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Osteochondral regeneration using a scaffold-free tissue engineered construct (TEC) derived from mesenchymal stem cells

Research Project

Project/Area Number 19390394
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

NAKAMURA Norimasa  Osaka University, 臨床医工学融合研究教育センター, 招聘教授 (50273719)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Jyun  大阪大学, 大学院・医学系研究科, 准教授 (40237938)
NAKATA Ken  大阪大学, 大学院・医学系研究科, 講師 (00283747)
YOSHIKAWA Hideki  大阪大学, 大学院・医学系研究科, 教授 (60191558)
藤江 祐道  工学院大学, 機械工学科, 教授 (20199300)
松崎 典弥  大阪大学, 工学研究科, 助教 (00419467)
Co-Investigator(Renkei-kenkyūsha) FUJIE Hiromichi  工学院大学, 工学部, 教授 (20199300)
AKASHI Mitsuru  大阪大学, 大学院・工学研究科, 教授 (20145460)
MTSUSAKI Michiya  大阪大学, 大学院・工学研究科, 講師 (00419467)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords幹細胞 / 軟骨分化 / 骨分化 / スキャフォールド / 再生医療 / メカニカルストレス / 骨形成因子 / ハイドロキシアパタイト / スキャフオールド
Research Abstract

We investigated the effect of scaffold-free tissue engineered construct (TEC) on osteochondral regeneration. We implanted either of the basic TEC, hydroxyapatite-adsorbed TEC, or hybrid material of the TEC and artificial bone (beta-TCP). Histological analysis at 4, 8 and 24 weeks following implantation revealed that the hybrid material of the TEC and artificial bone most effectively promoted osteochondral regeneration of the lesion. The TEC can adhere to the surface of artificial bone rapidly and stably, and further maintain hybrid condition in situ to promote osteochondral regeneration and thus could be a promising material for biological joint resurfacing.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (74 results)

All 2009 2008 2007

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (57 results)

  • [Journal Article] Compressive properties of cartilage-like tissues repaired in vivo with scaffold-free, tissue engineered constructs.2009

    • Author(s)
      Katakai D, Imura M, Ando W, Tateishi K, Yoshikawa H, Nakamura N, Fujie H
    • Journal Title

      Clin Biomech (Bristol, Avon) 24(1)

      Pages: 110-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systematic Review. Cell-Based Therapy in Articular Cartilage Lesions of the Knee2009

    • Author(s)
      Nakamura, N., Miyama, T., Engebretsen, L., Yoshikawa, H., Shino, K
    • Journal Title

      Arthroscopy 25

      Pages: 531-52

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scaffold-Free Tissue-Engineered Construct-Hydroxyapatite Composites Generated by an Alternate Soaking Process: Potential for Repair of Bone Defects.2009

    • Author(s)
      Matsusaki M, Kadowaki K, Tateishi K, Higuchi C, Ando W, Hart DA, Tanaka Y, Take Y, Akashi M, Yoshikawa H, Nakamura N
    • Journal Title

      Tissue Eng Part A 15

      Pages: 55-63

    • NAID

      120006517989

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Compressive properties of cartilage-like tissues repaired in vivo with scaffold-free, tissue engineered constructs.2009

    • Author(s)
      Katakai D, imura M, Anto W, Tateishi K, Yoshikawa H, Nakamura N, Fujie H.
    • Journal Title

      Club Biomech (Bristol, Avon). 24(1)

      Pages: 110-116

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient dynamic actin cytoskeletal change stimulates the osteoblastic differentiation.2009

    • Author(s)
      Higuchi C, Nakamura N, Yoshikawa H, Iton K.
    • Journal Title

      J Bone Miner Metab 27(2)

      Pages: 158-167

    • NAID

      10025336649

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic Review. Cell-Based Therapy in Articular Cartilage Lesions of the Knee.2009

    • Author(s)
      Nakamura, N., Miyama, T., Engebretsen, L., Yoshikawa, H., Shino, K.
    • Journal Title

      Arthroscopy 25

      Pages: 531-552

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of human serum with fetal bovine serum for expansion and differentiation of human synovial MSC-Potential feasibility for clinical applications.2008

    • Author(s)
      Tateishi K, Ando W, Higuchi C, Hart, DA, Hashimoto J, Nakata K, Yoshikawa H, Nakamura N
    • Journal Title

      Cell Transplant 17

      Pages: 549-57

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] I3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation.2008

    • Author(s)
      Kita K, Kimura T, Nakamura N, Yoshikawa H, Nakano T
    • Journal Title

      Genes Cells 13

      Pages: 839-50

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Generation of a Scaffold-Free Tissue Engineered Construct (TEC) Derived from Human Synovial Mesenchymal Stem Cells: Biological and Mechanical Properties and Further Chondrogenic Potential.2008

    • Author(s)
      Ando W, Tateishi K, Katakai D, Hart DA, Nakata K, Hashimoto J, Fujie H, Shino K, Yoshikawa H, Nakamura N
    • Journal Title

      Tissue Eng Part A 200814

      Pages: 2041-2049

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Update on Tissue Engineering : Bone and Cartilage. Articular cartilage regeneration using stem cells.2008

    • Author(s)
      Kanamoto T, Nakamura N, Nakata K, Yoshikawa H
    • Journal Title

      Clin Calcium 18

      Pages: 1744-9

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminaldifferentiation.2008

    • Author(s)
      Kita K, Kimura T, Nakamura N, Yoshikawa H, Nakano T
    • Journal Title

      Genes Cells 13

      Pages: 839-850

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Generation of a Scaffold-Free Tissue-Engineered Construct (TEC) Derived from Human Synovial Mesenchymal stem Cells : Biological and Mechanical Properties and Further Chondrogenic Potential.2008

    • Author(s)
      Ando W, Tateishi K, Katakai D, Hart DA, Higuchi c, Nakata K, Hashimoto J, Fujie H, Shino K, Yoshikawa H, Nakamura N
    • Journal Title

      Tissue Eng Part A 14

      Pages: 2041-2049

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of human serum with fetal bovine serum for expansion and differentiation of human synovial MSC -Potential feasibility for clinical applications.2008

    • Author(s)
      Tateishi K, Ando W, Higuchi C, Hart, DA, Hashimoto J, Nakata K, Yoshikawa H, Nakamura N
    • Journal Title

      Cell Transplant. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells.2007

    • Author(s)
      Ando W, Tateishi K, Hart DA, Nakata K, Hashimoto J, Fujie H, Shino K, Yoshikawa H, Nakamura N
    • Journal Title

      Biomaterials 28

      Pages: 5462-70

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The immunosuppressant FK506 promotes development of the chondrogenic phenotype in human synovial stromal cells via modulation of the Smad signaling pathway.2007

    • Author(s)
      Tateishi K, Higuchi C, Ando W, Nakata K, Hashimoto J, Hart DA, Yoshikawa H, Nakamura N
    • Journal Title

      Osteoarthritis Cartilage 15

      Pages: 709-18

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells.2007

    • Author(s)
      Ando W, Tateishi K, Hart DA, Katakai D, Tanaka Y, Nakata K, Hashimoto J, Fujie H, Shino K, Yoshikawa H, Nakamura N.
    • Journal Title

      Biomaterials. 28

      Pages: 5462-5470

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The immunosuppressant FK506 promotes development of the chondrogenic phenotype in human synovial stromal cells via modulation of the Smad signaling pathway.2007

    • Author(s)
      Tateishi K, Higuchi C, Ando W, Nakata K, Hashimoto J, Hart DA, Yoshikawa H, Nakamura N.
    • Journal Title

      Osteoarthritis Cartilage. 15

      Pages: 709-718

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Scaffold-free tissue engineered construct derived from synovial mesenchymal stem cells in cartilage repair.2009

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      3rd International Conference on Cell Therapy
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-11-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Scaffold-free tissue engineered construct derived from synovial mesenchymalstem cells in cartilage repair2009

    • Author(s)
      中村憲正
    • Organizer
      3^<rd> Intermational Conference on Cell Therapy
    • Place of Presentation
      韓国・ソウル
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] スキャフォールドフリー間葉系幹細胞由来三次元人工組織(TEC)による軟骨修復2009

    • Author(s)
      中村憲正, 他
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-05
    • Related Report
      2009 Final Research Report
  • [Presentation] スキャフオールドフリー間葉系幹細胞由来三次元人工組織(TEC)移植による軟骨修復2009

    • Author(s)
      中村憲正, 安藤渉, 藤江裕道, 中田研, 史野根生, 吉川秀樹
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] スキャフォールドフリー間葉系幹細胞由来三次元人工組織(TEC)による軟骨修復-生体力学的解析-2009

    • Author(s)
      中村憲正, 他
    • Organizer
      日本臨床バイオメカニクス学会学術集会
    • Place of Presentation
      松山
    • Year and Date
      2009-10-16
    • Related Report
      2009 Final Research Report
  • [Presentation] スキャフオールドフリー間葉系幹細胞由来三次元人工組織(TEC)移植による軟骨修復2009

    • Author(s)
      中村憲正, 安藤渉, 藤江裕道, 中田研, 史野根生, 吉川秀樹
    • Organizer
      日本臨床バイオメカニクス学会学術集会
    • Place of Presentation
      愛媛
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evidence-based cell-based therapy in chondral lesions A systematic review.2009

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      Korea-Japan Joint Symposium 2nd International Cartilage and Osteoarthritis Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-10-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Evidence-based cell-based therapy in chondral lesions A systematic review2009

    • Author(s)
      中村憲正
    • Organizer
      2nd International Cartilage and Osteoarthritis Symposium
    • Place of Presentation
      韓国・ソウル
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] スキャフオールドフリー間葉系幹細胞由来三次元人工組織(TEC)移植による軟骨修復2009

    • Author(s)
      中村憲正, 安藤渉, 藤江裕道, 中田研, 史野根生, 吉川秀樹
    • Organizer
      JOSKAS学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evidence-based cell-based therapy in chondral lesions A systematic review.2009

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      34th Singapore Orthopaedic Association
    • Place of Presentation
      Singapore
    • Related Report
      2009 Final Research Report
  • [Presentation] Translational stem cell research for cartilage and meniscal repair.2009

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      Prague Arthroscopy Symposium on Cartilage Surgery
    • Place of Presentation
      Prague, Checz
    • Related Report
      2009 Final Research Report
  • [Presentation] Evidence-based cell-based therapy in chondral lesions A systematic review.2009

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      1st I INTERNATIONAL CONGRESS OF SPORT TRAUMATOLOGY AND ARTHROSCOPY FOR CENTRAL-EASTERN EUROPE
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2009 Final Research Report
  • [Presentation] Translational research of cell-based therapy for chondral lesions in Japan.2009

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      8th World Congress of the International Cartilage Repair Society
    • Place of Presentation
      Miami, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Comparison of the mesenchymal progenitor cells derived from different porcine tissues for lineage-specific potential.2009

    • Author(s)
      Ando W, Nakamura N, et. al.
    • Organizer
      8th World Congress of the International Cartilage Repair Society
    • Place of Presentation
      Miami, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] PRP in cartilage repair Fact or fiction?2009

    • Author(s)
      中村憲正
    • Organizer
      34^<th> Singapore Orthopaedic Association
    • Place of Presentation
      シンガポール共和国・シンガポール
    • Related Report
      2009 Annual Research Report
  • [Presentation] Location specific healing response of damaged cartilage associated with ACL injury2009

    • Author(s)
      中村憲正
    • Organizer
      34^<th> Singapore Orthopaedic Association
    • Place of Presentation
      シンガポール共和国・シンガポール
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evidence-based cell-based therapy in chondral lesions A systematic review2009

    • Author(s)
      中村憲正
    • Organizer
      34^<th> Singapore Orthopaedic Association
    • Place of Presentation
      シンガポール共和国・シンガポール
    • Related Report
      2009 Annual Research Report
  • [Presentation] Translational stem cell research for cartilage and meniscal repair2009

    • Author(s)
      中村憲正
    • Organizer
      Prague Arthroscopy Symposium on Cartilage Surgery
    • Place of Presentation
      チェコ・プラハ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evidence-based cell-based therapy in chondral lesions A systematic review2009

    • Author(s)
      中村憲正
    • Organizer
      Prague Arthroscopy Symposium on Cartilage Surgery
    • Place of Presentation
      チェコ・プラハ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Location specific healing response of damaged cartilage associated with ACL injury2009

    • Author(s)
      中村憲正
    • Organizer
      1^<st> INTERNATIONAL CONGRESS OF SPORT TRAUMATOLOGY AND ARTHROSCOPY FOR CENTRAL-EASTERN EUROPE
    • Place of Presentation
      ポーランド・ワルシャワ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evidence-based cell-based therapy in chondral lesions A systematic review2009

    • Author(s)
      中村憲正
    • Organizer
      1^<st> INTERNATIONAL CONGRESS OF SPORT TRAUMATOLOGY AND ARTHROSCOPY FOR CENTRAL-EASTERN EUROPE
    • Place of Presentation
      ポーランド・ワルシャワ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Translational research of cell-based therapy for chondral lesions in Japan2009

    • Author(s)
      中村憲正
    • Organizer
      8^<th> World Congress of the International Cartilage Repair Society
    • Place of Presentation
      アメリカ合衆国・マイアミ
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1. the Future of Sports Medicine : Basics and Application2009

    • Author(s)
      Norimasa Nakamura, Chair, Savio Woo, Co-Chair, Ramon Cugat, Johnny Huard, William Rodkey, Russell Warren, Alberto Gobbi, Harukazu Tohyama,
    • Organizer
      7^<th> Biennial ISAKOS Congress
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Symposium : Standard Cartilage Repair-Present Status and Future Direction2009

    • Author(s)
      Mitsuo Ochi, Chair, Bert andelbaum, Co-Chair, Morimasa Nakamura, Mats Brittberg, Ronny Lorentzon, Nobuo Adachi
    • Organizer
      7^<th> Biennial ISAKOS Congress
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Instructuoanl Course Lecture : Therapy for Chondral Lesions-From Bench to Bedside2009

    • Author(s)
      Norimasa Nakamura, Chairlars Peterson, Mats BrittbergStephan Nehrer, Mitsuo Ochi, Stephan Vogt,
    • Organizer
      7^<th> Biennial ISAKOS Congress
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparison of the mesenchymal progenitor cells derived from different porcinetissues for lineage-specific potential.2009

    • Author(s)
      W.ANDO, C.B.Frank, N.Nakamura, D.A.Hart
    • Organizer
      8^<th> World Congress of the International Cartilage Repair Society
    • Place of Presentation
      アメリカ合衆国・マイアミ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Surface structure and stiffness of porcine cartilage-like tissues repaired with a scaffold-free, stem cell-based tissue engineered construct(TEC): An atomic force microscopic study.2009

    • Author(s)
      R.Nansai, M.Ogata, T.Suzuki, W.Ando, N.Nakamura, H.Fujie, (JP)
    • Organizer
      8^<th> World Congress of the International Cartilage Repair Society
    • Place of Presentation
      アメリカ合衆国・マイアミ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Compressive properties of normal and repaired cartilage depent on permeability at the surface layer : Cartilage repair using a stem cell-based scaffold-free tissue engineered construct.2009

    • Author(s)
      H.Fujie, M.Imura, D.Katakai, W.Ando, N.Nakamura
    • Organizer
      8^<th> World Congress of the International Cartilage Repair Society
    • Place of Presentation
      アメリカ合衆国・マイアミ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Alteration in distribution of cytoskeletal proteins in 3-dimensional cultured tissue of human synovium-derived stem cell and human meniscus cell with collagen scaffold2009

    • Author(s)
      T.Kanamoto, K.Nakata, N.Nakamura, Y.Akamine, H.Kouda, K.Shimomura, H.Yoshikawa
    • Organizer
      8^<th> World Congress of the International Cartilage Repair Society
    • Place of Presentation
      アメリカ合衆国・マイアミ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Frictional property of the mature porcine cartilage-like tissue repaired with a scaffold-free tissue engineered construct(TEC)bio-synthesized from synovium-derived mesenchymal stem cells.2009

    • Author(s)
      M.Ogata, J.Takeda, M.Imura, W.Anto, N.Nakamura, H.Fujie
    • Organizer
      8^<th> World Congress of the International Cartilage Repair Society
    • Place of Presentation
      アメリカ合衆国・マイアミ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synovial stem cell therapy to cartilage and meniscus2008

    • Author(s)
      Nakamura N
    • Organizer
      Orthobiologics 2008
    • Place of Presentation
      Calagry
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟骨損傷に対する先端医療と未来2008

    • Author(s)
      中村憲正
    • Organizer
      第19回日本臨床スポーツ医学会
    • Place of Presentation
      幕張
    • Year and Date
      2008-11-02
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] スキャフォールドフリー間葉系幹細胞由来三次元人工組織(TEC)移植による軟骨修復シンポジウム軟骨再生温故知新2008

    • Author(s)
      中村憲正, 他
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] スキャフォールドフリー間葉系幹細胞由来三次元人工組織(TEC)移植による軟骨修復シンポジウム軟骨再生 温故知新2008

    • Author(s)
      中村憲正 安藤渉 立石耕介藤江裕道 中田研 史野根生 吉川秀樹
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新鮮凍結同種腱による膝前十字靭帯再建術の長期成績パネル膝前十字靭帯再建術の長期成績2008

    • Author(s)
      中村憲正 中田研堀部秀二 吉川秀樹 史野根生
    • Organizer
      JOSKAS 2008
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Meniscal Repair using Scaffold-free Tissue Engineered Construct (TEC) derived from synovium.2008

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      8th World Biomaterials Congress
    • Place of Presentation
      Amsterdam
    • Year and Date
      2008-06-03
    • Related Report
      2009 Final Research Report
  • [Presentation] In Vitro Generation of a Scaffold-Free Tissue-Engineered Construct (TEC) Derived from Human Synovial Mesenchymal Stem Cells.2008

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      8th World Biomaterials Congress
    • Place of Presentation
      Amsterdam
    • Year and Date
      2008-06-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Meniscal Repair using Scaffold-free Tissue Engineered Construct (TEC)derived from synovium2008

    • Author(s)
      Nakamura N, Tateishi K, Ando W, Take Y, Katakai D, Fujie H, Nakata K, Shino K, Yoshikawa H
    • Organizer
      8^<th> World Biomaterials Congress
    • Place of Presentation
      Amsterdam
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] In Vitro Generation of a Scaffold-Free Tissue-Engineered Construct (TEC)Derived from Human Synovial Mesenchymal stem Cells2008

    • Author(s)
      Nakamura N, Tateishi K, Ando W, Take Y, Katakai D, Fuiie H, Hart DA, Nakata K, Yoshikawa H
    • Organizer
      8^<th> World Biomaterials Congress
    • Place of Presentation
      Amsterdam
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Translational stem cell research for cartilage and meniscal repair.2008

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      13th ESSKA Congress 2000
    • Place of Presentation
      Porto, Portgal
    • Year and Date
      2008-05-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Translational stem cell research for cartilage and meniscal repair2008

    • Author(s)
      Nakamura N, Ando W, Tateishi K, Fujie H, Nakata K, Shino K, Yoshikawa H
    • Organizer
      13^<th>ESSKA Congress 2008
    • Place of Presentation
      Porto
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cartilage and Meniscus-Future-2008

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      5th World Congress of Sports Trauma and 6th Asia-Pacific Orthopaedic Society for Sports Medicine Meeting
    • Place of Presentation
      Hong Kong
    • Year and Date
      2008-04-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Cartilage and Meniscus -Future-2008

    • Author(s)
      Nakamura N, Ando W, Tateishi K, Fujie H, Nakata K, Shino K, Yoshikawa H
    • Organizer
      5th World Congress of Sports Trauma and 6th Asia-Pacific Orthopaedic Society for Sports Medicine Meeting
    • Place of Presentation
      Hong kong
    • Year and Date
      2008-04-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] スキャフォールドフリー間葉系幹細胞由来三次元人工組織(TEC)移植による軟骨修復シンポジウム三次元組織構築のための戦略2008

    • Author(s)
      中村憲正, 他
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Stem cell-based therapy for musculoskeletal tissues. Lecture.2008

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      9th Turkish Sports Traumatology, Arthroscopy and Knee Surgery Congress
    • Place of Presentation
      Istanbul
    • Related Report
      2009 Final Research Report
  • [Presentation] Evidence-based medicine in cell-based cartilage repair.2008

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      Panel13: Knee and cartilage 9th Turkish Sports Traumatology, Arthroscopy and Knee Surgery Congress
    • Place of Presentation
      Istanbul
    • Related Report
      2009 Final Research Report
  • [Presentation] Stem cell-based therapy for musculoskeletal tissues.2008

    • Author(s)
      Nakamura N, et. al.
    • Organizer
      Lecture 9th Turkish Sports Traumatology, Arthroscopy and Knee Surgery Congress
    • Place of Presentation
      Istanbul
    • Related Report
      2009 Final Research Report
  • [Presentation] stem cell-based therapy for musculoskeletal tissues2008

    • Author(s)
      Nakamura N, Tateishi K, Ando W, Take Y, Katakai D, Fujie H, Nakata K, Shino K, Yoshikawa H
    • Organizer
      9th Turkish Sports Traumatology, Arthroscopy and Knee Surgery Congress
    • Place of Presentation
      Istanbul
    • Related Report
      2008 Annual Research Report
  • [Presentation] Evidence-based medicine in cell-based cartilage repair Panel13 : Knee and cartilage2008

    • Author(s)
      Nakamura N, Miyama T, Yoshikawa H
    • Organizer
      9th Turkish Sports Traumatology, Arthroscopy and Knee Surgery Congress
    • Place of Presentation
      Istanbul
    • Related Report
      2008 Annual Research Report
  • [Presentation] The location-specific healing response of damaged articular cartilage after ACL reconstructionMaster's course in sports medicine2008

    • Author(s)
      Nakamura N, Horibe s, Shino K
    • Organizer
      9th Turkish Sports Traumatology, Arthroscopy and Knee Surgery Congress
    • Place of Presentation
      Istanbul
    • Related Report
      2008 Annual Research Report
  • [Presentation] Use of synovial mesenchymal stem cells PANEL22 : KNEE / Biocompartmental Knee Replacement2008

    • Author(s)
      Nakamura N, Tateishi K, Ando W, Take Y, Katakai D, Fujie H, Hart DA, Nakata K, Yoshikawa H
    • Organizer
      9th Turkish Sports Traumatology, Arthroscopy and Knee Surgery Congress
    • Place of Presentation
      Istanbul
    • Related Report
      2008 Annual Research Report
  • [Presentation] 足場素材を用いない滑膜由来三次元人工組織(3DBT)を用いた関節内組織再生2007

    • Author(s)
      立石耕介, 信貴経夫, 城山晋, 葉山悦伸, 本田博嗣, 小石逸人, 杉安謙仁郎, 野口亮介, 大森信介, 橋本佳周, 倉都滋之
    • Organizer
      第73回呉整形外科研究会
    • Place of Presentation
      呉,広島
    • Year and Date
      2007-06-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] スキャホールドフリー滑膜由来三次元人工組織を用いた半月再生2007

    • Author(s)
      米谷泰一, 立石耕介, 安藤渉, 田中美成, 片貝大輔, 藤江裕道, 中田研, 吉川秀樹, 堀部秀二, 中村憲正
    • Organizer
      Combined Congress of JOSKAS 2007
    • Place of Presentation
      札幌,北海道
    • Related Report
      2007 Annual Research Report
  • [Presentation] スキャフォールドフリー間葉系幹細胞由来三次元人工組織による軟骨修復2007

    • Author(s)
      Combined Congress of JOSKAS 2007
    • Organizer
      Combined Congress of JOSKAS 2007
    • Place of Presentation
      札幌,北海道
    • Related Report
      2007 Annual Research Report
  • [Presentation] Meniscal Repair using Scaffold-Free Self-Organized 3D Bioengineered Tissue (3DBT) derived from synovium2007

    • Author(s)
      Kosuke Tateishi, Wataru Ando, Yasukazu Yonetani, Ken Nakata, Hideki Yoshikawa, Shuji Horibe, Konsei Shino, Norimasa Nakamura
    • Organizer
      International Cartilage Repair Society 2007
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2007 Annual Research Report
  • [Presentation] Histological and biomechanical assessment of cartilage repair by a scaffold-free 3D bioengineered tissue (3DBT) derived from synovial MSCs2007

    • Author(s)
      Ando W, Tateishi K, Katakai D, Imura M, Take Y, Nakata K, Fujie H, Hashimoto J, Shino K, Yoshikawa H, Nakamura N
    • Organizer
      International Cartilage Repair Society 2007
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2007 Annual Research Report
  • [Presentation] スキャフォールドフリー間葉系幹細胞由来三次元人工組織による軟骨修復2007

    • Author(s)
      中村憲正, 安藤渉, 立石耕介, 田中美成, 片貝大輔, 藤江裕道, 中田研, 吉川秀樹
    • Organizer
      日本整形外科学会 基礎学術集会
    • Place of Presentation
      浜松
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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