| Project/Area Number |
19380191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
NISHIKAWA Atsushi Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 教授 (30218127)
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| Co-Investigator(Kenkyū-buntansha) |
TONOZUKA Takashi 東京農工大学, 大学院・共生科学技術研究院, 准教授 (50285194)
DOHI Taeko 国立交際医療センター, 消化器疾患研究部, 部長 (60250221)
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| Research Collaborator |
武田 陽一 , 理化学研究所, 研究員
松尾 一郎 , 理化学研究所, 研究員
伊藤 幸成 , 理化学研究所, 主任研究員
中村 紀夫 , 研究員
小熊 恵二 岡山大学, 大学院, 教授
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Keywords | ボツリヌス毒素 / レクチン / ドラッグデリバリー / ムチン / ワクチン / 糖鎖 |
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| Research Abstract |
The botulinum toxin complex has the clever mechanism of the neurotoxin transit across the intestinal epithelial barrier using the lectin components. So it seems that the elucidation of this mechanism can be applied to the new drug delivery system and the vaccine development. In this study, we demonstrate that the type C HA3 can bind to the collagen. We also show the architecture and the properties of sugar-binding site of each HA1 mutants. These results yield new insights into the experimental planning of the creation of new complexes.
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