Relationship between periodontal disease and metabolic disorders, adipokines, arteriosclerosis, and gene polymorphism in community inhabitants

• Project/Area Number: 19390542
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Nagasaki University
• Principal Investigator: SAITO Toshiyuki Nagasaki University, 大学院・医歯薬学研究院, 教授 (10170515)
• Co-Investigator(Kenkyū-buntansha): HAYASHIDA Hideaki 長崎大学, 病院, 講師 (20238140) ; KAWASAKI Kouji 長崎大学, 病院, 准教授 (60161303) ; MAEDA Takahiro 長崎大学, 大学院・医歯薬学研究院, 教授 (40284674)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 歯周病 / 代謝 / アディポカイン / 動脈硬化 / 疫学 / 働脈硬化

Research Abstract

We conducted a comprehensive health examination including assessment of arteriosclerosis and periodontal disease to about 1000 adult inhabitants in Goto Islands. As a result of multivariate analyses, a decreased number of teeth is significantly associated with increased risk of hypertension and deeper periodontal pockets is significantly associated with increased intima-media thickness (IMT) of 〓1.1 mm, which means increased risk of arteripsclerosis.

Research Products

• [Journal Article] Relationship between adipokines and periodontitis (2010)
  • Author(s): Furugen R, Hayashida H, Kitamura M, Saito T
  • Journal Title: Japanese Dental Science Review 46(in press)
  • NAID: 10026519082
  • Peer Reviewed
• [Journal Article] relationship between adipokines and periodontitis (2010)
  • Author(s): Furugen
  • Journal Title: Japanese Dental Science Review 46(2)(In press)
  • Peer Reviewed
• [Journal Article] Relationship between periodontal status and HbA1c in non-diabetics (2009)
  • Author(s): Hayashida H, Kawasaki K, Yoshimura A, Kitamura M, Furugen R, Nakazato M, Takamura, N, Hara Y, Maeda T, Saito T, Furugen R
  • Journal Title: J Publ Health Dent 69(3) Pages: 204-206
  • Peer Reviewed
• [Journal Article] : Relationship between periodontal status and HbAlc in non-diabetics (2009)
  • Author(s): Hayashida H
  • Journal Title: J Publ Health Dent 69 Pages: 204-206
  • Peer Reviewed
• [Journal Article] The relationship between periodontal condition and serum levels of resistin and adiponectin in Japanese elderly people (2008)
  • Author(s): Hayashida H, Yoshihara A, Ogawa H, Miyazaki H, Saito T
  • Journal Title: J Periodont Res 43 Pages: 556-562
  • Peer Reviewed
• [Journal Article] The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese (2008)
  • Author(s): Furugen R
  • Journal Title: J Periodont Res 43 Pages: 556-552
  • Peer Reviewed
• [Presentation] 血清アディポネクチンと口腔状況との関連 (2009)
  • Author(s): 林田秀明
  • Organizer: 第2回日本口腔検査学会総会
  • Place of Presentation: 広島
  • Year and Date: 2009-10-04
• [Presentation] Relationship between metabolic syndrome and present teeth in Japanese (2009)
  • Author(s): Hayashida H
  • Organizer: The 9th World Congress on Preventive Dentistry(WCPD)
  • Place of Presentation: プーケット(タイ)
  • Year and Date: 2009-09-08
• [Presentation] 長崎県離島地域における健診受診者の歯科保健上の地域特性について (2009)
  • Author(s): 林田秀明
  • Organizer: 第31回日本口腔衛生学会九州地方会
  • Place of Presentation: 北九州
  • Year and Date: 2009-07-05
• [Presentation] 血清アディポネクチンと口腔状況との関連 (2009)
  • Author(s): 林田秀明, 川崎浩二, 古堅麗子, 中里未央, 山崎浩則, 前田隆浩, 齋藤俊行
  • Organizer: 第2回日本口腔検査学会総会
  • Place of Presentation: 広島市
• [Presentation] Relationship between Metabolic Syndrome and Present Teeth in Japanese (2009)
  • Author(s): Hayashida H, Kawasaki K, Furugen R, Nakazato M, Maeda T, Saito T
  • Organizer: 9th World Cogress on Preventive Dentistry
  • Place of Presentation: Phuket, Thailand
• [Presentation] 長崎県離島地域における健診受診者の歯科保健上の地域特性について (2009)
  • Author(s): 林田秀明, 川崎浩二, 中里未央, 前田隆浩, 齋藤俊行
  • Organizer: 第31回日本口腔衛生学会九州地方会総会
  • Place of Presentation: 北九州市
• [Presentation] 歯科健診受診者における歯周病関連細菌に対する血清抗体価 (2008)
  • Author(s): 林田秀明
  • Organizer: 第1回日本口腔検査学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-23
• [Presentation] Circulating resistin level and oral health condition in elderly japanese (2008)
  • Author(s): Hayashida H
  • Organizer: 86th general session of the IADR
  • Place of Presentation: Toronto
  • Year and Date: 2008-07-04
• [Presentation] 歯科健診受診者における歯周病関連細菌に対する血清抗体価 (2008)
  • Author(s): 林田秀明, 川崎浩二, 古堅麗子, 北村雅保, 齋藤俊行
  • Organizer: 第1回日本口腔検査学会総会・学術大会
  • Place of Presentation: 東京
• [Presentation] Circulating resistin level and oral health condition in elderly japanese. (2008)
  • Author(s): Hayashida H, Saito T, Furugen R, Yamaguchi N, Yoshihara A, Ogawa H, Miyazaki H
  • Organizer: 86th general session of the IADR Toronto
  • Place of Presentation: Canada
• [Presentation] 歯周組織の健康状態と血中糖化ヘモグロビンとの関連 (2007)
  • Author(s): 林田秀明, 川崎浩二, 古堅麗子, 北村雅保, 齋藤俊行
  • Organizer: 第56回日本口腔衛生学会総会
  • Place of Presentation: 東京
• [Book] Chapter 6 Circulating TNF-αand Oral Health Condition in Elderly Japanese (2009)
  • Author(s): Hayashida H, Saito T, Furugen R, Yamaguchi N, Yoshihara A, Ogawa H, Miyazaki H
  • Publisher: Nova Science Publishers
• [Book] Tumor Necrosis Factor (2009)
  • Author(s): Hayashida H
  • Total Pages: 8
  • Publisher: Nova Science Publishers, Inc.