| Project/Area Number |
19370025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Okayama University |
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Principal Investigator |
TAKAHASHI Sumio Okayama University, 大学院・自然科学研究科, 教授 (90144807)
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| Co-Investigator(Kenkyū-buntansha) |
竹内 栄 岡山大学, 大学院・自然科学研究科, 准教授 (20226989)
深町 博史 東京医科歯科大学, 医歯学総合研究科, 講師 (70134450)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Sakae 岡山大学, 大学院・自然科学研究科, 准教授 (20226989)
FUKAMACHI Hiroshi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70134450)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | 細胞増殖 / アポトーシス / 成長因子 / 下垂体 / 卵巣 / 子宮 / 遺伝子発現 / マウス / 細胞死 / ホルモン / 転写制御 / 子宮内膜 / プロモーター / IGF-1 / 発情ホルモン / 組織破壊 / 再構築 / 生殖 |
|---|
| Research Abstract |
Proliferation, differentiation and apoptosis (programmed cell-death) are regulated by signaling molecules secreted from cells, hormones, growth factors and cytokines, and by extracellular matrices surrounding cells. The present study was aimed at studying regulatory mechanism of the proliferation and apoptosis in the mouse pituitary and uterus. We showed regulatory mechanisms of gene expression of growth factors and hormones that were associated with proliferation in the pituitary and uterus, and also factors which modified actions of growth factors and hormones.
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