| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Research Abstract |
We developed several kinds of enantiopure phosphonothioic and phosphinothioic acids as new resolving agents having a chiral functional group. They showed a unique chirality-recognition ability to racemic amines and amino alcohols, depending on their chemical structure. Moreover, the X-ray crystallography of the diastereomeric salts revealed that halogen interaction plays an important role for the stabilization of less-soluble diastereomeric salt crystals other than hydrogen-bonding, CH/π, and van der Waals interactions. On the other hand, the present study suggested that the synthesis of compounds having a chiral tertiary amino group is not so difficult that they would be a new series of resolving agents with a chiral functional group.
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