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Inhibitory and excitatory neuronal networks in the motor-related cortices of the primate

Research Project

Project/Area Number 19500301
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionNihon University

Principal Investigator

YAMASHITA Akiko  Nihon University, 医学部, 講師 (30246889)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経科学 / 脳・神経 / 解剖学 / 細胞・組織 / 生理学 / 興奮性錐体細胞 / GABA抑制細胞 / GAP結合(電気的シナプス) / パルブアルブミン細胞 / バスケット細胞 / 霊長類 / forward皮質間投射 / feedback皮質間投射 / GAP結合 / ミトコンドリア / 抑制性細胞 / 錐体細胞 / 大脳皮質 / GABA細胞 / 領野間投射
Research Abstract

In the cortex of the rats and cat, parvalbumin (PV) containing GABA inhibitory cells connected each other by gap junction (electric synapses). Thirty to fifty junctions were reported to exist on the dendrites of a PV cell in the cats. In the cortex of the monkey, on the other hand, only several gap junctions were observed on dendrites of each PV cells. PV cells were also known to have basket terminals on the excitatory pyramidal cells. A higher density of PV-containing basket terminals was observed on the pyramidal cells in the primate cortex than in the rodent. In the cortex of the primate, inhibitory cells inhibit the excitatory pyramidal cells stronger than in the cortex of the rodents.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (37 results)

All 2010 2009 2008 2007

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (25 results)

  • [Journal Article] Amyloid beta (As) Proteinand Amyloid Precursor Protein (APP)-immunoreactive Structures in the Brains of Aged Tree Shrews2010

    • Author(s)
      Yamashita, A., Fuchs, E., Taira, M., Hayashi, M.
    • Journal Title

      Current Aging Science (印刷中)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional and histological properties of caudal intraparietal area of macaque monkey2010

    • Author(s)
      Katsuyama, N., Yamashita, A., Sawada, K., Naganuma, T., Sakata, H., Taira, M.
    • Journal Title

      Neuroscience 167

      Pages: 1-10

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional and histological properties of caudal intraparietal area of macaque monkey2010

    • Author(s)
      Katsuyama, N.
    • Journal Title

      Neuroscience 167

      Pages: 1-10

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-fos expression after chronic electrical stimulation of sensorimotor cortex in rats2008

    • Author(s)
      Shijo, K., Katayama, Y., Yamashita, A., Kobayashi, K., Oshima, H., Fukaya, C., Yamamoto, T.
    • Journal Title

      Neuromodulation 11

      Pages: 187-195

    • NAID

      10024368999

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大脳皮質頭頂連合野から一次運動野への多シナプス性投射様式-狂犬病ウイルスを用いた研究-2008

    • Author(s)
      澤田香織, 宮地重弘, 山下晶子, 今西美知子, 勝山成美, 泰羅雅登, 高田昌彦
    • Journal Title

      日本医学雑誌 67

      Pages: 115-122

    • NAID

      10024169926

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys.2008

    • Author(s)
      Murata, Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M., Yamane, S.
    • Journal Title

      Journal of Neurophysiology 99

      Pages: 773-786

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys.2008

    • Author(s)
      Murata, Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M., Yamane, S
    • Journal Title

      Journal of Neurophysiology 99

      Pages: 773-786

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-fos expression after chronic electrical stimulation of sensorimotor cortex in rats.2008

    • Author(s)
      Shijo, K., Katayama, Y., Yamashita, A., Kobayashi, K., Oshima, H., Fukaya, C., Yamamoto, T.
    • Journal Title

      Neuromodulation 11

      Pages: 115-122

    • NAID

      10024368999

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys2008

    • Author(s)
      Murata, Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M., Yamane, S.
    • Journal Title

      Journal of Neurophysiology 99

      Pages: 773-786

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of protein kinase-C substrate mRNA in the motor cortex of adult and infant macaque monkeys2007

    • Author(s)
      Higo, N., Oishi, T., Yamashita, A., Murata, Y., Matsuda, K., Hayashi, M.
    • Journal Title

      Brain Research 1171

      Pages: 30-41

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of protein kinase-C substrate mRNA in the motor cortex of adult and infant macaque monkeys2007

    • Author(s)
      Higo, N., Oishi, T., Yamashita, A., Murata, Y., Matsuda, K, Hayashi, M.
    • Journal Title

      Brain Research 1171

      Pages: 30-41

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大脳皮質への長期慢性電気刺激による神経修飾効果:ラットモデルにおけるc-Fos蛋白の発現を用いた検討2007

    • Author(s)
      四條克倫、小林一太、大島秀規、山下晶子、深谷親、山本隆充、片山容一
    • Journal Title

      機能的脳神経外科 46

      Pages: 159-165

    • NAID

      10024369361

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Parvalbumin/GABA cells in the monkey cerebral cortex: gap junctions, chandelier- and basket-terminals.2009

    • Author(s)
      Yamashita, A., Taira, M., Oishi, T, Hayashi, M.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Parvalbumin/GABA cells in the monkey cerebral cortex : gapjunctions, chandelier- and basket-terminals2009

    • Author(s)
      Akiko Yamashita
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reaction of neurons and glias by chronic cortical stimulation in rats: neurogenesis and morphological changes in astroglias.2009

    • Author(s)
      Yamashita, A., Morishita, T., Shijo, K, Kobayashi, K, Oshima, H., Fukaya, C., Takamitsu Yamamoto Yoichi Katayama
    • Organizer
      XXXVI International Congress of Physiological Science
    • Place of Presentation
      京都
    • Year and Date
      2009-07-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Reaction of neurons and glias by chronic cortical stimulation in rats : neurogenesis and morphological changes in astroglias2009

    • Author(s)
      Akiko Yamashita
    • Organizer
      XXXVI International Congress of Physiological Science
    • Place of Presentation
      京都
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大脳皮質細胞の発達過程における変遷 : 抑制性介在細胞を中心に2009

    • Author(s)
      山下晶子
    • Organizer
      京都大学霊長類研究所2008年度共同利用研究会
    • Place of Presentation
      愛知
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットのsensorimotor cortexに対する長期慢性電気刺激 : c-fos蛋白を用いた検討2009

    • Author(s)
      四條克倫, 小林一太, 大島秀規, 山下晶子, 深谷親, 山本隆充, 片山容一
    • Organizer
      第48回日本定位・機能神経外科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-01-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cortical connections of caudal intraparietal area (CIP) in macaque monkeys.2008

    • Author(s)
      勝山成美, 山下晶子, 沢田香織, 佐藤〓也, 海野俊平, 泰羅雅登
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Amyloid s-immunoreactive structures in the brain of aged tree shrews2008

    • Author(s)
      山下晶子, Fuchs, E., 泰羅雅登, 林基治
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Organization of multisynaptic projections from posterior parietal cortex to primary motor cortex in macaque monkeys.2008

    • Author(s)
      沢田香織, 宮地重弘, 山下晶子, 勝山成美, 今西美智子, 黒田呈子, 泰羅雅登, 高田昌彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Cortical connections of caudal intraparietal area (CIP)in macaque monkeys.2008

    • Author(s)
      勝山成美, 山下晶子, 沢田香織, 佐藤〓也, 海野俊平, 泰羅雅登
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Amyloid β-immunoractive structures in the brain of aged tree shrews.2008

    • Author(s)
      山下晶子, Fuchs, E., 泰羅雅登, 林基治
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットのsensorimotor cortexに対する長期慢性電気刺激によるグリア細胞の変化2008

    • Author(s)
      森下登史, 四條克倫, 加納利和, 小林一太, 大島秀規, 山下晶子, 深谷親, 山本隆充, 片山容一
    • Organizer
      第47回日本定位・機能神経外科学会
    • Place of Presentation
      浜松
    • Year and Date
      2008-01-26
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 慢性電気刺激が神経系に及ぼす長期的作用 -ラットモデルでの検討-2008

    • Author(s)
      山下晶子、森下登史、四條克倫、小林一太、大島秀規、深谷親、山本隆充、片山容一
    • Organizer
      第47回日本定位・機能神経外科学会
    • Place of Presentation
      浜松
    • Year and Date
      2008-01-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of motor training on the recovery of hand movemetn after primary motor cortex damage: what can be recovered and what cannot be recovered2007

    • Author(s)
      Murata、 Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M
    • Organizer
      37th Annual meeting Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of motor training on the recovery of hand movement after primary motor cortex damage: what can be recovered and what cannot be recovered2007

    • Author(s)
      Murata、Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M.
    • Organizer
      37th Annual meeting Society for Neuroscience, San Diego
    • Place of Presentation
      Society for Neuroscience Abstracts 33 (2007)
    • Year and Date
      2007-11-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Characterization of GAP-43 immunoreactive structures with neurotransmitter in the anterior horn of the macaque spinal cord2007

    • Author(s)
      Oishi, T., Higo, N., Yamashita A., Murata. Y., Matsuda, K., Hayashi, M
    • Organizer
      37th Annual meeting Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Characterization of GAP-43 immunoreactive structures with neurotransmitter in the anterior horn of the macaque spinal cord2007

    • Author(s)
      Oishi, T., Higo, N., Yamashita A., Murata. Y., Matsuda, K., Hayashi, M.
    • Organizer
      37th Annual meeting Society for Neuroscience, San Diego
    • Place of Presentation
      Society for Neuroscience Abstracts 33 (2007)
    • Year and Date
      2007-11-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Somatostatin-immunoreactive degenerating structures in prefrontal cortex of aged tree shrews (Tupaia) and macaque monkeys2007

    • Author(s)
      Yamashita, A., Shimizu, K., Fuchs, E., Hayashi, M., Taira, M.
    • Organizer
      第30回日本神経科学
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Somatostatin-immunoreactive degenerating structures in prefrontal cortex of aged tree shrews(Tupaia)and macaque monkeys2007

    • Author(s)
      Yamashita, A., Shimizu, K., Fuchs, E., Hayashi, M., Taira, M.
    • Organizer
      第30回日本神経科学
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 成熟期と老齢期のツパイ海馬体におけるBDNFとTrkBの免疫陽性構造2007

    • Author(s)
      林基治, 山下晶子, 清水慶子, Fuchs, E., 泰羅雅登
    • Organizer
      第23回日本霊長類学会
    • Place of Presentation
      彦根
    • Year and Date
      2007-07-14
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 第一次運動野損傷後の運動機能回復:行動学および組織化学的検証2007

    • Author(s)
      肥後範行、村田弓、大石高生、山下晶子、松田圭司、林基治
    • Organizer
      生理学研究所Motor Control研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脊髄運動系におけるGAP-43免疫陽性構造2007

    • Author(s)
      大石高生、肥後範行、山下晶子、村田弓、西村幸男、松田圭司、林基治、伊佐正
    • Organizer
      生理学研究所Motor Control研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Long-term effects of STN-DBS: nigral cell degeneration and glial reactions in cortico-thalamo-basal ganglia system2007

    • Author(s)
      Yamashita, A., Shijo, K., Kobayashi, K., Oshima, H., Fukaya, C., Yamamoto, T., Katayama, Y.
    • Organizer
      The 6th Congress of Asian Society for Stereotactic Functional and Computer Assisted Neurosurgery
    • Place of Presentation
      静岡
    • Year and Date
      2007-05-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Long-term effects of STN-DBS: nigral cell degeneration and glial reactions in cortico-thalamo-basal ganglia system2007

    • Author(s)
      Yamashita, A., Shijo, K., Kobayashi, K., Oshima, H., Fukaya, C., Yamamoto, T., and Katayama, Y.
    • Organizer
      The 6th Congress of Asian Society for Stereotactic Functional and Computer Assisted Neurosurgery
    • Place of Presentation
      富士吉田
    • Year and Date
      2007-05-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラットのsensorimotor cortex長期慢性電気刺激によるニューロンおよびグリア細胞におけるc-fos蛋白の発現2007

    • Author(s)
      山下晶子, 四條克倫, 森下登史, 小林一太, 大島秀規, 深谷親, 山本隆充, 片山容一
    • Organizer
      第23回日本ニューロモデュレーション学会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-12
    • Related Report
      2009 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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