The effect of ageing on the adult stem cells of tongue and masticatory muscles
Project/Area Number |
19390501
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
補綴理工系歯学
|
Research Institution | Tsurumi University |
Principal Investigator |
MORITO Mitsuhiko Tsurumi University, 歯学部, 教授 (30089429)
|
Co-Investigator(Kenkyū-buntansha) |
YAMANE Akira 鶴見大学, 歯学部, 教授 (20166763)
FUKUI Tadayoshi 鶴見大学, 歯学部, 助教 (10267544)
SUGA Takeo 鶴見大学, 歯学部, 助教 (40247333)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
|
Keywords | 成体幹細胞 / 骨格筋 / インスリン様増殖因子 / マイオスタチン / トリグリセロール / 成体型幹細胞 / 高脂肪食 / Rcal-time PCR法 / CPT-1β / Insulin receptor / エネルギー代謝関連遺伝子 / 老化促進マウス / ユビキチン・プロテアソーム系 / オートファゴソーム・リソソーム系 / 咬筋 / 舌筋 / 秘腹筋 / IGF / IGFR / Klothoマウス / 腓腹筋 |
Research Abstract |
The present results suggest that the extent of skeletal muscle atrophy is associated with activity of adult stem cells through IGFR1, myostatin down-regulate the velocity of differentiation of skeletal muscle cell lineage via activity of adult stem cell and the influence of triglycerol on the activity, proliferation and differentiation of adult stem cells is limited.
|
Report
(4 results)
Research Products
(80 results)
-
-
-
-
-
[Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice2010
Author(s)
NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A., ASADA, Y.
-
Journal Title
Pediatric Dent.J. (In press)
NAID
Related Report
Peer Reviewed
-
[Journal Article] BMP-2 Regulates the Formation of Oral Sulcus in Mouse Tongue by Altering the Balance between TIMP-1 and MMP-132010
Author(s)
FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y., YAMANE, A.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
[Journal Article] Effects of clenbuterol, aβ_2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles2009
Author(s)
ISHIKAWA, C., OGAWA, T., IKAWA, T., YAMANE, A.
-
Journal Title
Open Dent. J 3
Pages: 191-196
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Effects of clenbuterol, a β2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles2009
Author(s)
ISHIKAWA, C., OGAWA, T., IKAWA, T., YAMANE, A.
-
Journal Title
Open Dent.J. 3
Pages: 191-196
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] The inhibition of apoptosis by glycyrrhizin in hepatic injuryinduced by injection of lipopolysaccharide/D-galactosa mine in mice2008
Author(s)
IKEDA, T., KURODA, K., KIDA, N., INOUE, H., WAKE, K., MORITO, T., SATO, T.
-
Journal Title
Arch. Histol. Cytol. 71
Pages: 163-167
Related Report
Peer Reviewed
-
[Journal Article] Extracellular matrix-mediated tissue remodeling following axial movement of teeth2007
Author(s)
LUAN, X., ITO, Y., HOLLIDAY, S., WALKER, C., DANIELL, J., GALANG, T.M., FUKUI, T. YAMANE, A., BEGOLE, E., EVANS, C., DIEKWISCH, T.G.H
-
Journal Title
J. Histochem. Cytochem 55(2)
Pages: 127-140
Related Report
Peer Reviewed
-
[Journal Article] BMP2, BMP4, and their receptors are expressed in the differentiating muscle tissues of mouse embryonic tongue2007
Author(s)
SUGA, T., FUKUI, T., SHINOHARA, A., LUAN, X., DIEKWISCH, T.G.H., MORITO, M., YAMANE, A
-
Journal Title
Cell Tissue Res 329(1)
Pages: 103-117
Related Report
Peer Reviewed
-
-
-
[Journal Article] Extracellular matrix-mediated tissue remodeling following axial movement of teeth2007
Author(s)
LUAN, X., ITO, Y., HOLLIDAY, S., WALKER, C., DANIBLL, J., GALANG, T. M., FUKUI, T. YAMANE, A., BEGOLE, E., EVANS, C., DIEKWISCH, T. G. H.
-
Journal Title
J. Histochem. Cytochem. 55(2):, 2007 55
Pages: 127-140
Related Report
Peer Reviewed
-
[Journal Article] BMP2, BMP4, and their receptors are expressed in the differentiating muscle tissues of mouse embryonic tongue2007
Author(s)
SUGA, T., FUKUI, T., SHINOHARA, A., LUAN, X., DIEKWISCH, T. G. H., MORITO, M., YAMANE, A.
-
Journal Title
Cell Tissue Res. 329
Pages: 103-117
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice
Author(s)
NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A., ASADA, Y.
-
Journal Title
Pediatric Dent. J (In press)
NAID
Related Report
Peer Reviewed
-
[Journal Article] BMP-2 Regulates the Formation of Oral Sulcus in Mouse Tongue by Altering the Balance between TIMP-1 and MMP-13
Author(s)
FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y., YAMANE, A.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Function of occlusal activity in the synaptogenesis and myogenesis of masseter muscle2008
Author(s)
AMANE, A., KOUTA, Y., SUGA, T., KANEKO, N., MORITO, N, and ASADA, Y.
Organizer
Gordon Research Conference "Craniofacial morphogenesis and tissue regeneration"
Place of Presentation
Il Ciocco, Italy
Year and Date
2008-12-12
Related Report
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Effects of occlusal activity on masseter myogenesis and synaptogenesis2007
Author(s)
KOUTA, Y., YAMANE, A., TASHIMA, I., TOMOHIRO, T., ARITA, K. and ASADA, Y.
Organizer
55th Annual meeting of JADR
Place of Presentation
鶴見大学
Year and Date
2007-11-18
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-