Search for traditional medicines in Thailand and scientific evaluation of their pharmacological effects
| Project/Area Number |
19406004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
TAKANO Mikihisa Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (20211336)
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| Co-Investigator(Kenkyū-buntansha) |
永井 純也 広島大学, 大学院・歯薬学総合研究科, 准教授 (20301301)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Junya 広島大学, 大学院・医歯薬学総合研究科, 准教授 (20301301)
YUMOTO Ryoko 広島大学, 大学院・医歯薬学総合研究科, 助教 (70379915)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | タイ国伝承医薬 / 抗がん作用 / HepG2細胞 / パクリタキセル耐性 / 二糖類分解酵素 / 血糖値上昇抑制 / P-糖タンパク質 / キョウチクトウ科植物 / ツクバネカズラ科植物 / 抗がん薬 / 抗糖尿病薬 / 薬物トランスポーター / 培養がん細胞 / MRP / P-gp / 多剤耐性 |
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| Research Abstract |
In Thailand, many traditional medicines are used for therapy and health promotion. Based on the discussion with colleagues in Thailand, some Thai plant extracts and purified compounds were generously provided. The pharmacological effects of these extracts and compounds were examined ; especially the effects on anticancer drug-resistant tumor cells. It was found that certain extracts potentiated the effect of anticancer effect of the drug, while another extract has potential anticancer effect by itself. These results would provide important information for the development of novel anticancer chemotherapies.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Effect of Thai plant extracts on P-glycoprotein function and viability in paclitaxel-resistant HepG2 cells.2010
Author(s)
Kawami, M., Yumoto, R., Nagai, J., Junyaprasert, V., Soonthornchareonnon, N., Patanasethanont, D., Sripanidkulchai, B., Takano, M.
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Journal Title
Drug Metab. Pharmacokinet. (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in human hepatoma cell line HepG2.2009
Author(s)
Takano, M., Otani Y., Tanda, M., Kawami, M., Nagai, J., Yumoto, R.
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Journal Title
Drug Metab. Pharmacokinet. 24(5)
Pages: 418-427
NAID
Related Report
Peer Reviewed
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[Journal Article] Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components.2007
Author(s)
Patanasethanont, D., Nagai, J., Matsuura, C., Fukui, K., Sutthanut, K., Sripanidkulchai, B.-o., Yenjai, C., Yumoto, R., Takano, M.
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Journal Title
Eur. J. Pharmacol. 566(1-3)
Pages: 67-74
NAID
Related Report
Peer Reviewed
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