Elucidation of mechanism on "French Paradox" toward prevention of lifestyle-related diseases
| Project/Area Number |
19300250
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
INOUE Hiroyasu Nara Women's University, 生活環境学部, 教授 (40183743)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Rieko 奈良女子大学, 生活環境学部, 講師 (90198119)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | PPAR / シクロオキシゲナーゼ / 生活習慣病 / レスベラトロール / 精油成分 / 食品機能成分 / 核内受容体 / フレンチパラドックス / 発現制御 / 食品機能 |
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| Research Abstract |
Dairy oral intake of resveratrol, a phytoalexin contained in red wine, reduces plasma triglyceride concentration, and upregulates hepatic expression of PPAR-α responsive genes in the wild-type but not PPARα knockout mice. Moreover, long-term intake of 0.02% resveratrol with high fat diet prevents body weight gain observed after 46 weeks and accumulation of abdominal white adipose tissue, and improves survival of mice. These findings will account for a novel mechanism that may afford beneficial effects of preventing lifestyle-related diseases.
Several natural chemicals such as resveratrol have been identified as suppressors of COX-2 expression and activators of PPARs. These two properties targeted to COX-2 and PPARs will be useful in evaluating functional food components against lifestyle-related diseases. In this context, we evaluated oils from various plants in cell-based transfection assays, and found that six essential oils from thyme, rose, clove, fennel, eucalyptus, and bergamot, have these properties. From thyme oil, we identified carvacrol as a major component of the activator of PPARα and γ and suppressor of COX-2 expression, and PPARγ-dependent suppression of COX-2 promoter activity was observed in response to carvacrol treatment. These results will be important in understanding the anti-lifestyle-related disease properties of essential oils.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Carvacrol, a component of thyme oil, activates PPARa and g, and suppresses COX-2 Expression2010
Author(s)
Hotta M., Nakata R., Katsukawa M., Hori, K. Takahashi, S., Inoue, H.
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Journal Title
J. Lipid Res. 51
Pages: 132-139
Related Report
Peer Reviewed
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[Journal Article] Vaticanol C, a resveratrol tetramer2010
Author(s)
Tsukamoto T., Nakata R., Tamura E., Kosuge Y., Kariya A., Katsukawa M., Mishima S., Itoh, T., Iinuma M., Akao Y., NozawaY., Arai Y., Namura S., Inoue H.
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Journal Title
activates PPARαand PPARβ/δin vitro and in vivo Nutrition & Metabolism 7
Pages: 46-46
Related Report
Peer Reviewed
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[Presentation] Carvacrol and other components of essential oils activate PPARs and suppress COX-2 expression Hotta2009
Author(s)
Mariko, Katsukawa, Michiko, Hori, Kazuyuki, Takahashi, Saori, Nakata, Rieko, Hiroyau Inoue
Organizer
Bioactive Lipid Conference
Place of Presentation
Cancun, Mexico
Year and Date
2009-10-28
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