Molecular analysis of dietary derived-factors on the regulation of functional expression of obesity-related adipocytekine
| Project/Area Number |
19380074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
KAWADA Teruo Kyoto University, 大学院・農学研究科, 教授 (10177701)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Shizuka 京都大学, 大学院・農学研究科, 産学連携研究員 (90432343)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | メタボリックシンドローム / 肥満 / 脂肪細胞 / サイトカイン / 脂肪組織 |
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| Research Abstract |
Adipocytekines from obese adipose tissue are suggested to be key players on life-related diseases and metabolic syndrome. So we studied the mechanisms of formation and secretion of adipocytekines from adipocytes. It was revealed that dietary derived fatty acids and some plant compounds effects on the formation and secretion of adipocytekines from adipocytes through the transcriptional regulation of gene.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation.2008
Author(s)
Kang M-S, Hirai S, Goto T, Kuroyanagi K, Lee J-Y, Uemura T, Ezaki Y, Takahashi N, Kawada T
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Journal Title
Related Report
Peer Reviewed
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