Preparation of Poly (lactic acid) Stereocomplex Scaffold Materials

• Project/Area Number: 19500404
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Toyohashi University of Technology
• Principal Investigator: TSUJI Hideto Toyohashi University of Technology, 工学部, 教授 (60227395)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: ポリ乳酸 / ポリラクチド / ステレオコンプレックス / 再生医療 / 再生足場材料 / 医用材料 / 生分解性高分子 / 生分解性ポリエステル

Research Abstract

Optically active poly (lactic acid) s and substituted poly (lactic acid) s were synthesized and their homo- and hetero-stereocomlexation behavior, the optimal conditions for stereocomplexation, and the hydrolytic degradation behavior of stereocomplexed blends were investigated. The basic and crucial information for the preparation of poly (lactic acid) stereocomplex scaffold materials has been accumulated in this study.

Research Products

• [Journal Article] Accelerated Hydrolytic Degradation of Poly(Llactide)/ Poly(D-lactide) Stereocomplex up to Late Stage (2010)
  • Author(s): Hideto Tsuji, Tomonori Tsuruno
  • Journal Title: Polymer Degradation and Stability vol.95,No.4 Pages: 477-484
  • Peer Reviewed
• [Journal Article] Hetero-Stereocomplexation between Biodegradable and Optically Active Polyesters as a Versatile Preparation Method for Biodegradable Materials (2010)
  • Author(s): Hideto Tsuji, Satomi Yamamoto, Ayaka Okumura, Yu Sugiura
  • Journal Title: Biomacromolecules Vol.11,No.1 Pages: 252-258
  • Peer Reviewed
• [Journal Article] Accelerated Hydrolytic Degradation of Poly (L-lactide)/Poly(D-lactide) Stereocomplex up to Late Stage (2010)
  • Author(s): Hideto Tsuji, Tomonori Tsuruno
  • Journal Title: Polymer Degradation and Stability 95 Pages: 477-484
  • Peer Reviewed
• [Journal Article] Hetero-Stereocomplexation between Biodegradable and Optically Active Polyesters as a Versatile Preparation Method for Biodegradable Materials (2010)
  • Author(s): Hideto Tsuji, Satomi Yamamoto, Ayaka Okumura, Yu Sugiura
  • Journal Title: Biomacromolecules 11 Pages: 252-258
  • Peer Reviewed
• [Journal Article] Stereocomplex Formation between Enantiomeric Substituted Poly(lactide)s: Blends of Poly[(S)-2-hydroxybutyrate] and Poly[(R)-2-hydroxybutyrate] (2009)
  • Author(s): Hideto Tsuji, Ayaka Okumura
  • Journal Title: Macromolecules Vol.42,No.19 Pages: 7263-7266
  • Peer Reviewed
• [Journal Article] Stereocomplex Crystallization and Spherulite Growth of Low-Molecular-Weight Poly(L-lactide) and Poly(D-lactide) from the Melt (2009)
  • Author(s): Leevameng Bouapao, Hideto Tsuji
  • Journal Title: Macromolecular Chemistry and Physics Vol.210,No.12 Pages: 993-1002
  • Peer Reviewed
• [Journal Article] Stereocomplex Formation between Enantiomeric Substituted Poly (lactide) s : Blends of Poly [(S)-2-hydroxybutyrate] and Poly [(R)-2-hydroxybutyrate] (2009)
  • Author(s): Hideto Tsuji, Ayaka Okumura
  • Journal Title: Macromolecules 42 Pages: 7263-7266
  • Peer Reviewed
• [Journal Article] Stereoselective Interaction between Isotactic and Optically Active Poly(lactic acid) and Phenyl-Substituted Poly(lactic acid) (2008)
  • Author(s): Hideto Tsuji, Hiroshi Matsuoka
  • Journal Title: Macromolecular Rapid Communications Vol.29,No.16 Pages: 1372-1377
  • Peer Reviewed
• [Journal Article] Synthesis, Physical Properties, and Crystallization of Optically Active Poly(Lphenyllactic acid) and Poly(L-phenyllactic acid-co-L-lactic acid) (2008)
  • Author(s): Hideto Tsuji, Hiroshi Matsuoka, Shinichi Itsuno
  • Journal Title: Journal of Applied Polymer Science Vol.110,No.6 Pages: 3954-3962
  • Peer Reviewed
• [Journal Article] Stereoselective Interaction between Isotactic and Optically Active Poly (lactic acid) and Phenyl-Substituted Poly(lactic acid) (2008)
  • Author(s): Hideto Tsuji, Hiroshi Matsuoka
  • Journal Title: Macromolecular Rapid Communications 29 Pages: 1372-1377
  • Peer Reviewed
• [Journal Article] Synthesis, physical properties, and crystallization of optically active poly(L-phenyllactic acid) and poly(L-phenyl lactic acid-co-L-lactic acid) (2008)
  • Author(s): Hideto Tsuji, Hiroshi Matsuoka, Shinichi Itsuno
  • Journal Title: Journal of Applied Polymer Science 110 Pages: 3954-3962
  • Peer Reviewed
• [Journal Article] Investigation of Phase Transitional Behavior of Poly(Llactide)/ Poly(D-lactide) Blend Used to Prepare the Highly-Oriented Stereocomplex (2007)
  • Author(s): Jianming Zhang, Kohji Tashiro, Hideto Tsuji, Abraham J. Domb
  • Journal Title: Macromolecules Vol.40,No.4 Pages: 1049-1054
  • Peer Reviewed
• [Journal Article] Investigation of Phase Transitional Behavior of Poly(L-lactide)/Poly (D-lactide) Blend Used to Prepare the Highly-Oriented Stereocomplex (2007)
  • Author(s): Jianming Zhang, Koji Tashiro, Hldeto Tsuji, Abraham J.Domb
  • Journal Title: Macromolecules 40 Pages: 1049-1054
  • Peer Reviewed
• [Presentation] 光学活性ポリ(フェニル乳酸)とポリ(フェニル乳酸-乳酸)の合成・特性および光学活性ポリ乳酸との立体特異的相互作用 (2008)
  • Author(s): 辻秀人, 松岡浩史, 伊津野真一
  • Organizer: 高分子学会討論会
  • Place of Presentation: 大阪市立大学(大阪市)
  • Year and Date: 2008-09-24
• [Presentation] 反復キャスト法による高分子量ポリ乳酸のステレオコンプレックス形成の促進 (2008)
  • Author(s): 山本聡美, 辻秀人
  • Organizer: 高分子学会年次大会
  • Place of Presentation: 京都国際会館(京都市)
  • Year and Date: 2008-05-28
• [Presentation] ポリ乳酸およびそのステレオコンプレックスの結晶弾性率 (2008)
  • Author(s): 西野孝, 小寺賢, 木本真之, 辻秀人, 若木裕之, 成田淳一
  • Organizer: 高分子学会年次大会, 高分子学会予稿集
• [Presentation] 反復キャスト法による高分子量ポリ乳酸のステレオコンプレックス形成の促進 (2008)
  • Author(s): 山本聡美, 辻秀人
  • Organizer: 高分子学会年次大会, 高分子学会予稿集
• [Presentation] 光学活性ポリ(フェニル乳酸)とポリ(フェニル乳酸-乳酸)の合成・特性および光学活性ポリ乳酸との立体特異的相互作用 (2008)
  • Author(s): 辻秀人, 松岡浩史, 伊津野真一
  • Organizer: 高分子学会予稿集
• [Presentation] 高性能化ポリ乳酸繊維およびフィルム (2007)
  • Author(s): 辻秀人
  • Organizer: 繊維学会予稿集
• [Presentation] ポリ乳酸ステレオコンプレックスにおける分子鎖間相互作用の検討 (2007)
  • Author(s): 田代孝二, 辻秀人, 張建明
  • Organizer: 高分子討論会予稿集
• [Presentation] 高分子量ポリ(L-ラクチド)/ポリ(D-ラクチド)ブレンドにおけるホモ結晶化および球晶成長挙動 (2007)
  • Author(s): Bouapao Leevameng, 田代孝二, 辻秀人, Zhang Jianming
  • Organizer: 高分子討論会予稿集
• [Presentation] ポリ乳酸ステレオコンプレックスの水蒸気透過性 (2007)
  • Author(s): 鶴野智徳, 辻秀人
  • Organizer: 高分子学会年次大会, 高分子学会予稿集
• [Book] Poly (lactic acid) : Synthesis, structures, properties, processing and applications (2010)
  • Author(s): Hideto Tsuji
  • Publisher: Wiley(印刷中)
• [Book] ポリ乳酸-植物由来プラスチックの基礎と応用- (2008)
  • Author(s): 辻 秀人
  • Total Pages: 232
  • Publisher: 米田出版
• [Book] "Stereocomplex between Enantiomeric Poly(lactide)s", in "Biodegradable Polymer Blends and Composites from Renewable Resources" (L. Yu, Ed., Wiley) (2008)
  • Author(s): Hideto Tsuji, Yoshito Ikada
• [Book] "Hydrolytic Degradation", in "Poly(lactic acid): Synthesis, structures, properties, processing and applications (Eds. R. Auras, L-T, Lim, S. Selke, H. Tsuji, Wiley)
  • Author(s): Hideto Tsuji
  • Publisher: (in press)
• [Patent(Industrial Property Rights)] ステレオコンプレックスポリエステル (2009)
  • Inventor(s): 辻 秀人, 奥村彩香, 山本聡美
  • Industrial Property Rights Holder: 国立大学法人豊橋技術科学大学
  • Industrial Property Number: 2009-200772
  • Filing Date: 2009-08-31
• [Patent(Industrial Property Rights)] ステレオコンプレックスポリエステル (2009)
  • Inventor(s): 辻秀人, 奥村彩香, 山本聡美
  • Industrial Property Rights Holder: 国立大学法人豊橋技術科学大学
  • Industrial Property Number: 2009-200772
  • Filing Date: 2009-08-31