Morphology Formation Dynamics of Multi-Component Vesicles

• Project/Area Number: 19340118
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biophysics/Chemical physics
• Research Institution: Ochanomizu University
• Principal Investigator: IMAI Masayuki Ochanomizu University, 大学院・人間文化創成科学研究科, 教授 (60251485)
• Co-Investigator(Kenkyū-buntansha): URAKAMI Naohito 山口大学, 理工学研究科, 講師 (50314795) ; NAKAYA Kaori お茶の水女子大学, 大学院・人間文化創成科学研究科, 助教 (50323861)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: 多成分ベシクル / 生体膜 / 膜内相分離 / 自発曲率 / 膜接着 / 孔形成 / 膜変形 / コロイド / 拘束系 / 拡散ダイナミクス / ナノダイナミク / シミュレーション / ADEモデル / 発芽

Research Abstract

我々は生体膜の示す様々な膜変形現象を、多成分ベシクルを用いたモデルを通して研究した。様々な形状を持つベシクルで相分離を起こすことにより、ベシクルが内側に分裂したり、外側に分裂したりする現象、球状のベシクルが数珠状に繋がる現象等、相分離するベシクルに特徴的な変形を示す事がわかった。さらに、脂質分子の自発曲率と相分離を結合させることにより接着や孔形成などの機能性膜変形も再現できる事がわかった。

Research Products

• [Journal Article] Simulation of pseudopolyrotaxane formation and orientationalorder between pseudopolyrotaxanes (2010)
  • Author(s): N.Urakami, J.Imada, T.Yamamoto
  • Journal Title: J.Chem.Phys. 132
  • Peer Reviewed
• [Journal Article] n-アルカン薄膜の構造形成における基板構造の効果 (2010)
  • Author(s): 三根雅生, 浦上直人, 野崎浩二, 山本隆
  • Journal Title: 高分子論文集 67 Pages: 198-202
  • NAID: 10026213343
  • Peer Reviewed
• [Journal Article] Nano-meter-sized domain formation in lipid membranes observed by small angle neutron scattering (2008)
  • Author(s): T. Masui, N. Urakami, M. Imai
  • Journal Title: Eur. Phys. J. E 27 Pages: 379-389
  • Peer Reviewed
• [Journal Article] Shape Deformation of Vesicle Coupled with Phase Separation M. Yanagisawa (2008)
  • Author(s): M. Imai, T. TaniguchiProgress
  • Journal Title: of Theoretical Physics Supplement 175 Pages: 71-80
  • Peer Reviewed
• [Journal Article] Adhesion of Binary Giant Vesicles Containing Negative Spontaneous Curvature Lipids Induced by Phase Separation (2008)
  • Author(s): Y. Sakuma, M. Imai, M. Yanagisawa, S. Komura
  • Journal Title: Eur. Phys. J. E 25 Pages: 403-413
  • Peer Reviewed
• [Journal Article] Shape deformation of ternary vesicles coupled with phase separationM. Yanagisawa (2008)
  • Author(s): M. Imai, T. TaniguchiPhys
  • Journal Title: Rev. Lett. 100
• [Journal Article] Lamellar to Micelle Transition of Nonionic Surfactant Assemblies Induced by Addition of Colloidal Particles (2008)
  • Author(s): Y. Suganuma, N. Urakami, R. Mawatari, S. Komura, Kaori Nakaya-Yaegashi, M. Imai
  • Journal Title: J. Chem. Phys 129 Pages: 134903-134903
  • Peer Reviewed
• [Journal Article] Lamellar to Micelle Transition of Nonionic Surfactant Assemblies Induced by Addition of Colloidal Particles (2008)
  • Author(s): Y. Suganuma, N. Urakami, R. Mawatari, S. Komura, K. Nakaya-Yaegashi, M. Imai
  • Journal Title: J. Chem. Phys. 129
  • Peer Reviewed
• [Journal Article] Shape Deformation of Vesicle Coupled with Phase Separation (2008)
  • Author(s): M. Yanagisawa, M. Imai, and T. Taniguchi
  • Journal Title: American Institute of Physics Conference Proceedings 982 Pages: 667-671
  • NAID: 110007004939
  • Peer Reviewed
• [Journal Article] Dynamics of Nano-Meter-Sized Domains on a Vesicle (2008)
  • Author(s): Y. Sakuma, N. Urakami, Y. Ogata, M. Nagao, S. Komura and M. Imai
  • Journal Title: American Institute of Physics Conference Proceedings 982 Pages: 717-720
  • Peer Reviewed
• [Journal Article] り8) Concentration fluctuations in binary fluid membranes (2007)
  • Author(s): K. Seki, S. Komura, M. Imai
  • Journal Title: J. Phys. 19(Condens. Matter) Pages: 72101-72101
  • Peer Reviewed
• [Journal Article] Growth Dynamics of Domains in Ternary Fluid Vesicles (2007)
  • Author(s): M. Yanagisawa, M. Imai, T. Masui, S. Komura, Takao Ohta
  • Journal Title: Biophysical J 92 Pages: 115-125
  • NAID: 110004829153
• [Journal Article] Repulsive inter-lamellar interaction induced by addition of colloidal particles (2007)
  • Author(s): Y. Suganuma, M. Imai, and K. Nakaya
  • Journal Title: J. Applied Crystallography 40
  • Peer Reviewed
• [Journal Article] Pore Formation in a Binary Giant Vesicle Induced by Cone-Shaped Lipids
  • Author(s): Y. Sakuma, T. Taniguchi, M. Imai
  • Journal Title: Biophys. J. (in press)
  • Peer Reviewed
• [Journal Article] Diffusion of domains on nanometer sized vesicle
  • Author(s): Y. Sakuma, N. Urakami, Y. Ogata, M. Nagao, S. Komura, T. Kawakatsu, M. Imai
  • Journal Title: J. Phys. Conf. Ser. (in press)
  • Peer Reviewed
• [Journal Article] Drag coefficient of a liquid domain in a two-dimensional membrane
  • Author(s): S.Ramachandran, S.Komura, M.Imai, K.Seki
  • Journal Title: Eur.Phys.J.E (印刷中)
  • Peer Reviewed
• [Journal Article] Diffusion of domains on nanometer sized vesicle
  • Author(s): Y.Sakuma, N.Urakami, Y.Ogata, M.Nagao, S.Komura, T.Kawakatsu, M.Imai
  • Journal Title: J.Phys.Conf.Ser. (印刷中)
  • Peer Reviewed
• [Journal Article] Pore Formation in a Binary Giant Vesicle Induced by Cone-Shaped Lipids
  • Author(s): Y.Sakuma, N.Urakami, Y.Ogata, M.Nagao, S.Komura, T.Kawakatsu, M.Imai
  • Journal Title: Biophys.J. (印刷中)
  • Peer Reviewed
• [Journal Article] Shape deformation of ternary vesicles coupled with phase separation
  • Author(s): M. Yanagisawa, M. Imai, and T. Taniguchi
  • Journal Title: Phys. Rev. Lett. (印刷中)
  • Peer Reviewed
• [Journal Article] Adhesion of Binary Giant Vesicles Containing Negative Spontaneous Curvature Lipids Induced by Phase Separation
  • Author(s): Y. Sakuma, M. Imai, M. Yanagisawa and S. Komura
  • Journal Title: European Physical Journal E (印刷中)
  • Peer Reviewed
• [Presentation] Diffusion of nanometer-sized domains on a vesicle Biophys. Soc. (2010)
  • Author(s): M. Imai
  • Organizer: 54th annual meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2010-02-22
• [Presentation] 多成分ベシクルの変形挙動特定領域研究非平衡物理学の創成 (2009)
  • Author(s): 今井正幸
  • Organizer: 第3回公開シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2009-11-21
• [Presentation] Inter-membrane interactions modulated by addition of guest components (2009)
  • Author(s): M. Imai
  • Organizer: Conference on Neutron Scattering & Mesoscopic Systems
  • Place of Presentation: Goa, India
  • Year and Date: 2009-10-12
• [Presentation] Inter-membrane Interactions Modulated by Addition of Guest Components (2009)
  • Author(s): Masayuki Imai
  • Organizer: Conference on Neutron Scattering & Mesoscopic Systems
  • Place of Presentation: Goa, India
  • Year and Date: 2009-10-12
• [Presentation] Lamellar to Micelle Transition of Nonionic Surfactant Assemblies Induced by Confinement of Colloidal Particles (2009)
  • Author(s): Masayuki Imai
  • Organizer: International Conference on Neutron Scattering 2009
  • Place of Presentation: Goa, India
  • Year and Date: 2009-05-12
• [Presentation] Lamellar to Micelle Transition of Nonionic Surfactant Assemblies Induced by Confinement of Colloidal Particles. (2009)
  • Author(s): M. Imai
  • Place of Presentation: Knoxville USA
  • Year and Date: 2009-05-05
• [Presentation] Deformation of Vesicles Controlled by Spontaneous Curvatures of Lipids (2008)
  • Author(s): Y. Sakuma, M. Imai, T. Kawakatsu
  • Organizer: 7th Liquid matter conference
  • Place of Presentation: Lund, Sweden
  • Year and Date: 2008-07-01
• [Presentation] Shape Deformation of Ternary Vesicles Coupled with Phase Separation (2008)
  • Author(s): M. Yanagisawa, M. Imai, T. Taniguchi
  • Organizer: 7th Liquid matter conference
  • Place of Presentation: Lund, Sweden
  • Year and Date: 2008-07-01
• [Presentation] Effects of Spontaneous Curvature of Lipids on the Vesicle Shape (2008)
  • Author(s): Y. Sakuma, M. Imai, T. Kawakatsu
  • Organizer: International symposium on Non-Equilibrium Soft Matter
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-06-04
• [Presentation] Shape Deformation of Vesicle Coupled with Phase Separation (2008)
  • Author(s): M. Yanagisawa, M. Imai, T. Taniguchi
  • Organizer: International symposium on Non-Equilibrium Soft Matter
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-06-04
• [Presentation] Shape Deformation of Vesicle Coupled with Phase Separation International symposium on non-equilibrium soft matter (2008)
  • Author(s): M. Imai
  • Place of Presentation: Kyoto
  • Year and Date: 2008-06-03
• [Presentation] Shape Deformation of Vesicle Coupled with Phase Separation International Workshopn on Physical Phenomena in Multi-Component Membranes (2008)
  • Author(s): M. Imai
  • Place of Presentation: Tokyo
  • Year and Date: 2008-03-18
• [Presentation] Domain growth of deformed vesicles International Soft Matter Conference (2007)
  • Author(s): M. Imai
  • Place of Presentation: Aachen, Germany
  • Year and Date: 2007-10-01
• [Presentation] Shape Deformation of Vesicle Coupled with Phase Separation (2007)
  • Author(s): M. Imai
  • Organizer: The 5th International workshop on complex systems
  • Place of Presentation: Sendai
  • Year and Date: 2007-09-26
• [Presentation] Domain growth on deformed vesicles (2007)
  • Author(s): Masayuki Imai
  • Organizer: International Soft Matter Conference 2007
  • Place of Presentation: Aachen, Germany
• [Presentation] Shape Deformation of Vesicles Coupled with Phase separation (2007)
  • Author(s): Masayuki Imai
  • Organizer: The sth International Workshop on Complex Systems
  • Place of Presentation: Sendai, Japan
• [Presentation] Isotropic-Nematic Transition of Microemulsion Spheres Induced by Polymer Confinement (2007)
  • Author(s): Kaori Nakaya
  • Organizer: International Soft Matter Conference
  • Place of Presentation: Aachen, Germany
• [Book] ソフトマターの秩序形成 (2007)
  • Author(s): 今井正幸
  • Total Pages: 399
  • Publisher: シュプリンガー・ジャパン東京
• [Book] ソフトマターの秩序形成 (2007)
  • Author(s): 今井正幸
  • Total Pages: 399
  • Publisher: シュプリンガー・ジャパン
• [Remarks]
  • URL: http://sofia.phys.ocha.ac.jp/imailab/index.html
• [Patent(Industrial Property Rights)] 2成分ベシクルによるマイクロメートルサイズの物質輸送システム (2009)
  • Inventor(s): 佐久間由香・今井正幸
  • Industrial Property Rights Holder: お茶の水女子大学
  • Industrial Property Number: 2009-042357
  • Filing Date: 2009-02-25
• [Patent(Industrial Property Rights)] 2成分ベシクルによるマイクロメートルサイズの物質輸送システム (2009)
  • Inventor(s): 佐久間 由香, 今井 正幸
  • Industrial Property Rights Holder: お茶の水女子大学
  • Industrial Property Number: 2009-042357
  • Filing Date: 2009-02-25