| Project/Area Number |
19350051
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
RYU Ilhyong Osaka Prefecture University, 理学系研究科, 教授 (80210821)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Takahide 大阪府立大学, 理学系研究科, 講師 (60332962)
MATSUBARA Hiroshi 大阪府立大学, 理学系研究科, 准教授 (20239073)
KOBAYASHI Shoji 大阪府立大学, 理学系研究科, 助教 (30374903)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | ラジカル反応 / ハイブリッド型連鎖反応 / 環境調和型反応プロセス / イオン反応 / 遷移金属触媒反応 / カルボニル化反応 / ラジカル / 光照射反応 / 一酸化炭素 / 多成分連結反応 / ヒドロキシメチル化反応 / アセチレンケトン / 金属ラジカル / ラクトール / 連鎖反応 / 一電子移動 / 金属カルベノイド / 臭化銅 / ラジカル付加反応 / ヒドリド還元 / ハイブリッド型反応 / Giese型反応 / ヨウ素移動反応 |
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| Research Abstract |
This research aimed at development of new radical reactions in which both radical species and non-radical species play a key role. Borohydride reagents proved to function as efficient radical mediators. As a notable example, hydroxymethylation of iodoalkanes proceeded using atmospheric pressure of CO and tertrabutylammonium borohydride. Under photo-irradiation conditions, in the presence of Pd complexes, three component coupling reaction of iodoalkanes, CO and terminal alkynes proceeded efficiently to give good yields of acetylenic ketones. Lactol forming reaction was also attained via ionic trapping of acyl radicals by an internal hydroxy group.
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