INVENTION AND CHIRALITY-RECOGNITION ABILITY OF RESOLVING AGENTS HAVING A CHIRAL FUNCTIONAL GROUP AND ITS MECHANISM
| Project/Area Number |
19350064
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional materials chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAIGO Kazuhiko The University of Tokyo, 大学院・工学系研究科, 教授 (80016154)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | ジアステレオマー塩 / 光学分割 / キラル識別能 / チオホスホン酸 / チオホスフィン酸 / N-キラルモノアミン / X-線結晶構造解析 / 計算機化学手法 / キラル識別機構 / ハロゲン相互作用 / 分子長原則 / キラルリン化合物 / キラル窒素化合物 / キラリティー識別能 / ハロゲン相互作 / 結晶工学 / 分子認識 / キラル認識 / 中心性キラリティー / 水素結合 / キラル識別 |
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| Research Abstract |
We developed several kinds of enantiopure phosphonothioic and phosphinothioic acids as new resolving agents having a chiral functional group. They showed a unique chirality-recognition ability to racemic amines and amino alcohols, depending on their chemical structure. Moreover, the X-ray crystallography of the diastereomeric salts revealed that halogen interaction plays an important role for the stabilization of less-soluble diastereomeric salt crystals other than hydrogen-bonding, CH/π, and van der Waals interactions. On the other hand, the present study suggested that the synthesis of compounds having a chiral tertiary amino group is not so difficult that they would be a new series of resolving agents with a chiral functional group.
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Report
(4 results)
Research Products
(23 results)
