| Project/Area Number |
19390394
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAMURA Norimasa Osaka University, 臨床医工学融合研究教育センター, 招聘教授 (50273719)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Jyun 大阪大学, 大学院・医学系研究科, 准教授 (40237938)
NAKATA Ken 大阪大学, 大学院・医学系研究科, 講師 (00283747)
YOSHIKAWA Hideki 大阪大学, 大学院・医学系研究科, 教授 (60191558)
藤江 祐道 工学院大学, 機械工学科, 教授 (20199300)
松崎 典弥 大阪大学, 工学研究科, 助教 (00419467)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIE Hiromichi 工学院大学, 工学部, 教授 (20199300)
AKASHI Mitsuru 大阪大学, 大学院・工学研究科, 教授 (20145460)
MTSUSAKI Michiya 大阪大学, 大学院・工学研究科, 講師 (00419467)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 幹細胞 / 軟骨分化 / 骨分化 / スキャフォールド / 再生医療 / メカニカルストレス / 骨形成因子 / ハイドロキシアパタイト / スキャフオールド |
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| Research Abstract |
We investigated the effect of scaffold-free tissue engineered construct (TEC) on osteochondral regeneration. We implanted either of the basic TEC, hydroxyapatite-adsorbed TEC, or hybrid material of the TEC and artificial bone (beta-TCP). Histological analysis at 4, 8 and 24 weeks following implantation revealed that the hybrid material of the TEC and artificial bone most effectively promoted osteochondral regeneration of the lesion. The TEC can adhere to the surface of artificial bone rapidly and stably, and further maintain hybrid condition in situ to promote osteochondral regeneration and thus could be a promising material for biological joint resurfacing.
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