城市
    • Year and Date
      2009-02-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 音響光学効果による超音波タグ生体蛍光イメージングのための超音波プローブの検討2009

    • Author(s)
      鈴木知佳, 大内康平, 今勝史, 南部雄也, Trinh Quang Due, 小林正樹
    • Organizer
      平成21年東北地区若手研究者研究発表会
    • Place of Presentation
      東北学院大学, 多賀城市
    • Year and Date
      2009-02-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Basic examination of the endoscopic surgery using nanoparticle tracer2009

    • Author(s)
      M. Hikage, M. Takeda, T. Kamei, M. Kobayashi, K. Gonda, M. Kumasaka, T. Nakano, Y. Sakurai, M. Kawai, C. Li-man, Y. Hamanaka, Y. Hamada, S. Satomi, N. Ohuchi
    • Organizer
      2nd International Symposium on Nanomedicine 2009
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2009-02-06
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Fluorescence tomography based-on acousto-optic modulations with phased-array ultrasound transducer2009

    • Author(s)
      Q.D. Trinh, Y. Nanbu, T. Suzuki, S. Takahashi, M. Takeda, M. Kobayashi
    • Organizer
      BiOS Part of SPIE Photonic West
    • Place of Presentation
      San Jose, USA
    • Year and Date
      2009-01-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Basic study on application of the phased-array transducer to determine fluorescence in turbid media based-on acousto-optic effects2008

    • Author(s)
      Q.D. Trinh, Y. Nanbu, T. Suzuki, S. Takahashi, M. Takeda, M. Kobayashi
    • Organizer
      nternational Conference on Laser Applications in Life Sciences (LALS 2008)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-12-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Basic study on application of the phased-array transducer to determine fluorescence in turbid media based-on acousto-optic effects2008

    • Author(s)
      Q. D. Trinh, Y. Nanbu, T. Suzuki, S. Takahashi, M. Takeda, M. Kobayashi
    • Organizer
      International Conference on Laser Applications in Life Sciences
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Basic examination of the fluorescent endoscopic surgery using nanoparticle tracer2008

    • Author(s)
      M. Hikage, M. Takeda, T. Kamei, M. Kobayashi, K. Gonda, M. Kumasaka, T. Nakano, Y. Sakurai, M. Kawai, C. Li-man, Y. Hamanaka, Y. Hamada, S. Satomi, N. Ohuchi
    • Organizer
      11th World Congress of Endoscopic Surgery
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-09-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Basic examination of the fluorescent endoscopic surgery using nanoparticle tracer2008

    • Author(s)
      M. Hikage, M. Takeda, T. Kamei, M. Kobayashi, K. Gonda, M. Kumasaka, T. Nakano, Y. Sakurai, M. Kawai, C. Li-man, Y. Hamanaka, Y. Hamada, S. Satomi, N. Ohuchi
    • Organizer
      11th International Congress of Endoscopic Surgery
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-09-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノ蛍光微粒子によるセンチネルリンパ節検索のための腹腔内視鏡蛍光イメージングシステムの開発2008

    • Author(s)
      熊坂増高, 日景允, 亀井尚, 武田元博, 大内憲明, 小林正樹
    • Organizer
      平成20年度電気関係学会東北支部連合大会
    • Place of Presentation
      郡山
    • Year and Date
      2008-08-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 超音波タグ蛍光断層イメージング法による生体組織の蛍光断層画像計測2008

    • Author(s)
      南部雄也, 鈴木知佳, 高橋誠樹, Trinh Quang Duc, 小林正樹
    • Organizer
      平成20年度電気関係学会東北支部連合大会
    • Place of Presentation
      郡山
    • Year and Date
      2008-08-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 超音波タグ蛍光断層イメージング法による生体組織の蛍光断層画像計測2008

    • Author(s)
      南部雄也, 鈴木知佳, 高橋誠樹, Trinh Quang Due, 小林正樹
    • Organizer
      平成20年年度電気関係学会東北支部連合大会
    • Place of Presentation
      日本大学, 郡山市
    • Year and Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノ蛍光微粒子によるセンチネルリンパ節検索のための腹腔内視鏡蛍光イメージングシステムの開発2008

    • Author(s)
      熊坂増高, 日景允, 亀井尚, 武田元博, 大内憲明, 小林正樹
    • Organizer
      平成20年年度電気関係学会東北支部連合大会
    • Place of Presentation
      日本大学, 郡山市
    • Year and Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 機能性ナノ粒子によるナノからマクロレベルの生体イメージング2008

    • Author(s)
      武田元博, 樋口秀男, 小林正樹, 小林芳男, 大内憲明
    • Organizer
      第55回応用物理学関係連合講演会
    • Place of Presentation
      日本大学・船橋
    • Year and Date
      2008-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 超音波タグ蛍光断層イメージング法による生体試料灘の蛍光検出2008

    • Author(s)
      南部 雄也, 阿部 興志, 鈴木 知佳, 水本 喬, Trinh Quang Duc, 小林 正樹
    • Organizer
      平成20年東北地区若手研究者研究発表会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tomographic Imaging of Fluorophore Embedded in Biological Tissue Based on Ultrasound Tagging Technique2007

    • Author(s)
      Q.D. Trinh, T. Mizumoto, Y. Nanbu, M. Takeda, M. Kobayashi
    • Organizer
      The 7th pacific Rim Conference on Lasers and Electro-Optics (CLEO)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-08-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Fluorescence Tomography of Biological Tissue Based on Ultrasound Tagging Technique2007

    • Author(s)
      M. Kobayashi, T. Mizumoto, T.Q. Duc, M. Takeda
    • Organizer
      Europian conferences on Biomedical Optics/ in 18th International Congress on Photonics in Europe
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2007-06-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 音響光学効果を利用した超音波タグ生体蛍光断層イメージングI2007

    • Author(s)
      水本喬, Trinh Quang Duc, 武田元博, 小林正樹
    • Organizer
      第54回応用物理学関係連合講演会講演予稿集
    • Place of Presentation
      青山学院大学・相模原
    • Year and Date
      2007-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Tomographic imaging of fluorophore embedded in biological tssue based on ultrasound tagging technique2007

    • Author(s)
      T. Q. Duc, T. Mizumoto, Y. Nanbu, M. Takeda, M. Kobayashi
    • Organizer
      The 7th pacific Rim Conference on Lasers and Electro-Optics(CLEO)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2007 Annual Research Report
  • [Presentation] Fluorescence tomography of biological tissue based on ultrasound tagging technique2007

    • Author(s)
      M. Kobayashi, T. Mizumoto, T. Q. Duc, M. Takeda
    • Organizer
      Europian conferences on Biomedical Optics/ in 18th International Congress on Photonics in Europe
    • Place of Presentation
      Munich, Germany
    • Related Report
      2007 Annual Research Report
  • [Book] 機能性ナノ粒子による生体イメージング-がん診療への応用-. ナノメディシンナノテクの医療応用(宇理須恒雄)2008

    • Author(s)
      武田元博,小林芳男,小林正樹,桜井遊,甘利正和,石田孝宣,鈴木昭彦,大内憲明
    • Publisher
      オーム社
    • Related Report
      2009 Final Research Report
  • [Book] ナノメディシンナノテクの医療応用2008

    • Author(s)
      武田元博, 小林芳男, 小林正樹, 桜井遊, 甘利正和, 石田孝宣, 鈴木昭彦, 大内憲明(共著)(宇理須恒雄
    • Publisher
      オーム社
    • Related Report
      2008 Annual Research Report
  • [Book] 量子ドットを用いた生体機能非侵襲計測のための蛍光画像計測技術の開発. 量子ドットの生命科学領域への応用(山本重夫監)2007

    • Author(s)
      小林正樹
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Final Research Report
  • [Book] 量子ドットの生命科学領域への応用2007

    • Author(s)
      小林 正樹(共著)(監修:山本重夫)
    • Publisher
      シーエムシー出版
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.tohtech.ac.jp/~elecs/ca/kobayashilab_hp/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.tohtech.ac.jp/^-elecs/ca/kobayashilab_hp/index.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 蛍光断層画像計測装置2010

    • Inventor(s)
      小林正樹
    • Industrial Property Rights Holder
      小林正樹,(株)システム計測
    • Filing Date
      2010-05-28
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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