Molecular and phathobiological analysis of defects in quality control systems for DNA and free nucleotides by using mouse models

• Project/Area Number: 19390114
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kyushu University
• Principal Investigator: TSUCHIMOTO Daisuke Kyushu University, 生体防御医学研究所, 助教 (70363348)
• Co-Investigator(Kenkyū-buntansha): 中別府 雄作 九州大学, 生体防御医学研究所, 教授 (30180350)
• Co-Investigator(Renkei-kenkyūsha): NAKABEPPU Yusaku 九州大学, 生体防御医学研究所, 教授 (30180350)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 動物 / DNA酸化損傷 / 遊離ヌクレオチド損傷 / 遺伝子改変マウス / 細胞死 / 発がん / 神経変性

Research Abstract

We have revealed various roles of DNA repair enzymes or nucleotide pool sanitizing enzymes in immune cells, tumor suppression, suppression or induction of neural cell death in Hantington disease, development, and cell death induction and suppression under oxidative stress. We also identified and analyzed novel nuclotide pool sanitizing enzymes, RS21-C6 and NUDT16.

Research Products

• [Journal Article] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single strand breaks in nuclear DNA with growth arrest (2010)
  • Author(s): Iyama T, Abolhassani N, Tsuchimoto D (責任著者), Nonaka M, Nakabeppu Y
  • Journal Title: Nucleic Acids Res. 12
  • Peer Reviewed
• [Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals (2010)
  • Author(s): Abolhassani N, Iyama T, Tsuchimoto D(共同責任著者), Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y(共同責任著者)
  • Journal Title: Nucleic Acids Res. 15
  • NAID: 120005227421
  • Peer Reviewed
• [Journal Article] NUDT16 is a(deoxy)inosine diphosphatase, and its deficiency induces accumulation of single strand breaks in nuclear DNA with growth arrest. (2010)
  • Author(s): Iyama T, et al.
  • Journal Title: Nucleic Acids Research (In press)
  • Peer Reviewed
• [Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals. (2010)
  • Author(s): Abolhassani N, et al.
  • Journal Title: Nucleic Acids Research Jan 15.([Epub ahead of print])
  • Peer Reviewed
• [Journal Article] ITPase-deficient mice show growth retardation and die before weaning (2009)
  • Author(s): Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y(責任著者)
  • Journal Title: Cell Death Differ. 10 Pages: 1315-22
  • Peer Reviewed
• [Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. (2009)
  • Author(s): Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.
  • Journal Title: Int Immunol. 8 Pages: 947-55
  • NAID: 10025387710
  • Peer Reviewed
• [Journal Article] Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase (2009)
  • Author(s): Nonaka M, Tsuchimoto D(責任著者), Sakumi K, Nakabeppu Y
  • Journal Title: preferring 5-iodocytosine. FEBS J. 276(6) Pages: 1654-66
  • Peer Reviewed
• [Journal Article] Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson's disease. (2009)
  • Author(s): Fujita K, et al.
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. (2009)
  • Author(s): Sabouri Z, et al.
  • Journal Title: International Immunology 8 Pages: 947-55
  • Peer Reviewed
• [Journal Article] ITPase-deficient mice show growth retardation and die before weaning. (2009)
  • Author(s): Behmanesh M, et al.
  • Journal Title: Cell Death and Differentiation 10 Pages: 1315-22
  • Peer Reviewed
• [Journal Article] Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. (2009)
  • Author(s): Nonaka M., et al.
  • Journal Title: FEBS Journal 276 Pages: 1654-1666
  • Peer Reviewed
• [Journal Article] Galectln-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus. (2009)
  • Author(s): Kajitani K., et al.
  • Journal Title: Cell Death Differ. 16. Pages: 417-427
  • Peer Reviewed
• [Journal Article] A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration. (2008)
  • Author(s): De Luca G, Russo MT, Degan P, Tiveron C, Zijno A, Meccia E, Ventura I, Mattei E, Nakabeppu Y, Crescenzi M, Pepponi R, Pezzola A, Popoli P, Bignami M.
  • Journal Title: PLoS Genet. 4(11)
  • Peer Reviewed
• [Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus. (2008)
  • Author(s): Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, Kanda T, Sakumi K, Nakabeppu Y(責任著者)
  • Journal Title: DNA Repair (Amst). 7(9) Pages: 1437-54
  • Peer Reviewed
• [Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. (2008)
  • Author(s): Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y(責任著者).
  • Journal Title: EMBO J. 27(2) Pages: 421-32
  • Peer Reviewed
• [Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death. (2008)
  • Author(s): Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y(責任著者)
  • Journal Title: DNA Repair (Amst). 7(3) Pages: 418-30
  • Peer Reviewed
• [Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus. (2008)
  • Author(s): Dan Y., et al.
  • Journal Title: DNA Repair (Amst). 7(9) Pages: 1437-54
  • Peer Reviewed
• [Journal Article] Oxidation of mitochondrialdeoxynucleotide pools by exposure to sodium nitroprusside induces cell death. (2008)
  • Author(s): Ichikawa J., et. al.
  • Journal Title: DNA Repair 7(3) Pages: 418-430
  • Peer Reviewed
• [Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. (2008)
  • Author(s): Oka S., et. al.
  • Journal Title: EMBO J. 27(2) Pages: 421-432
  • Peer Reviewed
• [Journal Article] APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination. (2007)
  • Author(s): Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, Stavnezer J, Schrader CE.
  • Journal Title: J Exp Med. 204(12) Pages: 3017-26
  • Peer Reviewed
• [Journal Article] Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer. (2007)
  • Author(s): Kunisada M, Kumimoto H, Ishizaki K, Sakumi K, Nakabeppu Y, Nishigori C.
  • Journal Title: J Invest Dermatol. 127(12) Pages: 2865-71
  • Peer Reviewed
• [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. (2007)
  • Author(s): Sakamoto K, Tominaga Y, Yamauchi K, Nakatsu Y, Sakumi K, Yoshiyama K, Egashira A, Kura S, Yao T, Tsuneyoshi M, Maki H, Nakabeppu Y(共同責任著者), Tsuzuki T.
  • Journal Title: Cancer Res. 67(14) Pages: 6599-604
  • Peer Reviewed
• [Journal Article] Oxidative damage in nucleic acids and Parkinson's disease. (2007)
  • Author(s): Nakabeppu Y., et. al.
  • Journal Title: J Neurosci Res. 85(5) Pages: 919-934
  • Peer Reviewed
• [Journal Article] Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension. (2007)
  • Author(s): Ohtsubo T., et. al.
  • Journal Title: DNA Repair 6(6) Pages: 760-769
  • Peer Reviewed
• [Journal Article] RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. (2007)
  • Author(s): Kuraoka I., et. al.
  • Journal Title: DNA Repair 6(6) Pages: 841-851
  • Peer Reviewed
• [Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis. (2007)
  • Author(s): Tsuzuki T., et. al.
  • Journal Title: Cancer Sci. 98(4) Pages: 465-470
  • Peer Reviewed
• [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. (2007)
  • Author(s): Sakamoto K., et. al.
  • Journal Title: Cancer Res. 67(14) Pages: 6599-6604
  • Peer Reviewed
• [Journal Article] Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer. (2007)
  • Author(s): Kunisada M., et. al.
  • Journal Title: J Invest Dermatol. 127(12) Pages: 2865-2871
  • Peer Reviewed
• [Journal Article] APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination. (2007)
  • Author(s): Guikema J. E., et. al.
  • Journal Title: J Exp Med. 204(12) Pages: 3017-3026
  • Peer Reviewed
• [Presentation] 新規損傷ヌクレオチド浄化酵素ITPBP2の同定と機能解析 (2009)
  • Author(s): 土本大介ら
  • Organizer: 日本分子生物学会・日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-12-12
• [Presentation] 哺乳動物細胞における2-OH-ATPの生物学的影響 (2009)
  • Author(s): 太田詠子ら
  • Organizer: 日本分子生物学会・日本生化学会合同大会
  • Place of Presentation: 神戸ボードアイランド
  • Year and Date: 2009-12-12
• [Presentation] Human NUDT16 is a novel nucleotide pool sanitizing enzyme hydrolyzing(deoxy)inosine diphosphate to(deoxy)inosine monophosphate (2009)
  • Author(s): Tsuchimoto D, et al.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] An increased expression of NUDT16 with IDP/dIDP hydrolyzing activity in immortalized ITPA-null mouse embryonic fibroblasts suppressed ITPA-deficient phenotypes (2009)
  • Author(s): Abolhassani N, et al.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] 核とミトコンドリアゲノムヘの8-oxoguanineの同時蓄積によって起動されるッログラム細胞死 (2009)
  • Author(s): 岡素雅子ら
  • Organizer: 日本分子生物学会・日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-12-10
• [Presentation] 新規cAMP phosphodiesteraseの同定と癌転移に関与する可能性の検討 (2009)
  • Author(s): 岩間映二ら
  • Organizer: 日本分子生物学会・日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-12-10
• [Presentation] Novel pathway for hydrolysis of inosine nucleotides detected inimmortalized ITPA-null mouse embryo fibroblasts. (2009)
  • Author(s): アボルハッサニ・ノナら
  • Organizer: 日本分子生物学会・日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-12-09
• [Presentation] Human NUDT16 Is a Novel Nucleotide Pool Sanitizing Enzyme Hydrolyzing (Deoxy)Inosine Diphosphate to (Deoxy)Inosine Monophosphate. (2009)
  • Author(s): Teruaki Iyama, Daisuke Tsuchimoto, Nona Abolhassani, Yusaku Nakabeppu
  • Organizer: The 49th annual meeting of the American Society for Cell Biology, San Diego Convention Center, San Diego
  • Place of Presentation: CA, USA
  • Year and Date: 2009-12-07
• [Presentation] Human NUDT16 Is a Novel Nucleotide Pool Sanitizing Enzyme Hydrolyzing(Deoxy)Inosine Diphosphate to(Deoxy)Inosine Monophosphate. (2009)
  • Author(s): Iyama T, et al.
  • Organizer: The 49th annual meeting of the American Society for Cell Biology
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA
  • Year and Date: 2009-12-07
• [Presentation] ヒトNUDT16は(デオキシ)イノシンニリン酸を(デオキシ)イノシンーリン酸に加水分解する新規ヌクレオチドプール浄化酵素である (2009)
  • Author(s): 土本大介, ら、
  • Organizer: 第20回DNA複製・組換え・修復ワークショップ
  • Place of Presentation: 滋賀県彦根市琵琶湖コンファレンスセンター
  • Year and Date: 2009-11-01
• [Presentation] Identification of the full-length form of Prune2, a neuroblastoma-related protein. (2009)
  • Author(s): Daisuke Tsuchimoto, et al.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] Yusaku Nakabeppu Human NUDT16 is a novel nucleotide pool sanitizing enzyme hydrolyzing (deoxy)inosine diphosphate to (deoxy)inosine monophosphate. (2009)
  • Author(s): Daisuke Tsuchimoto, Teruaki Iyama, Nona Abolhassani
  • Organizer: 2009年第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] Yusaku Nakabeppu An increased expression of NUDT16 with IDP/dIDP hydrolyzing activity in immortalized ITPA-null mouse embryonic fibroblasts suppressed ITPA-deficient phenotypes. (2009)
  • Author(s): Nona Abolhassani, Teruaki Iyama, Daisuke Tsuchimoto, Kunihiko Sakumi, Mizuki Ohno, Behmanesh Mehrdad
  • Organizer: 2009年第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] ヒトnudt16は(デオキシ)イノシン二リン酸を(デオキシ)イノシン一リン酸に加水分解する新規ヌクレオチドプール浄化酵素である (2009)
  • Author(s): 土本大介、猪山輝昭、アボルハッサニ・ノナ、中別府雄作
  • Organizer: 2009年第20回DNA複製・組換え・修復ワークショップ
  • Place of Presentation: 滋賀県彦根市琵琶湖コンファレンスセンター
• [Presentation] Identification of the full-length form of Prune2, a neuroblastoma-related protein. (2009)
  • Author(s): aisuke Tsuchimoto, Eiji Iwama, Teruaki Iyama, Yusaku Nakabeppu
  • Organizer: 2009年第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
• [Presentation] Two distinct pathways of cell death thggered by oxidative damage to nuclear and mitochondrial DNAs. (2008)
  • Author(s): Oka S., et. al.
  • Organizer: The Joint Symposium of the 3^<rd> International Symposium of Institutes Network and Hot Spring Harbor-Global COE Symposium
  • Place of Presentation: 別府
  • Year and Date: 2008-02-01
• [Presentation] Novel pathway for hydrolysis of inosine nucleotides detected in immortalized ITPA-null mouse embryo fibroblasts (2008)
  • Author(s): アボルハッサニ・ノナ、作見邦彦、大野みずき、土本大介、ベーマネッシュ・メールダート、中別府雄作
  • Organizer: 2008年第31回日本分子生物学会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] 核とミトコンドリアゲノムへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死 (2008)
  • Author(s): 岡素雅子、大野みずき、土本大介、作見邦彦、中別府雄作
  • Organizer: 2008年第31回日本分子生物学会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] 新規損傷ヌクレオチド浄化酵素ITPBP2の同定と機能解析 (2008)
  • Author(s): 土本大介、吉田菜桜子、中別府雄作
  • Organizer: 2008年第31回日本分子生物学会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] 哺乳動物細胞における2-OH-ATPの生物学的影響 (2008)
  • Author(s): 太田詠子、土本大介、大野みずき、作見邦彦、中別府雄作
  • Organizer: 2008年第31回日本分子生物学会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] Oxidative stress-induced intestinal tumohgenesis in mice with a targeted disruption of the Mutyh gene. (2007)
  • Author(s): 中津 可道, ら
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Nitric oxide induces cell death through oxidation of mitochondrial deoxynucleotide pools. (2007)
  • Author(s): Ichikawa J, et. al.
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] ゲノムに蓄積した8-オキソグアニンは染色体組換えを誘発する。 (2007)
  • Author(s): 大野 みずき, ら
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] ITP結合タンパク質ITPBP1の生化学的特性の解析 (2007)
  • Author(s): 野中 麻里, ら
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] 哺乳動物細胞における2-OH-ATPの生物学的影響 (2007)
  • Author(s): 太田 詠子, ら
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] ITPA-deficient mouse embryonic fibroblasts exhibit chromosomal aberrations. (2007)
  • Author(s): Abolhassani N, et. al.
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] 核とミトコンドリアゲノムに蓄積した8-オキソグアニンは異なる2つの経路による細胞死を誘導する (2007)
  • Author(s): 岡素 雅子, ら
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice. (2007)
  • Author(s): Tsuzuki T, et. al.
  • Organizer: 日本環境変異学会・第36回大会
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] Msh2欠損マウスにおける酸化ストレス誘発消化管発癌 (2007)
  • Author(s): 朴 晶淑, ら
  • Organizer: 日本放射線影響学会・第50回大会
  • Place of Presentation: 千葉
  • Year and Date: 2007-11-15
• [Presentation] Mutyh遺伝子欠損マウスにおける酸化ストレス誘発消化管腫瘍の解析 (2007)
  • Author(s): 續 輝久, ら
  • Organizer: 日本放射線影響学会・第50回大会
  • Place of Presentation: 千葉
  • Year and Date: 2007-11-15
• [Presentation] Disruption of Defence Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polyphenols. (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Organizer: 3^<rd> International Conference on Polyphenol and Health
  • Place of Presentation: Kyoto
  • Year and Date: 2007-10-25
• [Presentation] Defenses against damage in nucleotide pools and the suppression of carcinogenesis,neurodegeneration and heart failure. (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Organizer: 38^<th> Annual Meeting of the Environmental Mutagen Society
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2007-10-22
• [Presentation] Oxidative stress induced tumorigenesis in the small intestine of Mutyh-deficient mice (2007)
  • Author(s): Tsuzuki T, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Oxidative stress-induced tumorigellesis in the small intestine of various DNA repair-deficient mice (2007)
  • Author(s): Piao J, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] 8-オキソグアニンのゲノム蓄積は染色体組換えを促進する。 (2007)
  • Author(s): 大野 みずき, ら
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-20
• [Presentation] Mutyh遺伝子欠損マウスに生じた酸化ストレス誘発腫瘍における癌関連遺伝子の突然変異解析。 (2007)
  • Author(s): 中津 可道, ら
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-20
• [Presentation] Oxidative damage in nucleic acids in Huntington's disease model (2007)
  • Author(s): Sheng Z, et. al.
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会合同学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 8-オキソグアニンのゲノム蓄積は相同染色体組換えを促進し遺伝的多様性を生み出す原動力となる。 (2007)
  • Author(s): 大野 みずき, ら
  • Organizer: 第9回日本進化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-01
• [Presentation] Oxidative stress-induced intestinal tumorigenesis in mice with a targete ddisruption of the Mutyh gene (2007)
  • Author(s): Tsuzuki T, et. al.
  • Organizer: The 13^<th> International Congress of Radiation Research
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2007-07-10
• [Presentation] Cell death caused by 8-oxoguanine (2007)
  • Author(s): Nakabeppu Y
  • Organizer: 3^<rd> Japan-US DNA Repair Meeting
  • Place of Presentation: Akiu, Sendai
  • Year and Date: 2007-05-08
• [Presentation] ITP結合タンパク質ITPBP1の生化学的特性の解析 (2007)
  • Author(s): 野中麻里、土本大介、太田詠子、作見邦彦、中別府雄作
  • Organizer: 2007年第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
• [Presentation] Nitric oxide induces cell death through oxidation of mitochondrial deoxynucleotide pools. (2007)
  • Author(s): 市川淳二、土本大介、岡素雅子、大野みずき、作見邦彦、中別府雄作
  • Organizer: 2007年第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. (2007)
  • Author(s): Oka S, et. al.
  • Organizer: Nordic Region Workshop on Mitochondria(Scandomit 07)
  • Place of Presentation: Mirikka, Finland
• [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides.In Evans, M.D.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids. (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Publisher: Springer,Austin,TX
• [Book] DNA Replication and Transcription:In Meyrers RA(eds), Genomics and Genetics:From Molecular Details to Analysis and Techniques. (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Publisher: Wiley-VCH Verlag GmbH and Co.,Weinheim,Germany
• [Remarks] ホームページ
  • URL: http://www.bioreg.kyushu-u.ac.jp/nfg/index.html
• [Remarks]
  • URL: http://www.bioreg.kyushu-u.ac.jp/nfg/index.html