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Research of the clinical issues relating to ventricular assist device treatment for severe heart failure

Research Project

Project/Area Number 19390343
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

NISHINAKA Tomohiro  Tokyo Women's Medical University, 医学部, 助教 (00256570)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Kenji  東京女子医科大学, 医学部, 教授 (30241087)
斉藤 聡  東京女子医科大学, 医学部, 講師 (60246551)
妙中 義之  東京女子医科大学, 国立循環器病センター研究所, 部長 (00142183)
巽 英介  東京女子医科大学, 国立循環器病センター研究所, 室長 (00216996)
水野 敏秀  東京女子医科大学, 国立循環器病センター研究所, 室長 (40426515)
Co-Investigator(Renkei-kenkyūsha) SAITO Satoshi  東京女子医科大学, 医学部, 講師 (60246551)
AENAKA Yoshiyuki  独立行政法人国立循環器病研究ヤンター, 研究所, 副所長 (00142183)
TATSUMI Eisuke  独立行政法人国立循環器病研究ヤンター, 人工臓器部, 部長 (00216996)
MIZUNO Toshihide  独立行政法人国立循環器病研究ヤンター, 人工臓器部, 室長 (40426515)
SHIOYA Kyoko  独立行政法人国立循環器病研究ヤンター, 動物実験管理室, 室長 (50426516)
TSUKIYA Tomonori  独立行政法人国立循環器病研究ヤンター, 人工臓器部, 室長 (00311449)
HOMMA Akihiko  東京電機大学, 理工学部, 准教授 (20287428)
UMEZU Kentaro  東京女子医科大学, 医学部, 助教 (30408596)
LEE Hwan Sung  ニプロ株式会社, 人工臓器開発センター, 顧問 (10463275)
KOMAGANINE Masahide  東京女子医科大学, 医学部, 医療練士研修生
YAMADA Yukiko  東京女子医科大学, 医学部, 医療練士研修生
TAKEWA Yoshiaki  独立行政法人国立循環器病研究センター, 人工臓器部, 室長 (20332405)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords心不全 / 循環補助 / 人工心臓 / 心臓 / 補助循環 / 血栓症
Research Abstract

The clinical issues relating to ventricular assist device (VAD) treatment for severe heart failure were studied. Circadian variation of circulatory assist flow with constant rotational speed control of continuous flow pump VAD, the problems of patient management under long-term VAD support at home, the problems of transportation of patients under VAD support, the effectiveness of comprehensive monitoring of coagulation and platelet function for anticoagulation and antiplatelet therapy, the possibility of monitoring of PT-INR at home, the problems of pediatric patient management under VAD support, the design parameters as well as material for VAD inflow cannulas in the left ventricle with characteristics for the prevention of thrombus formation,and the possibility of three-dimensional CT analysis for the evaluation of anatomical fitting of VAD patients were revealed, resulting in possible contribution to VAD treatment for severe heart failure.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 2008

All Journal Article (12 results) Presentation (18 results)

  • [Journal Article] 補助人工心臓装着患者の血液凝固管理2011

    • Author(s)
      西中知博
    • Journal Title

      呼吸と循環 59

    • Related Report
      2009 Final Research Report
  • [Journal Article] 補助人工心臓装着患者の血液凝固管理2011

    • Author(s)
      西中知博
    • Journal Title

      呼吸と循環

      Volume: 59

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 補助人工心臓(体内設置型)による循環補助2010

    • Author(s)
      西中知博,山崎健二
    • Journal Title

      Heart View 14

      Pages: 700-705

    • Related Report
      2009 Final Research Report
  • [Journal Article] 植込み型補助人工心臓-日本におけるEVAHEARTを用いた在宅治療2010

    • Author(s)
      西中知博,山崎健二, 他
    • Journal Title

      Clinical Engineering 21

      Pages: 562-567

    • Related Report
      2009 Final Research Report
  • [Journal Article] 左室心尖部より挿入される補助人工心臓脱血管の形状に関する流体工学的検討2010

    • Author(s)
      築谷朋典,水野敏秀,巽英介,妙中義之,西中知博,山崎健二
    • Journal Title

      日本機械学会2010年度年次大会講演論文集 10

      Pages: 157-158

    • Related Report
      2009 Final Research Report
  • [Journal Article] 体内埋込み型補助人工心臓と在宅治療2010

    • Author(s)
      西中知博
    • Journal Title

      人工臓器2010 26

      Pages: 65-70

    • Related Report
      2009 Final Research Report
  • [Journal Article] 体内埋込み型補助人工心臓と在宅治療2010

    • Author(s)
      西中知博
    • Journal Title

      人工臓器

      Volume: 26 Pages: 65-70

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 補助人工心臓(体内設置型)による循環補助2010

    • Author(s)
      西中知博, 他
    • Journal Title

      Heart View

      Volume: 14 Pages: 700-705

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 植込み型補助人工心臓-日本におけるEVAHEARTを用いた在宅治療2010

    • Author(s)
      西中知博, 他
    • Journal Title

      Clinical Engineering

      Volume: 21 Pages: 562-567

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 左室心尖部より挿入される補助人工心臓脱血管の形状に関する流体工学的検討2010

    • Author(s)
      築谷朋典, 他
    • Journal Title

      日本機械学会2010年度年次大会講演論文集

      Volume: 10 Pages: 157-158

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 補助人工心臓装着患者の搬送2008

    • Author(s)
      西中知博
    • Journal Title

      人工臓器2008 24

      Pages: 85-90

    • Related Report
      2009 Final Research Report
  • [Journal Article] 補助人工心臓装着患者の搬送2008

    • Author(s)
      西中 知博
    • Journal Title

      人工臓器2008 2008年度刊

      Pages: 85-90

    • Related Report
      2008 Annual Research Report
  • [Presentation] 植込み型補助人工心臓治療における在宅治療・外来管理2011

    • Author(s)
      西中知博
    • Organizer
      第39回人工心臓と補助循環懇話会
    • Place of Presentation
      米子
    • Year and Date
      2011-02-18
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 埋込み型連続式補助人工心臓による長期循環補助:現状と今後の課題2010

    • Author(s)
      西中知博
    • Organizer
      日本定常流ポンプ研究会2010
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-18
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] New generation LVAS accomplish a paradigm shift in the strategy for end-stage heart failure treatment2010

    • Author(s)
      山崎健二
    • Organizer
      第14回日本心不全学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 左室心尖部より挿入される補助人工心臓脱血管の形状に関する流体工学的検討2010

    • Author(s)
      築谷朋典
    • Organizer
      日本機械学会2010年度年次大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-05
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 近未来の補助人工心臓(LVAS)治療2010

    • Author(s)
      山崎健二
    • Organizer
      第31回循環制御医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-28
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Left Ventricular Assist for Japanese Pediatric Patients2010

    • Author(s)
      駒ヶ嶺正英
    • Organizer
      American Society for Artificial Internal Organs 56th Annual Conference
    • Place of Presentation
      Baltimore
    • Year and Date
      2010-05-27
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 小児領域における医工学治療の最前線:小児補助人工心臓治療の現状と今後の展望2010

    • Author(s)
      西中知博
    • Organizer
      第26回医工学治療学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-04
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 補助人工心臓治療に関する臨床的課題2010

    • Author(s)
      西中知博
    • Organizer
      第38回人工心臓と補助循環懇話会
    • Place of Presentation
      諏訪
    • Year and Date
      2010-02-26
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 重症心不全の補助人工心臓治療における臨床的課題の解決と基盤整備2009

    • Author(s)
      西中知博
    • Organizer
      第47回日本人工臓器学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 小児重症心不全に対する補助人工心臓治療に関する検討2009

    • Author(s)
      駒ヶ嶺正英
    • Organizer
      第15回日本臨床補助人工心臓研究会
    • Place of Presentation
      新潟
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] デバイスを用いた心不全治療:LVASの現況と将来2009

    • Author(s)
      山崎健二
    • Organizer
      第13回日本心不全学
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-01
    • Related Report
      2009 Final Research Report
  • [Presentation] デバイスを用いた心不全治療:LVASの現況と将来2009

    • Author(s)
      山崎健二
    • Organizer
      第13回日本心不全学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 国立循環器病センター型補助人工心臓植込みを施行した小児症例の検討2009

    • Author(s)
      駒ヶ嶺正英
    • Organizer
      第28回日本心臓移植研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 小児補助人工心臓植え込み症例の検討2009

    • Author(s)
      駒ヶ嶺正英
    • Organizer
      第62回日本胸部外科学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] New tissue engineered inflow cannula improves biocompatibility2009

    • Author(s)
      Yamada Yukiko
    • Organizer
      International Society for Rotary Blood Pumps 17th Annual Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2009-10-02
    • Related Report
      2009 Final Research Report
  • [Presentation] New tissue engineered inflow cannula improves biocompatibility.2009

    • Author(s)
      Yamada Yukiko, et al
    • Organizer
      International Society for Rotary Blood Pumps 17th Annual Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 補助人工心臓使用下における患者搬送2008

    • Author(s)
      西中知博
    • Organizer
      2008年度人工臓器教育セミナー
    • Place of Presentation
      東京
    • Year and Date
      2008-07-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 補助人工心臓使用下における患者搬送2008

    • Author(s)
      西中 知博
    • Organizer
      2008年度人工臓器教育セミナー
    • Place of Presentation
      東京都
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2020-09-29  

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