Neuronal mechanisms for determination of basic respiratory cycle by dual rhythm generators in the medulla
Project/Area Number |
19500277
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | Showa University |
Principal Investigator |
ONIMARU Hiroshi Showa University, 医学部・第二生理, 准教授 (30177258)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 呼吸リズム / 傍顔面呼吸ニューロン / 延髄 / 呼吸中枢 / 中枢化学受容 / Phox2b / 呼吸リズム形成 / 神経科学 / 脳・神経 / プレベッチンガー / 新生ラット / 摘出脳標本 / 顔面神経核 |
Research Abstract |
Two distinct neuronal networks ; the pre-Botzinger complex (pre-BotC) and the parafacial respiratory group (pFRG), in the ventrolateral medulla (VLM) are involved in respiratory rhythm generation. In the present study, we have studied the neuronal mechanisms for determination of basic respiratory rhythm by interaction between these neuron groups. We found that the pFRG is necessary for postnatal survival because of its involvement in rhythm generation and central chemoreception in the neonatal system.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column.2007
Author(s)
Iigaya K, Kumagai H, Onimaru H, Kawai A, Oshima N, Onami T, Takimoto C, Kamayachi T, Hayashi K, Saruta T, Itoh H.
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Journal Title
Am J Physiol Regul Integr Comp Physiol. 292
Related Report
Peer Reviewed
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