Stabilization mechanism of collagen helix by using host-guest model peptides
| Project/Area Number |
19350059
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
OKUYAMA Kenji Osaka University, 大学院・理学研究科, 教授 (30038020)
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Fumitoshi 大阪大学, 大学院・理学研究科, 准教授 (70214468)
KAWAGUCHI Tatsuya 大阪大学, 大学院・理学研究科, 助教 (10314353)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | コラーゲン / 三重らせん / モデルペプチド / 高分解能解析 / 構造安定化 / 三重らせん構造 / 構造安定化機構 / 単結晶解析 |
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| Research Abstract |
Understanding the mechanism of the stabilization and destabilization of a collagen helix induced by Hyp residues is one of important issues in structural study of collagen. The present study has revealed the rule for ring puckering of Hyp residues, which governs stabilization and destabilization of collagen helix, by the high resolution structure analyses of collagen-model peptides.
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Report
(4 results)
Research Products
(51 results)
