Advanced Imaging Method of Light Source Distributions in Biological Tissues

• Project/Area Number: 19360098
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thermal engineering
• Research Institution: The University of Electro-Communications
• Principal Investigator: YAMADA Yukio The University of Electro-Communications, 電気通信学部, 教授 (10334583)
• Co-Investigator(Kenkyū-buntansha): OKAWA Shinpei 電気通信大学, 電気通信学部, 助教 (20432049) ; SHIRAKAWA Hideki 電気通信大学, 電気通信学部, 准教授 (40241070) ; HOSHI Yoko (財)東京都医学研究機構, 精神医学総合研究所, 副参事研究員 (50332383) ; TANIKAWA Yukari (独)産業技術総合研究所, 主任研究員 (20344202)
• Research Collaborator: GAO Feng 天津大学, 精密機械・光電子工学科, 教授
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 熱 / 物質移動 / 蛍光トモグラフィ / 逆問題 / 蛍光特性 / インドシアニングリーン / 生体模擬試料 / 小動物試験 / 蛍光寿命

Research Abstract

新薬開発などにおけるコストと犠牲動物の低減を目指し,分子イメージング技術の一つである蛍光トモグラフィー法の高度化を目的として,画像再構成法の開発とシミュレーション,および,生体模擬試料やマウスを用いた実験を行った.画像再構成法の新しい手法を開発し,実験によりその手法を実証することができた.結果として,マウス体内に埋め込んだ蛍光物質の濃度分布に関する断層画像を得た.

Research Products

• [Journal Article] Effective optode configuration for the image reconstruction in diffuse optical tomography (2010)
  • Author(s): K. Uchida, S. Okawa, S. Matsuhashi, Y. Hoshi, Y. Yamada
  • Journal Title: Med. Laser Appl. (accepted for publication)
  • Peer Reviewed
• [Journal Article] Recognition of human emotions from cerebral blood flow changes in the frontal region: a study with event-related near-infrared spectroscopy (2010)
  • Author(s): Y. Hoshi, J. Huang, S. Kohri, Y. Iguchi, M. Naya, T. Okamoto, S. Ono
  • Journal Title: J. Neuroimaging (in press)
  • Peer Reviewed
• [Journal Article] Effective optode configuration for the image reconstruction in diffuse optical tomography (2010)
  • Author(s): K.Uchida, S.Okawa, S.Matsuhashi, Y.Hoshi, Y.Yamada
  • Journal Title: Medical Laser Application (accepted for publication)
  • Peer Reviewed
• [Journal Article] Recognition of human emotions from cerebral blood flow changes in the frontal region : a study with event-related near-infrared spectroscopy (2010)
  • Author(s): Y.Hoshi, J.Huang, S.Kohri, Y.Iguchi, M.Naya, T.Okamoto, S.Ono
  • Journal Title: J.Neuroimaging (In press)
  • Peer Reviewed
• [Journal Article] 3D light source reconstruction with spatial filter for fluorescence/bioluminescence diffuse optical tomography (2010)
  • Author(s): S.Okawa, Y.Yamada
  • Journal Title: Proceedings of SPIE 7369
  • Peer Reviewed
• [Journal Article] Estimation of the absorption coefficients of two-layered media by a simple method using spatially and time-resolved reflectances (2009)
  • Author(s): M. Shimada, C. Sato, Y. Hoshi, Y. Yamada
  • Journal Title: Physics in Medicine and Biology Vol.54,No.16 Pages: 5057-5071
  • Peer Reviewed
• [Journal Article] Estimation of the absorption coefficients of two-layered media by a simple method using spatially and time-resolved reflectances (2009)
  • Author(s): M.Shimada, C.Sato, Y Hoshi, Y.Yamada
  • Journal Title: Physics in Medicine and Biology 54 Pages: 5057-5071
  • Peer Reviewed
• [Journal Article] Persistence criteria for susceptibility genes for schizophrenia : a discussion from an evolutionary viewpoint (2009)
  • Author(s): N.Doi, Y.Hoshi, M.Itokawa, C.Usui, T.Yoshikawa, H.Tachikawa
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] 光を用いた脳と心の探究 (2009)
  • Author(s): 星詳子
  • Journal Title: 日本小児科学会雑誌 113 Pages: 1642-1648
  • NAID: 10026276440
• [Journal Article] 近赤外分光法 (NIRS) による脳機能計測 (2009)
  • Author(s): 星詳子
  • Journal Title: Med.Technol. 37 Pages: 248-252
• [Journal Article] 近赤外分光法(NIRS)による脳機能計測 (2009)
  • Author(s): 星 詳子
  • Journal Title: Medical Technology 37 Pages: 248-352
• [Journal Article] 散乱光情報を利用した脳活動の近赤外光イメージング (2009)
  • Author(s): 谷川ゆかり
  • Journal Title: 産総研 TODAY 9 Pages: 16-16
• [Journal Article] Microfluidic image cytometry for measuring number and sizes of biological cells flowing through a microchannel using the micro-PIV technique (2008)
  • Author(s): T. Hirono, H. Arimoto, S. Okawa, Y. Yamada
  • Journal Title: Meas. Sci. Tech. Vol.19,PaperNo.025401
  • Peer Reviewed
• [Journal Article] Total light approach of time-domain fluorescence diffuse optical tomography (2008)
  • Author(s): A. Marjono, A. Yano, S. Okawa, F. Gao, Y. Yamada
  • Journal Title: Optics Express Vol.16,No.19 Pages: 15268-15285
  • Peer Reviewed
• [Journal Article] A self-normalized, full time-resolved method for fluorescence diffuse optical tomography (2008)
  • Author(s): F. Gao, H. Zhao, L. Zhang, Y. Tanikawa, A. Marjono, Y. Yamada
  • Journal Title: Optics Express Vol.16,No.17 Pages: 13104-13121
  • Peer Reviewed
• [Journal Article] Microfluidic image cytometry for measuring number and sizes of biological cells flowing through a microchannel using the micro-PIV technique (2008)
  • Author(s): T. Hirono, H. Arimoto, S. Okawa, Y. Yamada
  • Journal Title: Measurement Science and Technology 19 Pages: 25401-25401
  • Peer Reviewed
• [Journal Article] A self-normalized, full time-resolved method for fluorescence diffuse optical tomography (2008)
  • Author(s): Feng Gao, Huijuan Zhao, Limin Zhang, Yukari Tanikawa, Andhi Marjono, Yukio Yamada
  • Journal Title: Optics Express 16 Pages: 13104-13121
  • Peer Reviewed
• [Journal Article] Total light approach of time-domain fluorescence diffuse optical tomography (2008)
  • Author(s): Andhi Marjono, Akira Yano, Shinpei Okawa, Feng Gao, Yukio Yamada
  • Journal Title: Optics Express 16 Pages: 15268-15285
  • Peer Reviewed
• [Journal Article] Pharmacological characterization of Ca^<2+> entry pathway during Ca^<2+>oscillations in fertilized mouse esgs. (2008)
  • Author(s): Takahashi, T., Shirakawa, H.
  • Journal Title: Journal of Physiological Sciences 58(Suppl)
• [Journal Article] 近赤外光による生体内血液状態分布測定技術 (2008)
  • Author(s): 山田幸生
  • Journal Title: 冷凍 83 Pages: 167-172
• [Journal Article] Intraoperative monitoring of depth-dependent hemoglobin concentration changes during carotid endarterectomy by time-resolved spectroscopy (2007)
  • Author(s): C. Sato, T. Yamaguchi, M. Seida, Y. Ota, I. Yu, Y. Iguchi, M. Nemoto, Y. Hoshi
  • Journal Title: Applied Optics Vol.46 Pages: 2785-2792
  • Peer Reviewed
• [Journal Article] Functional near-infrared spectroscopy: current status and feature prospects (2007)
  • Author(s): Y. Hoshi
  • Journal Title: J. Biomedical Optics Vol.12,No.6,paperNo.062106(CID)
  • Peer Reviewed
• [Journal Article] Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging (2007)
  • Author(s): H. Zhao, F. Gao, Y. Tanikawa, Y. Yamada
  • Journal Title: J. Biomedical Optics Vol.12,No.6,paperNo.062107(CID)
  • Peer Reviewed
• [Journal Article] Light Propagation for Time-Domain Fluorescence Diffuse Optical Tomography by Convolution Using Lifetime Function (2007)
  • Author(s): A. Marjono, S. Okawa, F. Gao, Y. Yamada
  • Journal Title: Optical Review Vol.14,No.3 Pages: 131-138
  • NAID: 10019506210
  • Peer Reviewed
• [Journal Article] Light Propagation for Timc-Domain Fluorcsccncc Diffusc Optical Tomography by Convolution Using Lifetime Function (2007)
  • Author(s): A. Marjono
  • Journal Title: Optical Review 14(3) Pages: 131-138
  • Peer Reviewed
• [Journal Article] Time-resolved diffuse optical tomography and its application to in vivo and in vivo imaging (2007)
  • Author(s): H. Zhao
  • Journal Title: Journal of Biomedical Optics 12(6)
  • Peer Reviewed
• [Journal Article] Microfluidic image cytometry for measuring number and sizes of biological cells flowing through a microchannel using the micro-PIV technique (2007)
  • Author(s): T. Hirono
  • Journal Title: Measurement Science and Technology 19
  • Peer Reviewed
• [Journal Article] Functional near-infrared spectroscopy: current status and feature prospects (2007)
  • Author(s): Y. Hoshi
  • Journal Title: Journal of Biomedical Optics 12(6)
  • Peer Reviewed
• [Journal Article] Intraoperative monitoring of depth-dependent hemoglobin concentration changes during carotid endarterectomy by time-resolved spectroscopy (2007)
  • Author(s): C. Sato
  • Journal Title: Applied Optics 46 Pages: 2785-2792
  • Peer Reviewed
• [Presentation] What can combined NIRS-EEG measurements tell us about brain function? (2010)
  • Author(s): Y. Hoshi
  • Organizer: UK-Japan Workshop Multimodal Measurements for Brain Function
  • Place of Presentation: Embassy, Tokyo, Japan(Invited talk)
  • Year and Date: 2010-01-27
• [Presentation] What can combined NIRS-EEG measurements tell us about brain function? (2010)
  • Author(s): 山田幸生
  • Organizer: UK-Japan Workshop Multimodal Measurements for Brain Function
  • Place of Presentation: UK Embassy, Tokyo, Japan
  • Year and Date: 2010-01-27
• [Presentation] 拡散光トモグラフィーによるヒト前腕の筋活動に関する研究 (2010)
  • Author(s): 遠藤泰臣, 谷川ゆかり, 星詳子, 大川晋平, 山田幸生
  • Organizer: 日本機械学会 第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山理科大学 (岡山市)
• [Presentation] 光散乱体中における蛍光特性の測定 (2010)
  • Author(s): 丸岡正二, 内田和希, 三井陽平, 大川晋平, 星詳子, 山田幸生
  • Organizer: 日本機械学会 第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山理科大学 (岡山市)
• [Presentation] ヒト角層の光学特性 (2010)
  • Author(s): 服部和久, 岡本光平, 畠山宗也, 桑原智裕, 大川晋平, 山田幸生
  • Organizer: 日本機械学会 第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山理科大学 (岡山市)
• [Presentation] 3次元拡散光トモグラフィーのシミュレーション (2010)
  • Author(s): 内田和浩, 松橋翔子, 星詳子, 大川晋平, 山田幸生
  • Organizer: 日本機械学会 第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山理科大学 (岡山市)
• [Presentation] 二光子励起法による脳組織光学特性の波長依存性を考慮した生体内脳微小血管イメージング (2010)
  • Author(s): 吉原光一, 米家一洋, 正本和人, 大川晋平, 菅野巌, 谷下一夫, 山田幸生
  • Organizer: 日本機械学会 第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山理科大学 (岡山市)
• [Presentation] Diffuse Light Spectroscopy and Imaging for Biomedical Engineering (2009)
  • Author(s): Y. Yamada
  • Organizer: Workshop on Information, Nano and Photonics Technology 2009
  • Place of Presentation: Kobe University, Kobe, Japan(Invited talk)
  • Year and Date: 2009-12-01
• [Presentation] (Invited talk) "Diffuse Light Spectroscopy and Imaging for Biomedical Engineering" (2009)
  • Author(s): 山田幸生
  • Organizer: Workshop on Information, Nano and Photonics Technology 2009
  • Place of Presentation: Kobe University, Kobe, Japan
  • Year and Date: 2009-12-01
• [Presentation] NIRS脳機能イメージングの神経生理学的基礎 : 神経血管カップリング (2009)
  • Author(s): 星詳子
  • Organizer: 第39回日本臨床神経生理学会
  • Place of Presentation: 西日本総合展示場 (北九州)
  • Year and Date: 2009-11-20
• [Presentation] Functional near-infrared spectroscopy: basic principles and applications (2009)
  • Author(s): Y. Hoshi
  • Organizer: Korean Society of Human Brain Mapping
  • Place of Presentation: Soul University, Soul, Korea(Invited talk)
  • Year and Date: 2009-11-06
• [Presentation] Functional near-infrared spectroscopy : basic principles and applications (2009)
  • Author(s): 山田幸生
  • Organizer: Korean Society of Human Brain Mapping
  • Place of Presentation: Soul University, Soul, Korea
  • Year and Date: 2009-11-06
• [Presentation] Gaze aversion : To see the invisible with eye movement (2009)
  • Author(s): Y.Hoshi, S-J.Chen
  • Organizer: Neuroscience 2009
  • Place of Presentation: McCormic Place Chicago, USA
  • Year and Date: 2009-10-19
• [Presentation] マウス受精卵におけるCa^<2+>オシレーション発生時のCa^<2+>流入の解析 (2009)
  • Author(s): 高橋徹, 畑中貴之, 原悠輔, 白川英樹
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: グランシップ (静岡市)
  • Year and Date: 2009-09-18
• [Presentation] マウス卵におけるSTIM/Orai タンパク質による細胞内Ca^<2+>濃度調節 (2009)
  • Author(s): 木所佑介, 日高裕華, 白川英樹
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: グランシップ (静岡市)
  • Year and Date: 2009-09-18
• [Presentation] 哺乳類受精時の細胞内Ca^<2+>振動の発生・維持に対するミトコンドリアの関与 (2009)
  • Author(s): 今井修, 宮川薫, 熊倉裕紀, 白川英樹
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: グランシップ (静岡市)
  • Year and Date: 2009-09-18
• [Presentation] 近赤外光を利用した生体イメージング技術の応用 (2009)
  • Author(s): 谷川ゆかり
  • Organizer: 電子情報通信学会2009年ソサイエティ大会
  • Place of Presentation: 新潟大学 (新潟市)
  • Year and Date: 2009-09-15
• [Presentation] Functional role of CRAC channels in the generation and maintenance of Ca^<2+> oscillations in mammalian eggs (2009)
  • Author(s): Kidokoro, Y., Takahashi, A., Shirakawa, H.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: 京都国際会館 (京都市)
  • Year and Date: 2009-07-29
• [Presentation] Characterization of Ca^<2+> influx pathway activated during Ca^<2+> oscillations in mouse eggs (2009)
  • Author(s): 高橋徹, 白川英樹
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: 京都国際会館 (京都市)
  • Year and Date: 2009-07-29
• [Presentation] Optical Mapping of Brain Activities : Effects of Spatial Variation of Skull and Cerebrospinal Fluid layers (2009)
  • Author(s): S.Wang, N.Shibahara, D.Kuramashi, S.Okawa, N.Kakuta, E.Okada, A.Maki, Y.Yamada
  • Organizer: 第11回日本光脳機能イメージング研究会
  • Place of Presentation: 星陵会館 (東京都千代田区)
  • Year and Date: 2009-07-18
• [Presentation] 3D light source reconstruction with spatial filter for fluorescence / bioluminescence diffuse optical tomography (2009)
  • Author(s): S. Okawa, Y. Yamada
  • Organizer: ECBO (European Conference on Biomedical Optics), Munich, Germany
  • Place of Presentation: Proceedings of SPIE
  • Year and Date: 2009-06-14
• [Presentation] 3D light source reconstruction with spatial filter for fluorescence/bioluminescence diffuse optical tomography (2009)
  • Author(s): 大川晋平, 山田幸生
  • Organizer: ECBO (European Conference on Biomedical Optics) 2009
  • Place of Presentation: International Conference Center Munich, Germany
  • Year and Date: 2009-06-14
• [Presentation] 近赤外分光法の限界と可能性-拡散光を用いた生体計測への応用- (2009)
  • Author(s): 谷川ゆかり
  • Organizer: 日本人間工学会第50回記念大会
  • Place of Presentation: 産業技術総合研究所 (つくば市)
  • Year and Date: 2009-06-12
• [Presentation] 空間フィルタによる生体内光源強度分布の三次元再構成 (2009)
  • Author(s): 大川晋平, 山田幸生
  • Organizer: 第48回日本生体医工学会大会
  • Place of Presentation: タワーホール船堀 (東京都江戸川区)
  • Year and Date: 2009-04-23
• [Presentation] 光を用いた脳と心の探究 (2009)
  • Author(s): 星詳子
  • Organizer: 第112回日本小児科学会
  • Place of Presentation: 奈良県新公会堂(奈良)(招待講演)
  • Year and Date: 2009-04-17
• [Presentation] 光を用いた脳と心の探究 (2009)
  • Author(s): 星詳子
  • Organizer: 第112回日本小児科学会
  • Place of Presentation: 奈良県新公会堂 (奈良)
  • Year and Date: 2009-04-17
• [Presentation] 前腕筋運動の拡散光イメージング (2009)
  • Author(s): 谷川ゆかり, 高峰, 遠藤泰臣, 山田幸生, 木竜徹, 宮川道夫
  • Organizer: 平成20年度第8回産総研・産技連LS-BT合同研究発表会
  • Place of Presentation: つくば市
  • Year and Date: 2009-01-29
• [Presentation] 光マッピング画像に対する脳脊髄液層及び頭蓋骨層厚さの影響 (2009)
  • Author(s): 王 淑萍, 芝原奈々恵, 倉増大士, 大川晋平, 角田直人, 岡田英史, 牧 敦, 山田幸生
  • Organizer: 日本機械学会 第21回バイオエンジニアリング講演会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-01-23
• [Presentation] 近赤外光を利用した生体計測技術の開発 (2009)
  • Author(s): 谷川ゆかり
  • Organizer: つくば医工連携フォーラム2009
  • Place of Presentation: つくば市
  • Year and Date: 2009-01-14
• [Presentation] Effects of the movement of probes on the images of diffuse optical tomography (2009)
  • Author(s): S. Matsuhashi, R. Fukuzawa, S. Okawa, Y. Hoshi, Y. Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009), Jeju, Korea
  • Place of Presentation: Proceedings of APBP2009
• [Presentation] Phantom experiments of fluorescence diffuse optical tomography (2009)
  • Author(s): A. Yano, A. Marjono, K. Uchida, T. Abe, S. Okawa, G. Nishimura, Y. Hoshi, F. Gao, Y. Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009), Jeju, Korea
  • Place of Presentation: Proceedings of APBP2009
• [Presentation] Effects of the anatomy of the head on optical mapping of brain activities (2009)
  • Author(s): M. Oki, N. Shibahara, R. Togashi, S. Okawa, Y. Hoshi, Y. Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009), Jeju, Korea
  • Place of Presentation: Proceedings of APBP2009
• [Presentation] Effects of Spatial Variation of Skull and Cerebrospinal Fluid Layers on Optical Mapping of Brain Activities (2009)
  • Author(s): Shuping Wang, N. Shibahara, D. Kuramashi, S. Okawa, N. Kakuta, E. Okada, A. Maki, Y. Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009), Jeju, Korea
  • Place of Presentation: Proceedings of APBP2009
• [Presentation] Effects of Spatial Variation of Skull and Cerebrospinal Fluid Layers on Optical Mapping of Brain Activities (2009)
  • Author(s): Shuping Wang, N.Shibahara, D.Kuramashi, S.Okawa, N.Kakuta, E.Okada, A.Maki, Y.Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009)
  • Place of Presentation: Shilla Hotel, Jeju, Korea
• [Presentation] Time-resolved DOT images of human forearm under excise (2009)
  • Author(s): Y.Tanikawa, Feng Gao, M.Miyakawa, T.Kiryu, Y.Endo, S.Okawa, Y.Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009)
  • Place of Presentation: Shilla Hotel, Jeju, Korea
• [Presentation] Effects of the anatomy of the head on optical mapping of brain activities (2009)
  • Author(s): M.Oki, N.Shibahara, R.Togashi, S.Okawa, Y.Hoshi, Y.Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009)
  • Place of Presentation: Shilla Hotel, Jeju, Korea
• [Presentation] Reduction of Poisson Noise from Time-Resolved Data for Diffuse Optical Tomography (2009)
  • Author(s): 大川晋平, 山田幸生
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009)
  • Place of Presentation: Shilla Hotel, Jeju, Korea
• [Presentation] Phantom experiments of fluorescence diffuse optical tomography (2009)
  • Author(s): A.Yano, A.Marjono, K.Uchida, T.Abe, S.Okawa, G.Nishimura, Y.Hoshi, F.Gao, Y.Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009)
  • Place of Presentation: Shilla Hotel, Jeju, Korea
• [Presentation] Effects of the movement of probes on the images of diffuse optical tomography (2009)
  • Author(s): S.Matsuhashi, R.Fukuzawa, S.Okawa, Y.Hoshi, Y.Yamada
  • Organizer: The 4th Asian and Pacific Rim Symposium on Biophotonics (APBP2009)
  • Place of Presentation: Shilla Hotel, Jeju, Korea
• [Presentation] Time-domain approach of angle projected diffused optical tomography : fluorescence probes and environmental dependency (2009)
  • Author(s): K.Awasthi, K.Locharoenrat, 西村吾朗, 大川晋平, 山田幸生
  • Organizer: 日本光学会 Optics Japan 2009
  • Place of Presentation: 新潟コンベンションセンター (新潟市)
• [Presentation] Time-domain approach of angle projected diffused optical tomography : Geometric dependency (2009)
  • Author(s): K.Locharoenrat, K.Awasthi, 西村吾朗, 大川晋平, 山田幸生
  • Organizer: 日本光学会 Optics Japan 2009
  • Place of Presentation: 新潟コンベンションセンター (新潟市)
• [Presentation] 時間分解計測法による蛍光トモグラフィーの実験的研究 (2009)
  • Author(s): 内田和希, 三井陽平, A.Marjono, 矢野亮, 丸岡正二, 大川晋平, 西村吾朗, 星詳子, 高峰, 山田幸生
  • Organizer: 日本光学会 Optics Japan 2009
  • Place of Presentation: 新潟コンベンションセンター (新潟市)
• [Presentation] 拡散光トモグラフィーにおける光プローブの接触不良による画像への影響とその除去方法について (2009)
  • Author(s): 松橋翔子, 福沢遼, 大川晋平, 山田幸生, 星詳子
  • Organizer: 日本光学会 Optics Japan 2009
  • Place of Presentation: 新潟コンベンションセンター (新潟市)
• [Presentation] 光マッピング技術の基礎研究 (2009)
  • Author(s): 冨樫陵, 王淑萍, 大川晋平, 星詳子, 山田幸生
  • Organizer: 日本光学会 Optics Japan 2009
  • Place of Presentation: 新潟コンベンションセンター (新潟市)
• [Presentation] 非侵襲血糖値測定法の開発---光学的手法におけるブレークスルー--- (2008)
  • Author(s): 山田幸生
  • Organizer: 応用物理学会・光波センシング技術研究会 第42回光波センシング技術研究会講演会
  • Place of Presentation: 東京都
  • Year and Date: 2008-12-09
• [Presentation] 近赤外光の生体内伝播と拡散光トモグラフィー (2008)
  • Author(s): 山田幸生
  • Organizer: (社)電子情報通信学会九州支部 平成20年度専門講習会
  • Place of Presentation: 宮崎市
  • Year and Date: 2008-12-05
• [Presentation] NIRS装置(近赤外光)用モデル(ファントム) (2008)
  • Author(s): 谷川ゆかり
  • Organizer: 産総研研究講演会in中部2008
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-11-19
• [Presentation] 未熟児頭部の拡散光トモグラフィの研究 (2008)
  • Author(s): 福沢遼, 松橋翔子, 大川晋平, 高峰, 星詳子, 山田幸生
  • Organizer: 日本光学会Optics & Photonics Japan 2008 (OPJ2008)
  • Place of Presentation: つくば市
  • Year and Date: 2008-11-06
• [Presentation] 未熟児頭部の拡散光トモグラフィの研究 (2008)
  • Author(s): 福沢 遼, 松橋翔子, 大川晋平, 高 峰, 星 詳子, 山田幸生
  • Organizer: 日本光学会 Optics & Photonics Japan 2008 (OPJ2008)
  • Place of Presentation: つくば市
  • Year and Date: 2008-11-06
• [Presentation] 近赤外光を用いた非侵襲血糖値測定法の開発 (2008)
  • Author(s): 山田幸生, 丸尾勝彦, 田村守, 尾崎幸洋
  • Organizer: 日本光学会 Optics & Photonics Japan 2008 (OPJ2008)
  • Place of Presentation: つくば市
  • Year and Date: 2008-11-05
• [Presentation] 局所的光学特性値変化を再構成する拡散光トモグラフィ正則化法の検討 (2008)
  • Author(s): 大川晋平, 山田幸生
  • Organizer: 日本光学会 Optics & Photonics Japan 2008 (OPJ2008)
  • Place of Presentation: つくば市
  • Year and Date: 2008-11-05
• [Presentation] 拡散光トモグラフィによるヒト前腕の筋活動の画像再構成 (2008)
  • Author(s): 谷川ゆかり, 高峰, 宮崎康彰, 岩田直之, 中村康雄, 木竜徹, 宮川道夫, 遠藤泰臣, 山田幸生
  • Organizer: 日本光学会 Optics & Photonics Japan 2008 (OPJ2008)
  • Place of Presentation: つくば市
  • Year and Date: 2008-11-05
• [Presentation] 拡散光トモグラフィを用いたハンドグリップ運動時のヒト前腕のin vivo測定 (2008)
  • Author(s): 谷川ゆかり, 高峰, 宮崎康彰, 岩田直之, 中村康雄, 大川晋平, 山田幸生, 木竜徹, 宮川道夫
  • Organizer: 日本機械学会第19回バイオフロンティア講演会
  • Place of Presentation: 八王子市
  • Year and Date: 2008-09-24
• [Presentation] 光マッピング技術における頭部構造の影響 (2008)
  • Author(s): 大木万里子, 芝原奈々恵, 冨樫 陵, 王 淑萍, 大川晋平, 星 詳子, 山田幸生
  • Organizer: 日本機械学会 第19回バイオフロンティア講演会
  • Place of Presentation: 八王子市
  • Year and Date: 2008-09-24
• [Presentation] 拡散光トモグラフィを用いたハンドグリップ運動時のヒト前腕のin vivo測定 (2008)
  • Author(s): 谷川ゆかり, 高峰, 宮崎康彰, 岩田直之, 中村康雄, 大川晋平, 山田幸生, 木竜徹, 宮川道夫
  • Organizer: 日本機械学会 第19回バイオフロンティア講演会
  • Place of Presentation: 八王子市
  • Year and Date: 2008-09-24
• [Presentation] 哺乳類受精時のCa2 +反応におけるCa2 +流入の機能的な関与の検証 (2008)
  • Author(s): 高橋徹, 白川英樹
  • Organizer: 日本動物学会第79回大会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-09-06
• [Presentation] 哺乳類受精時のCa^<2+>反応におけるCa^<2+>流入の機能的な関与の検証 (2008)
  • Author(s): 高橋 徹, 白川英樹
  • Organizer: 日本動物学会第79回大会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-09-06
• [Presentation] 光脳機能イメージングの原理 (2008)
  • Author(s): 山田幸生
  • Organizer: 第9回日本光脳機能イメージング研究会
  • Place of Presentation: 東京都.(教育講演)
  • Year and Date: 2008-07-19
• [Presentation] 光脳機能イメージングの原理 (2008)
  • Author(s): 山田幸生
  • Organizer: 第9回日本光脳機能イメージング研究会
  • Place of Presentation: 東京都
  • Year and Date: 2008-07-19
• [Presentation] NIRS計測のための標準ファントムの開発とNIRS装置標準化 (2008)
  • Author(s): 谷川ゆかり, 灰田宗孝, 山田幸生, 岡田英史, 江田英雄, 市川祝善, 藤原倫行, 鈴木弘道, 網田孝司, 小田元樹, 木口雅史
  • Organizer: 第9回日本光脳機能イメージング研究会
  • Place of Presentation: 東京都
  • Year and Date: 2008-07-19
• [Presentation] マウス受精卵内カルシウムオシレーションの維持に関与するカルシウム流入経路の薬理学的特性 (2008)
  • Author(s): 高橋徹
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-27
• [Presentation] Quantitative Imaging of Platelet Aggregation in a Microchannel Using an Interfacial Collision Reactor (2008)
  • Author(s): T. Hirono
  • Organizer: OSA Optical and Photonics Congress, Biomedical Optics
  • Place of Presentation: Florida USA
  • Year and Date: 2008-03-18
• [Presentation] Full Time-Resolved Fluorescence Diffuse Optical Tomography Using Total Light Approach (2008)
  • Author(s): A. Marjono
  • Organizer: OSA Optical and Photonics Congress, Biomedical Optics
  • Place of Presentation: Florida USA
  • Year and Date: 2008-03-17
• [Presentation] Source Estimation with Spatial Filter for Fluorescence Diffuse Optical Tomography (2008)
  • Author(s): S. Okawa
  • Organizer: OSA Optical and Photonics Congress, Biomedical Optics
  • Place of Presentation: Florida USA
  • Year and Date: 2008-03-16
• [Presentation] 拡散光を利用した生体診断技術の開発 (2008)
  • Author(s): 谷川ゆかり
  • Organizer: テクノロジー・ショーケース・イン・ツクバ
  • Place of Presentation: つくば市
  • Year and Date: 2008-01-25
• [Presentation] Optical brain imaging in infants by use of near-infrared diffuse optical tomography (2008)
  • Author(s): T. Kusaka, S. Okawa, M. Ueno, R. Fukuzawa, T. Nishida, K. Isobe, Y. Tanikawa, F. Gao, C. Sato, Y. Hoshi, Y. Yamada
  • Organizer: The 36th Annual Conference of International Society of Oxygen Transport to Tissue (ISOTT2008)
  • Place of Presentation: Sapporo, Japan
• [Presentation] The accuracy and reliability of near-infrared spectroscopy in measuring neuronal activity-related cerebral oxygenation changes (2008)
  • Author(s): Y. Hoshi
  • Organizer: The 36th Annual Conference of International Society of Oxygen Transport to Tissue (ISOTT2008)
  • Place of Presentation: Sapporo, Japan(Invited talk)
• [Presentation] Physical fundamentals of optical mapping and diffuse optical tomography using NIRS (2008)
  • Author(s): Y. Yamada
  • Organizer: The 36th Annual Conference of International Society of Oxygen Transport to Tissue (ISOTT2008)
  • Place of Presentation: Sapporo, Japan(Invited talk)
• [Presentation] Source estimation with spatial filter for fluorescence diffuse optical tomography (2008)
  • Author(s): S. Okawa, Y. Yamada
  • Organizer: 2008 Biomedical Optics Topical Meeting, OSA, Florida, USA
  • Place of Presentation: Poster No. BSuE41
• [Presentation] Full Time-Resolved Fluorescence Diffuse Optical Tomography using Total Light Approach (2008)
  • Author(s): A. Marjono, A. Yano, S. Okawa, Y. Yamada
  • Organizer: 2008 Biomedical Optics Topical Meeting, OSA, Florida, USA
  • Place of Presentation: Poster No. BMD33
• [Presentation] Physical fundamentals of optical mapping and diffuse optical tomographyusing NIRS (2008)
  • Author(s): Yukio Yamada
  • Organizer: The 36th Annual Conference of International Society of Oxygen Transport to Tissue (ISOTT2008)
  • Place of Presentation: Sapporo, Japan
• [Presentation] The accuracy and reliability of near-infrared spectroscopy in measuring neuronal activity-related cerebral oxysenation changes. (2008)
  • Author(s): Yoko Hoshi
  • Organizer: The 36th Annual Conference of International Society of Oxygen Transport to Tissue (ISOTT2008)
  • Place of Presentation: Sapporo, Japan
• [Presentation] 患者の負担を軽減する高精度診断技術の開発-拡散光を利用した生体診断技術の開発- (2007)
  • Author(s): 谷川ゆかり
  • Organizer: 人間福祉医工学研究部門平成19年度成果発表会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2007-12-03
• [Presentation] ヒト角層の光学特性値測定 (2007)
  • Author(s): 岡本光平
  • Organizer: 日本光学会年次学術講演会
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-28
• [Presentation] 光学特性値分布の特徴を考慮した拡散光トモグラフィ (2007)
  • Author(s): 大川晋平, 山田幸生
  • Organizer: 日本光学会年次学術講演会
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] 空間フィルタによる生体内光源強度分布再構成 (2007)
  • Author(s): 大川晋平
  • Organizer: 日本光学会年次学術講演会
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] 光が映し出す脳機能-神経血管カップリング機構から高次脳機能まで- (2007)
  • Author(s): 星詳子
  • Organizer: 第5回北海道大学脳科学教育センターシンポジウム 脳と心の探求
  • Place of Presentation: 北海道大学百年記念会館
  • Year and Date: 2007-11-26
• [Presentation] 非翻訳領域を付加したRNAを用いたマウス卵での外来タンパク質発現方法の検討 (2007)
  • Author(s): 高橋篤
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-21
• [Presentation] NIRS計測の原理と時間分解分光法の応用-拡散光を用いた生体診断- (2007)
  • Author(s): 谷川ゆかり
  • Organizer: モバイルセミナー「NIRS計測原理と医用・工学的応用、およびデータ解析法」
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2007-09-06
• [Presentation] NIRS計測の原理と時間分解分光法の応用-拡散光を用いた生体診断- (2007)
  • Author(s): 谷川ゆかり
  • Organizer: モバイルセミナー「NIRS計測原理と医用・工学的応用、およびデータ解析法
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2007-09-06
• [Presentation] Effects of the CSF Layer on the Optical Mapping of Brain Activity (2007)
  • Author(s): N. Shibahara
  • Organizer: 3rd Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: Cairns Australia
  • Year and Date: 2007-07-09
• [Presentation] Microfluidic Image Cytomotry for Measurcing of Number and Size of Biological Particlcs (2007)
  • Author(s): T. Hirono
  • Organizer: 3rd Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: Cairns Australia
  • Year and Date: 2007-07-09
• [Presentation] Full Time-Resolved Data Schemc Using Total Light Approach in Time Domain Fluorcsccncc Diffusc Optical Tomography (2007)
  • Author(s): A. Marjono
  • Organizer: 3rd Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: Cairns Australia
  • Year and Date: 2007-07-09
• [Presentation] In vivo measurement of premature neonate head using diffuse optical tomography (2007)
  • Author(s): S. Okawa
  • Organizer: 3rd Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: Cairns Australia
  • Year and Date: 2007-07-09
• [Presentation] Frontiers of cognitive neuroscience with near-infrared spectroscopy: applications to developmental psychology and psychiatry (2007)
  • Author(s): Y. Hoshi
  • Organizer: Organization for Human Brain Mapping 13th Annual Meeting
  • Place of Presentation: Chicago, USA(Invited talk)
  • Year and Date: 2007-06-14
• [Presentation] Frontiers of cognitive neuroscience with near-infrared spectroscopy:applications to developmental psychology and psychiatry. (2007)
  • Author(s): Y. Hoshi
  • Organizer: Organization for Human Brain Mapping 13th Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2007-06-14
• [Presentation] Near-infrared spectroscopy study on prefrontal activity associated with emotions inevent-related design (2007)
  • Author(s): J. Huang
  • Organizer: Organization for Human Brain Mapping 13th Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2007-06-12
• [Presentation] In vivo measurement of premature neonate head using diffuse optical tomography (2007)
  • Author(s): M. Ueno, R. Fukuzawa, S. Okawa, Y. Yamada, T. Kusaka, T. Nishida, K. Isobe, Y. Tanikawa, F. Gao, C. Sato, Y. Hoshi
  • Organizer: APBP 2007, 3rd Asian and Pacific Rim Symposium on Biophotonics, Abstract Book
  • Place of Presentation: Cairns, Australia
• [Presentation] Microfluidic Image Cytometry for Measuring of Number and Sizes of Biological Particles (2007)
  • Author(s): T. Hirono, S. Okawa, H. Arimoto, Y. Yamada
  • Organizer: APBP 2007, 3rd Asian and Pacific Rim Symposium on Biophotonics, Abstract Book
  • Place of Presentation: Cairns, Australia
• [Presentation] Effects of the CSF Layer on the Optical Mapping of Brain Activity (2007)
  • Author(s): N. Shibahara, S. Okawa, Y. Yamada
  • Organizer: APBP 2007, 3rd Asian and Pacific Rim Symposium on Biophotonics, Abstract Book
  • Place of Presentation: Cairns, Australia
• [Book] 生体のふく射in伝熱工学資料改訂第5版 (2009)
  • Author(s): 山田幸生
  • Publisher: 日本機械学会
• [Book] 「酸素代謝を利用した脳機能イメージングIn:からだと酸素の事典」,酸素ダイナミクス研究会編 (2009)
  • Author(s): 星詳子
  • Total Pages: 583
  • Publisher: 朝倉書店
• [Book] 酸素代謝を利用した脳機能イメージングIn : からだと酸素の事典 (酸素ダイナミクス研究会編) (2009)
  • Author(s): 星詳子
  • Total Pages: 583
  • Publisher: 朝倉書店
• [Book] 伝熱工学資料 改訂第5版「6・5・5 生体のふく射」(分担執筆pp. 157-158) (2009)
  • Author(s): 山田幸生
  • Total Pages: 332
  • Publisher: 日本機械学会
• [Book] Book Series of Thinking (2008)
  • Author(s): Y. Hoshi
  • Total Pages: 285
  • Publisher: Springer
• [Book] 機械工学便覧 応用システム編γ9医療・福祉・バイオ機器, 「4・11その他の映像検査装置 4・11・1 CT」 (2008)
  • Author(s): 山田幸生
  • Publisher: 日本機械学会
• [Book] Book Series of Thinking. Vol. I Neural Correlates of Thinking. (2008)
  • Author(s): Yoko Hoshi
  • Total Pages: 285
  • Publisher: Springer
• [Book] Springer (2007)
  • Author(s): Y. Hoshi
  • Publisher: Complex Medical Engineering
• [Book] (株)エヌ・ティー・エス (2007)
  • Author(s): 山田幸生
  • Publisher: エヌ・ティー・エス
• [Book] 非侵襲・可視化技術ハンドブック (2007)
  • Author(s): 山田幸生
  • Publisher: (株)エヌ・ティー・エス
• [Book] 非侵襲・可視化技術ハンドブック (2007)
  • Author(s): 星 詳子
  • Publisher: (株)エヌ・ティー・エス
• [Book] KEY WORD精神 第4版 (2007)
  • Author(s): 星 詳子
  • Publisher: 先端医学社
• [Book] Complex Medical Engineering (2007)
  • Author(s): Y. Hoshi
  • Publisher: Springer
• [Patent(Industrial Property Rights)] 計測対象保持具 (2009)
  • Inventor(s): 山田幸生, 清水仁
  • Industrial Property Rights Holder: 電気通信大学,富士フィルム(株)
  • Industrial Property Number: 2009-020331
  • Filing Date: 2009-11-30
• [Patent(Industrial Property Rights)] 光断層像の生成法 (2009)
  • Inventor(s): 山田幸生, 大川晋平, 山本拓明
  • Industrial Property Rights Holder: 電気通信大学,富士フィルム(株)
  • Industrial Property Number: 2009-020330
  • Filing Date: 2009-11-30