Investigation on regulation of the human blood group ABO gene transcription with a novel antisense RNA transcribed from the opposite strand

• Project/Area Number: 19390183
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Gunma University
• Principal Investigator: KOMINATO Yoshihiko Gunma University, 大学院・医学系研究科, 教授 (30205512)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Tamiko 群馬大学, 大学院・医学系研究科, 助教 (40008561) ; SANO Rie 群馬大学, 大学院・医学系研究科, 助教 (70455955) ; 田島 裕 群馬大学, 大学院・医学系研究科, 准教授 (20227078)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2007: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: 血液型 / ABO式血液型遺伝子 / 転写因子CTCF / クロマチンリモデリング / ABO式血液型 / 転写調節 / non-coding RNA / 遺伝子 / 糖転移酵素 / 遺伝学 / 癌 / 糖鎖 / 発現制御

Research Abstract

We found a novel antisense RNA transcribed from the opposite strand of the human blood group ABO gene, and showed that the ABO and ABOAS transcripts appeared to exhibit reciprocal expression patterns in the cells expressing the ABO gene. These results suggest that ABOAS transcribed from the opposite strand of the ABO gene might be involved in the regulation of ABO gene expression.

Research Products

• [Journal Article] Development of a Sensitive Enzyme-Linked Immunosorbent Assay for Measurement of DNase I in Human Serum (2009)
  • Author(s): Nakajima T, Takagi-R, Tajima Y, Makita C, Kominato Y, Kuribara J, Ohshima S, Tada H, Tsurugaya H, Kobayashi Y, Takeshita H, Kawai Y, Yasuda T.
  • Journal Title: Clinica Chimica Acta 403 Pages: 219-222
  • Peer Reviewed
• [Journal Article] 11-Tungstophosphate with iron (II) and hydrogen peroxide efficiently detached bacterial biofilm (2009)
  • Author(s): Tajima Y, Takagi R, Nakajima T, Yasuda T, Kominato Y.
  • Journal Title: Biol Pharm Bull 32 Pages: 1783-1789
  • NAID: 130000116943
  • Peer Reviewed
• [Journal Article] A fatal case of myocardial damage due to misuse of the "designer drug" MDMA (2009)
  • Author(s): Sano R, Hasuike T, Nakano M, Kominato Y, Itoh H.
  • Journal Title: Legal Med 11(6) Pages: 294-297
  • Peer Reviewed
• [Journal Article] A case of acute myocardial infarction after intracoronary stent implantation : demonstration of the stent location by postmortem X-ray examination (2009)
  • Author(s): Tajima Y, Takagi R, Kominato Y.
  • Journal Title: Legal Med 11 Pages: 226-228
  • Peer Reviewed
• [Journal Article] Serum deoxyribonuclease I can be used as a useful marker for diagnosis of death due to ischemic heart disease (2009)
  • Author(s): Yasuda T, Iida R, Kawai Y, Nakajima T, Kominato Y, Fujihara J, Takeshita H.
  • Journal Title: Legal Med 11
  • NAID: 10027262728
  • Peer Reviewed
• [Journal Article] Levels of serum deoxyribonuclease I activity on admission in patients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling (2009)
  • Author(s): Kuribara J, Tada H, Kawai Y, Kawaguchi R, Hoshizaki H, Arakawa K, Kitayama M, Kajinami K, Kurabayashi M, Oshima S, Taniguchi K, Kominato Y, Yasuda T.
  • Journal Title: Journal of Cardiology 53 Pages: 196-203
  • NAID: 10025183040
  • Peer Reviewed
• [Journal Article] Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme (2009)
  • Author(s): Ueki M, Takeshita H, Fujihara J, Iida R, Yuasa I, Kato H, Panduro A, Nakajima-T, Kominato-Y, Yasuda T.
  • Journal Title: Clinica Chimica Acta 407 Pages: 20-24
  • Peer Reviewed
• [Journal Article] Genotyping of five single nucleotide polymorphisms in the OCA2 and HERC2 genes associated with blue-brown eye color in the Japanese population (2009)
  • Author(s): Iida R, Ueki M, Takeshita H, Fujihara J, Nakajima T, Kominato Y, Nagao M, Yasuda T.
  • Journal Title: Cell Biochem Funct 27(5) Pages: 323-327
  • Peer Reviewed
• [Journal Article] Serum deoxyribonuclease I can be used as a useful marker for diagnosis of death due to ischemic heart disease. (2009)
  • Author(s): Yasuda T, 他
  • Journal Title: Legal Med 11
  • Peer Reviewed
• [Journal Article] Development of a Sensitive Enzyme-Linked Immunosorbent Assay for Measurement of DNase I in Human Serum. (2009)
  • Author(s): Nakajima T, 他
  • Journal Title: Clinica Chimica Acta 403 Pages: 219-222
  • Peer Reviewed
• [Journal Article] Genotyping of five single nucleotide polymorphisms in the OCA2 and HERC2 genes associated with blue-brown eye color in the Japanese population. (2009)
  • Author(s): Iida R, 他
  • Journal Title: Cell Biochem Funct 27 Pages: 323-327
  • Peer Reviewed
• [Journal Article] A case of acute myocardial infarction after intracoronary stent implantation : demonstration of the stent location by postmortem X-ray examination. (2009)
  • Author(s): Tajima Y, 他
  • Journal Title: Legal Med 11 Pages: 226-228
  • Peer Reviewed
• [Journal Article] Levels of serum deoxyribonuclease I activity on admission in patients with acute myocardial infarction can be useful in predicting left vent ricular enlargement due to remodeling. (2009)
  • Author(s): Kuribara J, 他
  • Journal Title: Journal of Cardiology. 53 Pages: 196-203
  • Peer Reviewed
• [Journal Article] Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme (2009)
  • Author(s): Ueki M, 他
  • Journal Title: Clinica Chimica Acta 407 Pages: 20-24
  • Peer Reviewed
• [Journal Article] 11-Tungstophosphate with iron(II)and hydrogen peroxide efficiently detached bacterial biofilm (2009)
  • Author(s): Tajima Y, 他
  • Journal Title: Biol Pharm Bull 32 Pages: 1783-1789
  • Peer Reviewed
• [Journal Article] A fatal case of myocardial damage due to misuse of the "designer drug" MDMA. (2009)
  • Author(s): Sano R, 他
  • Journal Title: Legal Med 11 Pages: 294-297
  • Peer Reviewed
• [Journal Article] 核酸分解酵素DNaseI遺伝子の転写調節機構の解明 (2009)
  • Author(s): 高木利恵, 他
  • Journal Title: DNA多型 17 Pages: 177-179
  • Peer Reviewed
• [Journal Article] ヒトRNase superfamily遺伝子における非同義置換型SNP解析 (2009)
  • Author(s): 藤原純子, 他
  • Journal Title: DNA多型 17 Pages: 260-264
  • Peer Reviewed
• [Journal Article] Development of a sensitive enzyme-linked immunosorbentassay for measurement of DNase I in human serum. (2009)
  • Author(s): Nakajima T, Takagi R, Tajima Y, Makita C, Komina to Y, Kuribara J, Ohshima S, Tada H, Tsurugaya H, Kobayashi Y, Takeshita H, Kawai Y, Yasuda T.
  • Journal Title: Clin Chim Acta. (in press)
  • Peer Reviewed
• [Journal Article] Intracellula HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1 (2008)
  • Author(s): Mouri F, Tsukada J, Mizobe T, Higashi T, Yoshida Y, Minami Y, Izumi H, Kominato Y, Kohno K, Tanaka Y.
  • Journal Title: European Journal of Heamatology 80(1) Pages: 10-19
  • Peer Reviewed
• [Journal Article] Development of genotyping methods for single nucleotide polymorphism in the human pancreatic ribonuclease gene (RNASE1) and their application to population studies (2008)
  • Author(s): Ueki M, Iida R, Fujihara J, Takeshita H, Yuasa I, Kominato Y, Yasuda T.
  • Journal Title: Biochemical Genetics 46(3-4) Pages: 145-153
  • Peer Reviewed
• [Journal Article] Immunohistochemical study of thyroid transcription factor-1 and surfactant-associated protein A for investigation of periphe- ral airway structure in perinatal fatality (2008)
  • Author(s): Shimada I, Matsui K, Kominato Y, Hata Y, Takizawa H, Nishida N.
  • Journal Title: Legal Med 10 Pages: 96-100
  • Peer Reviewed
• [Journal Article] Intracellular HMGB1 transactivates the human IL1B gene promoter through asso- ciation with an Ets transcription factor PU.1 (2008)
  • Author(s): Mouri F, Tsukada J, Mizobe T, Higashi T, Yoshida Y, Minami Y, Izumi H, Kominato Y, Kohno K, Tanaka Y.
  • Journal Title: Eur J Haematol 80(1) Pages: 10-9
  • Peer Reviewed
• [Journal Article] An infant with asymptomatic hepatic granuloma probably caused by bacillus Calmette-Guerin (BCG) vaccination found incidentally at autopsy : a case report (2008)
  • Author(s): Tajima Y, Takagi R, Nakajima T, Kominato Y.
  • Journal Title: Cases J. 337 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Genetic variation of FUT2 in Ovambos, Turks, and Mongolians (2008)
  • Author(s): Soejima M, Nakajima T, Fujihara J, Takeshita H, Koda Y.
  • Journal Title: Transfusion 48(7) Pages: 1423-1431
  • Peer Reviewed
• [Journal Article] Extremely high prevalence of DNase 1*1 allele in African populations (2008)
  • Author(s): Takeshita H, Fujihara J, Soejima M, Koda Y, Yasuda T, Nakajima T.
  • Journal Title: Cell Biochem Funct 26(2) Pages: 151-153
  • Peer Reviewed
• [Journal Article] Immunohistochemical study of thyroid transcription factor-1 and surfactant-associated protein A for investigation of peripheral airway structure in perinatal fatality. (2008)
  • Author(s): Shimada I, Matsui K, Kominato Y, Hata Y, Takizawa H. Nishida N.
  • Journal Title: Legal Med. 10 Pages: 96-100
  • NAID: 120001788016
  • Peer Reviewed
• [Journal Article] Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1. (2008)
  • Author(s): Mouri F, Tsukada J, Mizobe T, Higashi T, Yoshida Y, Minami Y, Izumi H, Kominato Y. Kohno K. Tanaka Y.
  • Journal Title: Eur J Haematol. 80(1) Pages: 10-19
  • Peer Reviewed
• [Journal Article] Development of genotyping methods for single nucleotide polymorphism in the human pancreatic ribonuclease gene (RNASE1) and their application to population studies. (2008)
  • Author(s): Ueki M, Iida R, Fujihara J, Takeshita H, Yuasa I, Kominato Y, Yasuda T.
  • Journal Title: Biochem Genet. 46(3-4) Pages: 145-153
  • Peer Reviewed
• [Journal Article] Time-suppression test using a colorimetric probe (alamarBlue) that measures bacterial metabolic activity. (2008)
  • Author(s): Komatsu M, Tajima Y, Ito T, Yamashiro Y, Hiramatsu K.
  • Journal Title: Biomed Res. 29 Pages: 171-3
  • Peer Reviewed
• [Journal Article] An infant with asymptomatic hepatic granuloma probably caused by bacillus Calmette-Guerin (BCG) vaccination fo and incidentally at autopsy: a case report. (2008)
  • Author(s): Tajima Y, Takagi R, Nakajima T, Kominato Y.
  • Journal Title: Cases J. 1:337 Pages: 151-153
  • Peer Reviewed
• [Journal Article] Genetic variation of FUT2 in Ovambos, Turks, and Mongolians. (2008)
  • Author(s): Soejima M, Nakajima T, Fujiwara J, Takeshita H, Koda Y.
  • Journal Title: Transfusion 48(7) Pages: 1423-1431
  • Peer Reviewed
• [Journal Article] 心筋梗塞の新規な感受性遺伝子としてのDNase I遺伝子. (2008)
  • Author(s): 藤原純子,竹下治男,高塚尚和,安田年博,植木美鈴,河合康幸,中島たみ子,小湊慶彦,副島美貴子,神田芳郎
  • Journal Title: DNA多型 16 Pages: 189-193
  • NAID: 10025753654
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel antisense RNA transcribed from the opposite strand of the human blood group ABO gene (2007)
  • Author(s): Hata Y, Kominato Y, Takizawa H.
  • Journal Title: TRANSFUSION 47 Pages: 842-851
  • Peer Reviewed
• [Journal Article] Hypoxia induces up-regulation of the deoxyribonuclease I gene in the human pancreatic cancer cell line QGP-1 (2007)
  • Author(s): Kominato Y, Iida R, Nakajima T, Tajima Y, Takagi R, Makita C, Kishi K, Ueki M, Kawai Y, Yasuda T.
  • Journal Title: Biochimica et Biophysica Acta 1770 Pages: 1567-1575
  • NAID: 10029668461
  • Peer Reviewed
• [Journal Article] A case of a gunshot wound in which the rupture of the left internal carotid artery was demonstrated by postmortem angiography (2007)
  • Author(s): Kominato Y, Tajima Y, Fujikura T, Matsui K, Shimada I, Kuwayama N, Takizawa H.
  • Journal Title: Legal Med 9(1) Pages: 22-24
  • NAID: 10020570495
  • Peer Reviewed
• [Journal Article] α1, 2Fucosylation Is a Superior Predictor of Postoperative Prognosis for Colorectal Cancer Compared with Blood Group A, B, or Sialyl Lewis X Antigen Generated within Colorectal Tumor Tissues (2007)
  • Author(s): Tsuboi K, Asao T, Ide M, Hashimoto S, Noguchi K, Kominato Y, Kuwano H, Yazawa S.
  • Journal Title: Annals of Surgical Oncology 146(6) Pages: 1880-1889
  • Peer Reviewed
• [Journal Article] A case of iatrogenic cerebral infarction demonstrated by postmortem cerebral angiography (2007)
  • Author(s): Tajima Y, Takagi R, Kominato Y, Kuwayama N.
  • Journal Title: Legal Med 9(6) Pages: 326-329
  • NAID: 10024173097
  • Peer Reviewed
• [Journal Article] Susceptibility of mammalian deoxyribonuclease I (DNase I) to proteolysis by proteases and its relationships to tissue distribution : Biochemical and molecular analysis of equine DNase I. Comparative Biochem (2007)
  • Author(s): Ueki M, Takeshita H, Fujihara J, Ueta G, Nakajima T, Kominato Y, Kishi K, Iida R, Yasuda T.
  • Journal Title: Physiol.B Biochem.Mol.Biol. 148(1) Pages: 93-102
  • Peer Reviewed
• [Journal Article] Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischaemia : results in vasospastic angina pectoris induced by provocation test (2007)
  • Author(s): Morikawa N, Kawai Y, Arakawa K, Kumamoto T, Miyamori I, Akao H, Kitayama M, Kajinami K, Lee J-D, Takeshita H, Kominato Y, Yasuda T.
  • Journal Title: Eur.Heart J 28(24) Pages: 2992-2997
  • Peer Reviewed
• [Journal Article] Hypoxia induces upregulation of the deoxyribonuclease I gene in the human pancreatic cancer cell line QGP-1 (2007)
  • Author(s): Kominato Y
  • Journal Title: Biochimica et biophysica acta 1770 Pages: 1567-1575
  • NAID: 10029668461
  • Peer Reviewed
• [Journal Article] A case of a gunshot wound in which the rupture of the 1eft internal carotid artery was demonstrated by postmortem angiography (2007)
  • Author(s): Kominato Y
  • Journal Title: Lega1 Med 9(1) Pages: 22-24
  • Peer Reviewed
• [Journal Article] Identhication and characterization of a novel antisense RNA transcribed from the opposite strand of the human blood group ABO gene (2007)
  • Author(s): Hata Y
  • Journal Title: TRANSFUSION 47 Pages: 842-851
  • Peer Reviewed
• [Journal Article] A case of iatrogenic cerebral infarction demonstrated by postmor tem oerebral angiography (2007)
  • Author(s): Tajina Y
  • Journal Title: Legal Med 9(6) Pages: 326-329
  • Peer Reviewed
• [Journal Article] Rapid detection of Staphylococcus aureus strains having reduced susceptibility to vancomycin using a chemiluminescence-based drug-susceptibility test (2007)
  • Author(s): Tajima Y
  • Journal Title: J Microbiol Methods 70 Pages: 434-441
  • Peer Reviewed
• [Journal Article] α1, 2Fucosylation Is a Superior Predictor of Postoperative Prognosis for Colorectal Cancer Compared with Blood Group A, B, or Sialyl Lewis X Antigen Generated within Colorectal Tumor Tissues (2007)
  • Author(s): Tsuboi K
  • Journal Title: Annals of Surgical Oncology 146(6) Pages: 1880-1889
  • Peer Reviewed
• [Journal Article] Serum deoxyribonudease I activity can be used as a novel marker of transient myocardial ischaemia:results in vasospastic angina pectoris induced byprovocation test (2007)
  • Author(s): Morikawa N
  • Journal Title: Eur Heart J 28(24) Pages: 2992-2997
  • Peer Reviewed
• [Journal Article] 脊椎動物DNaselの分子進化:サメ酵素に見られる特異な構造特性 (2007)
  • Author(s): 藤原 純子
  • Journal Title: DNA多型 15 Pages: 31-34
  • Peer Reviewed
• [Presentation] DNASE I13遺伝子の非同義置換型SNPにおけるコーカソイド特異的アレルは不活性な酵素を産生する (2009)
  • Author(s): 藤原純子, 中島たみ子, 小湊慶彦, 湯浅勲, 加藤秀章, 飯田礼子, 植木美鈴, 安田年博
  • Organizer: 日本DNA多型学会第18回学術集会
  • Place of Presentation: 久留米
  • Year and Date: 2009-11-20
• [Presentation] 低酸素による核酸分解酵素DNase I遺伝子の転写調節 (2009)
  • Author(s): 佐野利恵, 中島たみ子, 小湊慶彦, 加藤恵理子, 高士祐一, 山根庸弘, 新田みなみ, 藤原純子, 竹下治男, 植木美鈴, 安田年博
  • Organizer: 日本DNA多型学会第18回学術集会
  • Place of Presentation: 久留米
  • Year and Date: 2009-11-19
• [Presentation] DNASE I13遺伝子の非同義置換型 SNPにおけるコーカソイド特異的アレルは不活性な酵素を産生する (2009)
  • Author(s): 藤原純子, 他
  • Organizer: 日本DNA多型学会第18回学術集会
  • Place of Presentation: 久留米
  • Year and Date: 2009-11-19
• [Presentation] DNASE I exon内SNP検索 : アジア人においてDNase I Gln222Argのみが多型性を有する (2009)
  • Author(s): 藤原純子, 高塚尚和, 竹下治男, 神田芳郎, 副島美貴子,小湊慶彦, 田島裕, 中島たみ子, 飯田礼子, 安田年博
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-15
• [Presentation] RNase superfamily遺伝子における分子多様性:非同義置換型SNP (2009)
  • Author(s): 安田年博, 他
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-15
• [Presentation] DNASE I exon内SNP検索:アジア人においてDNase I Gln222Argのみが多型性を有する (2009)
  • Author(s): 藤原純子, 他
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-15
• [Presentation] RNase superfamily 遺伝子における分子多様性 : 非同義置換型SNP (2009)
  • Author(s): 安田年博, 飯田礼子, 藤原純子, 竹下治男, 中島たみ子, 小湊慶彦, 湯浅勲
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-14
• [Presentation] 低酸素による核酸分解酵素DNASE 1遺伝子の発現増加と転写 (2009)
  • Author(s): 小湊慶彦, 佐野利恵, 中島たみ子, 田島裕, 藤原純子, 竹下治男, 飯田礼子, 安田年博
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-14
• [Presentation] 死後のCT撮影により過去の受傷痕を証明し得た暴行死の一例 (2009)
  • Author(s): 田島裕, 高木利恵, 小湊慶彦
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-14
• [Presentation] 核酸分解酵素DNase I遺伝子の転 写調節機構の解明 (2008)
  • Author(s): 高木利恵, 中島たみ子, 小湊慶彦, 加藤恵理子, 高士祐一, 山根庸弘, 新田みなみ, 藤原純子, 竹下治男, 植木美鈴, 安田年博
  • Organizer: 日本DNA多型学会第17回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-26
• [Presentation] ヒトRNase superfamily 遺伝子における非同義置換型SNP解析 (2008)
  • Author(s): 藤原純子, 竹下治男, 中島たみ子, 小湊慶彦, 湯浅勲, 植木美鈴, 飯田礼子, 安田年博
  • Organizer: 日本DNA多型学会第17回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-26
• [Presentation] ヒ素代謝に関与するAS3MT M287T多型はアジア人特異的低変異性を示す (2008)
  • Author(s): 藤原純子, 阿草哲郎, 副島美貴子, 中島たみ子, 竹下治男
  • Organizer: 日本DNA多型学会第17回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-26
• [Presentation] 死後の単純X線撮影によりステント留置部位を特定し得た急性心筋梗塞の一例 (2008)
  • Author(s): 田島裕, 高木利恵, 小湊慶彦
  • Organizer: 第77回日本法医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-01
• [Presentation] Serum DNase I can be used as a useful marker for diagnosis of death due to ischemic heart disease (2008)
  • Author(s): Takeshita H, Fujihara J, Iida R, Kawai Y, Kominato Y, Nakajima T, Yasuda T.
  • Organizer: 7th International Symposium ADVANCED IN LEGAL MEDICINE
  • Place of Presentation: Osaka
  • Year and Date: 2008-09-05
• [Presentation] 一過性心筋虚血マーカーとしての血清DNase I : 冠攣縮誘発試験の検討 (2008)
  • Author(s): 安田年博, 飯田礼子, 河合康幸, 中島たみ子, 小湊慶彦, 藤原純子, 竹下治男
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-25
• [Presentation] 急死した乳児の肝臓に類上皮結節が見られた一例 (2008)
  • Author(s): 田島裕, 高木利恵, 小湊慶彦
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-25
• [Presentation] DNase I多型 Database の構築 : 民族特異的頻度分布の発見 (2008)
  • Author(s): 竹下治男, 安田年博, 副島美貴子, 神田芳郎, 高塚尚和, ジョンショウキ, 藤井由己, 小湊慶彦, 中島たみ子, 藤原純子
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-25
• [Presentation] 生産・死産の判別に於ける、免疫染色 (TTF-1及びPE-10) の利用 (2008)
  • Author(s): 島田一郎, 小湊慶彦, 松井一裕, 飯田礼子, 坪田悦子, 松木孝澄
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-25
• [Presentation] 核酸分解酵素DNASE 1遺伝子の転写調節機構の解明 (2008)
  • Author(s): 小湊慶彦, 中島たみ子, 田島裕, 高木利恵, 竹下治男, 藤原純子, 飯田礼子, 安田年博
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24
• [Presentation] -過性心筋虚血マーカーとしての血清DNase I:冠攣縮誘発試験の検討. (2008)
  • Author(s): 安田年博,飯田礼子,河合康幸,中島たみ子,小湊慶彦,藤原純子,竹下治男
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
• [Presentation] DNase I多型Databaseの構築:民族特異的頻度分布の発見 (2008)
  • Author(s): 竹下治男,安田年博,副島美貴子,神田芳郎,高塚尚和,ジョンショウキ,藤井由己,小湊慶彦,中島たみ子,藤原純子
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
• [Presentation] 生産・死産の判別に於ける、免疫染色(TTF-1及びPE-10)の利用 (2008)
  • Author(s): 島田一郎,小湊慶彦,松井一裕,飯田礼子,坪田悦子,松木孝澄
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
• [Presentation] Serum DNase I can be used as a useful marker for diagnosis of death due to ischemic heart disease. (2008)
  • Author(s): Takeshita H, Fujiwara J, Iida R, Kawai Y, Kominato Y, Nakajima T, Yasuda T.
  • Organizer: 7th International Symposium ADVANCED IN LEGAL MEDICINE
  • Place of Presentation: 大阪
• [Presentation] 核酸分解酵素DNase I遺伝子の転写調節機構の解明 (2008)
  • Author(s): 高木利恵,中島たみ子,小湊慶彦,加藤恵理子,高士祐一,山根庸弘,新田みなみ,藤原純子,竹下治男,植木美鈴,安田年博
  • Organizer: 日本DNA多型学会第17回学術集会
  • Place of Presentation: 東京
• [Presentation] ヒトRNase superfamily遺伝子における非同義置換型SNP解析 (2008)
  • Author(s): 藤原純子,竹下治男,中島たみ子,小湊慶彦,湯浅勲,植木美鈴,飯田礼子,安田年博
  • Organizer: 日本DNA多型学会第17回学術集会
  • Place of Presentation: 東京
• [Presentation] α1,2Fucosylation Is a Superior Predictor of Postoperative Prognosis for Colorectal Cancer Compared with Blood Group A, B, or Sialyl Lewis X Antigen in Colorectal Tumor Tissues (2007)
  • Author(s): Tsuboi K, Asao T, Ide M, Hashimoto S, Kominato Y, Kuwano H, Yazawa S.
  • Organizer: Molecular Targets and Cancer Therapeutics
  • Place of Presentation: San Francisco
  • Year and Date: 2007-10-28
• [Presentation] 死後の血管造影により塞栓部位を推定した医原性脳梗塞の一例 (2007)
  • Author(s): 田島裕, 高木利恵, 小湊慶彦
  • Organizer: 日本法医学会関東地方会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-20
• [Presentation] 法医学からみた子供の虐待 (2007)
  • Author(s): 小湊慶彦
  • Organizer: 第54回日本小児保健学会
  • Place of Presentation: 前橋
  • Year and Date: 2007-09-22
• [Presentation] DNase I遺伝子は心筋梗塞の新規な疾患感受性遺伝子である (2007)
  • Author(s): 中島たみ子, 小湊慶彦, 田島裕, 飯田礼子, 竹下治男, 藤原純子, 河合康幸, 安田年博
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2007-05-18
• [Presentation] 現行のICD分類には当てはまらず、外的要因と内的要因とが共同して死因を構成した一事例 (2007)
  • Author(s): 田島裕, 小湊慶彦
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2007-05-18
• [Presentation] ABO遺伝子の発現制御におけるポリADP-リボシル化の関与の検討 (2007)
  • Author(s): 畑由紀子, 小湊慶彦, 松井一裕, 島田一郎, 滝沢久夫
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2007-05-17
• [Presentation] ABO遺伝子の発現制御におけるポリADP・リボシル化の関与の検討 (2007)
  • Author(s): 畑 由紀子
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田
• [Presentation] α1,2Fucosylation Is a Superior Predictor of Postoperative Prognosis for Coloreqtal Cancer Compared With Blood Group A,B,or Sialyl Lewis X Antigen in Colorectal Tumor Tissues (2007)
  • Author(s): Tsuboi K
  • Organizer: Molecular Targets and Cancer Therapeutics
  • Place of Presentation: San Francisco
• [Patent(Industrial Property Rights)] 血液型関連物質を用いたノロウイルスの感染防御又は除去 (2009)
  • Inventor(s): 矢澤伸、牛島廣治、小湊慶彦
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Filing Date: 2009-07-24
  • Overseas
• [Patent(Industrial Property Rights)] 血液型関連物質を用いたノロウイルスの感染防御又は除去 (2008)
  • Inventor(s): 矢澤伸, 小湊慶彦, 牛島廣治
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Filing Date: 2008-07-24
• [Patent(Industrial Property Rights)] 血液型関連物質を用いたノロウイルスの感染防御 (2008)
  • Inventor(s): 矢澤伸, 小湊慶彦, 牛島廣治
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Industrial Property Number: 2009-003804
  • Filing Date: 2008-01-09
• [Patent(Industrial Property Rights)] 血液型関連物質を用いたノロウイルスの感染防御 (2007)
  • Inventor(s): 矢澤伸, 小湊慶彦, 牛島廣治
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Filing Date: 2007-07-25