Evaluation of effects of salt reduction on blood pressure and behavior with genetic polymorphism information

• Project/Area Number: 19390173
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Keio University (2008-2009); Kyoto University (2007)
• Principal Investigator: 宮木 幸一 Keio University, 医療情報解析研究部, 室長 (20327498)
• Co-Investigator(Kenkyū-buntansha): 村松 正明 東京医科歯科大学, 難治疾患研究所, 教授 (50230008) ; 中山 健夫 京都大学, 医学研究科, 教授 (70217933) ; 福原 俊一 京都大学, 医学研究科, 教授 (30238505) ; 小杉 眞司 京都大学, 医学研究科, 教授 (50252432)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000); Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2007: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
• Keywords: 成人保健 / テイラーメイド予防 / 遺伝子多型 / 減塩介入 / 行動理論 / 高血圧 / 減塩指導 / SNP / 行動変容 / ランダム化比較試験 / 質問票調査

Research Abstract

We evaluated the effects of our salt reduction intervention developed by the behavioral theory on blood pressure and behavior with genetic polymorphism information. We assessed the interaction of salt intake and genetic polymorphisms selected by candidate gene approach and Genome Wide Association Studies in Japanese population. Risk allele score of our results showed significant linear association with blood pressure. Information of polymorphism which affects blood pressure and the responsiveness to the salt reduction was gained which will be useful for future tailor-made prevention of hypertension.

Research Products

• [Journal Article] CDKAL1 polymorphism is associated with elevated HbA1c levels and the prevalence of metabolic syndrome in Japanese men: Interaction with dietary energy intake. (2010)
  • Author(s): Miyaki K, Oo T, Song Y, Lwin H, Tomita Y, Hoshino H, Suzuki N, Muramatsu M
  • Journal Title: Am J Epidemiol (in press)
• [Journal Article] Genetic Polymorphisms in Homocysteine Metabolism and Response to Folate Intake. -A Comprehensive Strategy to Elucidate the Useful Genetic Information- (2010)
  • Author(s): Miyaki K.
  • Journal Title: J Epidemiol (in press)
• [Journal Article] CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men. (2010)
  • Author(s): Zhang L, Miyaki K, Wang W, Muramatsu M
  • Journal Title: J Hum Hypertens 24 Pages: 345-50
• [Journal Article] CDKAL1 polymorphism is associated with elevated HbA1c levels and the prevalence of metabolic syndrome in Japanese men (2010)
  • Author(s): Miyaki K, Muramatsu M, et al.
  • Journal Title: Am J Epidemiol (In press)
  • Peer Reviewed
• [Journal Article] Genetic Polymorphisms in Homocysteine Metabolism and Response to Folate Intake (2010)
  • Author(s): Miyaki K.
  • Journal Title: J Epidemiol (In press)
  • Peer Reviewed
• [Journal Article] CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men (2010)
  • Author(s): Miyaki K, Muramatsu M, et al.
  • Journal Title: J Hum Hypertens 24 Pages: 345-350
  • Peer Reviewed
• [Journal Article] Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects. (2009)
  • Author(s): Miyaki K, Lwin H, Masaki K, Song Y, Takahashi Y, Muramatsu M, Nakayama T
  • Journal Title: Int J Environ Res Public Health 6 Pages: 999-1009
• [Journal Article] Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD)Gene and Blood Lead Levels in Japanese Subjects. (2009)
  • Author(s): Miyaki K. Lwin H, Masaki K, Song Y, Takahashi Y, M uramatsu M, Nakayama T
  • Journal Title: International Journal of Environmental Research and Public Health 6 Pages: 999-1009
  • Peer Reviewed
• [Journal Article] Increasing the number of SNPs loci does not necessarily improve prediction power at least in the comparison of MTHFR SNP and haplotypes. (2008)
  • Author(s): Miyaki K, Takahashi Y, Song Y, Zhang L, Muramatsu M, Nakayama T
  • Journal Title: J Epidemiol 18 Pages: 243-50
  • NAID: 10024796805
• [Journal Article] Influence of CYP11B2 Gene Polymorphism on the Prevalence of Hypertension and the Blood Pressure in Japanese Men: Interaction with Dietary Salt Intake. (2008)
  • Author(s): Song Y, Miyaki K, Araki J, Zhang L, Takahashi Y, Nakayama T, Muramatsu M
  • Journal Title: J Nutrigenetics and Nutrigenomics 1 Pages: 252-8
• [Journal Article] Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. (2008)
  • Author(s): Zhang L, Miyaki K, Nakayama T, Muramatsu M
  • Journal Title: Metabolism 57 Pages: 502-5
• [Journal Article] Increasing the number of SNPs loci does not necessarily improve prediction power at least in the comparison of MTHFRSNP and haplotypes. (2008)
  • Author(s): Miyaki K, Takahashi Y, Song Y, Zhang L, Muramatsu M, Nakayama T.
  • Journal Title: Journal of Epidemiology 18 Pages: 243-250
  • NAID: 10024796805
  • Peer Reviewed
• [Journal Article] Influence of CYP11B2 Gene Polymorphism on the Prevalence of Hypertension and the Blood Pressure in Japanese Men : Interaction with Dietary Salt Intake. (2008)
  • Author(s): Song Y. Mivaki K, Araki J, Zhang L, Takahashi Y, Nakayama T, Muramatsu M
  • Journal Title: Journal of Nutrigenetics and Nutrigenomics 18 Pages: 252-258
  • Peer Reviewed
• [Journal Article] Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men. (2007)
  • Author(s): Naito M, Miyaki K, Naito T, Zhang L, Hoshi K, Hara A, Masaki K, Tohyama S, Muramatsu M, Hamajima N, Nakayama T
  • Journal Title: Int J Med Sci 4 Pages: 216-22
• [Journal Article] The relation between nicotinamide N-methyltransferase gene polymorphism and plasma homocysteine concentration in healthy Japanese men. (2007)
  • Author(s): Zhang L, Miyaki K, Araki J, Nakayama T, Muramatsu M
  • Journal Title: Thromb Res 121 Pages: 55-8
• [Journal Article] The interaction between the IL6R genotype and dietary energy intake on abdominal obesity in Japanese men. (2007)
  • Author(s): Song Y, Miyaki K, Araki J, Zhang L, Omae K, Muramatsu M
  • Journal Title: Metabolism 56 Pages: 925-30
• [Journal Article] Interaction of Angiotensin I converting enzyme I/D polymorphism and daily salt intake influences hypertension in Japanese men. (2006)
  • Author(s): Zhang L, Miyaki K, Araki J, Song Y, Kimura T, Omae K, Muramatsu M
  • Journal Title: J Hypertens 29 Pages: 751-58
• [Presentation] Salt reduction intervention in workplace based on behavioral theories -Rationale and desien of a randomized controlled trial- (2010)
  • Author(s): Miyaki K, Muramatsu M, et al.
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
  • Place of Presentation: 埼玉県立大学
  • Year and Date: 2010-01-08
• [Presentation] The Evaluation of the Focused Health Checkup/Focused Health Consultation System Focusing on Metabolic Syndrome with Hypertension (2010)
  • Author(s): Miyaki K, Muramatsu M, et al.
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
  • Place of Presentation: 埼玉県立大学
  • Year and Date: 2010-01-08
• [Presentation] Salt reduction intervention in workplace based on behavioral theories-Rationale and design of a randomized controlled trial- (2010)
  • Author(s): Koichi Miyaki, Htay Lwin, Saeko Fujii, Hirofumi Sakurazawa, Hidehiko Ando, Yixuan Song, Masaaki Muramatsu, Yoshimitsu Takahashi, Haruhiko Hoshino, NorihiroSuzuki, Takuro Shimb
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
  • Place of Presentation: Saitama, Japan
• [Presentation] The Evaluation of the Focused Health Checkup/Focused Health Consultation System Focusing on Metabolic Syndrome with Hypertension (2010)
  • Author(s): Htay Lwin, Koichi Miyaki, Saeko Fujii, Hirofumi Sakurazawa, Hidehiko Ando, Yixuan Song, Masaaki Muramatsu, Yoshimitsu Takahashi, Takeo Nakayama, Haruhiko Hoshino, Norihiro Suzuki, Takuro Shimbo
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
  • Place of Presentation: Saitama, Japan
• [Presentation] The Effect of CDKAL1 Polymorphism on Metabolic Phenotypes in an Occupational Cohort in Japan (2010)
  • Author(s): Shinobu Ikeda, Koichi Miyaki, Htay Lwin, Saeko Fujii, Hirofumi Sakurazawa, Hidehiko Ando, Yixuan Song, Masaaki Muramatsu, Yoshimitsu Takahashi, Haruhiko Hoshino, NorihiroSuzuki, Takuro Shimbo
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
  • Place of Presentation: Saitama, Japan
• [Presentation] HapMapデータベースにより構築したMTHFR遺伝子多型ハプロタイプ情報を用いたランダム化比較試験による葉酸投与時のホモシステイン低下量の差異の検討 (2008)
  • Author(s): 宮木幸一, 高橋由光, 宋毅シュアン, 張玲, 村松正明, 中山健夫
  • Organizer: 第18回日本疫学会学術総会
  • Place of Presentation: 順天堂大学
• [Presentation] 日本人男性におけるCYP11B2遺伝子多型と高血圧との関連性と塩分摂取量との相互作用宋毅シュアン (2008)
  • Author(s): 宮木幸一, 荒木淳吾, 張玲, 高橋由光, 中山健夫, 村松正明
  • Organizer: 第18回日本疫学会学術総会
  • Place of Presentation: 順天堂大学
• [Presentation] 塩分感受性高血圧SNPs情報提供が高校生の減塩行動に及ぼす影響の評価-自記式質問票によるパイロット調査- (2007)
  • Author(s): 宮木幸一, 友田茉莉, 西山深雪, 加納圭, 上田英未, 張玲, 加藤和
  • Organizer: 日本人類遺伝学会 第52回大会
  • Place of Presentation: 京王プラザ、東京
  • Year and Date: 2007-09-13
• [Presentation] 塩分感受性高血圧SNPs情報提供が高校生の減塩行動に及ぼす影響の評価--自記式質問票によるパイロット調査-- (2007)
  • Author(s): 宮木幸一, 友田茉莉, 西山深雪, 加納圭, 上田英未, 張玲, 加藤和人, 小杉眞司, 中山健夫
  • Organizer: 日本人類遺伝学会第52回大会
  • Place of Presentation: 京王プラザ、東京
• [Presentation] 日本人男性におけるNNMT遺伝子A/G多型とホモシステイン、葉酸、MTHFR遺伝子C677T多型との関連の検討 (2007)
  • Author(s): 張玲, 宮木幸一, 荒木淳吾, 中山健夫, 村松正明
  • Organizer: 第17回日本疫学会学術総会
  • Place of Presentation: 広島市南区民文化センター
• [Presentation] 日本人男性におけるProstacyclin Synthase遺伝子多型と高血圧との関連性宋毅シュアン (2007)
  • Author(s): 宮木幸一, 荒木淳吾, 張玲, タンウー, 中山健夫, 村松正明
  • Organizer: 第17回日本疫学会学術総会
  • Place of Presentation: 広島市南区民文化センター