Molecular analysis of dietary derived-factors on the regulation of functional expression of obesity-related adipocytekine

• Project/Area Number: 19380074
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Kyoto University
• Principal Investigator: KAWADA Teruo Kyoto University, 大学院・農学研究科, 教授 (10177701)
• Co-Investigator(Kenkyū-buntansha): HIRAI Shizuka 京都大学, 大学院・農学研究科, 産学連携研究員 (90432343)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: メタボリックシンドローム / 肥満 / 脂肪細胞 / サイトカイン / 脂肪組織

Research Abstract

Adipocytekines from obese adipose tissue are suggested to be key players on life-related diseases and metabolic syndrome. So we studied the mechanisms of formation and secretion of adipocytekines from adipocytes. It was revealed that dietary derived fatty acids and some plant compounds effects on the formation and secretion of adipocytekines from adipocytes through the transcriptional regulation of gene.

Research Products

• [Journal Article] Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo. (2010)
  • Author(s): Fujitani Y, et al.(7名, 代表者:7番目)
  • Journal Title: FEBS J. 277 Pages: 410-419
  • Peer Reviewed
• [Journal Article] Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues (2010)
  • Author(s): Uemura T., et al.
  • Journal Title: Mol.Nutr.Food Res. (In press)
  • Peer Reviewed
• [Journal Article] Various terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism (2010)
  • Author(s): Goto T., et al.
  • Journal Title: PPAR Research (In press)
  • Peer Reviewed
• [Journal Article] Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo (2010)
  • Author(s): Fujitani Y., et al.
  • Journal Title: FEBS J. 277 Pages: 410-419
  • Peer Reviewed
• [Journal Article] Luteolin, a food-derived flavonoid, inhibits adipocyte-dependent activation of macrophages in adipose tissues. (2009)
  • Author(s): Ando C, et al.(7名, 代表者:7番目, 分担者:3番目)
  • Journal Title: FEBS Lett. 283 Pages: 3649-3654
  • Peer Reviewed
• [Journal Article] Luteolin, a food-derived flavonoid, inhibits adipocyte-dependent activation of macrophages in adipose tissues (2009)
  • Author(s): Ando C., et al.
  • Journal Title: FEBS Lett. 583 Pages: 3649-3654
  • Peer Reviewed
• [Journal Article] Auraptene, a citrus fruit compound, regulates gene expression as a PPARalpha agonist in HepG2 hepatocytes. (2008)
  • Author(s): Takahashi N, et al.(9名, 代表者:12番目, 分担者:5番目)
  • Journal Title: BioFactors 33 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Visceral fat accumulation causes the atrophy of mesenteric lymph nodes in obese mice fed a high-fat diet. (2008)
  • Author(s): Kim C-S, et al.(7名, 代表者:5番目)
  • Journal Title: Obesity 16 Pages: 1261-1269
  • Peer Reviewed
• [Journal Article] Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. (2008)
  • Author(s): Kang M-S, et al.(9名, 代表者:9番目)
  • Journal Title: BBRC 369 Pages: 333-338
  • Peer Reviewed
• [Journal Article] Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. (2008)
  • Author(s): Kuroyanagi K, et al.(11名, 代表者:11番目, 分担者:4番目)
  • Journal Title: BBRC 366 Pages: 9219-225
  • Peer Reviewed
• [Journal Article] Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in Macrophages and adipocytes to regulate inflammation (2008)
  • Author(s): Kang MS, et al.
  • Journal Title: Biochem Biophys Res Comraun 369 Pages: 333-338
  • Peer Reviewed
• [Journal Article] Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocyte (2008)
  • Author(s): Kuroyanagi K, et al.
  • Journal Title: Biochem Biophys Res Commun. 366 Pages: 219-225
  • Peer Reviewed
• [Journal Article] Visceral fat accumulation causes the atrophy of mesenteric lymph nodes in obese mice fed a high-fat diet. (2008)
  • Author(s): Kim C-S, et. al.
  • Journal Title: Obesity (In press)
  • Peer Reviewed
• [Journal Article] Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. (2008)
  • Author(s): Kang M-S, Hirai S, Goto T, Kuroyanagi K, Lee J-Y, Uemura T, Ezaki Y, Takahashi N, Kawada T
  • Journal Title: BBRC. 369 Pages: 333-338
  • Peer Reviewed
• [Journal Article] Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. (2008)
  • Author(s): Kuroyanagi K, Kang M-S, Goto T, Hirai S, Ohyama K, Kusudo T, Yu R, Yano
  • Journal Title: BBRC. 366 Pages: 219-225
  • Peer Reviewed
• [Journal Article] Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. (2007)
  • Author(s): Hirai S, et al.(8名, 代表者:8番目)
  • Journal Title: Life Sci 81 Pages: 1272-1279
  • Peer Reviewed
• [Journal Article] Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. (2007)
  • Author(s): Hirai S, Kim Y-I, Goto T, Kang M-S, Yoshimura M, Obata A, Yu R, Kawada T.
  • Journal Title: Life Sci. 81 Pages: 1272-1279
  • Peer Reviewed
• [Journal Article] Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.
  • Author(s): Uemura T, et al.(13名, 代表者:13番目, 分担者:2番目)
  • Journal Title: Mol. Nutr. Food Res. (in press)
  • Peer Reviewed
• [Journal Article] Various terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism.
  • Author(s): Goto T, et al.(4名, 代表者:4番目, 分担者:2番目)
  • Journal Title: PPAR Research (in press)
  • Peer Reviewed
• [Journal Article] Auraptene, a citrus fruit compound, regulates gene expression as a PPARalpha agonist in HepG2 hepatocytes
  • Author(s): Takahashi N, et al.
  • Journal Title: BioFactors (In press)
• [Presentation] オーラプテンが肥満に伴う脂肪組織の炎症反応に及ぼす影響 (2010)
  • Author(s): 林珊
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: 静岡県浜松市アクトシティ浜松
  • Year and Date: 2010-10-10
• [Presentation] オーラプテン摂取により、肥満・糖尿病モデルマウスの糖・脂質代謝は改善される (2010)
  • Author(s): 千田真里
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: 静岡県浜松市アクトシティ浜松
  • Year and Date: 2010-10-10
• [Presentation] オーラプテンが肥満に伴う脂肪組織の炎症反応に及ぼす影響 (2010)
  • Author(s): 林珊
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: アクトシティ浜松 (静岡)
  • Year and Date: 2010-10-10
• [Presentation] オーラプテン摂取により、肥満・糖尿病モデルマウスの糖・脂質代謝は改善される (2010)
  • Author(s): 千田真里
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: アクトシティ浜松 (静岡)
  • Year and Date: 2010-10-10
• [Presentation] Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibition JNK activation. (2010)
  • Author(s): 西村加奈子
  • Organizer: 14th International Congress of Endocrinology(ICE 2010)
  • Place of Presentation: 京都市京都国際会館
  • Year and Date: 2010-03-28
• [Presentation] Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibition JNK activation (2010)
  • Author(s): 西村加奈子
  • Organizer: 14th International Congress of Endocrinology (ICE 2010)
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-03-28
• [Presentation] メタボリックシンドロームの発症機構と予防 (2008)
  • Author(s): 河田照雄
  • Organizer: 第62回日本栄養・食糧学会大会
  • Place of Presentation: 埼玉県板戸市
  • Year and Date: 2008-05-03
• [Presentation] メタボリックシンドロームの発症機構と予防 (2008)
  • Author(s): 河田 照雄
  • Organizer: 第62回日本栄養・食糧学会大会
  • Place of Presentation: 埼玉県坂戸市
  • Year and Date: 2008-05-03