Nano molecular design for functionalized nucleotides and peptides

• Project/Area Number: 19390008
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Kyushu University
• Principal Investigator: SUEMUNE Hiroshi Kyushu University, 薬学研究院, 教授 (20095897)
• Co-Investigator(Kenkyū-buntansha): ASO Mariko 九州大学, 大学院・薬学研究院, 准教授 (30201891)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: らせん分子 / ナノ分子 / 核酸 / ペプチド / ヘリックス / α,α-ジ置換環状αアミノ酸 / ペプチド2次構造 / 不斉エポキシ化反応 / 不斉分子触媒 / スピンラベル化核酸 / ペプチド二次構造 / α,α-ジ置換環状α-アミノ酸 / スピンラベル化ヌクレオシド / スピン-スピン相互作用

Research Abstract

The followings are purposes of this project. Using the nucleotides and peptides, synthesis of novel Nano-helix functional molecules and its structural analysis. 1. Synthesis of optically active alpha-, alpha-disubstituted cyclic alpha-amino acids, and its peptides ; 2. Development novel asymmetric reaction using Nano-helix structure. Above studies gave us fruitful results.

Research Products

• [Journal Article] ロジウム錯体触媒によるヒドロアシル化反応-分子内反応から分子間反応への展開- (2011)
  • Author(s): 今井幹典、末宗洋、田中正一
  • Journal Title: 有機合成化学協会誌 69(3) Pages: 236-251
  • NAID: 10027916893
  • Peer Reviewed
• [Journal Article] ロジウム錯体触媒によるヒドロアシル化反応-分子内反応から分子間反応への展開- (2011)
  • Author(s): 今井幹典, ら
  • Journal Title: 有機合成化学協会誌 Volume: 69(3) Pages: 236-251
  • Peer Reviewed
• [Journal Article] Conformations of peptides containing a chiral cyclic α, α-disubstituted α-amino acid within the sequence of Aib residues (2010)
  • Author(s): Demizu, Y., Tanaka M., Doi, M., Kurihara, M., Okuda, H., Suemune H.
  • Journal Title: Journal of Peptide Science 16(11) Pages: 621-626
  • Peer Reviewed
• [Journal Article] Stabilized α-Helix-Catalyzed Enantioselective Epoxidation of α, β-Unsaturated Ketones (2010)
  • Author(s): Nagano, M., Doi, M., Kurihara, M., Suemune H., Tanaka M.
  • Journal Title: Organic Letters 12(15) Pages: 3564-3566
  • Peer Reviewed
• [Journal Article] Computational study on helical structure of chiral α, α-disubstituted oligopeptides (2010)
  • Author(s): Kurihara, M., Sato, Y., Yamagata, N., Demizu, Yosuke, Okuda, Haruhiro, Nagano, Masanobu, Doi, Mitsunobu, Tanaka Masakazu ; Suemune Hiroshi
  • Journal Title: Peptide Science 2009 Pages: 385-386
• [Journal Article] Controlling the helical screw sense of peptides by N-terminal proline (2010)
  • Author(s): Yamagata, N., Demizu, Y., Sato, Y., Oba, M., Tanaka M., Doi, M., Nagasawa, K., Suemune H., Okuda, H., Kurihara, M.
  • Journal Title: Peptide Science 2009 Pages: 383-384
• [Journal Article] Conformational analysis of water-soluble oligopeptides composed of chiral cyclic α, α-disubstituted α-amino acids (2010)
  • Author(s): Demizu, Y., Tanaka M., Suemune H., Doi, M., Sato, Y., Okuda, H., Kurihara, M.
  • Journal Title: Peptide Science 2009 Pages: 381-382
• [Journal Article] Solid-state conformation of diastereomeric Pro-Pro-(Aib)4 sequences (2010)
  • Author(s): Oba, M., Demizu, Y., Yamagata, N., Sato, Y., Doi, M., Tanaka M., Suemune H., Okuda, H., Kurihara, M.
  • Journal Title: Tetrahedron 66(13) Pages: 2293-2296
  • Peer Reviewed
• [Journal Article] Conformations of peptides containing a chiral cyclic α,α-disubstituted α-amino acid within the sequence of Aib residues (2010)
  • Author(s): Demizu, Y., et al.
  • Journal Title: Journal of Peptide Science Volume: 16(11) Pages: 621-626
  • Peer Reviewed
• [Journal Article] Stabilized α-Helix-Catalyzed Enantioselective Epoxidation of α,β-Unsaturated Ketones (2010)
  • Author(s): Nagano, M., et al.
  • Journal Title: Organic Letters Volume: 12(15) Pages: 3564-3566
  • Peer Reviewed
• [Journal Article] Computational study on helical structure of chiral α,α-disubstituted oligo-peptides (2010)
  • Author(s): Kurihara, M., et al.
  • Journal Title: Peptide Science 2009 Pages: 385-386
• [Journal Article] Controlling the helical screw sense of peptides by N-terminal proline (2010)
  • Author(s): Yamagata, N., et al.
  • Journal Title: Peptide Science 2009 Pages: 383-384
• [Journal Article] Conformational analysis of water-soluble oligopeptides composed of chiral cyclic α,α-disubstituted α-amino acids (2010)
  • Author(s): Demizu, Y., et al.
  • Journal Title: Peptide Science 2009 Pages: 381-382
• [Journal Article] Solid-state conformation of diastereomeric Pro-Pro-(Aib)4 sequences (2010)
  • Author(s): Oba, M., et al.
  • Journal Title: Tetrahedron Volume: 66(13) Pages: 2293-2296
  • Peer Reviewed
• [Journal Article] Solid-state conformation of diastereome ric-Pro-Pro-(Aib) 4 sequences (2010)
  • Author(s): M. Oba, H. Suemune, (他7名)
  • Journal Title: Tetrahedron 66 Pages: 2293-2296
  • Peer Reviewed
• [Journal Article] Solid-state conformation of diastereomeric -Pro-Pro-(Aib)4 sequences (2010)
  • Author(s): M.Oba, et al.
  • Journal Title: Tetrahedron 66(13) Pages: 2293-2296
  • Peer Reviewed
• [Journal Article] Controlling alpha-Helical Secondary Structure of Oligopeptides and Its Use as a Chiral Catalyst (2009)
  • Author(s): Tanaka M., Nagano, M., Demizu, Y., Doi, M., Kurihara, M., Suemune H
  • Journal Title: Peptide 2008 Pages: 104-105
• [Journal Article] Helical-screw Handedness of Peptides Composed of Diastereomeric Cyclic Amino Acids (2009)
  • Author(s): Nagano, M., 田中正一, Doi, M., Kurihara, M., 末宗洋
  • Journal Title: Peptide 2008 Pages: 106-107
• [Journal Article] Computational Study on Helical Structure of Disubstituted Oligopeptides Containing Amino Acids (2009)
  • Author(s): Kurihara, M., Sato, Y., Yamagata, N., Okuda, H., Nagano,M., Demizu, Y., Doi, M., Tanaka M., Suemune H.
  • Journal Title: Peptide Science 2008
• [Journal Article] Helical-screw Handedness of Peptides Composed of Diastereomeric Cyclic Amino Acids (2009)
  • Author(s): Nagano, M., Tanaka M., Doi, M., Kurihara, M., Suemune H.
  • Journal Title: Peptide 2008
• [Journal Article] Controlling Helical Secondary Structure of Oligopeptides and Its Use as a Chiral Catalyst (2009)
  • Author(s): Tanaka M., Nagano, M., Demizu, Y., Doi, M., Kurihara, M., Suemune H
  • Journal Title: Peptide 2008
• [Journal Article] Photochemical generation and reaction of 2'-substituted analogues of C4'-oxidized abasic lesion (2009)
  • Author(s): E.Tomi, M.Aso, S.Inoue, Y.Toguchi, K.Usui, M.Hamdy, A.Jinnouchi, H.Suemune
  • Journal Title: Nucleic Acids Symposium Series 53 Pages: 151-153
• [Journal Article] Evaluation of mobility of 2-N-tert-butylaminoxyladenosine incorporated into oligodeoxy- nucleotide (2009)
  • Author(s): Y.Higuchi, M.Aso, R.Harada, N.Koga, H.Suemume
  • Journal Title: Nucleic Acids Symposium Series 53 Pages: 185-186
• [Journal Article] Helical-Screw Directions of Diastereoisomeric Cyclic α-Amino Acid Oligomers (2009)
  • Author(s): Nagano, M., Tanaka M., Doi, M., Demizu, Y., Kurihara, M., Suemune H.
  • Journal Title: Organic Letters
  • Peer Reviewed
• [Journal Article] Design and synthesis of chiral cyclic α, α-disubstituted amino acid having azido functions, and its oligopeptides (2009)
  • Author(s): Takazaki, H., Tanaka M., Kawabe, N., Nagano, M., Doi, M., Kurihara, M., Suemune H
  • Journal Title: Peptide Science
  • NAID: 10027166134
• [Journal Article] Asymmetric Rh-catalyzed intermolecular hydroacylation of 1,5-hexadiene with salicylaldehyde (2009)
  • Author(s): Yasuhiro Inui, Masakazu Tanaka, Masanori Imai, Keitaro Tanaka, Hiroshi Suemune
  • Journal Title: Chem.Pharm.Bull.
  • NAID: 130000124799
  • Peer Reviewed
• [Journal Article] ラジカルの導入で見える生体分子の姿,化学 (2009)
  • Author(s): 麻生真理子、末宗洋
  • Journal Title: 化学同人
• [Journal Article] Helical-Screw Directions of Diastereoisomeric Cyclic α-Amino Acid Oligomers (2009)
  • Author(s): M. Nagano, H. Suemune, (他4名)
  • Journal Title: Organic Letters 11 Pages: 1135-1137
  • Peer Reviewed
• [Journal Article] Helical-Screw Directions of Diastereoisomeric Cyclic α-Amino Acid Oligomers (2009)
  • Author(s): M.Nagano, et al.
  • Journal Title: Organic Letters 11(5) Pages: 1135-1137
  • Peer Reviewed
• [Journal Article] Design and synthesis of chiral cyclic α,α-disubstituted amino acid having azido functions, and its oligopeptides (2009)
  • Author(s): H.Takasaki, et al.
  • Journal Title: Peptide Science Pages: 159-160
• [Journal Article] Asymmetric Rh-catalyzed intermolecular hydroacylation of 1,5-hexadiene with salicylaldehyde (2009)
  • Author(s): Y.Inui, et al.
  • Journal Title: Chem. Pharm. Bull. 57(10) Pages: 1158-1160
  • Peer Reviewed
• [Journal Article] Photochemical generation and reaction of 2'-substituted analogs of C4'-oxidized abasic lesion (2009)
  • Author(s): E.Tomi, et al.
  • Journal Title: Nucleic Acids Symposium Series 53(1) Pages: 185-186
• [Journal Article] Evaluation of mobility of 2-N-tert-butylaminoxyladenosine incorporated into oligodeoxynucleotides (2009)
  • Author(s): Y.Higuchi, et al.
  • Journal Title: Nucleic Acids Symposium Series 53(1) Pages: 151-152
• [Journal Article] Helical-screw Handedness of Peptides Composed of Diastereomeric Cyclic Amino Acids (2009)
  • Author(s): M.Nagano, et al
  • Journal Title: Peptide 2008 Pages: 106-107
• [Journal Article] Controlling α-Helical Secondary Structure of Oligopeptides and Its Use as a Chiral Catalyst (2009)
  • Author(s): M.Tanaka, et al
  • Journal Title: Peptide 2008 Pages: 104-105
• [Journal Article] Computational Study on Helical Structure of α,α-Disubstituted Oligopeptides Containing α-Amino Acids (2009)
  • Author(s): M.Kurihara, et al
  • Journal Title: Peptide Science 2008 Pages: 149-150
• [Journal Article] Computational Study on Secondary Structure of Oligopeptides Containing ・,・-Disubstituted ・-Amino Acids (2008)
  • Author(s): M.Kurihara, Y.Sato, N.Yamagata, H.Okuda, M.Nagano, Y.Demizu, M.Doi, M.Tanaka, H.Suemune
  • Journal Title: Peptide Science 2007 Pages: 137-138
• [Journal Article] Water-Proton Relaxivities of DNA Oligomers Carrying TEMPO Radicals (2008)
  • Author(s): Y.Sato, H.Hayashi, M, Okazaki, M.Aso, S, Karasawa, S.Ueki, H.Suemune, N.Koga
  • Journal Title: Magn.Reson.Chem. 46 Pages: 1055-1058
  • Peer Reviewed
• [Journal Article] Synthesis of Nitroxylradicals for Overhuser-enhanced magnetic resonance imaging (2008)
  • Author(s): K.Yamada, Y.Kinoshita, T.Yamasaki, H.Sadasue, F.Mito, M.Nagai, S.Matsumoto, M.Aso, H.Suemune, K.Sakai, H.Utsumi
  • Journal Title: Arch.Pharm. 341(9) Pages: 548-553
  • Peer Reviewed
• [Journal Article] Dynamics of 2-N-tert-butylaminoxyladenosine Incorporated into Oligodeoxynucleotides (2008)
  • Author(s): M.Aso, M.Kurita, J.W.Mirc, T.Kaneko, Y, Higuchi, N, Koga, H.Suemune
  • Journal Title: Nucleic Acids Symposium Series 52 Pages: 151-152
• [Journal Article] Photochemical Generation of Oligodeoxynucleotide Containing a C4'-Oxidized Abasic Site and Its Efficient Amine Modification : Dependence on Structure and Microenvironment (2008)
  • Author(s): K.Usui, M.Aso, M.Fukuda, H.Suemune
  • Journal Title: J.Org.Chem. 73 Pages: 241-248
  • Peer Reviewed
• [Journal Article] Photochemical Generation of Oligodeoxy nucleotide Containing a C4'-Oxidized Abasic Site and Its Efficient Amine Modification : Dependence on Structure and Microenvironment (2008)
  • Author(s): K. Usui, M. Aso, H. Suemune, (他1名)
  • Journal Title: Organic Chemistry 73 Pages: 241-248
  • Peer Reviewed
• [Journal Article] Dynamics of 2-N-tert-butylaminoxyladeno sine incorporated into oligodeoxynucleotides (2008)
  • Author(s): M. Aso, H. Suemune, (他5名)
  • Journal Title: Nucleic Acids Symposium Series 52 Pages: 151-152
• [Journal Article] Photochemical Generation of Oligodeoxynucleotide Containing a C4'-Oxidized Abasic Site and Its Efficient Amine Modification : Dependence on Structure and Microenvironment (2008)
  • Author(s): K.Usui, et al.
  • Journal Title: Organic Chemistry 73(1) Pages: 241-248
  • Peer Reviewed
• [Journal Article] Dynamics of 2-N-tert-butylaminoxyladenosine incorporated into oligodeoxynucleotides (2008)
  • Author(s): M.Aso, et al.
  • Journal Title: Nucleic Acids Symposium Series 52(1) Pages: 151-152
• [Journal Article] Water-proton relaxivities of DNA oligomers carrying TEMPO radicals (2008)
  • Author(s): Y.Sato, et al.
  • Journal Title: Magnetic Resonance in Chemistry 46(11) Pages: 1055-1058
  • Peer Reviewed
• [Journal Article] Synthesis of nitroxyl radicals for Overhauser-enhanced magnetic resonance imaging (2008)
  • Author(s): K.Yamada, et al.
  • Journal Title: Archiv der Pharmazie 341(9) Pages: 548-553
  • Peer Reviewed
• [Journal Article] Computational Study on Secondary Structure of Oligopeptides Containing α,α-Disubstituted α-Amino Acids (2008)
  • Author(s): M.Kurihara
  • Journal Title: Peptide Science Pages: 137-138
• [Journal Article] Photochemical Generation of Oligodeoxynucleotide Containing C4'-Oxidized Abasic Site and Its Efficient Amine Modification:Dependence on Structure and Microenvironment (2008)
  • Author(s): K. Usui, et. al.
  • Journal Title: J. Org. Chem. 73 Pages: 241-248
  • Peer Reviewed
• [Journal Article] ピペリジン骨格を有する非天然型アミノ酸の合成法 (2008)
  • Author(s): 田中 正一, et. al.
  • Journal Title: ファインケミカル 37 Pages: 42-48
• [Journal Article] Nitrile-Promoted Rh-Catalyzed Intermolecular Hydroacylation of Olefins with Salicylaldehyde (2007)
  • Author(s): M.Imai, M.Tanaka, S.Nagumo, N.Kawahara, H.Suemune
  • Journal Title: J.Org.Chem. 72 Pages: 2543-2546
  • Peer Reviewed
• [Journal Article] Controlling 3_<10>-helix and alpha-helix of short peptides in the solid state (2007)
  • Author(s): Y.Demizu, M.Tanaka, M.Nagano, M.Kurihara, M.Doi, T.Maruyama, H.Suemune
  • Journal Title: Chem.Pharm.Bull. 55(5) Pages: 840-842
  • Peer Reviewed
• [Journal Article] Lipase-Catalyzed Kinetic Resolution of Cyclic trans-1, 2-Diols Bearing a Diester Moiety : Synthetic Application to Chiral Seven-Membered Ring α, α-Disubstituted α-Amino Acid (2007)
  • Author(s): M.Tanaka, Y.Demizu, M.Nagano, M.Hama, Y.Yoshida, M.Kurihara, H.Suemune
  • Journal Title: J.Org.Chem. 72(20) Pages: 7750-7756
  • Peer Reviewed
• [Journal Article] Studies on DNA dynamics using 2-N-tert-butylaminoxylpurines (2007)
  • Author(s): M.Aso, J.W.Mirc, M.Kurita, N.Koga, H.Suemune
  • Journal Title: Nucleic Acids Symposium Serie 51 Pages: 163-164
• [Journal Article] The photoreactivity of the caged precursors of oligonucleotides containing C4'-oxidized abasic site and reaction of the generated lesion (2007)
  • Author(s): K.Usui, M.Aso, M.Fukuda, Y.Toguchi, H.Suemune
  • Journal Title: Nucleic Acids Symposium Series 51 Pages: 33-34
• [Journal Article] Side-chain chiral centers of amino acids and helical-screw handedness of their peptides (2007)
  • Author(s): M.Tanaka, M.Nagano, Y.Demizu, K.Anan, M.Kurihara, M.Doi, H.Suemune
  • Journal Title: Peptides 2006 (Proceedings of the 29th European Peptide Symposium) Pages: 268-269
• [Journal Article] Controlling the helical secondary structure of heteropeptides using chiral cyclic alpha, alpha-disubstituted amino acids (2007)
  • Author(s): M.Nagano, Y.Sato, Y.Demizu, M.Kurihara, M.Doi, H.Suemune
  • Journal Title: Peptides 2006 (Proceedings of the 29th European Peptide Symposium) Pages: 476-477
• [Journal Article] Computational study on conformation of oligopeptides containing chiral cyclic disubstituted amino acids (2007)
  • Author(s): M.Kurihara, Y.Sato, W.Hakamata, H.Okuda, Y.Demizu, M.Nagano, N.Kawabe, M.Doi, M.Tanaka, H.Suemune
  • Journal Title: Peptides 2006 (Proceedings of the 29th European Peptide Symposium) Pages: 546-547
• [Journal Article] Lipase-Catalyzed Kinetic Resolution of Cyclic trans-1,2-Diols Bearing a Diester Moiety : Synthetic Application to Chiral Seven-Membered Ring α, α-Disubstituted α-Amino Acid (2007)
  • Author(s): M. Tanaka, H. Suemune, (他6名)
  • Journal Title: J.Org.Chem. 72 Pages: 7750-7756
  • Peer Reviewed
• [Journal Article] Lipase-Catalyzed Kinetic Resolution of Cyclic trans-1,2-Diols Bearing a Diester Moiety:Synthetic Application to Chiral Seven-Membered Ring α,α-Disubstituted α-Amino Acid (2007)
  • Author(s): M. Tanaka, et. al.
  • Journal Title: J. Org. Chem. 72 Pages: 7750-7756
  • Peer Reviewed
• [Journal Article] Side chain chiral centers of amino acids and helical-screw handedness of their peptides (2007)
  • Author(s): M. Tanaka, et. al.
  • Journal Title: Peptides 2006 Pages: 268-269
• [Journal Article] Computational study on conformation of oligopeptides containing chiral cyclic disubstituted amino acids (2007)
  • Author(s): M. Kurihara, et. al.
  • Journal Title: Peptides 2006 Pages: 546-547
• [Journal Article] Controlling the helical secondary structure of heteropeptides using chiral cyclic alpha,alpha-disubstituted amino acids (2007)
  • Author(s): M. Nagano, et. al.
  • Journal Title: Peptides 2006 Pages: 476-477
• [Journal Article] Studies on DNA dynamics using 2-N-tert-butylaminoxylpurines (2007)
  • Author(s): M. Aso, et. al.
  • Journal Title: Nucleic Acids Symposium Series 51 Pages: 163-164
• [Presentation] 活性制御可能なヘリセン型アミン触媒の合成研究 (2011)
  • Author(s): 小木曽俊孝
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 1,4-ジカルボニル構造の反応性を利用したリジン修飾化合物の開発 (2011)
  • Author(s): 稲富由香
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 新規スピンラベルピリミジンC-ヌクレオシド誘導体の合成と機能研究 (2011)
  • Author(s): 佐藤 光
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] アセタールを有するキラル6員環状アミノ酸からなるペプチドの合成と2次構造解析 (2011)
  • Author(s): 加藤和也
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] α、α-ジ置換アミノ酸を含むオリゴペプチドのコンフォメーション予測と解析 (2011)
  • Author(s): 栗原正明, ら
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 高い骨親和性を持つ抗腫瘍性白金(II)錯体の合成と評価 (2011)
  • Author(s): 稲垣優, ら
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] Synthetic approach of a tertiary amine containing [6]helicene for asymmetric catalysis (2010)
  • Author(s): Usui, K., et al.
  • Organizer: Pacifichem 2010
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2010-12-19
• [Presentation] Synthetic approach of a tertiary amine containing [6] helicene for asymmetric catalysis (2010)
  • Author(s): 臼井一晃
  • Organizer: Pacifichem 2010
  • Place of Presentation: USA, Hawaii.
  • Year and Date: 2010-12-18
• [Presentation] [6]ヘリセン骨格を利用したアミン触媒の合成研究 (2010)
  • Author(s): 小木曽俊孝
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
  • Year and Date: 2010-12-11
• [Presentation] 2つの異なる不斉中心を有する6員環状ジ置換アミノ酸の合成とそのペプチドの二次構造研究 (2010)
  • Author(s): 平田貴之
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
  • Year and Date: 2010-12-11
• [Presentation] C4'酸化型核酸誘導体のアミン反応性に対する2'位置換基の効果 (2010)
  • Author(s): 陳之内章子
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
  • Year and Date: 2010-12-11
• [Presentation] ジアルキルビスフォスフォネート白金錯体の骨転移がん治療薬としての可能性 (2010)
  • Author(s): 中武秀聡
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-11-18
• [Presentation] Design and synthesis of oligodeoxynucleotides containing 2'-substituted analogues of C4'-oxidized abasic lesion (2010)
  • Author(s): A.Jinnouchi
  • Organizer: the 37th International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: Gifu
  • Year and Date: 2010-11-10
• [Presentation] 光反応を用いた2'位置換C4'酸化型DNA誘導体の生成と反応性研究 (2010)
  • Author(s): 井上智
  • Organizer: 第36回反応と合成の進歩シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-02
• [Presentation] 光応答性キラルアミン有機触媒の合成研究 (2010)
  • Author(s): 小木曽俊孝
  • Organizer: 第130回年会 日本薬学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] スピンラベル化核酸の運動性研究-配列依存性の検討- (2010)
  • Author(s): 樋口祥隆
  • Organizer: 第130回年会日本薬学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] 2つのアセタールを有する6員環状アミノ酸の合成とそのオリゴマーの2次構造解析 (2010)
  • Author(s): 加藤和也
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] 光学活性5員環アミノ酸の設計・合成とそのペプチドの二次構造解析 (2010)
  • Author(s): 平田陽子
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] ジ置換アミノ酸オリゴペプチドのコンフォメーション予測と解析 (2010)
  • Author(s): 栗原正明
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] 光学活性6員環状ジ置換アミノ酸の合成とそのペプチドの2次構造研究 (2010)
  • Author(s): 平田貴之
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] Design and synthesis of oligodeoxynucleotides containing 2'-substituted analogues of C4'-oxidized abasic lesion as amine reactive ODN (2010)
  • Author(s): Jinnouchi, A., et al.
  • Organizer: the 37th International Symposium on Nucleic Acids Chemistry(pp.212-213)
  • Place of Presentation: Gifu
• [Presentation] ジアルキルビスフォスフォネート白金(II)錯体の骨転移がん治療薬としての可能性 (2010)
  • Author(s): 中武秀聡, ら
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
• [Presentation] 光学活性6員環状ジ置換アミノ酸の合成とそのペプチドの2次構造研究 (2010)
  • Author(s): 平田貴之, ら
  • Organizer: 第130回年会 日本薬学会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] α, α-ジ置換アミノ酸オリゴペプチドのコンフォメーション予測と解析 (2010)
  • Author(s): 栗原正明, ら
  • Organizer: 第130回年会 日本薬学会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] 光学活性5員環アミノ酸の設計・合成とそのペプチドの二次構造解析 (2010)
  • Author(s): 平田陽子, ら
  • Organizer: 第130回年会 日本薬学会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] 2つのアセタールを有する6員環状アミノ酸の合成とそのオリゴマーの2次構造解析 (2010)
  • Author(s): 加藤和也, ら
  • Organizer: 第130回年会 日本薬学会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] 2位に置換基をもつC4'位酸化型脱塩基部位誘導体の合成とアミン分子との反応性研究 (2010)
  • Author(s): 井上智, ら
  • Organizer: 第130回年会 日本薬学会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] スピンラベル化核酸の運動性評価-配列依存性の検討- (2010)
  • Author(s): 樋口祥隆, ら
  • Organizer: 第130回年会 日本薬学会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] 光応答性キラルアミン有機触媒の合成研究 (2010)
  • Author(s): 小木曽俊孝, ら
  • Organizer: 第130回年会 日本薬学会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] スピン直結型ヌクレオシドを導入した二本鎖ODNのESRによる運動性評 (2009)
  • Author(s): 樋口祥隆
  • Organizer: 第26回日本薬学会九州支部大会
  • Year and Date: 2009-12-12
• [Presentation] 光反応性保護基を用いたアミン捕捉能を持つC4'酸化型核酸誘導体の設計と合成 (2009)
  • Author(s): 冨襟子
  • Organizer: 第26回日本薬学会九州支部大会
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-12
• [Presentation] アジド基を持つ環状アミノ酸からなるペプチドの2次構造研究 (2009)
  • Author(s): 田中正一
  • Organizer: 第35回反応と合成の進歩シンポジウム
  • Place of Presentation: 金沢
  • Year and Date: 2009-11-16
• [Presentation] スピン直結型新規スピンラベル化核酸の合成とESRによる運動性評価 (2009)
  • Author(s): 樋口祥隆
  • Organizer: 第35回反応と合成の進歩シンポジウム
  • Place of Presentation: 金沢
  • Year and Date: 2009-11-16
• [Presentation] Computational Study on Helical Structure of Chiral Disubstituted Oligopeptides (2009)
  • Author(s): 栗原正明
  • Organizer: 第46回ペプチド討論会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-11-05
• [Presentation] オリゴデオキシヌクレオチドに組み込んだ2-N-tert-ブチルアミノキシル-2'-デオキシアデノシンの運動性評価 (2009)
  • Author(s): 樋口祥隆
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-29
• [Presentation] α、α-ジ置換アミノ酸ペプチドのコンフォメーション予測 (2009)
  • Author(s): 栗原正明
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-29
• [Presentation] キラルアセタールを有する六員環状アミノ酸の合成とそのペプチドのコンフォメーション解析 (2009)
  • Author(s): 石川奈保子
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-29
• [Presentation] ラジカル・蛍光二重標識オリゴデオキシヌクレオチドの蛍光特性 (2009)
  • Author(s): 原田涼子
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-29
• [Presentation] C4'酸化型RNAおよびDNAのアミン分子との反応性研究 (2009)
  • Author(s): 井上智
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-29
• [Presentation] ヘリカルペプチドを触媒とした不斉エポキシ化反応 (2009)
  • Author(s): 長野正展
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-29
• [Presentation] Asymmetric Epoxidation of Unsaturated Ketones Using Helical Secondary Structures (2009)
  • Author(s): 長野正展
  • Organizer: The 11^<th> International KYOTO conference on New Aspects of Organic Chemistry
• [Presentation] Evaluation of mobility of 2-N-tert-butylaminoxyladenosine incorporated into oligodeoxynucleotide (2009)
  • Author(s): Y.Higuchi, et al.
  • Organizer: The 6th International Sumposium on Nucleic Acids Chemistry
  • Place of Presentation: 高山市
• [Presentation] Photochemical generation and reaction of 2' -substituted analogues of C4' -oxidized abasic lesion (2009)
  • Author(s): E.Tomi, et al.
  • Organizer: The 6th International Sumposium on Nucleic Acids Chemistry
  • Place of Presentation: 高山市
• [Presentation] Asymmetric Epoxidation of α, β-Unsaturated Ketones Using Helical Secondary Structures (2009)
  • Author(s): 長野正展, ら
  • Organizer: 第11回有機化学の新思考-京都国際会議(IKCOC-11)
  • Place of Presentation: 京都リーガロイヤルホテル(京都府)
• [Presentation] アジド基を持つ環状アミノ酸からなるペプチドの2次構造研究 (2009)
  • Author(s): 田中正一, ら
  • Organizer: 第35回反応と合成の進歩シンポジウム
  • Place of Presentation: 金沢市文化ホール(金沢市)
• [Presentation] Computational Study on Helical Structure of Chiral α,α-Disubstituted Oligopeptides (2009)
  • Author(s): 栗原正明, ら
  • Organizer: 第46回ペプチド討論会
  • Place of Presentation: 北九州国際会議場(北九州市)
• [Presentation] ヘリカルペプチドを触媒とした不斉エポキシ化反応 (2009)
  • Author(s): 長野正展, ら
  • Organizer: 第129回日本薬学会年会
  • Place of Presentation: 京都府
• [Presentation] ラジカル・蛍光二重標識オリゴデオキシヌクレオチドの蛍光特性 (2009)
  • Author(s): 原田涼子, ら
  • Organizer: 第129回日本薬学会年会
  • Place of Presentation: 京都府
• [Presentation] C4'位酸化型RNA及びDNAのアミン分子との反応性研究 (2009)
  • Author(s): 井上智, ら
  • Organizer: 第129回日本薬学会年会
  • Place of Presentation: 京都府
• [Presentation] オリゴデオキシヌクレオチドに組み込んだ2-N-tert-ブチルアミノキシル-2'-デオキシアデノシンの運動性評価 (2009)
  • Author(s): 樋口祥隆, ら
  • Organizer: 第129回日本薬学会年会
  • Place of Presentation: 京都府
• [Presentation] ラジカル直結型ヌクレオシドを導入したODNの機能研究 (2008)
  • Author(s): 樋口祥隆
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 延岡
  • Year and Date: 2008-12-06
• [Presentation] 4つの不斉中心を有する環状アミノ酸の合成とそのペプチドの二次構造解析 (2008)
  • Author(s): 反田和弘
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 延岡
  • Year and Date: 2008-12-06
• [Presentation] ケージド前駆体を用いて生成したC4'酸化型DNA及びRNAの反応性 (2008)
  • Author(s): 井上智
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 延岡
  • Year and Date: 2008-12-06
• [Presentation] Design of a new class of spin-labeled nucleosides with N-tertbutylaminoxyl group directly introduced into nucleobase (2008)
  • Author(s): M. Aso
  • Organizer: The 3rd International Conference on Cutting-Edge Organic Chemistry in Asia under Asian Core
  • Place of Presentation: 中国・杭州市
  • Year and Date: 2008-10-20
• [Presentation] Design of a new class of spin-labeled nucleosides with N-tert-butylaminoxyl group directly introduced into nucleobase (2008)
  • Author(s): M.Aso
  • Organizer: The 3^<rd> International Conference on Cutting-Edge Organic Chemistry in Asia under Asian Core
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-10-13
• [Presentation] Dynamics of 2-N-tert-butylaminoxyladenosine Incorporated into Oligodeoxynucleotides (2008)
  • Author(s): M.Aso
  • Organizer: Joint Symposium of the 18^<th> International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35^<th> International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: Kyoto
  • Year and Date: 2008-09-09
• [Presentation] 環状ジ置換アミノ酸を含有したヘリカルフォールドマーと不斉エポキシ化への応用 (2008)
  • Author(s): 長野正展, ら
  • Organizer: 第20回万札幌万有シンポジウム
  • Place of Presentation: 札幌市
  • Year and Date: 2008-07-05
• [Presentation] 環状ジ置換アミノ酸を含有したヘリカルフォールドマーと不斉エポキシ化への応用 (2008)
  • Author(s): 長野正展, ら
  • Organizer: 第18回福岡万有シンポジウム
  • Place of Presentation: 福岡市
  • Year and Date: 2008-05-10
• [Presentation] キラル環状ジ置換アミノ酸を用いたヘリカル2次構造の制御と不斉エポキシ化反応への応用 (2008)
  • Author(s): 長野正展
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-29
• [Presentation] ロジウム錯体によるサリチルアルデヒドとジエンの分子間ヒドロアシル化反応 (2008)
  • Author(s): 今井幹典
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-29
• [Presentation] ケージド前駆体を用いたC4'酸化型RNAの生成とその反応性研究 (2008)
  • Author(s): 渡口由希子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] 2-N-tert-ブチルアミノキシルアデノシンを導入したオリゴデオキシヌクレオチドのESR研究 (2008)
  • Author(s): 栗田真奈美
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] Helical-screw handedness of peptides composed of diastereomeric cyclic amino acids (2008)
  • Author(s): M. Nagano
  • Organizer: 第30回ヨーロッパペプチドシンポジウム
  • Place of Presentation: フィンランド国ヘルシンキ
• [Presentation] 環状ジ置換アミノ酸によるヘリカル二次構造の制御と不斉エポキシ化反応への応用 (2008)
  • Author(s): 長野正展, ら
  • Organizer: 第6回次世代を担う有機化学シンポジウム
  • Place of Presentation: 東京都・渋谷
• [Presentation] Helical-screw handedness of peptides composed of diastereomeric cyclic amino acids (2008)
  • Author(s): 長野正展, ら
  • Organizer: 第30回ヨーロッパ・ペプチドシンポジウム
  • Place of Presentation: フィンランド国ヘルシンキ
• [Presentation] Dynamics of 2-N-tert-butylaminoxyladenosine Incorporated into Oligodeoxynucleotides (2008)
  • Author(s): M.Aso, et al.
  • Organizer: Joint Symposium of the 18th International Round table on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: 京都市
• [Presentation] 環状アミノ酸含有ヘリカルペプチドを用いた不斉エポキシ化反応 (2008)
  • Author(s): 長野正展, ら
  • Organizer: 第34回反応と合成の進歩シンポジウム
  • Place of Presentation: 京都府
• [Presentation] ラジカル直結型ヌクレオシドを導入したODNの機能研究 (2008)
  • Author(s): 樋口祥隆, ら
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 延岡市
• [Presentation] キラルアセタールを有する六員環状アミノ酸の合成とそのペプチドのコンフォメーション解析 (2008)
  • Author(s): 石川奈保子, ら
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 延岡市
• [Presentation] 4つの不斉中心を有する環状アミノ酸の合成とそのペプチドの二次構造解析 (2008)
  • Author(s): 反田和弘, ら
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 延岡市
• [Presentation] ケージド前駆体を用いて生成したC4'酸化型DNA及びRNAの反応性 (2008)
  • Author(s): 井上智, ら
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 延岡市
• [Presentation] α,α-ジ置換ペプチドのコンフォメーション予測法の検討 (2008)
  • Author(s): 佐藤 由紀子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜市
• [Presentation] キラル環状ジ置換アミノ酸を用いたヘリカル二次構造の制御と不斉エポキシ化反応への応用 (2008)
  • Author(s): 長野 正展
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜市
• [Presentation] Molecular design for chiral cyclic α, α-disubstituted amino acids and conformational study of their peptides (2007)
  • Author(s): 田中正一
  • Organizer: 4^<th> International Peptide Symposium/7^<th> Australian Peptide, Conference/2^<nd> Asia-Pacific International Peptide Symposium
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2007-11-23
• [Presentation] Studies on DNA dynamics using 2-N-tert-butylaminoxylpurines (2007)
  • Author(s): M.Aso
  • Organizer: 5th International Synposium on Nucleic Acids Chemistry
  • Place of Presentation: Tokyo.
  • Year and Date: 2007-11-20
• [Presentation] The photoreactivity of the caged precursors of oligodeoxynucleotides containing C4'-oxidized abasic site and the reaction of the generated lesion (2007)
  • Author(s): 臼井一晃
  • Organizer: 5th International Synposium on Nucleic Acids Chemistry
  • Place of Presentation: Tokyo.
  • Year and Date: 2007-11-20
• [Presentation] Controlling 3_<10>-helix and alpha-helix of short L-leucine-peptides by alpha, alpha- disubstituted amino acid (2007)
  • Author(s): 長野正展
  • Organizer: 4th International Peptide Symposium/7th Australian Peptide, Conference/2nd Asia-Pacific International Peptide Symposium
  • Place of Presentation: Cairns.
  • Year and Date: 2007-10-22
• [Presentation] The structure-reactivity relationship of caged precursors of oligonucleotide containing C4'-oxidized abasic site (2007)
  • Author(s): 臼井一晃
  • Organizer: 2007光化学討論会
  • Place of Presentation: 長野
  • Year and Date: 2007-09-27
• [Presentation] コンドロシアミドAの立体選択的合成研究 (2007)
  • Author(s): 森貴浩
  • Organizer: 第44回化学関連支部合同九州大会
  • Place of Presentation: 北九州
  • Year and Date: 2007-07-07
• [Presentation] ジアステレオメリックなジ置換アミノ酸よりなるペプチドのヘリカル2次構造 (2007)
  • Author(s): 長野正展
  • Organizer: 第44回化学関連支部合同九州大会
  • Place of Presentation: 北九州
  • Year and Date: 2007-07-07
• [Presentation] ジアステレオメリックなジ置換アミノ酸よりなるペプチドのヘリカル2次構造 (2007)
  • Author(s): 長野 正展
  • Organizer: 第44回化学関連支部合同九州大会
  • Place of Presentation: 北九州市
  • Year and Date: 2007-07-07
• [Presentation] Synthesis and EPR Studies of 2-N-tert-Butylaminoxylpurine Containing Oligodeoxynucleotides (2007)
  • Author(s): M. Aso
  • Organizer: Gordon Research Conference Bioorganic Chemistry
  • Place of Presentation: アメリカ合衆国ニューハンプシャー
  • Year and Date: 2007-06-14
• [Presentation] キラル環状α,α-ジ置換アミノ酸ペプチドのコンフォメーション予測 (2007)
  • Author(s): 栗原正明
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-29
• [Presentation] リパーゼによる環状1,2-ジオールの速度論的光学分割とキラル環状ジ置換アミノ酸含有ペプチドの合成 (2007)
  • Author(s): 田中正一
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-29
• [Presentation] C4'酸化型RNAのケージド誘導体の合成と反応性 (2007)
  • Author(s): 渡口由希子
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-29
• [Presentation] 2'-デオキシN-tert-ブチルヒドロキシルアミノプリンの効率的合成とその水素結合能評価 (2007)
  • Author(s): 栗田麻奈美
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-29
• [Presentation] ケージドDNAによる効率的C4'酸化脱塩基部位の生成とその反応性 (2007)
  • Author(s): 臼井一晃
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-29
• [Presentation] ジアステレオメリックな環状ジ置換アミノ酸の合成とそのホモペプチドの2次構造 (2007)
  • Author(s): 長野正展
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-29
• [Presentation] Molecular design for chiral cyclic α,α-disubstituted amino acids and conformational study of their peptides (2007)
  • Author(s): M. Tanaka
  • Organizer: 4^<th> International Peptide Symposium/7^<th> Australian Peptide, Conference/2^<nd> Asia-Pacific International Peptide Symposium
  • Place of Presentation: Cairns(Australia)
• [Presentation] Controlling 3_<10>helix and α-helix of short L-leucine-peptides by α,α-disubstituted amino acid (2007)
  • Author(s): M. Nagano
  • Organizer: 4^<th> International Peptide Symposium/7^<th> Australian Peptide, Conference/2^<nd> Asia-Pacific International Peptide Symposium
  • Place of Presentation: Cairns(Australia)
• [Presentation] 各種官能基を有する5員環状ジ置換アミノ酸の設計・合成とそのペプチド (2007)
  • Author(s): 高崎 紘臣
  • Organizer: 第33回反応と合成の進歩シンポジウム
  • Place of Presentation: 長崎市
• [Presentation] α,α-ジ置換アミノ酸を含むオリゴペプチドのコンフォメーション予測 (2007)
  • Author(s): 栗原 正明
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山市
• [Presentation] キラル環状ジ置換アミノ酸を用いたヘリカル二次構造の制御とその応用 (2007)
  • Author(s): 長野 正展
  • Organizer: 第24回日本薬学会九州支部大会
  • Place of Presentation: 福岡市
• [Presentation] α、α-ジ置換アミノ酸を含むオリゴペプチドのコンフォメーション予測と解析
  • Author(s): 栗原正明
  • Organizer: 日本薬学会第131年会
• [Presentation] 高い骨親和性を持つ抗腫瘍性白金錯体の合成と評価
  • Author(s): 稲垣優
  • Organizer: 日本薬学会第131年会
• [Presentation] 2位に置換基を持つC4'位酸化型脱塩基部位誘導体の合成とアミン分子との反応性研究
  • Author(s): 井上智
  • Organizer: 日本薬学会第130年会
• [Remarks] ホームページ
  • URL: http://sekkei.phar.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://sekkei.phar.kyushu-u.ac.jp/Publication4.html
• [Remarks] ホームページ
  • URL: http://sekkei.phar.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://210.233.60.66/~sekkei/