| Project/Area Number |
19390411
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Akita University |
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Principal Investigator |
HABUCHI Tomonori Akita University, 大学院・医学系研究科, 教授 (00293861)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Akira 九州大学, 生体防御研究所, 教授 (10311565)
NAKAMURA Akira 秋田大学, 大学院・医学系研究科, 教授 (20155815)
OYAMA Chikara 弘前大学, 大学院・医学系研究科, 教授 (80282135)
TSUCHIYA Norihiko 秋田大学, 大学院・医学系研究科, 准教授 (70282176)
YUASA Takeshi 財団法人癌研究会, 附属病院化学療法科, 医長 (00314162)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 前立腺癌 / 高脂肪食 / マイクロアレイ / 発現解析 / IGF-1 / LNCaP / Fn-14 / TWEAK / Xenograft / RT-PCR |
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| Research Abstract |
The purpose of this study project is to delineate the molecular mechanisms underlying the progression of prostate cancer associated with high-fat diet, and to identify molecular targets to prevent the high-fat associated progression of prostate cancer. As results, we found that the tumor growth of the LNCaP xenograft was markedly enhanced by high-fat diet. The several candidate target genes associated with the high-fat diet associated progression were identified and confirmed by using microarray mRNA expression and quantitative RTPCR. Next, we focused on the TWEAK-Fn14 signal system as a target. We found that the TWEAK-Fn14 signal promote invasion and progression of prostate cancers in vitro and in clinical settings.
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