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The effect of ageing on the adult stem cells of tongue and masticatory muscles

Research Project

Project/Area Number 19390501
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionTsurumi University

Principal Investigator

MORITO Mitsuhiko  Tsurumi University, 歯学部, 教授 (30089429)

Co-Investigator(Kenkyū-buntansha) YAMANE Akira  鶴見大学, 歯学部, 教授 (20166763)
FUKUI Tadayoshi  鶴見大学, 歯学部, 助教 (10267544)
SUGA Takeo  鶴見大学, 歯学部, 助教 (40247333)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords成体幹細胞 / 骨格筋 / インスリン様増殖因子 / マイオスタチン / トリグリセロール / 成体型幹細胞 / 高脂肪食 / Rcal-time PCR法 / CPT-1β / Insulin receptor / エネルギー代謝関連遺伝子 / 老化促進マウス / ユビキチン・プロテアソーム系 / オートファゴソーム・リソソーム系 / 咬筋 / 舌筋 / 秘腹筋 / IGF / IGFR / Klothoマウス / 腓腹筋
Research Abstract

The present results suggest that the extent of skeletal muscle atrophy is associated with activity of adult stem cells through IGFR1, myostatin down-regulate the velocity of differentiation of skeletal muscle cell lineage via activity of adult stem cell and the influence of triglycerol on the activity, proliferation and differentiation of adult stem cells is limited.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (80 results)

All 2010 2009 2008 2007 Other

All Journal Article (35 results) (of which Peer Reviewed: 33 results) Presentation (38 results) Book (7 results)

  • [Journal Article] TGFβ3 is expressed in differentiating muscle of the embryonic mouse tongue2010

    • Author(s)
      YAMANE, A., FUKUI, T., SUGA, T., IIDA, R., MORITO, M.
    • Journal Title

      Int. J. Dev. Biol 54(1)

      Pages: 221-226

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the expression of myosins during postnatal development of masseter muscle in the microphthalmic mouse2010

    • Author(s)
      KATAYMA, R., YAMANE, A., FUKUI, T.
    • Journal Title

      Open Dent. J 4

      Pages: 1-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the expression of myosins during postnatal development of masseter muscle in the microphthalmic mouse2010

    • Author(s)
      KATAYMA, R., YAMANE, A., FUKUI, T.
    • Journal Title

      Open Dent.J. 4

      Pages: 1-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGFβ3 is expressed in differentiating muscle of the embryonic mouse tongue2010

    • Author(s)
      YAMANE, A., FUKUI, T., SUGA, T., IIDA, R., MORITO, M
    • Journal Title

      Int.J.Dev.Biol. 54

      Pages: 221-226

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice2010

    • Author(s)
      NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A., ASADA, Y.
    • Journal Title

      Pediatric Dent.J. (In press)

    • NAID

      10027485798

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 Regulates the Formation of Oral Sulcus in Mouse Tongue by Altering the Balance between TIMP-1 and MMP-132010

    • Author(s)
      FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y., YAMANE, A.
    • Journal Title

      Anat.Rec. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Klotho遺伝子突然変異マウス骨格筋におけるインスリン様増殖因子およびその受容体mRNA2010

    • Author(s)
      飯田良平、菅武雄、山根明、森戸光彦
    • Journal Title

      鶴見歯学雑誌 (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of occlusal activity to synaptogenesis in masticatory muscles2009

    • Author(s)
      KOTA, Y., YAMANE, A., TOMOHIRO, T., ASADA, Y.
    • Journal Title

      J. Dent. Res 88(8)

      Pages: 768-772

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of clenbuterol, aβ_2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles2009

    • Author(s)
      ISHIKAWA, C., OGAWA, T., IKAWA, T., YAMANE, A.
    • Journal Title

      Open Dent. J 3

      Pages: 191-196

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Availability of saliva for the assessment of alterations in the autonomic nervous system caused by physical exercise training2009

    • Author(s)
      YOSHINO, Y., YAMANE, A., SUZUKI, M., NAKAGAWA, Y.
    • Journal Title

      Arch. Oral Biol 54(11)

      Pages: 977-985

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of lecithinized SOD on reactive oxygen species-induced xerostomia2009

    • Author(s)
      TAI, T., MORITO, M., (他7名、5番目)
    • Journal Title

      Radiation Res 172

      Pages: 331-3381

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment with invisible multiloop appliance of a horizontal open bite female young adult patient with tooth trauma2009

    • Author(s)
      FUKUI, T., CHOI, Y.B., YAMAGUCHI, H., TSURUTA, M.
    • Journal Title

      Am.J.Orthod. Dentofac. Orthop. 136

      Pages: 596-606

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of occlusal activity to synaptogenesis in masticatory muscles2009

    • Author(s)
      KOTA, Y., YAMANE, A., TOMOHIRO, T., ASADA, Y.
    • Journal Title

      J.Dent.Res. 88

      Pages: 768-772

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of clenbuterol, a β2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles2009

    • Author(s)
      ISHIKAWA, C., OGAWA, T., IKAWA, T., YAMANE, A.
    • Journal Title

      Open Dent.J. 3

      Pages: 191-196

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Availability of saliva for the assessment of alterations in the autonomic nervous system caused by physical exercise training2009

    • Author(s)
      YOSHINO, Y., YAMANE, A., SUZUKI, M., NAKAGAWA, Y.
    • Journal Title

      Arch.Oral Biol.54 54

      Pages: 977-985

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] シリーズ 分析機器-何がわかるか 「リアルタイムPCR」2009

    • Author(s)
      山根明
    • Journal Title

      DE 171

      Pages: 30-32

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibition of apoptosis by glycyrrhizin in hepatic injury induced by injection of lipopolysaccharide /D-galactosamine in mice2008

    • Author(s)
      IKEDA, T., MORITO, M., (他5名6番目)
    • Journal Title

      Arch. Histol. Cytol 71(3)

      Pages: 163-167

    • NAID

      10025095857

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ビスホスホネートの薬理2008

    • Author(s)
      山根 明
    • Journal Title

      歯界展望 111

      Pages: 1094-1097

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Response of Human Gingival Epithelial Cells (HGE-15 cells) to Bioactive Glass RKKP (surfaces as machined)2008

    • Author(s)
      OGUCHI, H., KARUBE, Y., MATSUMOTO, K., MORITO, M.
    • Journal Title

      PRP 17

      Pages: 5-11

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibition of apoptosis by glycyrrhizin in hepatic injuryinduced by injection of lipopolysaccharide/D-galactosa mine in mice2008

    • Author(s)
      IKEDA, T., KURODA, K., KIDA, N., INOUE, H., WAKE, K., MORITO, T., SATO, T.
    • Journal Title

      Arch. Histol. Cytol. 71

      Pages: 163-167

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular matrix-mediated tissue remodeling following axial movement of teeth2007

    • Author(s)
      LUAN, X., ITO, Y., HOLLIDAY, S., WALKER, C., DANIELL, J., GALANG, T.M., FUKUI, T. YAMANE, A., BEGOLE, E., EVANS, C., DIEKWISCH, T.G.H
    • Journal Title

      J. Histochem. Cytochem 55(2)

      Pages: 127-140

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMP2, BMP4, and their receptors are expressed in the differentiating muscle tissues of mouse embryonic tongue2007

    • Author(s)
      SUGA, T., FUKUI, T., SHINOHARA, A., LUAN, X., DIEKWISCH, T.G.H., MORITO, M., YAMANE, A
    • Journal Title

      Cell Tissue Res 329(1)

      Pages: 103-117

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of excess hard tissue occurring in the mesio-labial surface of the mandibular first molar in microphthalmic mouse2007

    • Author(s)
      TOMOHIRO, T., YAMANE, A., ASADA, Y
    • Journal Title

      Archs. Oral Biol 52(9)

      Pages: 828-835

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expressions of BMP2, BMP4, and their receptors during the development of mouse tongue muscle2007

    • Author(s)
      SUGA, T., FUKUI, T., MORITO, M., YAMANE, A
    • Journal Title

      Jpn. J. Gerodontol 22(3)

      Pages: 280-287

    • NAID

      10025742851

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular matrix-mediated tissue remodeling following axial movement of teeth2007

    • Author(s)
      LUAN, X., ITO, Y., HOLLIDAY, S., WALKER, C., DANIBLL, J., GALANG, T. M., FUKUI, T. YAMANE, A., BEGOLE, E., EVANS, C., DIEKWISCH, T. G. H.
    • Journal Title

      J. Histochem. Cytochem. 55(2):, 2007 55

      Pages: 127-140

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMP2, BMP4, and their receptors are expressed in the differentiating muscle tissues of mouse embryonic tongue2007

    • Author(s)
      SUGA, T., FUKUI, T., SHINOHARA, A., LUAN, X., DIEKWISCH, T. G. H., MORITO, M., YAMANE, A.
    • Journal Title

      Cell Tissue Res. 329

      Pages: 103-117

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of excess hard tissue occurring in the mesio-labial surface of the mandibular first molar in microphthalmic mouse2007

    • Author(s)
      TOMOHIRO, T., YAMANE, A., ASADA, Y.
    • Journal Title

      Archs. Oral Biol. 52(9): 828-835, 20 52

      Pages: 828-835

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expressions of BMP2, BMP4, and their receptors during the development of mouse tongue muscle2007

    • Author(s)
      SUGA, T., FUKUI, T., MORITO, M., YAMANE, A.
    • Journal Title

      Jpn. J. Gerodontol. 22

      Pages: 280-287

    • NAID

      10025742851

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of masticatory and tongue muscles2007

    • Author(s)
      YAMANE, A., FUKUI. T.
    • Journal Title

      J. Oral Biosci. 49

      Pages: 206-210

    • NAID

      10027102855

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 舌筋、咀嚼筋の発生、発達、再生2007

    • Author(s)
      山根 明、天野 修
    • Journal Title

      口腔組織培養学会誌 16

      Pages: 1-10

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice

    • Author(s)
      NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A., ASADA, Y.
    • Journal Title

      Pediatric Dent. J (In press)

    • NAID

      10027485798

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 Regulates the Formation of Oral Sulcus in Mouse Tongue by Altering the Balance between TIMP-1 and MMP-13

    • Author(s)
      FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y., YAMANE, A.
    • Journal Title

      Anat. Rec (In press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TGFβ3 is expressed in differentiating muscle of the embryonic mouse tongue

    • Author(s)
      YAMANE, A., EUKUI, T., SUGA, T., IIDA, R., MORITO, M.
    • Journal Title

      Int. J. Dev. Biol. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of occlusal activity on synaptogenesis in masticatory muscles

    • Author(s)
      KOUTA, Y., YAMANE, A., TOMOHIRO, T.
    • Journal Title

      J. Dent. Res. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment with invisible multiloop appliance of a horizontal open bite female young adult patient with tooth trauma

    • Author(s)
      FUKUI, T.
    • Journal Title

      Am. J. Orthod. Dentofac. Orthop. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス胎仔舌発生におけるBMP2の機能2010

    • Author(s)
      山根明、福井只美
    • Organizer
      第83回日本薬理学会学会年会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 歯が欠損している小眼球症マウスの咀嚼筋におけるミオシン重鎖の発現2009

    • Author(s)
      山根明
    • Organizer
      筋生理の集い
    • Place of Presentation
      東京慈恵会医科大
    • Year and Date
      2009-12-19
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] トリグリセロール蓄積がラット骨格筋のエネルギー代謝関連遺伝子発現に及ぼす影響2009

    • Author(s)
      金子周平、飯田良平、菅武雄、福井只美、山根明、森戸光彦
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 血小板由来増殖因子アンタゴニストが培養マウス舌筋細胞の増殖、分化に及ぼす影響2009

    • Author(s)
      鈴木栄里佳、福井只美、山根明、中村芳樹
    • Organizer
      第46回日本口腔組織培養学会学術大会
    • Place of Presentation
      昭和大学、東京
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 小眼球症マウスの生後発達過程における咬筋ミオシン重鎖mRNA発現の経時的変化2009

    • Author(s)
      片山理奈、福井只美、山根明
    • Organizer
      第51回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      朱鷺メッセ、新潟コンベンションセンター
    • Year and Date
      2009-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] 小眼球症マウスの生後発達過程における咬筋ミオシン重鎖mRNA発現の経時的変化2009

    • Author(s)
      片山理奈、福井只美、山根明
    • Organizer
      第51回歯科基礎医学会学術大会ならびに総会、
    • Place of Presentation
      朱鷺メッセ、新潟コンベンションセンター
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高脂肪食を摂取させたラット骨格筋におけるトリグリセロールの蓄積について2009

    • Author(s)
      金子周平、飯田良平、菅武雄、福井只美、篠原暁子、山根明、森戸光彦
    • Organizer
      第20回日本老年歯科医学会総会・学術大会
    • Place of Presentation
      横浜パシフィコ、横浜
    • Year and Date
      2009-06-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 高脂肪食を摂取させたラット咬筋におけるアセチルコリン受容体サブユニットの発現2009

    • Author(s)
      山根明、金子周平、飯田良平、菅武雄、福井只美、篠原暁子、森戸光彦
    • Organizer
      第20回日本老年歯科医学会総会・学術大会
    • Place of Presentation
      横浜パシフィコ、横浜
    • Year and Date
      2009-06-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 高脂肪食を摂取させたラット咬筋におけるアセチルコリン受容体サブユニットの発現2009

    • Author(s)
      山根明、金子周平、飯田良平、菅武雄、福井只美、篠原暁子、森戸光彦
    • Organizer
      第20回日本老年歯科医学会総会・学術大会
    • Place of Presentation
      横浜パシフィコ、横浜、
    • Year and Date
      2009-06-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高脂肪食を摂取させたラット骨格筋におけるトリグリセロールの蓄積について2009

    • Author(s)
      金子周平、飯田良平、菅武雄、福井只美、篠原暁子、山根明、森戸光彦
    • Organizer
      第20回日本老年歯科医学会総会・学術大会
    • Place of Presentation
      横浜パシフィコ、横浜、
    • Year and Date
      2009-06-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Study on adipogenic change of lingual muscles in the obese rat2009

    • Author(s)
      SAITO, T., YAMANE, A., KANEKO, S., OGAWA, T
    • Organizer
      87th General session & exhibition of the IADR
    • Place of Presentation
      Miami Beach Convention Center, USA
    • Year and Date
      2009-04-02
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] マイオスタチンのアンタゴニストであるActRIIB/Fcはクレンブテロールにより誘導されるC2C12の分化を一時的に加速した2009

    • Author(s)
      山根明、金子周平、飯田良平、菅武雄、森戸光彦
    • Organizer
      第82回日本薬理学会学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-03-17
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 器官培養系を用いたマウス舌形態形成の研究2009

    • Author(s)
      山根明、福井只美
    • Organizer
      生体運動合同班会議
    • Place of Presentation
      東京大学駒場キャンパス
    • Year and Date
      2009-01-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Contribution of occlusal activity on expression of MyHC in masseter muscle2009

    • Author(s)
      KOTA, Y., YAMANE, A., ASADA, Y.
    • Organizer
      50th Korean academy of pediatric dentistry
    • Place of Presentation
      SETEC, Seoul, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高脂肪食がラット咬筋におけるミオシン重鎖、アセチルコリン受容体サブユニットに与える影響2008

    • Author(s)
      金子周平、飯田良平、菅武雄、斎藤高、福井只美、山根明、森戸光彦
    • Organizer
      第68回鶴見大学歯学会例会
    • Place of Presentation
      鶴見大学会館、横浜
    • Year and Date
      2008-12-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 高脂肪食がラット咬筋におけるミオシン重鎖、アセチルコリン受容体サブユニットに与える影響2008

    • Author(s)
      金子周平, 飯田 良平, 菅武雄, 斎藤 高, 福井只美, 山根 明, 森戸光彦
    • Organizer
      第68回鶴見大学歯学会例会
    • Place of Presentation
      鶴見大学会館
    • Year and Date
      2008-12-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Klothoマウス骨格筋萎縮における蛋白質分解系について2008

    • Author(s)
      山根明、飯田良平、菅武雄、金子周平、森戸光彦
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-12
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Function of occlusal activity in the synaptogenesis and myogenesis of masseter muscle2008

    • Author(s)
      AMANE, A., KOUTA, Y., SUGA, T., KANEKO, N., MORITO, N, and ASADA, Y.
    • Organizer
      Gordon Research Conference "Craniofacial morphogenesis and tissue regeneration"
    • Place of Presentation
      Il Ciocco, Italy
    • Year and Date
      2008-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] マイオスタチンはクレンブテロールによる培養筋芽細胞C2C12の分化促進に拮抗している2008

    • Author(s)
      山根明、金子周平、飯田良平、菅武雄、森戸光彦
    • Organizer
      第45回日本口腔組織培養学会
    • Place of Presentation
      松本歯科大学
    • Year and Date
      2008-11-15
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 分化過程のマウス舌筋細胞におけるTGFβおよびその受容体、シグナル伝達因子の発現2008

    • Author(s)
      山根明、福井只美
    • Organizer
      第50回歯科基礎医学会学術大会・総会
    • Place of Presentation
      有明コンベンションセンター
    • Year and Date
      2008-09-25
    • Related Report
      2009 Final Research Report
  • [Presentation] マイオスタチンはクレンブテロールによる筋量増大調節機構に関与している2008

    • Author(s)
      山根明、飯田良平、菅武雄、森戸光彦.
    • Organizer
      日本動物学会第79回大会
    • Place of Presentation
      福岡大学
    • Year and Date
      2008-09-05
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Synaptogenesis of craniofacial muscles is affected by occlusal activity2008

    • Author(s)
      KOUTA, Y., TOMOHIRO, T., YAMANE, A., ASADA, Y
    • Organizer
      87th General Session & Exhibition of the IADR
    • Place of Presentation
      Metro Toronto Convention Center
    • Year and Date
      2008-07-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 腓腹筋における蛋白質分解系について2008

    • Author(s)
      飯田良平、菅武雄、金子夏樹、山根明、森戸光彦.老化促進(Klotho)マウス咬筋、舌筋
    • Organizer
      第19回日本老年歯科医学会総会・学術大会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-06-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯の萌出不全モデルマウスを用いた咀嚼筋のプロテオーム解析2008

    • Author(s)
      古宇田ゆき、山根明、友廣忠文、田島格、小西博和、有田浩一朗、朝田芳信
    • Organizer
      第46回日本小児歯科学会大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2008-06-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 老化促進(Klotho)マウス咬筋、舌筋、腓腹筋における蛋白質分解系について2008

    • Author(s)
      飯田良平, 菅 武雄, 金子夏樹, 山根 明, 森戸光彦
    • Organizer
      第19回日本老年歯科医学会総会・学術大会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-06-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] マイオスタチンはクレンブテロールが誘導する培養筋芽細胞C2C12の分化促進を調節している2008

    • Author(s)
      山根明、菅武雄、篠原暁子、金子夏樹、森戸光彦
    • Organizer
      第81回日本薬理学会学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-03-18
    • Related Report
      2009 Final Research Report
  • [Presentation] BMP2はTIMPとMMPの発現を調節することによりマウス舌側溝形成を制御している2008

    • Author(s)
      福井只美、山根明
    • Organizer
      第67回日本矯正歯科学会大会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2009 Final Research Report
  • [Presentation] クレンブテロールによる咬筋量調節メカニズムにおいてマイオスタチンとインスリン様増殖因子が機能する時期は異なっている2007

    • Author(s)
      山根 明、中川洋一、篠原暁子、菅 武雄、森戸光彦
    • Organizer
      第30回分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of occlusal activity on masseter myogenesis and synaptogenesis2007

    • Author(s)
      KOUTA, Y., YAMANE, A., TASHIMA, I., TOMOHIRO, T., ARITA, K. and ASADA, Y.
    • Organizer
      55th Annual meeting of JADR
    • Place of Presentation
      鶴見大学
    • Year and Date
      2007-11-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of exercise and diet on mouse saliva2007

    • Author(s)
      YOSHINO, Y., YAMANE, A., NAKAGAWA, Y. and SUZUKI, M.
    • Organizer
      55th Annual meeting of JADR
    • Place of Presentation
      鶴見大学
    • Year and Date
      2007-11-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] トランスフォーミング増殖因子βはマウス舌筋分化調節過程に関与している2007

    • Author(s)
      山根 明、福井 只美、菅 武雄、篠原 暁子、森戸 光彦
    • Organizer
      日本動物学会第78回大会
    • Place of Presentation
      弘前大学
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 飼料性状の違いがマウス咬筋のシナプス形成に及ぼす影響2007

    • Author(s)
      古宇田ゆき、山根 明、朝田芳信
    • Organizer
      第49回歯科基礎医学会学術大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2007-08-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] クレンブテロール(β2作動薬)による咬筋、顎二腹筋、側頭筋の肥大は体肢の筋より大きい2007

    • Author(s)
      山根 明、古宇田ゆき、朝田芳信
    • Organizer
      第49回歯科基礎医学会学術大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2007-08-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 咬合様式の違いが咀嚼筋の筋タンパク発現に及ぼす影響2007

    • Author(s)
      古宇田ゆき、山根 明、友廣忠文、有田浩一朗、田島格、朝田芳信
    • Organizer
      第45回日本小児歯科医学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2007-07-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス舌の発生過程におけるBMPの発現2007

    • Author(s)
      門松伸一、菅 武雄、山根 明、池田美智子、森戸光彦
    • Organizer
      第18回日本老年歯科医学会総会学術大会
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 活発に分化しているマウス舌筋組織にBMPおよびその受容体が局在している2007

    • Author(s)
      菅 武雄、山根 明、森戸光彦
    • Organizer
      第18回日本老年歯科医学会総会学術大会
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2007-06-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] クレンブテロール(β2アゴニスト)による咬筋量増大の調節にマイオスタチンが関与している2007

    • Author(s)
      山根 明、中川洋一、篠原暁子、菅武雄、森戸光彦
    • Organizer
      第116回日本薬理学会関東部会
    • Place of Presentation
      日本大学
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] BMP2 functions as a negative regulator for the differentiation of muscle, but not as an inducer for cartilage and bone in the embryonic development of mouse tongue2007

    • Author(s)
      YAMANE, A.
    • Organizer
      Gordon Research Conference "Myogenesis"
    • Place of Presentation
      II Ciocco, Italy
    • Year and Date
      2007-05-16
    • Related Report
      2007 Annual Research Report
  • [Book] スタディ歯科薬理学2009

    • Author(s)
      山根明
    • Total Pages
      260
    • Publisher
      永末書店
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Book] スタディ歯科薬理学2009

    • Author(s)
      山根 明
    • Total Pages
      260
    • Publisher
      永末書店
    • Related Report
      2008 Annual Research Report
  • [Book] 歯界展望別冊 Q&A 歯科のくすりがわかる本2008「くすりの副作用、有害作用はどのようにして起こるのですか?」2007

    • Author(s)
      山根 明
    • Total Pages
      3
    • Publisher
      医歯薬出版
    • Related Report
      2007 Annual Research Report
  • [Book] 歯界展望別冊 Q&A 歯科のくすりがわかる本2008「くすりの相互作用はどのようにして起こるのですか?」2007

    • Author(s)
      山根 明
    • Total Pages
      4
    • Publisher
      医歯薬出版
    • Related Report
      2007 Annual Research Report
  • [Book] 歯界展望別冊 Q&A 歯科のくすりがわかる本2008「くすりの正しい保管・管理方法」2007

    • Author(s)
      山根 明
    • Total Pages
      1
    • Publisher
      医歯薬出版
    • Related Report
      2007 Annual Research Report
  • [Book] 歯界展望別冊 Q&A 歯科のくすりがわかる本2008「アセトアミノフェンはほんとうに安全か?」2007

    • Author(s)
      山根 明
    • Total Pages
      1
    • Publisher
      医歯薬出版
    • Related Report
      2007 Annual Research Report
  • [Book] 歯界展望別冊 Q&A 歯科のくすりがわかる本2008 pp116「問診時にくすりに関して必要な項目」2007

    • Author(s)
      山根 明
    • Total Pages
      1
    • Publisher
      医歯薬出版
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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