Roles of prostanoids in the pathogenesis of cardiovascular diseases

• Project/Area Number: 19390060
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Asahikawa Medical College
• Principal Investigator: USHIKUBI Fumitaka Asahikawa Medical College, 医学部, 教授 (50243035)
• Co-Investigator(Kenkyū-buntansha): YUHKI Koh-ichi 旭川医科大学, 医学部, 講師 (80302420) ; SUZUKI Yasuhiro 旭川医科大学, 医学部, 助教 (80451459)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: プロスタノイド / プロスタグランジン / トロンボキサン / 循環器

Research Abstract

We intended to clarify the roles of prostanoids in the pathogenesis of cardiovascular diseases using mice lacking each prostanoid receptor and murine model of cardiovascular diseases. We clarified the cardioprotective effect of PGE_2 and the suppressive effect of PGI_2 on vascular remodeling. We also found an anti-platelet effect of PGE_2 via EP4 receptor.

Research Products

• [Journal Article] Prostaglandin I_2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling (2010)
  • Author(s): Kawabe, J., Yuhki, K., Okada, M., Kanno, T., Yamauchi, A., Tashiro, N., Sasaki, T., Okumura, S., Nakagawa, N., Aburakawa, Y., Takehara, N., Fujino, T., Hasebe, N., Narumiya, S., Ushikubi, F.
  • Journal Title: Arterioscler Thromb Vasc Biol. 30 Pages: 464-470
• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases (2010)
  • Author(s): Yuhki, K., Kashiwagi, H., Kojima, F., Kawabe, J., Ushikubi, F.
  • Journal Title: Int Angiol. 29(Suppl 2) Pages: 19-27
• [Journal Article] Prostaglandin I_2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling (2009)
  • Author(s): Kawabe, J., Yuhki, K., et al.
  • Journal Title: Arterioscler.Thromb.Vasc.Biol. 30 Pages: 464-470
  • Peer Reviewed
• [Journal Article] Prostaglandin I_2 plays a key role in zymosan-induced mouse pleurisy (2008)
  • Author(s): Yuhki, K., Ushikubi, F., Naraba, H., Ueno, A., Kato, H., Kojima, F., Narumiya, S., Sugimoto, Y., Matsushita, M., Oh-ishi, S.
  • Journal Title: J Pharmacol Exp Ther. 325 Pages: 601-609
• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases : Novel insights from knockout mouse studies
  • Author(s): Yuhki, K., Kojima, F., Kashiwagi, H., Kawabe, J., Fujino, T., Narumiya, S., Ushikubi, F.
  • Journal Title: Pharmacol Ther. (In press)
• [Journal Article] Selective activation of prostaflandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation
  • Author(s): Kuriyama, S., Kashiwagi, H., Yuhki, K., Kojima, F., Yamada, T., Fujino, T., Hara, A., Takayama, K., Maruyama, T., Yoshida, A., Narumiya, S., Ushikubi F.
  • Journal Title: Thromb Haemost. (In press)
• [Journal Article] Prostaglandin I_2 plays a key role in zymosan-induced mouse pleurisy
  • Author(s): Yuhki, K., Ushikubi, F., et. al.
  • Journal Title: J. Pharmacol. Exp. Ther. (in press)
  • Peer Reviewed