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Development of therapy killing or activating targeted cells using bio-techniques

Research Project

Project/Area Number 19360378
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biofunction/Bioprocess
Research InstitutionChubu University

Principal Investigator

KOBAYASHI Takeshi  Chubu University, 応用生物学部, 教授 (10043324)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsがん / バイオテクノロジー / マグネタイト微粒子 / 温熱療法 / 加温 / リポソーム / 癌 / 生物・生体工学 / 熱死滅の促進
Research Abstract

I have developed a new cancer hyperthermia using magnetic nanoparticles. Combination therapy with injection of imiquimod well known as immuno-inducer and hyperthermia was synergistic. Translational research was started at Shinshu University from Oct.30, 2008, at Nagoya University from Nov.11, 2009, and Tobata Kyouritu Hospital from Feb.8, 2010.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (43 results)

All 2010 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (21 results) Book (3 results) Remarks (4 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes2009

    • Author(s)
      T. Kikumori, T. Kobayashi, M. Sawaki, T. Imai
    • Journal Title

      Breast Cancer Research Treatment 113

      Pages: 435-441

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes2009

    • Author(s)
      Toyone Kikumori
    • Journal Title

      Breast Cancer Research Treatment 113

      Pages: 435-441

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular hyperthermia using magnetic nanoparticles : A novel method for hyperthermia clinical applications2008

    • Author(s)
      A. Ito, T. Kobayashi
    • Journal Title

      Thermal Medicine 24

      Pages: 113-129

    • NAID

      120006518510

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Knowledge-based fuzzy adaptive resonance theory and its application to the analysis of gene expression2008

    • Author(s)
      Hiro Takahashi
    • Journal Title

      Journal of Bioscience and Bioengineering 106

      Pages: 587-593

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular hyperthermia using magnetic nanoparticles : A novel method for hyperthermia clinical applications2008

    • Author(s)
      Akira Ito
    • Journal Title

      Thermal Medicine 24

      Pages: 113-129

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles2008

    • Author(s)
      Jun Motoyama
    • Journal Title

      BioMagnetic Research and Technology 6(On line)(http://www.biomagres.com/content/6/1/2)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes2008

    • Author(s)
      Toyone Kikumori
    • Journal Title

      Breast Cancer Research Treatment (On line)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy2008

    • Author(s)
      Tun Motoyama
    • Journal Title

      BioMagnetic Research and Technology 6(On line)(http://www.biomagres.com/content/6/1/4)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗体付きマグネトリポソームを用いたがん温熱免疫療法2008

    • Author(s)
      小林 猛
    • Journal Title

      分子細胞療法 7

      Pages: 124-128

    • Related Report
      2008 Annual Research Report
  • [Journal Article] New cancer diagnosis modeling using boosting and projective adaptive resonance theory with improved reliable index2007

    • Author(s)
      H. Takahashi
    • Journal Title

      Biochem. Eng. J. 33

      Pages: 100-109

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 爪部悪性黒色腫の識別のための周期的画像パターン抽出法の開発2007

    • Author(s)
      中朽昌弘
    • Journal Title

      化学工学論文集 33

      Pages: 570-580

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced activity of 3α-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium(L)-lactate in aqueous phase of biphasic systems for reduction of steroids2007

    • Author(s)
      M. Okochi
    • Journal Title

      J. Biotechnol. 128

      Pages: 376-382

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 磁性ナノ粒子の調製と抗体結合2009

    • Author(s)
      伊東真弓, 井村美香, 鈴木信和, 椎木峰行, 堤内要, 小林猛
    • Organizer
      日本生物工学会
    • Place of Presentation
      名古屋大学(名古屋市)
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高温熱分解法などを利用した温熱治療のための磁性ナノ粒子の調製2009

    • Author(s)
      伊東真弓, 亀田めぐみ, 井村美香, 鈴木伸和, 椎木峰行, 堤内要, 小林猛
    • Organizer
      日本ハイパーサーミア学会
    • Place of Presentation
      千葉大学(千葉市)
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 磁性微粒子を利用した癌の温熱免疫療法の開発2009

    • Author(s)
      小林猛
    • Organizer
      分子病理学研究会
    • Place of Presentation
      神戸大学(神戸市)
    • Year and Date
      2009-07-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] メラノーマに対する温熱療法と樹状細胞の併用療法の効果2008

    • Author(s)
      小林猛
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report
  • [Presentation] メラノーマに対する温熱療法と樹状細胞の併用療法の効果2008

    • Author(s)
      小林 猛
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 進行期メラノーマに対する温熱免疫療法2008

    • Author(s)
      高田 実
    • Organizer
      日本ハイパーサーミア学会第25回大会
    • Place of Presentation
      中部大学 名古屋キャンパス(愛知県)
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 扁平上皮癌に対する樹状細胞を用いた磁場誘導組織内温熱免疫療法2008

    • Author(s)
      斉藤昌樹
    • Organizer
      日本ハイパーサーミア学会第25回大会
    • Place of Presentation
      中部大学 名古屋キャンパス(愛知県)
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] カラギーナン混錬マグネタイト製剤を用いた温熱治療2008

    • Author(s)
      鈴木伸和
    • Organizer
      日本ハイパーサーミア学会第25回大会
    • Place of Presentation
      中部大学 名古屋キャンパス(愛知県)
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 温熱療法におけるMMP阻害剤の細胞死促進効果2008

    • Author(s)
      吉田章乃
    • Organizer
      日本ハイパーサーミア学会第25回大会
    • Place of Presentation
      中部大学 名古屋キャンパス(愛知県)
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] ハーセプチン結合型マグネトリポソームを用いる乳がんの温熱療法2008

    • Author(s)
      小林 猛
    • Organizer
      日本ハイパーサーミア学会第25回大会
    • Place of Presentation
      中部大学 名古屋キャンパス(愛知県)
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝的アルゴリズムとパーミュテーションテストを組み合わせた遺伝子セットの抽出とその評価方法の開発2008

    • Author(s)
      小塩 高広
    • Organizer
      第60回日本生物工学会大会
    • Place of Presentation
      東北学院大学 土樋キャンパス(宮城県)
    • Year and Date
      2008-08-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 射影適応共鳴理論とブースティングの組み合わせ手法PART-BFCSを用いたがん組織の発現解析2007

    • Author(s)
      高橋広夫
    • Organizer
      日本生物工学会
    • Place of Presentation
      広島大学
    • Year and Date
      2007-09-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 網羅的な遺伝子発現情報を用いた植物の形態制御関連遺伝子解析2007

    • Author(s)
      中尾幸子
    • Organizer
      日本生物工学会
    • Place of Presentation
      広島大学
    • Year and Date
      2007-09-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] シロイヌナズナの葉の形態制御遺伝子解析のためのクラスタリングを用いた新アプローチの開発2007

    • Author(s)
      中尾幸子
    • Organizer
      日本農芸化学会2007年度関西支部・中部支部合同大会
    • Place of Presentation
      中部大学(愛知県)
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 温熱治療におけるmatrix metalloproteinase-3 (MMP-3)阻害剤の細胞死滅促進効果2007

    • Author(s)
      小林猛、西村奈津実、奥田和智、尾藤宗俊
    • Organizer
      日本ハイパーサーミア学会第24回大会
    • Place of Presentation
      前橋
    • Year and Date
      2007-09-14
    • Related Report
      2009 Final Research Report
  • [Presentation] ハイパーサーミアにおける加温方式の新しい潮流2007

    • Author(s)
      小林 猛
    • Organizer
      日本ハイパーサーミア学会第24回大会
    • Place of Presentation
      前橋テルサ(群馬県)
    • Year and Date
      2007-09-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 温熱治療におけるmatrix metalloproteinase-3(MMP-3)阻害剤の細胞死滅促進効果2007

    • Author(s)
      西村奈津実
    • Organizer
      日本ハイパーサーミア学会第24回大会
    • Place of Presentation
      前橋テルサ(群馬県)
    • Year and Date
      2007-09-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 温熱療法と樹状細胞を用いた細胞療法の併用効果2007

    • Author(s)
      横地佐世子
    • Organizer
      日本ハイパーサーミア学会第24回大会
    • Place of Presentation
      前橋テルサ(群馬県)
    • Year and Date
      2007-09-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] The ASYMMETRIC LEAVES2 gene regulates adaxial cell proliferation involved in the development of symmetric and flat leaf laminae.2007

    • Author(s)
      H. Iwakawa
    • Organizer
      18th International Conference on Arabidopsis Research,
    • Place of Presentation
      Beijing, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] The ASYMMETRIC LEAVES2 regulates leaf polarity by repressing ETTIN in Arabidopsis.2007

    • Author(s)
      M. Iwasaki
    • Organizer
      18th International Conference on Arabidopsis Research,
    • Place of Presentation
      Beijing, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Construction of screening system for inhibitory peptide using peptide array2007

    • Author(s)
      T. Kobayashi
    • Organizer
      International Seminar; -Advances in Biological Science-
    • Place of Presentation
      Gadjah Mada University, Indonesia
    • Related Report
      2007 Annual Research Report
  • [Book] ナノ粒子・マイクロ粒子の調製と応用技術(川口春馬監修)(磁性ナノ粒子を用いた新しいがん治療法の開発)2010

    • Author(s)
      小林猛、井藤彰、本多裕之
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Final Research Report
  • [Book] ハイパーサーミア がん温熱療法ガイドブック2008

    • Author(s)
      日本ハイパニサーミア学会(編)
    • Total Pages
      199
    • Publisher
      毎日健康サロン
    • Related Report
      2008 Annual Research Report
  • [Book] 腫瘍部位だけを加温する温熱免疫療法の開発-環境と健康-2007

    • Author(s)
      小林 猛
    • Total Pages
      7
    • Publisher
      共和書院
    • Related Report
      2007 Annual Research Report
  • [Remarks] その他関連した成果 中日新聞記事、2007年10月30日

    • URL

      http://stu.isc.chubu.ac.jp/bio/public/Bio_Chem/labo/kobayashi_lab/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://stu.isc.chubu.ac.jp/bio/public/Bio_Chem/labo/kobayashi_lab/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://stu.isc.chubu.ac.jp/bio/public/Bio_Chem/labo/kobayashi_lab/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://stu.isc.chubu.ac.jp/bio/public/Bio_Chem/labo/kobayashi_lab/research00.htm

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞培養方法及び培養組織2009

    • Inventor(s)
      井藤彰、本多裕之、小林猛、上田実、各務秀明、畠賢一郎
    • Industrial Property Rights Holder
      名古屋大学
    • Acquisition Date
      2009-06-12
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞培養方法2008

    • Inventor(s)
      井藤彰、本多裕之、小林猛、上田実、各務秀明、畠賢一郎
    • Industrial Property Rights Holder
      名古屋大学
    • Acquisition Date
      2008-07-25
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞培養方法2008

    • Inventor(s)
      井藤 彰, 本多裕之, 小林 猛, 上田 実, 各務秀明, 畠 賢一郎
    • Industrial Property Rights Holder
      名古屋大学
    • Acquisition Date
      2008-07-25
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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