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High-performance glucose-sensitive nanocapsules

Research Project

Project/Area Number 19390010
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionTohoku University

Principal Investigator

ANZAI Jun-ichi  Tohoku University, 大学院・薬学研究科, 教授 (40159520)

Co-Investigator(Kenkyū-buntansha) SATO Katsuhiko  東北大学, 大学院・薬学研究科, 助教 (80400266)
星 友典  東北大学, 大学院・薬学研究科, 講師 (50302170)
江川 祐哉  東北大学, 大学院・薬学研究科, 助教 (90400267)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsグルコース / ナノカプセル / インスリン / ミクロカプセル / 糖応答性 / 高分子電解質 / 累積膜 / グルコースセンサー / フェニルボロン酸 / フエニルボロン酸 / グルコース応答性 / 交互累積法 / センサー
Research Abstract

The development of nanocapsules for glucose determination and for release insulin in response to enhanced glucose level have been studied. CaCO_3 nanoparticles containing lectin complexes or insulin were coated with polyelectrolyte thin films followed by dissolution of the nanoparticle, resulting in nanocapsules. The nanocapsules thus prepared were successfully used for glucose determination and for insulin release in response to enhanced glucose level.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (35 results)

All 2010 2009 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (21 results)

  • [Journal Article] Sugar-dependent solubility and fluorescence property of copolymers consisting of phenylboronic acid and 2-hydroxyethyl methacrylate moieties2010

    • Author(s)
      Katsuhiko Sato, Tatsuya Nakajima, Yu Yasukawa, Jun-ichi Anzai
    • Journal Title

      Polymer Bulletin (印刷中)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Layer-by-layer polyelectrolyte films containing insulin for pH-triggered release2010

    • Author(s)
      Kentaro Yoshida, Katsuhiko Sato, Jun-ichi Anzai
    • Journal Title

      Journal of Materials Chemistry 20

      Pages: 1546-1552

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Layer-by-layer polyelectrolyte films containing insulin for pH-triggered release2010

    • Author(s)
      Yoshida, Kentaro
    • Journal Title

      Journal of Materials Chemistry 20

      Pages: 1546-1552

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Layer-by-layer thin films containing proteins for biosensor applications2009

    • Author(s)
      Katsuhiko Sato, Jun-ichi Anzai, Jiadong Huang, Qiang Chen
    • Journal Title

      Bottom-up Nanofabrication 5

      Pages: 219-233

    • Related Report
      2009 Final Research Report
  • [Journal Article] Preparation of dendrimer-loaded microcapsules by a layer-by-layer deposition of polyelectrolytes2009

    • Author(s)
      Shigeru Tomita, Katsuhiko Sato, Jun-ichi Anzai
    • Journal Title

      Materials Science and Engineering C 29

      Pages: 2024-2028

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sugar response of boronic acid-substituted azobenzene dye-modified polymer2009

    • Author(s)
      Yuya Egawa, Ryota Gotoh, Toshinobu Seki, Jun-ichi Anzai
    • Journal Title

      Materials Science and Engineering C 29

      Pages: 115-118

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of insulin-containing microcapsules by a layer-by-layer deposition of concanavalin A and glucose2009

    • Author(s)
      Katsuhiko Sato, Daisuke Kodama, Yoshihiro Endo, Jun-ichi Anzai
    • Journal Title

      Journal of Nanoscience and Nanotechnology 9

      Pages: 386-390

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of dendrimer-loaded microcapsules by a layer-by-layer deposition of polyelectrolytes2009

    • Author(s)
      Tomita, Shigeru
    • Journal Title

      Materials Science & Engineering C 29

      Pages: 2024-2028

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Layer-by-layer assembled thin films composed of carboxyl-terminated poly (amidoamine) dendrimer as a pH-sensitive nano-device2008

    • Author(s)
      Shigeru Tomita, Katsuhiko Sato, Jun-ichi Anzai
    • Journal Title

      Journal of Colloid and Interface Science 326

      Pages: 35-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of layer-by-layer thin films containing insulin and its pH-sensitive decomposition2008

    • Author(s)
      Kentaro Yoshida, Hiroshi Sato, Shigehiro Takahashi, Jun-ichi Anzai
    • Journal Title

      Polymer Journal 40

      Pages: 90-91

    • NAID

      10021116024

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 交互累積法によるナノ薄膜およびナノカプセルを用いたバイオセンサ2008

    • Author(s)
      王保珍, 江川祐哉, 佐藤勝彦, 安齋順一
    • Journal Title

      マテリアルインテグレーション 21

      Pages: 282-287

    • Related Report
      2009 Final Research Report
  • [Journal Article] Layer-by-layer assembled thin films composed of carboxyl-terminated poly(amidoamine) dendrimer as a pH-sensitive nano-device2008

    • Author(s)
      Tomita, Shigeru
    • Journal Title

      Journal of Colloid & Interface Science 325

      Pages: 35-40

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of layer-by-layer thin films containing insulin and its pH-sensitive decomposition2008

    • Author(s)
      Yoshida, Kentaro
    • Journal Title

      Polymer Journal 40

      Pages: 90-91

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hydrogen peroxide on the electrochemical decomposition of layer-by-layer thin films composed of 2-iminobiotin-labeled poly(ethyleneimine)and avidin2007

    • Author(s)
      Sato, Katsuhiko
    • Journal Title

      Journal of Colloid and Interface Science 315

      Pages: 396-399

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Sugar-sensitive films and microcapsules for sensing and release2009

    • Author(s)
      Jun-ichi Anzai
    • Organizer
      8^<th> Asian Conference on Chemical Sensors
    • Place of Presentation
      Daegu
    • Year and Date
      2009-11-15
    • Related Report
      2009 Final Research Report
  • [Presentation] pH-or glucose-sensitive thin films and microcapsules containing insulin2009

    • Author(s)
      Kentaro Yoshida, Jun-ichi Anzai
    • Organizer
      8^<th> Asian Conference on Chemical Sensors
    • Place of Presentation
      Daegu
    • Year and Date
      2009-11-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Sugar-sensitive films and microcapsules for sensing and release2009

    • Author(s)
      Anzai, Jun-ichi
    • Organizer
      8^<th> Asian Conference on Chemical Sensors
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 刺激応答性インスリン放出システムの開発2009

    • Author(s)
      吉田健太郎, 安齋順一
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 糖存在下におけるフェロセンボロン酸の電気化学応答2009

    • Author(s)
      安齋順一
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] グルコースセンサ機能をもつインスリンカプセル2009

    • Author(s)
      佐藤勝彦, 安齋順一
    • Organizer
      第48回化学センサ研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] pH応答性インスリン放出カプセルの開発2009

    • Author(s)
      吉田健太郎, 安齋順一
    • Organizer
      みちのく分析科学シンポジウム2009
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-25
    • Related Report
      2009 Final Research Report
  • [Presentation] グルコースオキシダーゼを固定化した微粒子およびカプセルの糖応答性の評価2009

    • Author(s)
      保科直, 安齋順一
    • Organizer
      みちのく分析科学シンポジウム2009
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Insulin-containing thin films and nano-particles for glucose-triggered controlled release2008

    • Author(s)
      Kentaro Yoshida, Jun-ichi Anzai
    • Organizer
      The 3^<rd> International Symposium on Environmental Economy and Technology
    • Place of Presentation
      深谷
    • Year and Date
      2008-08-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Sugar-sensitive thin films composed of phenylboronic acid-modified dendrimers2008

    • Author(s)
      Satoshi Niina, Jun-ichi Anzai
    • Organizer
      The 3^<rd> International Symposium on Environmental Economy and Technology
    • Place of Presentation
      深谷
    • Year and Date
      2008-08-26
    • Related Report
      2009 Final Research Report
  • [Presentation] フェニルボロン酸修飾デンドリマーとポリビニルアルコールを用いた糖応答性薄膜2008

    • Author(s)
      新名聖, 安齋順一
    • Organizer
      みちのく分析科学シンポジウム2008
    • Place of Presentation
      仙台
    • Year and Date
      2008-07-19
    • Related Report
      2009 Final Research Report
  • [Presentation] コンカナバリンAを用いたミクロカプセルの調製と糖応答性2008

    • Author(s)
      佐藤勝彦, 安齋順一
    • Organizer
      第69回分析化学討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-05-15
    • Related Report
      2009 Final Research Report
  • [Presentation] コンカナバリンAを用いたカプセルの調製と糖応答性2008

    • Author(s)
      佐藤勝彦
    • Organizer
      第69回分析化学討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] pH応答性インスリン含有ミクロカプセルの調製2008

    • Author(s)
      吉田健太郎, 安齋順一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 糖類の刺激でインスリンを放出するマイクロカプセルの調製2008

    • Author(s)
      児玉大祐, 安齋順一
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 交互累積方により作製したマイクロカプセルの透過性2008

    • Author(s)
      遠藤好弘, 安齋順一
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Insulin nano-films sensitive to pH and glucose2007

    • Author(s)
      Shigehiro Takahashi, Jun-ichi Anzai
    • Organizer
      7^<th> East Asia Conference on Chemical Sensors
    • Place of Presentation
      シンガポール
    • Year and Date
      2007-12-03
    • Related Report
      2009 Final Research Report
  • [Presentation] インスリンを含有する交互累積膜の調製と性質2007

    • Author(s)
      吉田健太郎, 安齋順一
    • Organizer
      2007高分子学会東北支部研究発表会
    • Place of Presentation
      秋田
    • Year and Date
      2007-11-15
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] レクチンを構成成分とするミクロカプセルの糖応答性2007

    • Author(s)
      児玉大祐, 安齋順一
    • Organizer
      みちのく分析科学シンポジウム2007
    • Place of Presentation
      仙台
    • Year and Date
      2007-07-27
    • Related Report
      2009 Final Research Report
  • [Presentation] インスリン累積膜の調製とpH応答性2007

    • Author(s)
      吉田健太郎, 安齋順一
    • Organizer
      みちのく分析科学シンポジウム2007
    • Place of Presentation
      仙台
    • Year and Date
      2007-07-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 交互累積膜によるナノ薄膜・ナノカプセルの機能開発2007

    • Author(s)
      安齋順一
    • Organizer
      みちのく分析科学シンポジウム2007
    • Place of Presentation
      仙台
    • Year and Date
      2007-07-27
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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