Regulatory mechanism of breakdown and reconstruction of reproductive organs

• Project/Area Number: 19370025
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: Okayama University
• Principal Investigator: TAKAHASHI Sumio Okayama University, 大学院・自然科学研究科, 教授 (90144807)
• Co-Investigator(Kenkyū-buntansha): 竹内 栄 岡山大学, 大学院・自然科学研究科, 准教授 (20226989) ; 深町 博史 東京医科歯科大学, 医歯学総合研究科, 講師 (70134450)
• Co-Investigator(Renkei-kenkyūsha): TAKEUCHI Sakae 岡山大学, 大学院・自然科学研究科, 准教授 (20226989) ; FUKAMACHI Hiroshi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70134450)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 細胞増殖 / アポトーシス / 成長因子 / 下垂体 / 卵巣 / 子宮 / 遺伝子発現 / マウス / 細胞死 / ホルモン / 転写制御 / 子宮内膜 / プロモーター / IGF-1 / 発情ホルモン / 組織破壊 / 再構築 / 生殖

Research Abstract

Proliferation, differentiation and apoptosis (programmed cell-death) are regulated by signaling molecules secreted from cells, hormones, growth factors and cytokines, and by extracellular matrices surrounding cells. The present study was aimed at studying regulatory mechanism of the proliferation and apoptosis in the mouse pituitary and uterus. We showed regulatory mechanisms of gene expression of growth factors and hormones that were associated with proliferation in the pituitary and uterus, and also factors which modified actions of growth factors and hormones.

Research Products

• [Journal Article] Local agouti signaling protein/ melanocortin signaling system that possibly regulates lipid metabolism in adipose tissues of chickens. (2010)
  • Author(s): Yabuuchi, M., Bando, K., Hiramatsu, M., Takahashi, S., Takeuchi, S.
  • Journal Title: Journal of Poultry Science (in press)
  • NAID: 10026253772
  • Peer Reviewed
• [Journal Article] Local agouti signaling protein/melanocortin signaling system that possibly regulates lipid metabolism in adipose tissues of chickens. (2010)
  • Author(s): Yabuuchi, Masafumi
  • Journal Title: Journal of Poultry Science (印刷中)
  • Peer Reviewed
• [Journal Article] Estradiol, progesterone and transforming growth factorαregulate insulin-like growth factor-3 (IGFBP3) expression in mouse endometrial cells. (2009)
  • Author(s): Maekawa, T., Takeuchi, S., Kanayama, M., Takahashi, S.
  • Journal Title: Zool. Sci. 26 Pages: 131-138
  • Peer Reviewed
• [Journal Article] Estradiol, progesterone and transforming growth factor α regulate insulin-like growth factor-3(IGFBP3)expression in mouse endometrial cells (2009)
  • Author(s): Maekawa, Tetsuya
  • Journal Title: Zoological Science 26 Pages: 131-138
  • Peer Reviewed
• [Journal Article] Estradiol, progesterone transforming growth factor α regulate insulin-like growth factor-3(IGFBP3)expression in mouse endometrial cells (2009)
  • Author(s): Maekawa, Tetsuya
  • Journal Title: Zoological Science 26 Pages: 131-138
  • Peer Reviewed
• [Journal Article] Identification of unique thyrotropin receptor (TSHR) splice variants in the chicken: The chicken TSHR gene revisited (2008)
  • Author(s): Grommen, S.V., Taniuchi, S., Darras, V.M., S Takahashi, Takeuchi, S., Groef, B.D.
  • Journal Title: Gen Comp Endocrinol 156 Pages: 460-463
  • Peer Reviewed
• [Journal Article] Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice. (2008)
  • Author(s): Sakuma, A., Fukamachi, H., Ito, K., Ito, Y., Takeuchi, S., Takahashi, S.
  • Journal Title: Molec. Reprod. Dev. 75 Pages: 1653-1661
  • Peer Reviewed
• [Journal Article] Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice (2008)
  • Author(s): Sakuma, Atsuko
  • Journal Title: Molecular Reproduction and Development 75 Pages: 1653-1661
  • Peer Reviewed
• [Journal Article] Identification of unique thyrotropin receptor(TSHR)splice variants in the chicken : The chicken TSHR gene revisited (2008)
  • Author(s): Grommen, SV
  • Journal Title: General and Comparative Endocrinology 156 Pages: 460-463
  • Peer Reviewed
• [Journal Article] Corticotropin-releasing hormone or dexamethasone regulate rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter. (2007)
  • Author(s): Murakami, I, Takeuchi, S., Kudo, T., Sutou, S., Takahashi, S.
  • Journal Title: J. Endocrinol. 193 Pages: 279-290
  • Peer Reviewed
• [Journal Article] Expression of interleukin-18 receptor mRNA in the mouse endometrium. (2007)
  • Author(s): Otsuki, M., Kusumoto, K., Murakami, Y., Kanayama, M., Takeuchi, S., Takahashi, S.
  • Journal Title: J. Reprod. Dev. 53 Pages: 59-68
  • NAID: 10027327046
  • Peer Reviewed
• [Journal Article] Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growth. (2007)
  • Author(s): Rajapakse, S., Yamano, N., Ogiwara, K., Hirata, K., Takahashi, S., Takahashi, T.
  • Journal Title: Molec. Reprod. Dev. 74 Pages: 1053-1063
  • Peer Reviewed
• [Journal Article] Alternative leader exon usage in mouse IGF-I mRNA variants: class 1 and class 2 IGF-I mRNAs. (2007)
  • Author(s): Ohtsuki, T., Otsuki, M., Murakami, Y., Hirata, K., Takeuchi, S., Takahashi, S.
  • Journal Title: Zool. Sci. 24 Pages: 241-247
  • NAID: 130000016944
  • Peer Reviewed
• [Journal Article] Corticotropin-releasing hormone or dexamethasone regulate rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter (2007)
  • Author(s): Itsuo Murakami
  • Journal Title: Journal of Endocrinology 193 Pages: 279-290
  • Peer Reviewed
• [Journal Article] Expression of interleukin-18 receptor mRNA in the mouse endometrium (2007)
  • Author(s): Mariko Otsuki
  • Journal Title: Journal of Reproduction and Development 53 Pages: 59-68
  • Peer Reviewed
• [Journal Article] Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growth (2007)
  • Author(s): Rajapakse, S.
  • Journal Title: Molecular Reproduction and Development 74 Pages: 1053-1063
  • Peer Reviewed
• [Presentation] Transfroming growth factor-αregulates insulin-like growth factor binding protein-3 gene expression in the mouse endometrial stromal cells. (2010)
  • Author(s): Takahashi, S., Maekawa, T., Sakuma, A., Taniuchi, S., Kanayama, M., Iguchi, T., Takeuchi, S.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-27
• [Presentation] Decreased expression of IGF1 and TGFαmRNAs in the uterus of streptozotocin- induced diabetic mice. (2010)
  • Author(s): Tochigi, M., Manabe, Y., Moriwaki, A., Kanayama, M., Takeuchi, S., Takahashi, S.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-27
• [Presentation] Transfroming growth factor-α regulates insulin-like growth factor binding protein-3 geneexpression in the mouse endometrial stromal cells (2010)
  • Author(s): Takahashi, Sumio
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-03-27
• [Presentation] 糖尿病マウスの子宮におけるインスリン様成長因子-1mRNAの発現 (2009)
  • Author(s): 都知木誠・真鍋芳江・鑛山宗利・竹内栄・高橋純夫
  • Organizer: 第34回日本比較内分泌学会大会日本比較生理生化学会第31回大会合同大会
  • Place of Presentation: 豊中
  • Year and Date: 2009-10-23
• [Presentation] マウス下垂体前葉および子宮内膜における細胞増殖とアポトーシス (2009)
  • Author(s): 矢田篤志・鑛山宗利・竹内栄・高橋純夫
  • Organizer: 第80回日本動物学会大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-17
• [Presentation] マウス卵巣および子宮におけるRunx3遺伝子の発現 (2009)
  • Author(s): 土家由起子・佐久間敦子・谷内秀輔・鑛山宗利・竹内栄・高橋純夫
  • Organizer: 第80回日本動物学会大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-17
• [Presentation] マウス下垂体前葉および子宮内膜における細胞増殖とアポトーシス (2009)
  • Author(s): 矢田篤志
  • Organizer: 第80回日本動物学会大会
  • Place of Presentation: 静岡市グランシップ(静岡県)
  • Year and Date: 2009-09-17
• [Presentation] マウスのインスリン様成長因子I遺伝子プロモーターの解析 (2008)
  • Author(s): 高橋純夫・村上逸雄・入江紗弥香・竹内栄
  • Organizer: 第79回日本動物学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-05
• [Presentation] マウス子宮内膜細胞におけるIGFBP-3の発現制御の解析 (2008)
  • Author(s): 前川哲弥・竹内栄・高橋純夫
  • Organizer: 第79回日本動物学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-05
• [Presentation] マウスのインスリン様成長因子I遺伝子プロモーターの解析 (2008)
  • Author(s): 高橋純夫
  • Organizer: 日本動物学会第79回大会
  • Place of Presentation: 福岡大学
  • Year and Date: 2008-09-05
• [Presentation] Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice. (2008)
  • Author(s): Takahashi, S., Sakuma, A., Fukamachi, H., Ito, K., Ito, Y., S. Takeuchi, S.
  • Organizer: The Endocrine Society, 90th Annual Meeting, Program & Abstracts
  • Place of Presentation: San Francisco
  • Year and Date: 2008-06-16
• [Presentation] マウスにおけるインスリン様成長因子I遺伝子発現の解析 (2007)
  • Author(s): 高橋純夫・稲熊あすみ・矢部祥子・村上逸雄・竹内栄
  • Organizer: 第78回日本動物学会大会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-22
• [Presentation] マウスにおけるインスリン様成長因子I遺伝子発現の解析 (2007)
  • Author(s): 高橋純夫
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前市
  • Year and Date: 2007-09-22
• [Presentation] マウス子宮におけるTGF-alphaおよびIGFBP-3 mRNAの発現制御の解析 (2007)
  • Author(s): 11前川哲弥・竹内栄・高橋純夫
  • Organizer: 第78回日本動物学会大会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-20
• [Presentation] ラットPOMC遺伝子プロモーターのCRHとグルココルチコイドによる制御 (2007)
  • Author(s): 村上逸雄・竹内栄・工藤季之・須藤鎮世・高橋純夫
  • Organizer: 第78回日本動物学会大会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-20
• [Presentation] メラノコルチン3受容体遺伝子発現のプロノーター解析
  • Author(s): 1青木健司・竹内栄・高橋純夫
  • Organizer: 第78回日本動物学会大会
  • Place of Presentation: 弘前
• [Book] 現代生物学入門 (2009)
  • Author(s): 高橋純夫, 他
  • Total Pages: 142
  • Publisher: 岡山大学出版会
• [Book] 現代生物学入門 (2009)
  • Author(s): 岡山大学生物学教科書作成グループ(監修高橋純夫)
  • Total Pages: 142
  • Publisher: 岡山大学出版会
• [Remarks]
  • URL: http://www.biol.okayama-u.ac.jp/cccrg/index.html
• [Remarks]
  • URL: http://www.biol.okayama-u.ac.jp/cccrg/index.html