TLR/Nod proteins in infants from dysregulation Pathological analysis Cytokine Storm
| Project/Area Number |
19390287
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yokohama City University |
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Principal Investigator |
YOKOTA Shumpei Yokohama City University, 医学研究科, 教授 (10158363)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masaaki 横浜市立大学, 市民総合医療センター, 准教授 (30254204)
IMAGAWA Tomoyuki 横浜市立大学, 附属病院, 准教授 (20336548)
成戸 卓也 横浜市立大学, 医学部, 博士研究員 (60438124)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2007: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Keywords | 自然免疫 / 乳幼児 / 免疫疾患 / サイトカインストーム / cytokine storm / TLR蛋白 / Nod蛋白 |
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| Research Abstract |
Immune diseases in childhood, Kawasaki disease, influenza-associated encephalopathy, virus-associated hemophagocytic syndrome, and systemic-onset juvenile idiopathic arthritis, excessive inflammatory cytokines are involved in disease pathogenesis. We investigated the relationship between innate immunity to these diseases in excess of inflammatory cytokines.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis.2010
Author(s)
Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N, Yokota S
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Journal Title
Nephrol Dial Transplant. (On line)
Related Report
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[Journal Article] Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis2010
Author(s)
Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N, Yokota S
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Journal Title
Nephrol Dial Transplant On line
Related Report
Peer Reviewed
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[Presentation] The Peripheral Blood Genes That Account for Predictability of Clinical Response to Tocilizumab (TCZ) Treatment, Corticosteroid Dose Reduction, and Serum IL-6 Normalization at Week 48 On Systemic Onset Juvenile Idiopathic Arthritis (sJIA) Patients.2009
Author(s)
Norihiro Nishimoto, Yuichi Kawata, Hooi-Ming Lee, Chieko Aoki, Yasuo Adachi, Hidehiko Sugino, Tomoyuki Imagawa, Masaaki Mori, Minako Tomiita, Naomi Iwata, Takuji Murata, Mari Miyoshi, Syuji Takei, Yukoh Aihara, Takahiro Ochi, Shumpei Yokota
Organizer
American College of Rheumatology, annual scientific meeting
Place of Presentation
Philadelphia
Related Report
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[Presentation] Drug-Free Remission of Patients with Systemic Juvenile Idiopathic Arthritis Receiving Tocilizumab for Treatment.2009
Author(s)
Shumpei Yokota, Takuma Hara, Masako Kikuchi, Takayuki Kishi, Ryoki Hara, Rumiko Kurosawa, Remi Ozawa, Takako Miyamae, Tomoyuki Imagawa, Masaaki Mori
Organizer
American College of Rheumatology, annual scientific meeting
Place of Presentation
Philadelphia
Related Report
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