| Project/Area Number |
19390291
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
HATTA Toshihisa Kanazawa Medical University, 医学部, 教授 (20238025)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OTANI Hiroki 島根大学, 医学部, 教授 (20160533)
HASHIMOTO Ryuju 島根大学, 医学部, 助教 (90252907)
UDAGAWA Jun 島根大学, 医学部, 助教 (10284027)
MATSUMOTO Akihiro 島根大学, 医学部, 助教 (70346378)
SIMAMURA Eriko 金沢医科大学, 医学部, 講師 (00267741)
SHIMADA Hiroki 金沢医科大学, 医学部, 講師 (60278108)
HIGASHI Nobuaki 金沢医科大学, 医学部, 講師 (00139784)
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|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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|---|
| Keywords | 白血病抑制因子 / 副腎皮質刺激ホルモン / 胎盤 / 脳 / 赤血球 / 発生 / サイトカイン / 胎児 / 脳脊髄液 / 絨毛 / giant cell / leukemia inhibitory factor / 成長因子 |
|---|
| Research Abstract |
Placental trophoblasts in rats are stimulated by maternal leukemia inhibitory factor (LIF) to secrete adrenocorticotropic hormone (ACTH) into the fetal blood circulation. Then, fetal nucleated red blood cells are reactive to placental ACTH to secrete LIF, which induces an increase of LIF level in the fetal cerebrospinal fluid. Finally, the neuron production in the fetal forebrain increased.
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