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Development of light-heat converting medical materials responding to near infrared light

Research Project

Project/Area Number 19300172
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKyushu University

Principal Investigator

NIIDOME Takuro  Kyushu University, 大学院・工学研究院, 准教授 (20264210)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywords医用光 / 熱工学 / 金ナノ粒子 / 金ナノロッド / 近赤外光 / フォトサーマル治療 / バイオイメージング
Research Abstract

Gold nanorods adsorb infrared light, then, the light energy is converted to heat. In this study, we optimized condition of PEG-modification of the gold nanorods to make them circulate blood stably and show EPR effect. Furthermore, we succeeded in preparing thermosensitive polymer-modified gold nanorods that accumulated to light-irradiated site.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (75 results)

All 2010 2009 2008 2007 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (31 results) Book (9 results) Remarks (2 results) Patent(Industrial Property Rights) (11 results)

  • [Journal Article] The effects of PEG grafting level and injection dose on gold nanorod biodistribution in the tumor-bearing mice2009

    • Author(s)
      Y. Akiyama, T. Mori, Y. Katayama, T. Niidome
    • Journal Title

      J. Control. Release. 139

      Pages: 81-84

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Poly(ethylene glycol)-modified gold nanorods as a photothermal nanodevice for hyperthermia2009

    • Author(s)
      T. Niidome, Y. Akiyama, M. Yamagata, T. Kawano, T. Mori, Y. Niidome, Y. Katayama
    • Journal Title

      J. Biomater. Sci.-Polym. Ed. 20

      Pages: 1203-1215

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] PNIPAM gel-coated gold nanorods for targeted delivery responding to a near-infrared laser2009

    • Author(s)
      T. Kawano, Y. Niidome, T. Mori, Y. Katayama, T. Niidome
    • Journal Title

      Bioconjugate Chem. 20

      Pages: 209-212

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of PEG grafting level and injection dose on gold nanorod biodistribution in the tumor-bearing mice2009

    • Author(s)
      Y.Akiyama, et al.
    • Journal Title

      J. Control. Release 139

      Pages: 81-84

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PNIPAM gel-coated gold nanorods for targeted delivery responding to a near-infrared laser2009

    • Author(s)
      T.Kawano, et al.
    • Journal Title

      Bioconjugate Chem. 20

      Pages: 209-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Poly(ethylene glycol)-modified gold nanorods as a photothermal nanodevice for hyperthermia2009

    • Author(s)
      T.Niidome, et al.
    • Journal Title

      J. Biomater. Sci.-Polym. Ed. 20

      Pages: 1203-1215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF κ B decoy delivery using dendritic poly(L-lysine)for treatment of end otoxin-induced hepatitis in mice2009

    • Author(s)
      Y.Sugao, et al.
    • Journal Title

      Bioorg. Med. Chem. 17

      Pages: 4990-4995

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticles of adaptive supramolecular networks self-assembled from nucleotides and lanthanide ions2009

    • Author(s)
      R.Nishiyabu, et al.
    • Journal Title

      J. Am. Chem. Soc. 20

      Pages: 215-218

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo siRNA delivery with dendritic poly(L-lysine)for the treatment of hyperchofesterolemia2009

    • Author(s)
      K.Watanabe, et al.
    • Journal Title

      Molecular BioSystems 20

      Pages: 1306-1310

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photochemical reaction of poly(ethylene glycol)on gold nanorods induced by near infrared pulsed-laser irradiation2009

    • Author(s)
      S.Yamashita, et al.
    • Journal Title

      Chem. Lett. 20

      Pages: 226-227

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene transfer into cells from solid surfaces and its application to in vivo systems2009

    • Author(s)
      T.Niidome, et al.
    • Journal Title

      Chem. Lett. 20

      Pages: 36-37

    • NAID

      10023990229

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo monitoring of intravenously injected gold nanorods using near-infrared light2008

    • Author(s)
      T. Niidome, Y. Akiyama, K. Shimoda, T. Kawano, T. Mori, Y. Katayama, Y. Niidome
    • Journal Title

      Small 4

      Pages: 1001-1007

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photoinduced release of oligonucleotide-conjugated silica-coated gold nanorods accompanied by moderate morphological changes2008

    • Author(s)
      Y. Horiguchi, S. Yamashita, T. Niidome, N. Nakashima, Y. Niidome
    • Journal Title

      Chem. Lett. 265

      Pages: 281-288

    • NAID

      10021082084

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface modification of gold nanorods using layer-by-layer technique for cellular uptake2008

    • Author(s)
      H. Takahashi, T. Niidome, T. Kawano, Y. Niidome, S. Yamada
    • Journal Title

      J. Nanopart. Res. 10

      Pages: 221-228

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo monitoring of intravenously injected gold nanorods using near-infrared light2008

    • Author(s)
      T. Niidome, et al.
    • Journal Title

      Small 4

      Pages: 1001-1007

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoinduced release of oligonucleotide-conjugated silica-coated gold nanorods accompanied by moderate morphological changes2008

    • Author(s)
      Y. Horiguchi, et al.
    • Journal Title

      Chem. Lett. 265

      Pages: 281-288

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface modification of gold nanorods using layer-by-layer technique for cellular uptake2008

    • Author(s)
      H. Takahashi, et al.
    • Journal Title

      J. Nanopart. Res. 10

      Pages: 221-228

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of plasmid DNA released from DNA conjugates of gold nanorods2007

    • Author(s)
      Y. Horiguchi, T. Niidome, S. Yamada, N. Nakashima, Y. Niidome
    • Journal Title

      Chem. Lett. 36

      Pages: 952-953

    • NAID

      10019746014

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stable incorporation of gold nanorods into N-isopropylacrylamide hydrogels and their rapid shrinkage induced by near-IR laser irradiation2007

    • Author(s)
      A. Shiotani, T. Mori, T. Niidome, Y. Niidome, Y. Katayama
    • Journal Title

      Langmuir 23

      Pages: 4012-4018

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of plasmid DNA released from DNA conjugates of gold nanorods2007

    • Author(s)
      Y.Horiguchi, et. al.
    • Journal Title

      Chem.Lett. 36

      Pages: 952-953

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stable incorporation of gold nanorods into N-isopropylacrylamide hydrogels and their rapid shrinkage induced by near-IR laser irradiation2007

    • Author(s)
      A.Shiotani, et. al.
    • Journal Title

      Langmuir 23

      Pages: 4012-4018

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overall interaction of cytosolic proteins with the PEI/DNA complex2007

    • Author(s)
      T.Iida, et. al.
    • Journal Title

      J.Control.Release 118

      Pages: 364-369

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 金ナノロッドと近赤外光を用いた診断・治療システム2010

    • Author(s)
      新留琢郎
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山市、ホテルグランヴィア
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 金ナノロッド表面の機能性修飾とそれを使った診断・治療システム2010

    • Author(s)
      新留琢郎
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      東大阪市、近畿大学
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光あるいは電磁波に応答するマルチ機能性ナノデバイスの創製2010

    • Author(s)
      新留琢郎、井藤彰
    • Organizer
      公開シンポジウム:生体ナノ環境の時空間制御を目指して
    • Place of Presentation
      北海道大学(招待講演)
    • Year and Date
      2010-01-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 光あるいは電磁波に応答するマルチ機能性ナノデバイスの創製2010

    • Author(s)
      新留琢郎、井藤彰
    • Organizer
      公開シンポジウム : 生体ナノ環境の時空間制御を目指して
    • Place of Presentation
      札幌市、北海道大学
    • Year and Date
      2010-01-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Surface Modification of Gold Nanorods for Photothermal Tumor Therapy and Targeted Delivery to Specific Site2009

    • Author(s)
      Takuro Niidome, Takahito Kawano, Akira Ohga, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama
    • Organizer
      2009 Pusan-Kyeongnam/Kyushu-Seibu Joint Symposium
    • Place of Presentation
      鹿児島市、鹿児島大学
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Functional Gold Nanorods for Bioimaging and Photothermal Therapy2009

    • Author(s)
      Takuro Niidome
    • Organizer
      The 4th International Symposium on Atomic Technology
    • Place of Presentation
      神戸市、シーサイドホテル舞子ビラ神戸
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protease-Triggered Targeted Delivery of Gold Nanorods into Tumor2009

    • Author(s)
      Takuro Niidome, Akira Ohga, Tsuyoshi Ando, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama
    • Organizer
      2009 Materials Research Society Fall Meeting
    • Place of Presentation
      米国マサチューセッツ州ボストン
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] The effect of PEG grafted on gold nanorods and their injection dose on biodistribution in tumor-bearing mice2009

    • Author(s)
      Yasuyuki Akiyama, Mori Takeshi, Yoshiki Katayama, Takuro Niidome
    • Organizer
      2009 Materials Research Society Fall Meeting
    • Place of Presentation
      米国マサチューセッツ州ボストン
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 診断・治療を支えるハイブリッド金ナノ粒子の創製2009

    • Author(s)
      新留琢郎
    • Organizer
      第12回日本化学会バイオテクノロジー部会シンポジウム
    • Place of Presentation
      福岡市東区、九州大学医系キャンパス・百年記念講堂
    • Year and Date
      2009-09-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of tumor therapy system using gold nanorods with photothermal effect2009

    • Author(s)
      Takuro Niidome, Yasuyuki Akiyama, Akira Ohga, Takahito Kawano, Y asuro Niidome, Takeshi Mori, Yoshiki Katayama
    • Organizer
      The 7th Asia 3 foresight symposium on gene therapy and biomaterials
    • Place of Presentation
      International cooperation building, KIST, Seoul, KOREA
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Photothermal Tumor Therapy Using Gold Nanorods and TheirTargeted Delivery2009

    • Author(s)
      Takuro Niidome, Yasuyuki Akiyama, Akira Ohga, Takahito Kawano, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama
    • Organizer
      8th International Symposium on Frontiers in Biomedical Polymers
    • Place of Presentation
      静岡県三島市、東レ総合研修センター
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional Controlled Release Systems Triggered by Photothermal Effect of Gold Nanorods2009

    • Author(s)
      山下秀治、福島寛満、新留康郎、森健、片山佳樹、新留琢郎
    • Organizer
      2009 MRS Fall Meeting
    • Place of Presentation
      米国
    • Related Report
      2009 Final Research Report
  • [Presentation] The effect of PEG grafted on gold nanorods and their injection dose on biodistribution in tumor-bearing mice2009

    • Author(s)
      秋山泰之、森健、片山佳樹、新留琢郎
    • Organizer
      2009 MRS Fall Meeting
    • Place of Presentation
      米国
    • Related Report
      2009 Final Research Report
  • [Presentation] Protease-Triggered Targeted Delivery of Gold Nanorods into Tumor2009

    • Author(s)
      T. Niidome, A. Ohga, T. Ando, Y. Niidome, T. Mori, Y. Katayama
    • Organizer
      2009 Materials Research Society Fall Meeting
    • Place of Presentation
      米国
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of Functional Gold Nanorods for Bioimaging and Photothermal Therapy2009

    • Author(s)
      T. Niidome
    • Organizer
      The 4th International Symposium on Atomic Technology
    • Place of Presentation
      神戸市(招待講演)
    • Related Report
      2009 Final Research Report
  • [Presentation] Surface Modification of Gold Nanorods for Photothermal Tumor Therapy and Targeted Delivery to Specific Site2009

    • Author(s)
      T. Niidome, T. Kawano, A. Ohga, Y. Niidome, T. Mori, Y. Katayama
    • Organizer
      Pusan-Kyeongnam/Kyushu-Seibu Joint Symposium
    • Place of Presentation
      鹿児島大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 診断・治療を支えるハイブリッド金ナノ粒子の創製2009

    • Author(s)
      新留琢郎
    • Organizer
      第12回日本化学会バイオテクノロジー部会シンポジウム
    • Place of Presentation
      九州大学(招待講演)
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of tumor therapy system using gold nanorods with photothermal effect2009

    • Author(s)
      T. Niidome, Y. Akiyama, A. Ohga, T. Kawano, Y. Niidome, T. Mori, Y. Katayama
    • Organizer
      The 7th Asia 3 foresight symposium on gene therapy and biomaterials
    • Place of Presentation
      韓国(招待講演)
    • Related Report
      2009 Final Research Report
  • [Presentation] Photothermal Tumor Therapy Using Gold Nanorods and TheirTargeted Delivery2009

    • Author(s)
      T. Niidome, Y. Akiyama, A. Ohga, T. Kawano, Y. Niidome, T. Mori, Y. Katayama
    • Organizer
      8th International Symposium on Frontiers in Biomedical Polymers
    • Place of Presentation
      三島市
    • Related Report
      2009 Final Research Report
  • [Presentation] Gold nanorods for photothermal tumor therapy2009

    • Author(s)
      T. Niidome, A. Ohga, Y. Niidome, T. Mori, Y. Katayama
    • Organizer
      14th International Symposium on Recent Advances in Drug Delivery Systems
    • Place of Presentation
      米国
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of gold nanorods that accumulate into tumor2008

    • Author(s)
      T. Niidome, et al.
    • Organizer
      45th Japanese Peptide Sympojium
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] バイオマテリアルとしての金ナノロッド:近赤外光応答性ナノゲルのマウスへの静脈投与における体内分布2008

    • Author(s)
      塩谷淳、河野喬仁、森健、新留康郎、片山佳樹、新留琢郎
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京大学
    • Related Report
      2009 Final Research Report
  • [Presentation] バイオマテリアルとしての金ナノロッド:PEG-g-PLL修飾金ナノロッドの作製と評価2008

    • Author(s)
      安藤豪、岡本悠里、新留康郎、森健、狩野有宏、丸山厚、片山佳樹、新留琢郎
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京大学
    • Related Report
      2009 Final Research Report
  • [Presentation] バイオマテリアルとしての金ナノロッド:EPR効果を狙った投与条件の最適化2008

    • Author(s)
      秋山泰之、新留康郎、森健、片山佳樹、新留琢郎
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京大学
    • Related Report
      2009 Final Research Report
  • [Presentation] バイオマテリアルとしての金ナノロッド:プロテアーゼに応答し凝集する金ナノロッドの作製2008

    • Author(s)
      大賀晃、森健、新留康郎、片山佳樹、新留琢郎
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京大学
    • Related Report
      2009 Final Research Report
  • [Presentation] バイオマテリアルとしての金ナノロッド:金ナノロッドを用いた培養細胞イメージングとin vivoモニタリング2008

    • Author(s)
      山下秀治、岡本悠里、秋山泰之、下田康平、森健、片山佳樹、新留康郎、新留琢郎
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京大学
    • Related Report
      2009 Final Research Report
  • [Presentation] Preparation of N-Isopropylacrylamide Hydrogel-Coated Gold Nanorods2008

    • Author(s)
      A. Shiotani, T. Kawano, T. Mori, Y. Niidome, Y. Katayama, T. Niidome
    • Organizer
      The 35th Annual Meeting and Exposition of the Controlled ReleaseSociety
    • Place of Presentation
      米国
    • Related Report
      2009 Final Research Report
  • [Presentation] 温度感受性ポリマーをコートした金ナノロッドの光応答2008

    • Author(s)
      河野喬仁、新留康郎、森健、片山佳樹、新留琢郎
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      東京都港区
    • Related Report
      2009 Final Research Report
  • [Presentation] Real-time monitoring of gold nanorods in vivo using infrared light2007

    • Author(s)
      T.Niidome, et. al.
    • Organizer
      234th ACS National Meeting and Exposition
    • Place of Presentation
      米国ボストン
    • Year and Date
      2007-08-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 金ナノロッドを使ったフォトサーマル治療2007

    • Author(s)
      新留琢郎、新留康郎、秋山泰之、山形真人、河野喬仁、森健、片山佳樹
    • Organizer
      第56回高分子討論会
    • Place of Presentation
      名古屋工業大学
    • Related Report
      2009 Final Research Report
  • [Presentation] Bioimaging and photothermal therapy using biocompatible gold nanorods2007

    • Author(s)
      T. Niidome
    • Organizer
      IO KOREA 2007 Conference
    • Place of Presentation
      韓国(招待講演)
    • Related Report
      2009 Final Research Report
  • [Book] プラズモンナノ材料の最新技術(山田淳監修)第2. 3章バイオ関連分野への応用展開2009

    • Author(s)
      新留琢郎、新留康郎
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Final Research Report
  • [Book] 金属ナノ・マイクロ粒子の形状・構造制御技術(米澤徹監修)第8. 1章医療用ナノ材料としての金ナノロッド-バイオイメージングとフォトサーマル治療2009

    • Author(s)
      新留琢郎、新留康郎
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Final Research Report
  • [Book] プラズモンナノ材料の最新技術2009

    • Author(s)
      新留琢郎、新留康郎
    • Total Pages
      14
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Annual Research Report
  • [Book] 金属ナノ・マイクロ粒子の形状・構造制御技術2009

    • Author(s)
      新留琢郎、新留康郎
    • Total Pages
      11
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Annual Research Report
  • [Book] ナノ粒子の創製と応用展開(米澤徹編集)第5章ナノ粒子のバイオ・医療材料への応用2008

    • Author(s)
      新留琢郎
    • Publisher
      フロンティア出版
    • Related Report
      2009 Final Research Report
  • [Book] ナノ粒子の創製と応用展開、米澤 徹編集、第5章ナノ粒子のバイオ・医療材料への応用2008

    • Author(s)
      新留琢郎
    • Total Pages
      322
    • Publisher
      フロンティア出版
    • Related Report
      2008 Annual Research Report
  • [Book] 遺伝子医学MOOK別冊、絵で見てわかるナノDDS、マテリアルから見た治療・診断・予後・予防、ヘルスケア技術の最先端(原島秀吉、田端泰彦編集)第3章22007

    • Author(s)
      新留琢郎、新留康郎
    • Publisher
      金属ナノ粒子
    • Related Report
      2009 Final Research Report
  • [Book] Gold nanorods: application to biosceince and medicine2007

    • Author(s)
      Y. Niiodome, T. Niidome
    • Publisher
      Nano Biophotonics, Science and Technology, Elsevier
    • Related Report
      2009 Final Research Report
  • [Book] 遺伝子医学MOOK別冊、絵で見てわかるナノDDS、マテリアルから見た治療・診断・予後・予防、ヘルスケア技術の最先端 第3章2, 金ナノ粒子2007

    • Author(s)
      新留 琢郎、新留 康郎
    • Total Pages
      246
    • Publisher
      メディカルドゥ
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.chem.kyushu-u.ac.jp/~katayama/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.chem.kyushu-u.ac.jp/~katayama/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 金微粒子被覆体とその製造方法、およびその用途2009

    • Inventor(s)
      新留琢郎、新留康郎、片山佳樹、秋山泰之
    • Industrial Property Rights Holder
      国立大学法人九州大学、大日本塗料株式会社、三菱マテリアル株式会社
    • Industrial Property Number
      2009-217241
    • Filing Date
      2009-09-18
    • Acquisition Date
      2009-09-18
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] Diels-Alder金ナノロッド2009

    • Inventor(s)
      新留琢郎、新留康郎、片山佳樹
    • Industrial Property Rights Holder
      国立大学法人九州大学、大日本塗料株式会社、三菱マテリアル株式会社
    • Industrial Property Number
      2009-198974
    • Filing Date
      2009-08-28
    • Acquisition Date
      2009-08-28
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 金微粒子被覆体とその製造方法およびその用途2009

    • Inventor(s)
      新留琢郎、新留康郎、片山佳樹、秋山泰之
    • Industrial Property Rights Holder
      国立大学法人九州大学、大日本塗料株式会社、三菱マテリアル株式会社
    • Industrial Property Number
      2009-217241
    • Filing Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] ロッド状金微粒子構造体とその製造方法および用途2009

    • Inventor(s)
      新留琢郎、新留康郎、片山佳樹
    • Industrial Property Rights Holder
      国立大学法人九州大学、大日本塗料株式会社、三菱マテリアル株式会社
    • Industrial Property Number
      2009-198974
    • Filing Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] cRGDペプチド修飾金ナノロッド2008

    • Inventor(s)
      新留琢郎、新留康郎、森健、片山佳樹
    • Industrial Property Rights Holder
      国立大学法人九州大学、大日本塗料株式会社、三菱マテリアル株式会社
    • Industrial Property Number
      2008-257675
    • Filing Date
      2008-09-30
    • Acquisition Date
      2008-09-30
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] PLL-g-PEG修飾金ナノロッド2008

    • Inventor(s)
      新留琢郎、新留康郎、森健、片山佳樹、丸山厚、狩野有宏
    • Industrial Property Rights Holder
      国立大学法人九州大学、三菱マテリアル株式会社、大日本塗料株式会社
    • Industrial Property Number
      2008-222952
    • Filing Date
      2008-08-30
    • Acquisition Date
      2008-08-30
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] uPAsub修飾金ナノロッド2008

    • Inventor(s)
      新留琢郎、新留康郎、大賀晃、森健、片山佳樹
    • Industrial Property Rights Holder
      国立大学法人九州大学、大日本塗料株式会社、三菱マテリアル株式会社
    • Industrial Property Number
      2008-171300
    • Filing Date
      2008-06-30
    • Acquisition Date
      2008-06-30
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] cRGDペプチド修飾金ナノロッド2008

    • Inventor(s)
      新留琢郎, 他
    • Industrial Property Rights Holder
      九州大学, 他
    • Industrial Property Number
      2008-257675
    • Filing Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体の近赤外分光法とその装置2007

    • Inventor(s)
      新留康郎、新留琢郎
    • Industrial Property Rights Holder
      大日本塗料株式会社、三菱マテリアル株式会社、新留康郎、新留琢郎
    • Industrial Property Number
      2008-091675
    • Filing Date
      2007-03-31
    • Acquisition Date
      2007-03-31
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 理包微粒子とその調製方法、および用途2007

    • Inventor(s)
      新留琢郎、新留康郎、河野喬仁、森健、片山佳樹
    • Industrial Property Rights Holder
      国立大学法人九州大学、大日本塗料株式会社、三菱マテリアル株式会社
    • Industrial Property Number
      2008-104014
    • Filing Date
      2007-11-29
    • Acquisition Date
      2007-11-29
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 理包微粒子とその調製方法、および用途2007

    • Inventor(s)
      新留 琢郎、新留 康郎、河野 喬仁、森 健、片山 佳樹
    • Industrial Property Rights Holder
      国立大学法人九州大学、大日本塗料株式会社、三菱マテリアル株式会社
    • Industrial Property Number
      2007-308197
    • Filing Date
      2007-11-29
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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