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Epidemiological research for the relationship between Helicobacter pylori infection and gastrointestinal diseases in Asia

Research Project

Project/Area Number 19406025
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Gastroenterology
Research InstitutionKobe University

Principal Investigator

AZUMA Takeshi  Kobe University, 医学研究科, 教授 (60221040)

Co-Investigator(Kenkyū-buntansha) UGA Shoji  神戸大学, 保健学研究科, 教授 (90071399)
YOSHIDA Masaru  神戸大学, 医学研究科, 准教授 (00419475)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
KeywordsH.pylori / 消化器疾患 / 疫学調査 / 感染症 / Helicobacter pylori / 胃がん / 胃・十二指腸潰瘍 / アジア / CagA / 胃癌
Research Abstract

In this study, the pathological conditions in H.pylori infection were analyzed with the molecular epidemiological methods, because those had the problem, so called Ethnical enigma. As a result, it was revealed that the infection of East Asian type CagA positive H.pylori was closely associated with the degree of atrophic gastritis and the development of gastric cancer. In the future, by the personalized eradication therapy for the patients infected with East Asian type CagA positive H.pylori, which is considered to be associated strongly with the development of atrophic gastritis and subsequent gastric cancer, it is expected that the incidence rate of peptic ulcer and gastric cancer might be decreased in Asia

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2009 2008 2007 Other

All Journal Article (25 results) (of which Peer Reviewed: 9 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] D iverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer2009

    • Author(s)
      Truong BX, et al
    • Journal Title

      J Clin Microbiol 47(12)

      Pages: 4021-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] A method for assessment of Helicobacter pylori genotype using stool specimens2009

    • Author(s)
      Hirai I, et al
    • Journal Title

      FEMS Immunol Med Microbiol 56(1)

      Pages: 63-6

    • Related Report
      2009 Final Research Report
  • [Journal Article] D etection of Helicobacter pylori (H. pylori) DNA in digestive systems from cadavers by real-time PCR2009

    • Author(s)
      Nagasawa S, et al
    • Journal Title

      Leg Med 11

      Pages: 458-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] T he effects of Helicobacter pylori eradication on body mass index and dyspeptic symptoms2009

    • Author(s)
      Suto H, et al
    • Journal Title

      Digestion 79(4)

      Pages: 235-42

    • Related Report
      2009 Final Research Report
  • [Journal Article] E nhanced expression of CCL20 in human Helicobacter pylori-associated gastritis.2009

    • Author(s)
      Yoshida A, et al
    • Journal Title

      Clin Immunol 130(3)

      Pages: 290-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] H elicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.2009

    • Author(s)
      Nakayama M, et al
    • Journal Title

      J Biol Chem. 284(3)

      Pages: 1612-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] Diverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer2009

    • Author(s)
      Truong BX, et al.
    • Journal Title

      J Clin Microbiol. 47(12)

      Pages: 4021-4028

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis2009

    • Author(s)
      Yoshida A, et al.
    • Journal Title

      Clin Immunol. 130(3)

      Pages: 290-297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori VacA-induced Inhibition of GSK3 through the PI3K/Akt Signaling Pathway2009

    • Author(s)
      Nakayama M
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 1612-1619

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M olecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation.2008

    • Author(s)
      Hisatsune J, et al
    • Journal Title

      J Immunol. 180(7)

      Pages: 5017-27

    • Related Report
      2009 Final Research Report
  • [Journal Article] T ransgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.2008

    • Author(s)
      Ohnishi N, et al
    • Journal Title

      Proc Natl Acad Sci U S A. 105(3)

      Pages: 1003-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] D eregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence.2008

    • Author(s)
      Kurashima Y, et al
    • Journal Title

      Int J Cancer. 122(4)

      Pages: 823-31

    • Related Report
      2009 Final Research Report
  • [Journal Article] R ole of metallothionein in Helicobacter pylori-positive gastric mucosa with or without early gastric cancer and the effect on its expression after eradication therapy.2008

    • Author(s)
      Mitani T, et al
    • Journal Title

      J Gastroenterol Hepatol. 23(8Pt2)

      Pages: 334-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] Helicobacter pylori CagA protein induces gastrointestinal carcinoma and leukemias in mice.2008

    • Author(s)
      Ohnishi N
    • Journal Title

      Proceedings of the National Academy of Sciencesof the United States of America 105

      Pages: 1003-1008

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of beta-catenin signal by Heiicobacter pylori CagA requires the CagA-multimerization sequence2008

    • Author(s)
      Kurashima Y
    • Journal Title

      International Journal of Cancer 122

      Pages: 823-831

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.2008

    • Author(s)
      Ohnishi N
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 1003-1008

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence.2008

    • Author(s)
      Kurashima Y
    • Journal Title

      Int J Cancer 122

      Pages: 823-831

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C hanging antimicrobial susceptibility epidemiology of Helicobacter pylori strains in Japan between 2002 and 2005.2007

    • Author(s)
      Kobayashi I, et al
    • Journal Title

      J Clin Microbiol. 45(12)

      Pages: 4006-10

    • Related Report
      2009 Final Research Report
  • [Journal Article] H elicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.2007

    • Author(s)
      Saadat I, et al
    • Journal Title

      Nature. 447(7142)

      Pages: 330-3

    • Related Report
      2009 Final Research Report
  • [Journal Article] H elicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.2007

    • Author(s)
      Matsumoto Y, et al
    • Journal Title

      Nat Med. 13(4)

      Pages: 470-6

    • Related Report
      2009 Final Research Report
  • [Journal Article] E ast Asian-type Helicobacter pylori cytotoxin-associated gene A protein has a more significant effect on growth of rat gastric mucosal cells than the Western type.2007

    • Author(s)
      Fu HY, et al
    • Journal Title

      Gastroenterol Hepatol. 22(3)

      Pages: 355-62

    • Related Report
      2009 Final Research Report
  • [Journal Article] H elicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells.2007

    • Author(s)
      Murata-Kamiya N, et al
    • Journal Title

      Oncogene. 26(32)

      Pages: 4617-26

    • Related Report
      2009 Final Research Report
  • [Journal Article] Helicobacter pylori CagA targets PAR-1/MARK kinase to disrupt epithelial cell polarity.2007

    • Author(s)
      Saadat I
    • Journal Title

      Nature 447

      Pages: 330-333

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] I nfection of less virulent Helicobacter pylori strains in asymptomatic healthy individuals in Thailand as a potential contributing factor to the Asian enigma

    • Author(s)
      Hirai I, et al
    • Journal Title

      Microbes Infect

    • Related Report
      2009 Final Research Report
  • [Journal Article] Infection of less virulent Helicobacter pylori strains in asymptomatic healthy individuals in Thailand as a potential contributing factor to the Asian enigma

    • Author(s)
      Hirai I, et al.
    • Journal Title

      Microbes Infect. (in press(掲載確定))

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of cagA in H. pylori infection2009

    • Author(s)
      田中擴址, ら
    • Organizer
      第14回国際粘膜免疫学会
    • Place of Presentation
      ボストン
    • Related Report
      2009 Final Research Report
  • [Presentation] CagA分子多型と胃発癌2008

    • Author(s)
      田中擴址, ら
    • Organizer
      第16回JDDW
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] CagA分子多型と胃発癌2007

    • Author(s)
      田中擴址, ら
    • Organizer
      第3回消化管学会総会学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] The relationship between cagA diversity and gastric cancer2007

    • Author(s)
      田中擴址, ら
    • Organizer
      第13回国際粘膜免疫学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] CagA分子多型と胃発癌2007

    • Author(s)
      田中擴址, ら
    • Organizer
      第15回JDDW
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Remarks] 海外研究協力者とは平成20-21年度において年1回来日し、研究打ち合わせを続けているとともに、若手研究者を受け入れ技術指導も行っている。ホームページを作成し、インターネット上で研究成果を社会・国民に発信した。また、一般の人を対象に市民公開講座を設け、研究成果を公開するとともに、H. pylori感染に対して啓蒙活動を行った

    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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