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Search for traditional medicines in Thailand and scientific evaluation of their pharmacological effects

Research Project

Project/Area Number 19406004
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental pharmacy
Research InstitutionHiroshima University

Principal Investigator

TAKANO Mikihisa  Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (20211336)

Co-Investigator(Kenkyū-buntansha) 永井 純也  広島大学, 大学院・歯薬学総合研究科, 准教授 (20301301)
Co-Investigator(Renkei-kenkyūsha) NAGAI Junya  広島大学, 大学院・医歯薬学総合研究科, 准教授 (20301301)
YUMOTO Ryoko  広島大学, 大学院・医歯薬学総合研究科, 助教 (70379915)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsタイ国伝承医薬 / 抗がん作用 / HepG2細胞 / パクリタキセル耐性 / 二糖類分解酵素 / 血糖値上昇抑制 / P-糖タンパク質 / キョウチクトウ科植物 / ツクバネカズラ科植物 / 抗がん薬 / 抗糖尿病薬 / 薬物トランスポーター / 培養がん細胞 / MRP / P-gp / 多剤耐性
Research Abstract

In Thailand, many traditional medicines are used for therapy and health promotion. Based on the discussion with colleagues in Thailand, some Thai plant extracts and purified compounds were generously provided. The pharmacological effects of these extracts and compounds were examined ; especially the effects on anticancer drug-resistant tumor cells. It was found that certain extracts potentiated the effect of anticancer effect of the drug, while another extract has potential anticancer effect by itself. These results would provide important information for the development of novel anticancer chemotherapies.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (14 results)

  • [Journal Article] Effect of Thai plant extracts on P-glycoprotein function and viability in paclitaxel-resistant HepG2 cells.2010

    • Author(s)
      Kawami, M., Yumoto, R., Nagai, J., Junyaprasert, V., Soonthornchareonnon, N., Patanasethanont, D., Sripanidkulchai, B., Takano, M.
    • Journal Title

      Drug Metab. Pharmacokinet. (in press)

    • NAID

      10027582439

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Thai plant extracts on P-glycoprotein function and viability in paclitaxel-resistant HepG2 cells2010

    • Author(s)
      Kawami, M., et al.
    • Journal Title

      Drug Metabolism and Pharmacokinetics 25(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in human hepatoma cell line HepG2.2009

    • Author(s)
      Takano, M., Otani Y., Tanda, M., Kawami, M., Nagai, J., Yumoto, R.
    • Journal Title

      Drug Metab. Pharmacokinet. 24(5)

      Pages: 418-427

    • NAID

      10025724568

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in human hepatoma cell line HepG22009

    • Author(s)
      Takano, M., et al.
    • Journal Title

      Drug Metabolism and Pharmacokinetics 24(5)

      Pages: 418-427

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Thai plant extracts on P-glycoprotein function and cell viability in HepG2 and paclitaxel-resistant HepG2 cells2009

    • Author(s)
      Yumoto, R., et al.
    • Journal Title

      Drug Metabolism and Review 41

      Pages: 62-62

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components.2007

    • Author(s)
      Patanasethanont, D., Nagai, J., Matsuura, C., Fukui, K., Sutthanut, K., Sripanidkulchai, B.-o., Yenjai, C., Yumoto, R., Takano, M.
    • Journal Title

      Eur. J. Pharmacol. 566(1-3)

      Pages: 67-74

    • NAID

      120000875392

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components2007

    • Author(s)
      Patanasethanont, D.
    • Journal Title

      Eur. J. Pharmacol. 566

      Pages: 67-74

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] タイ国産植物抽出物の抗がん作用および耐性克服作用に関する研究2010

    • Author(s)
      川見昌史
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山桃太郎アリーナ
    • Related Report
      2009 Final Research Report
  • [Presentation] タイ国産植物抽出物の抗がん作用および耐性克服作用に関する研究2010

    • Author(s)
      川見昌史, 外
    • Organizer
      第130年会 日本薬学会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Thai plant extracts on P-glycoprotein function and cell viability in HepG2 and paclitaxel-resistant HepG2 cells22009

    • Author(s)
      Ryoko Yumoto
    • Organizer
      The 3rd Asian Pacific Regional ISSX Meeting in Thailand
    • Place of Presentation
      The Imperial Queen's Park Hotel, タイ
    • Related Report
      2009 Final Research Report
  • [Presentation] タイ国産植物成分のP-glycoprotein阻害作用, paclitaxel耐性克服作用および抗がん作用に関する検討2009

    • Author(s)
      川見昌史
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎県立総合体育館
    • Related Report
      2009 Final Research Report
  • [Presentation] タイ国産植物成分が及ぼすがん細胞のP-glycoprotein機能およびviabilityへの影響解析2009

    • Author(s)
      川見昌史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会館
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of Thai plant extracts on P-glycoprotein function and cell viability in HepG2 and paclitaxel-resistant HepG2 cells22009

    • Author(s)
      Yumoto, R., et al.
    • Organizer
      The 3rd Asian Pacific Regional ISSX Meeting in Thailand
    • Place of Presentation
      The Imperial Queen's Park Hotel, Thailand
    • Related Report
      2009 Annual Research Report
  • [Presentation] タイ国産植物成分の P-glycoprotein 阻害作用、paclitaxel 耐性克服作用および抗がん作用に関する検討2009

    • Author(s)
      川見昌史, 外
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎ブリックホール
    • Related Report
      2009 Annual Research Report
  • [Presentation] タイ国産植物成分の多剤耐性克服作用および抗がん作用に関する検討2009

    • Author(s)
      川見 昌史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] ん細胞のP-glycoprotein機能およびviabilityに対するタイ国産植物成分の影響解析2008

    • Author(s)
      川見昌史
    • Organizer
      第47回日本薬学会中国四国支部学術大会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト肝がん由来HepG2細胞におけるパクリタキセルの輸送・細胞毒性とタイ国産植物成分の影響2008

    • Author(s)
      湯元良子
    • Organizer
      医療薬学フォーラム2008
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト肝がん由来HepG2細胞におけるパクリタキセルの輸送・細胞毒性とタイ国産植物成分の影響2008

    • Author(s)
      湯元 良子
    • Organizer
      医療薬学フォーラム2008
    • Place of Presentation
      東京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 旗心細胞のP-glycoprotein機能およびviabilityに対するタイ国産植物成分の影響解析2008

    • Author(s)
      川見 昌史
    • Organizer
      第47回日本薬学会中国四国支部学術大会
    • Place of Presentation
      岡山市
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト肝がん由来HepG2細胞のパクリタキセル耐性と輸送機能2007

    • Author(s)
      大谷佳文
    • Organizer
      第46回日本薬学会中国四国支部学術大会
    • Place of Presentation
      高知市文化プラザ
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗癌剤処理によるcell viability の変動とABCトランスポーターの発現・機能との相関解析:ヒト肺癌由来A549細胞を用いて2007

    • Author(s)
      福井 杏子
    • Organizer
      日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知市
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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