High-performance glucose-sensitive nanocapsules
Project/Area Number |
19390010
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Physical pharmacy
|
Research Institution | Tohoku University |
Principal Investigator |
ANZAI Jun-ichi Tohoku University, 大学院・薬学研究科, 教授 (40159520)
|
Co-Investigator(Kenkyū-buntansha) |
SATO Katsuhiko 東北大学, 大学院・薬学研究科, 助教 (80400266)
星 友典 東北大学, 大学院・薬学研究科, 講師 (50302170)
江川 祐哉 東北大学, 大学院・薬学研究科, 助教 (90400267)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
Keywords | グルコース / ナノカプセル / インスリン / ミクロカプセル / 糖応答性 / 高分子電解質 / 累積膜 / グルコースセンサー / フェニルボロン酸 / フエニルボロン酸 / グルコース応答性 / 交互累積法 / センサー |
Research Abstract |
The development of nanocapsules for glucose determination and for release insulin in response to enhanced glucose level have been studied. CaCO_3 nanoparticles containing lectin complexes or insulin were coated with polyelectrolyte thin films followed by dissolution of the nanoparticle, resulting in nanocapsules. The nanocapsules thus prepared were successfully used for glucose determination and for insulin release in response to enhanced glucose level.
|
Report
(4 results)
Research Products
(35 results)