TLR/Nod proteins in infants from dysregulation Pathological analysis Cytokine Storm

• Project/Area Number: 19390287
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Yokohama City University
• Principal Investigator: YOKOTA Shumpei Yokohama City University, 医学研究科, 教授 (10158363)
• Co-Investigator(Kenkyū-buntansha): MORI Masaaki 横浜市立大学, 市民総合医療センター, 准教授 (30254204) ; IMAGAWA Tomoyuki 横浜市立大学, 附属病院, 准教授 (20336548) ; 成戸 卓也 横浜市立大学, 医学部, 博士研究員 (60438124)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2007: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
• Keywords: 自然免疫 / 乳幼児 / 免疫疾患 / サイトカインストーム / cytokine storm / TLR蛋白 / Nod蛋白

Research Abstract

Immune diseases in childhood, Kawasaki disease, influenza-associated encephalopathy, virus-associated hemophagocytic syndrome, and systemic-onset juvenile idiopathic arthritis, excessive inflammatory cytokines are involved in disease pathogenesis. We investigated the relationship between innate immunity to these diseases in excess of inflammatory cytokines.

Research Products

• [Journal Article] Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis. (2010)
  • Author(s): Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N, Yokota S
  • Journal Title: Nephrol Dial Transplant. (On line)
• [Journal Article] Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis (2010)
  • Author(s): Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N, Yokota S
  • Journal Title: Nephrol Dial Transplant On line
  • Peer Reviewed
• [Journal Article] Whole blood interferon-gamma assay for tuberculosis in children in Japan. (2009)
  • Author(s): Higuchi R, Mori M, Ozawa R, Miyamae T, Imagawa T, Nishimaki S, Mitsuda T, Aihara Y, Yokota S
  • Journal Title: Pediatr Int. 51(1) Pages: 97-102
• [Journal Article] The role of heme oxygenase-1 in systemic-onset juvenile idiopathic arthritis. (2009)
  • Author(s): Takahashi A, Mori M, Naruto T, Nakajima S, Miyamae T, Imagawa T, Yokota S
  • Journal Title: Mod Rheumatol. 19(3) Pages: 302-8
  • NAID: 10025113098
• [Journal Article] 子どもの脳死臓器移植を巡る日本小児科学会会長として考えたこと今後の議論のために. (2009)
  • Author(s): 横田俊平
  • Journal Title: 日本小児科学会雑誌 113巻9号 Pages: 1-8
  • NAID: 10026275909
• [Journal Article] 日本小児リウマチ学会:若年性特発性関節炎に対する生物学的製剤治療の手引き2009エタネルセプト. (2009)
  • Author(s): 横田俊平, 森雅亮, 今川智之, 村田卓士, 冨板美奈子, 伊藤保彦, 藤川敏, 武井修治
  • Journal Title: 日本小児科学会雑誌 113巻8号 Pages: 1344-1352
• [Journal Article] 小児シェーグレン症候群における小唾液腺組織の経時的変化を観察しえた8例の経験. (2009)
  • Author(s): 岩田直美, 宮前多佳子, 菊地雅子, 岸崇之, 原良紀, 金子詩子, 篠木敏彦, 今川智之, 稲山嘉明, 横田俊平
  • Journal Title: 日本臨床免疫学会会誌 32巻3号 Pages: 195-200
  • NAID: 10025636516
• [Journal Article] 抗IL-6受容体抗体療法の軟骨内骨化への効果. (2009)
  • Author(s): 中島章子, 横田俊平
  • Journal Title: THE BONE 23巻4号 Pages: 451-457
• [Journal Article] 自己炎症疾患自己炎症症候群ベーチェット病、クローン病. (2009)
  • Author(s): 横田俊平
  • Journal Title: Topics in Atopy 8巻3号 Pages: 8-13
• [Journal Article] 【ステロイド療法の実際】特殊な状態におけるステロイドの使い方小児に対するステロイド使用の注意点. (2009)
  • Author(s): 横田俊平
  • Journal Title: Modern Physician 29巻5号 Pages: 667-671
• [Journal Article] 【新たな生物学的製剤によるリウマチ性疾患の治療】Tocilizumabによる若年性特発性関節炎の治療. (2009)
  • Author(s): 横田俊平
  • Journal Title: リウマチ科 41巻3号 Pages: 240-245
• [Journal Article] 【小児診療のピットフォール】子どもの診かた正常、異常、バリエーション. (2009)
  • Author(s): 横田俊平
  • Journal Title: 臨牀と研究 86巻4号 Pages: 405-409
• [Journal Article] 【注意すべきウイルス感染症】インフルエンザと精神症状. (2009)
  • Author(s): 横田俊平, 鈴木ゆめ
  • Journal Title: 診断と治療 97巻3号 Pages: 601-605
• [Journal Article] 【リウマチ性疾患診療における日本のエビデンス】小児リウマチ治療における生物学的製剤の有効性. (2009)
  • Author(s): 横田俊平
  • Journal Title: リウマチ科 41巻1号 Pages: 48-53
• [Journal Article] 小児線維筋痛症と疲労. (2009)
  • Author(s): 宮前多佳子, 横田俊平
  • Journal Title: 日本疲労学会誌 4巻2号 Pages: 40-45
• [Journal Article] 【小児リウマチ性疾患をどう診るか変貌した一次医療と専門医療】若年性特発性関節炎難治例に対するIL-6阻害薬. (2009)
  • Author(s): 今川智之
  • Journal Title: 小児科臨床 62巻9号 Pages: 1995-2002
• [Journal Article] 【ステロイド薬の上手な使い方】ステロイド薬の使用方法、減量方法. (2009)
  • Author(s): 今川智之
  • Journal Title: 小児内科 41巻5号 Pages: 726-729
• [Journal Article] Hyper-IgD syndrome with novel mutation in a Japanese girl. (2009)
  • Author(s): Takuya Naruto
  • Journal Title: Mod Rheumatol 19-1 Pages: 96-99
  • NAID: 10025112230
  • Peer Reviewed
• [Journal Article] Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis : a randomised, double-blind, placebo-controlled, withdrawal phase III trial. (2008)
  • Author(s): Shumpei Yokota
  • Journal Title: Lancet 371 Pages: 998-1006
  • Peer Reviewed
• [Journal Article] Cross-cultural adaptation and validation of the Japanese version of the Childhood Health Assessment questionnaire (CHAQ). (2008)
  • Author(s): Shumpei Yokota
  • Journal Title: Mod Rheum 18 Pages: 336-343
  • Peer Reviewed
• [Presentation] The Peripheral Blood Genes That Account for Predictability of Clinical Response to Tocilizumab (TCZ) Treatment, Corticosteroid Dose Reduction, and Serum IL-6 Normalization at Week 48 On Systemic Onset Juvenile Idiopathic Arthritis (sJIA) Patients. (2009)
  • Author(s): Norihiro Nishimoto, Yuichi Kawata, Hooi-Ming Lee, Chieko Aoki, Yasuo Adachi, Hidehiko Sugino, Tomoyuki Imagawa, Masaaki Mori, Minako Tomiita, Naomi Iwata, Takuji Murata, Mari Miyoshi, Syuji Takei, Yukoh Aihara, Takahiro Ochi, Shumpei Yokota
  • Organizer: American College of Rheumatology, annual scientific meeting
  • Place of Presentation: Philadelphia
• [Presentation] Drug-Free Remission of Patients with Systemic Juvenile Idiopathic Arthritis Receiving Tocilizumab for Treatment. (2009)
  • Author(s): Shumpei Yokota, Takuma Hara, Masako Kikuchi, Takayuki Kishi, Ryoki Hara, Rumiko Kurosawa, Remi Ozawa, Takako Miyamae, Tomoyuki Imagawa, Masaaki Mori
  • Organizer: American College of Rheumatology, annual scientific meeting
  • Place of Presentation: Philadelphia
• [Presentation] Auto-inflammatory Diseases in Childhood - Clinical and Genetic Advances. (2009)
  • Author(s): Shumpei Yokota
  • Organizer: World Congress on Inflammation
  • Place of Presentation: Tokyo
• [Presentation] Effect of Anakinra on arthlopathy in CINCA/NOMID syndrome. (2009)
  • Author(s): Takako Miyamae, Yutaka Inaba, Takayuki Kishi, Utakako Kaneko, Tomoyuki Imagawa, Shumpei Yokota
  • Organizer: World Congress on Inflammation
  • Place of Presentation: Tokyo
• [Presentation] Clinical Analysis of Juvenile Dermatomyositis; A Retrospective Study of 45 Japanese. (2009)
  • Author(s): Takayuki Kishi, Masako Kikuchi, Ryoki Hara, Utako Kaneko, Toshihiko Shinoki, Takako Miyamae, Tomoyuki Imagawa, Masaaki Mori, Shumpei Yokota
  • Organizer: The European League Against Rheumatism, The Annual European Congress of Rheumatology
  • Place of Presentation: Copenhagen
• [Presentation] SAFETY AND EFFICACY OF UP TO THREE YEARS OF CONTINUOUS TOCILIZUMAB THERAPY IN CHILDREN WITH SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS. (2009)
  • Author(s): Shumpei Yokota, Tomoyuki Imagawa, Takako Miyamae, Takayuki Kishi, Utako Kaneko, Norihiro Nishimoto, Tadamitsu KIshimoto
  • Organizer: The European League Against Rheumatism, The Annual European Congress of Rheumatology
  • Place of Presentation: Copenhagen
• [Presentation] IL-6 and Beyond. (2009)
  • Author(s): Shumpei Yokota
  • Organizer: Rheumatism, The Annual European Congress of Rheumatology
  • Place of Presentation: Copenhagen
• [Presentation] EFFECTS OF TOCILIZUMAB ON RADIOLOGICAL FINDINGS IN POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS. (2009)
  • Author(s): Chie Aoki, Yutaka Inaba, Remi Ozawa, Tomoyuki Imagawa, Takako Miyamae, Masaaki Mori, Tomoyuki Saito, Shumpei Yokota
  • Organizer: The European League Against Rheumatism, The Annual European Congress of Rheumatology
  • Place of Presentation: Copenhagen
• [Presentation] Effect of Anakinra on arthlopathy in CINCA/NOMID syndrome. (2009)
  • Author(s): Takako Miyamae, Yutaka Inaba, Takayuki Kishi, Utakako Kaneko, Tomoyuki Imagawa, Shumpei Yokota
  • Organizer: The European League Against Rheumatism, The Annual European Congress of Rheumatology
  • Place of Presentation: Copenhagen
• [Presentation] RADIOLOGIC EVALUATION OF LARGE JOINTS DURING TOCILIZUMAB TREATMENT IN CHILDREN WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS. (2009)
  • Author(s): Yutaka Inaba, Chie Aoki, Remi Ozawa, Tomoyuki Imagawa, Takako Miyamae, Masaaki Mori, T. omoyuki Saito1, Shumpei Yokota
  • Organizer: The European League Against Rheumatism, The Annual European Congress of Rheumatology
  • Place of Presentation: Copenhagen
• [Presentation] DISCREPANCY BETWEEN PROGRESSION OF JOINT DAMAGE AND IMPROVEMENT OF SYSTEMIC INFLAMMATION IN PATIENTS WITH SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS TREATED WITH TOCILIZUMAB. (2009)
  • Author(s): Utako Kaneko, Tomoyuki Imagawa, Takayuki Kishi, Masako Kikuchi, Ryoki Hara, T. oshihiko Shinoki, Takako Miyamae, Masaaki Mori, Shumpei Yokota
  • Organizer: The European League Against Rheumatism, The Annual European Congress of Rheumatology
  • Place of Presentation: Copenhagen
• [Presentation] A new Biologictespsise Modifier: Toulizumab. A New challenge against JIA. (2009)
  • Author(s): Shumpei Yokota
  • Organizer: アジア小児科学会&アジア太平洋小児科学会
  • Place of Presentation: 上海
• [Presentation] Recent progress of diagnosis and treatment in children with systemic juvenile idiopathic arthritis. (2009)
  • Author(s): Shumpei Yokota
  • Organizer: First Indonesia-Japan Rheumatology Forum
  • Place of Presentation: Indonesia
• [Presentation] Long-term Safety And Efficacy Of Tocilizumab In Patients With Systemic Juvenile Idiopathic Arthritis (JIA) Under The Extension And Long-term Trials (2008)
  • Author(s): Shumpei Yokotal, Tomoyuki Imagawal, Takako Miyamael, Masaaki Mori, et al.
  • Organizer: 米国リウマチ学会
  • Place of Presentation: 米国、サンフランシスコ
  • Year and Date: 2008-10-24
• [Book] 若年性特発性関節炎 トシリズマブ治療の理論と実際2009 (2009)
  • Author(s): 横田俊平/監修 武井修治/監修
  • Total Pages: 228
  • Publisher: メディカルレビュー社
• [Book] 若年性特発性関節炎トシリズマブ治療の理論と実際2009 (2009)
  • Author(s): 横田俊平/監修, 武井修治/監修
  • Total Pages: 228
  • Publisher: メディカルレビュー社