Inhibitory and excitatory neuronal networks in the motor-related cortices of the primate

• Project/Area Number: 19500301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Nihon University
• Principal Investigator: YAMASHITA Akiko Nihon University, 医学部, 講師 (30246889)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 神経科学 / 脳・神経 / 解剖学 / 細胞・組織 / 生理学 / 興奮性錐体細胞 / GABA抑制細胞 / GAP結合(電気的シナプス) / パルブアルブミン細胞 / バスケット細胞 / 霊長類 / forward皮質間投射 / feedback皮質間投射 / GAP結合 / ミトコンドリア / 抑制性細胞 / 錐体細胞 / 大脳皮質 / GABA細胞 / 領野間投射

Research Abstract

In the cortex of the rats and cat, parvalbumin (PV) containing GABA inhibitory cells connected each other by gap junction (electric synapses). Thirty to fifty junctions were reported to exist on the dendrites of a PV cell in the cats. In the cortex of the monkey, on the other hand, only several gap junctions were observed on dendrites of each PV cells. PV cells were also known to have basket terminals on the excitatory pyramidal cells. A higher density of PV-containing basket terminals was observed on the pyramidal cells in the primate cortex than in the rodent. In the cortex of the primate, inhibitory cells inhibit the excitatory pyramidal cells stronger than in the cortex of the rodents.

Research Products

• [Journal Article] Amyloid beta (As) Proteinand Amyloid Precursor Protein (APP)-immunoreactive Structures in the Brains of Aged Tree Shrews (2010)
  • Author(s): Yamashita, A., Fuchs, E., Taira, M., Hayashi, M.
  • Journal Title: Current Aging Science (印刷中)
  • Peer Reviewed
• [Journal Article] Functional and histological properties of caudal intraparietal area of macaque monkey (2010)
  • Author(s): Katsuyama, N., Yamashita, A., Sawada, K., Naganuma, T., Sakata, H., Taira, M.
  • Journal Title: Neuroscience 167 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Functional and histological properties of caudal intraparietal area of macaque monkey (2010)
  • Author(s): Katsuyama, N.
  • Journal Title: Neuroscience 167 Pages: 1-10
  • Peer Reviewed
• [Journal Article] c-fos expression after chronic electrical stimulation of sensorimotor cortex in rats (2008)
  • Author(s): Shijo, K., Katayama, Y., Yamashita, A., Kobayashi, K., Oshima, H., Fukaya, C., Yamamoto, T.
  • Journal Title: Neuromodulation 11 Pages: 187-195
  • NAID: 10024368999
  • Peer Reviewed
• [Journal Article] 大脳皮質頭頂連合野から一次運動野への多シナプス性投射様式-狂犬病ウイルスを用いた研究- (2008)
  • Author(s): 澤田香織, 宮地重弘, 山下晶子, 今西美知子, 勝山成美, 泰羅雅登, 高田昌彦
  • Journal Title: 日本医学雑誌 67 Pages: 115-122
  • NAID: 10024169926
  • Peer Reviewed
• [Journal Article] Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys. (2008)
  • Author(s): Murata, Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M., Yamane, S.
  • Journal Title: Journal of Neurophysiology 99 Pages: 773-786
  • Peer Reviewed
• [Journal Article] Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys. (2008)
  • Author(s): Murata, Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M., Yamane, S
  • Journal Title: Journal of Neurophysiology 99 Pages: 773-786
  • Peer Reviewed
• [Journal Article] c-fos expression after chronic electrical stimulation of sensorimotor cortex in rats. (2008)
  • Author(s): Shijo, K., Katayama, Y., Yamashita, A., Kobayashi, K., Oshima, H., Fukaya, C., Yamamoto, T.
  • Journal Title: Neuromodulation 11 Pages: 115-122
  • NAID: 10024368999
  • Peer Reviewed
• [Journal Article] Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys (2008)
  • Author(s): Murata, Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M., Yamane, S.
  • Journal Title: Journal of Neurophysiology 99 Pages: 773-786
  • Peer Reviewed
• [Journal Article] Expression of protein kinase-C substrate mRNA in the motor cortex of adult and infant macaque monkeys (2007)
  • Author(s): Higo, N., Oishi, T., Yamashita, A., Murata, Y., Matsuda, K., Hayashi, M.
  • Journal Title: Brain Research 1171 Pages: 30-41
  • Peer Reviewed
• [Journal Article] Expression of protein kinase-C substrate mRNA in the motor cortex of adult and infant macaque monkeys (2007)
  • Author(s): Higo, N., Oishi, T., Yamashita, A., Murata, Y., Matsuda, K, Hayashi, M.
  • Journal Title: Brain Research 1171 Pages: 30-41
  • Peer Reviewed
• [Journal Article] 大脳皮質への長期慢性電気刺激による神経修飾効果:ラットモデルにおけるc-Fos蛋白の発現を用いた検討 (2007)
  • Author(s): 四條克倫、小林一太、大島秀規、山下晶子、深谷親、山本隆充、片山容一
  • Journal Title: 機能的脳神経外科 46 Pages: 159-165
  • NAID: 10024369361
  • Peer Reviewed
• [Presentation] Parvalbumin/GABA cells in the monkey cerebral cortex: gap junctions, chandelier- and basket-terminals. (2009)
  • Author(s): Yamashita, A., Taira, M., Oishi, T, Hayashi, M.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Parvalbumin/GABA cells in the monkey cerebral cortex : gapjunctions, chandelier- and basket-terminals (2009)
  • Author(s): Akiko Yamashita
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Reaction of neurons and glias by chronic cortical stimulation in rats: neurogenesis and morphological changes in astroglias. (2009)
  • Author(s): Yamashita, A., Morishita, T., Shijo, K, Kobayashi, K, Oshima, H., Fukaya, C., Takamitsu Yamamoto Yoichi Katayama
  • Organizer: XXXVI International Congress of Physiological Science
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Reaction of neurons and glias by chronic cortical stimulation in rats : neurogenesis and morphological changes in astroglias (2009)
  • Author(s): Akiko Yamashita
  • Organizer: XXXVI International Congress of Physiological Science
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] 大脳皮質細胞の発達過程における変遷 : 抑制性介在細胞を中心に (2009)
  • Author(s): 山下晶子
  • Organizer: 京都大学霊長類研究所2008年度共同利用研究会
  • Place of Presentation: 愛知
  • Year and Date: 2009-03-06
• [Presentation] ラットのsensorimotor cortexに対する長期慢性電気刺激 : c-fos蛋白を用いた検討 (2009)
  • Author(s): 四條克倫, 小林一太, 大島秀規, 山下晶子, 深谷親, 山本隆充, 片山容一
  • Organizer: 第48回日本定位・機能神経外科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-23
• [Presentation] Cortical connections of caudal intraparietal area (CIP) in macaque monkeys. (2008)
  • Author(s): 勝山成美, 山下晶子, 沢田香織, 佐藤〓也, 海野俊平, 泰羅雅登
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] Amyloid s-immunoreactive structures in the brain of aged tree shrews (2008)
  • Author(s): 山下晶子, Fuchs, E., 泰羅雅登, 林基治
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Organization of multisynaptic projections from posterior parietal cortex to primary motor cortex in macaque monkeys. (2008)
  • Author(s): 沢田香織, 宮地重弘, 山下晶子, 勝山成美, 今西美智子, 黒田呈子, 泰羅雅登, 高田昌彦
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Cortical connections of caudal intraparietal area (CIP)in macaque monkeys. (2008)
  • Author(s): 勝山成美, 山下晶子, 沢田香織, 佐藤〓也, 海野俊平, 泰羅雅登
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Amyloid β-immunoractive structures in the brain of aged tree shrews. (2008)
  • Author(s): 山下晶子, Fuchs, E., 泰羅雅登, 林基治
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] ラットのsensorimotor cortexに対する長期慢性電気刺激によるグリア細胞の変化 (2008)
  • Author(s): 森下登史, 四條克倫, 加納利和, 小林一太, 大島秀規, 山下晶子, 深谷親, 山本隆充, 片山容一
  • Organizer: 第47回日本定位・機能神経外科学会
  • Place of Presentation: 浜松
  • Year and Date: 2008-01-26
• [Presentation] 慢性電気刺激が神経系に及ぼす長期的作用 -ラットモデルでの検討- (2008)
  • Author(s): 山下晶子、森下登史、四條克倫、小林一太、大島秀規、深谷親、山本隆充、片山容一
  • Organizer: 第47回日本定位・機能神経外科学会
  • Place of Presentation: 浜松
  • Year and Date: 2008-01-26
• [Presentation] Effects of motor training on the recovery of hand movemetn after primary motor cortex damage: what can be recovered and what cannot be recovered (2007)
  • Author(s): Murata、 Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M
  • Organizer: 37th Annual meeting Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-07
• [Presentation] Effects of motor training on the recovery of hand movement after primary motor cortex damage: what can be recovered and what cannot be recovered (2007)
  • Author(s): Murata、Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M.
  • Organizer: 37th Annual meeting Society for Neuroscience, San Diego
  • Place of Presentation: Society for Neuroscience Abstracts 33 (2007)
  • Year and Date: 2007-11-05
• [Presentation] Characterization of GAP-43 immunoreactive structures with neurotransmitter in the anterior horn of the macaque spinal cord (2007)
  • Author(s): Oishi, T., Higo, N., Yamashita A., Murata. Y., Matsuda, K., Hayashi, M
  • Organizer: 37th Annual meeting Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-05
• [Presentation] Characterization of GAP-43 immunoreactive structures with neurotransmitter in the anterior horn of the macaque spinal cord (2007)
  • Author(s): Oishi, T., Higo, N., Yamashita A., Murata. Y., Matsuda, K., Hayashi, M.
  • Organizer: 37th Annual meeting Society for Neuroscience, San Diego
  • Place of Presentation: Society for Neuroscience Abstracts 33 (2007)
  • Year and Date: 2007-11-04
• [Presentation] Somatostatin-immunoreactive degenerating structures in prefrontal cortex of aged tree shrews (Tupaia) and macaque monkeys (2007)
  • Author(s): Yamashita, A., Shimizu, K., Fuchs, E., Hayashi, M., Taira, M.
  • Organizer: 第30回日本神経科学
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Somatostatin-immunoreactive degenerating structures in prefrontal cortex of aged tree shrews(Tupaia)and macaque monkeys (2007)
  • Author(s): Yamashita, A., Shimizu, K., Fuchs, E., Hayashi, M., Taira, M.
  • Organizer: 第30回日本神経科学
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 成熟期と老齢期のツパイ海馬体におけるBDNFとTrkBの免疫陽性構造 (2007)
  • Author(s): 林基治, 山下晶子, 清水慶子, Fuchs, E., 泰羅雅登
  • Organizer: 第23回日本霊長類学会
  • Place of Presentation: 彦根
  • Year and Date: 2007-07-14
• [Presentation] 第一次運動野損傷後の運動機能回復:行動学および組織化学的検証 (2007)
  • Author(s): 肥後範行、村田弓、大石高生、山下晶子、松田圭司、林基治
  • Organizer: 生理学研究所Motor Control研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2007-06-29
• [Presentation] 脊髄運動系におけるGAP-43免疫陽性構造 (2007)
  • Author(s): 大石高生、肥後範行、山下晶子、村田弓、西村幸男、松田圭司、林基治、伊佐正
  • Organizer: 生理学研究所Motor Control研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2007-06-29
• [Presentation] Long-term effects of STN-DBS: nigral cell degeneration and glial reactions in cortico-thalamo-basal ganglia system (2007)
  • Author(s): Yamashita, A., Shijo, K., Kobayashi, K., Oshima, H., Fukaya, C., Yamamoto, T., Katayama, Y.
  • Organizer: The 6th Congress of Asian Society for Stereotactic Functional and Computer Assisted Neurosurgery
  • Place of Presentation: 静岡
  • Year and Date: 2007-05-24
• [Presentation] Long-term effects of STN-DBS: nigral cell degeneration and glial reactions in cortico-thalamo-basal ganglia system (2007)
  • Author(s): Yamashita, A., Shijo, K., Kobayashi, K., Oshima, H., Fukaya, C., Yamamoto, T., and Katayama, Y.
  • Organizer: The 6th Congress of Asian Society for Stereotactic Functional and Computer Assisted Neurosurgery
  • Place of Presentation: 富士吉田
  • Year and Date: 2007-05-24
• [Presentation] ラットのsensorimotor cortex長期慢性電気刺激によるニューロンおよびグリア細胞におけるc-fos蛋白の発現 (2007)
  • Author(s): 山下晶子, 四條克倫, 森下登史, 小林一太, 大島秀規, 深谷親, 山本隆充, 片山容一
  • Organizer: 第23回日本ニューロモデュレーション学会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-12