The effects of exercise on immune senescence in elderly

• Project/Area Number: 19300228
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: KONO Ichiro University of Tsukuba, 大学院・人間総合科学研究科, 教授 (00132994)
• Co-Investigator(Kenkyū-buntansha): AKAMA Takao 早稲田大学, スポーツ科学学術院, 教授 (60212411) ; AKIMOTO Takayuki 東京大学, 大学院・医科学系研究科, 講師 (00323460)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2007: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 運動 / 免疫機能 / 加齢

Research Abstract

The purpose of this study was to examine the effects of exercise training on immune function in elderly individuals. Moderate exercise training might up-regulate T-cell activation in elderly. In older rat, moderate exercise training might increase splenic lymphocyte-subsets in relation to T-cell activation. Moreover, combined lactobacillus intake and moderate exercise training might bolster mucosal immune function in elderly subjects. Consequently, exercise training might enhance immune function in elderly people.

Research Products

• [Journal Article] Effect of moderate exercise training on T-helper cell subpopulations in elderly people (2008)
  • Author(s): Shimizu K, Kimura F, Akimoto T, Akama T, Tanabe K, Nishijima T, Kuno S, Kono I
  • Journal Title: Exercise Immunology Review 14 Pages: 24-37
  • Peer Reviewed
• [Journal Article] Effect of moderate exercise training on T-helper subpopulations in elderly people (2008)
  • Author(s): K. Shimizu, F. Kimura, T. Akimoto, T. Akama, K. Tanabe, T. Nishijima, S. Kuno, I. Kono
  • Journal Title: Exercise Immunology Review 14 Pages: 24-37
  • Peer Reviewed
• [Journal Article] 高レベルの身体活動が中高齢者の免疫機能に及ぼす影響 (2008)
  • Author(s): 清水和弘、木村文律、田辺匠、小林大祐、秋本崇之、赤間高雄、河野一郎
  • Journal Title: スポーツ科学研究 3 Pages: 19-33
  • Peer Reviewed
• [Presentation] 乳酸菌b240摂取と適度な運動の実施が低身体活動量の高齢者の唾液分泌型免疫グロブリンAに及ぼす影響 (2009)
  • Author(s): 清水和弘, 佐藤広徳, 菅洋子, 山平聡子, 戸羽正道, 甲田哲之, 河野一郎, 赤間高雄, 久野譜也
  • Organizer: 第64回日本体力医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-20
• [Presentation] 乳酸菌b240摂取と適度な運動の実施が低身体活動量の高齢者の唾液分泌型免疫グロブリンAに及ぼす影響 (2009)
  • Author(s): 清水和弘, 佐藤広徳, 菅洋子, 山平聡子, 戸羽正道, 甲田哲之, 河野一郎, 赤間高雄, 久野譜, 也
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟朱鷺メッセ
  • Year and Date: 2009-09-20
• [Presentation] Effect of resistive training on immune function in elderly people (2009)
  • Author(s): Shimizu, K., Suzuki N, Imai T, Aizawa K, Nanba H, Akimoto T, Kuno S, Mesaki N, Kono I, Akama T
  • Organizer: European College of Sport Science 14th annual meeting
  • Place of Presentation: Oslo, Norway
  • Year and Date: 2009-06-25
• [Presentation] Effect of resistive training on immune function in elderly people (2009)
  • Author(s): K.Shimizu, N Suzuki, T Imai, K Aizawa, H Nanba, T Akimoto, S Kuno, N Mesaki, I Kono, T Akama
  • Organizer: 15th annual congress of the European College of Sport Science
  • Place of Presentation: オスロ(ノルウェー)
  • Year and Date: 2009-06-23
• [Presentation] 継続性運動による高齢ラットのリンパ球の変動 (2008)
  • Author(s): 野倉圭輔,清水和弘,木村文律,鈴木智弓,荘雅筑,枝伸彦,亀井雄太,河野一郎,赤問高雄
  • Organizer: 第63回日 本体力医学会大会
  • Place of Presentation: 別府ビーコンプラザ
  • Year and Date: 2008-09-20
• [Presentation] 高齢者における免疫機能の低下に対する運動効果 (2008)
  • Author(s): 清水和弘, 相澤勝治, 鈴木なつ未, 難波秀行, 今井智子, 秋本崇之, 久野譜也, 目崎登, 河野一郎, 赤間高雄
  • Organizer: 第63回日本体力医学会
  • Place of Presentation: 大分
  • Year and Date: 2008-09-18
• [Presentation] 継続性運動による高齢ラットのリンパ球数の変動 (2008)
  • Author(s): 野倉圭輔, 清水和弘, 木村文律, 鈴木智弓, 荘雅筑, 枝伸彦, 亀井雄太, 河野一郎, 赤間高雄
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 大分
  • Year and Date: 2008-09-18
• [Presentation] 高齢者における免疫機能の低下に対する運動効果 (2008)
  • Author(s): 清水和弘,相澤勝治,鈴木なつ未,難波秀行,今井智子,秋本崇之,久野譜也,目崎登,河野一郎,赤間高雄
  • Organizer: 第63回 日本体力医学会大会
  • Place of Presentation: 別府ビーコンプラザ
  • Year and Date: 2008-09-18