| Project/Area Number |
19300250
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Nara Women's University |
|---|
Principal Investigator |
INOUE Hiroyasu Nara Women's University, 生活環境学部, 教授 (40183743)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKATA Rieko 奈良女子大学, 生活環境学部, 講師 (90198119)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
|
|---|
| Keywords | PPAR / シクロオキシゲナーゼ / 生活習慣病 / レスベラトロール / 精油成分 / 食品機能成分 / 核内受容体 / フレンチパラドックス / 発現制御 / 食品機能 |
|---|
| Research Abstract |
Dairy oral intake of resveratrol, a phytoalexin contained in red wine, reduces plasma triglyceride concentration, and upregulates hepatic expression of PPAR-α responsive genes in the wild-type but not PPARα knockout mice. Moreover, long-term intake of 0.02% resveratrol with high fat diet prevents body weight gain observed after 46 weeks and accumulation of abdominal white adipose tissue, and improves survival of mice. These findings will account for a novel mechanism that may afford beneficial effects of preventing lifestyle-related diseases.
Several natural chemicals such as resveratrol have been identified as suppressors of COX-2 expression and activators of PPARs. These two properties targeted to COX-2 and PPARs will be useful in evaluating functional food components against lifestyle-related diseases. In this context, we evaluated oils from various plants in cell-based transfection assays, and found that six essential oils from thyme, rose, clove, fennel, eucalyptus, and bergamot, have these properties. From thyme oil, we identified carvacrol as a major component of the activator of PPARα and γ and suppressor of COX-2 expression, and PPARγ-dependent suppression of COX-2 promoter activity was observed in response to carvacrol treatment. These results will be important in understanding the anti-lifestyle-related disease properties of essential oils.
|
