Type I alveolar epithelial cell injury in perioperative acute lung injury : clinical evaluation of severity using biomarker proteins

• Project/Area Number: 19390404
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: UCHIDA Tokujiro Tokyo Medical and Dental University, 医学部附属病院, 講師 (40262183)
• Research Collaborator: MATTHAY Michael A. University of California, San Francisco ; 大野 長良 東京大学, 医学部麻酔科 ; 山口 修 横浜市立大学, 附属市民総合医療センター ; 山川 直子 武蔵野赤十字病院, 麻酔科
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2007: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 肺胞上皮 / バイオマーカー / 急性肺傷害 / 肺傷害

Research Abstract

手術に際して肺機能が低下した際の診断法の開発し、より早期に治療的な介入ができるように、Receptor for Advanced Glycation End Products(RAGE)の肺傷害マーカーとしての臨床的意義の検討を行った。周術期に採血し、血液中で、手術を契機にRAGEをはじめとするいくつかの因子の濃度がどのように変化するかを検討した。血中のRAGE濃度は、術直後をピークに上昇し、上昇度と人工呼吸器期間やICU滞在期間の間に草加案があることが示された。術直後のRAGEレベルは、肺の臓器機能傷害の指標として使用できることが明らかとなった。

Research Products

• [Journal Article] Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs (2009)
  • Author(s): Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA
  • Journal Title: Chest 135 Pages: 269-275
• [Journal Article] Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. (2009)
  • Author(s): Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA
  • Journal Title: Chest 135 Pages: 269-275
  • Peer Reviewed
• [Journal Article] 急性肺傷害の病態と治療-上皮機能からのアプローチ (2008)
  • Author(s): 内田篤治郎, 槇田浩史
  • Journal Title: 麻酔 57 Pages: 51-59
• [Journal Article] Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. (2007)
  • Author(s): Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC.
  • Journal Title: J Heart Lung Transplant 26 Pages: 675-680
• [Journal Article] Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats (2007)
  • Author(s): Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA.
  • Journal Title: Am J Respir Cell Mol Biol 37 Pages: 186-192
• [Journal Article] Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs (2007)
  • Author(s): Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 293
• [Journal Article] Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats (2007)
  • Author(s): Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA
  • Journal Title: Am J Respir Cell Mol Biol 37 Pages: 186-192
  • Peer Reviewed
• [Journal Article] Physiological, and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. (2007)
  • Author(s): Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 293
  • Peer Reviewed
• [Presentation] 急性肺障害-上皮機能からのアプローチ- (2010)
  • Author(s): 内田篤治郎
  • Organizer: 第57回日本麻酔科学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Expression of receptor for advanced glycation end-products (RAGE)in cultured alveolar epithelial cells. (2008)
  • Author(s): Yamakawa N, Uchida T, Matthay MA, Makita K.
  • Organizer: American Thoracic Society InternationalConference 2008
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2008-05-18
• [Presentation] 急性肺傷害と Receptor for Advanced Glycation Ehd-products (2008)
  • Author(s): 内田篤治郎
  • Organizer: 第28回急性呼吸不全に関する研究会
  • Place of Presentation: 東京
• [Presentation] 肺傷害とReceptor for Advanced Glycation End-products (2008)
  • Author(s): 内田篤治郎
  • Organizer: 第2回麻酔と細胞保護シグナル研究会
  • Place of Presentation: 東京
• [Presentation] Expression of receptor for advanced glycation end-products (RAGE) in cultured alveolar epithelial cells (2008)
  • Author(s): Yamakawa N, Uchida T, Matthay MA, K M
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Toronto, Canada