| Project/Area Number |
19500464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KYUHOU Shinichi Kansai Medical University, 医学部, 准教授 (60195394)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Ryuichi 関西医科大学, 医学部, 助教 (70239002)
NAKAO Kazuko 関西医科大学, 医学部, 助教 (60351540)
雨夜 勇作 四條畷学園大学, リハビリテーション学部, 講師 (50353008)
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| Co-Investigator(Renkei-kenkyūsha) |
AMAYA Yusaku 四条畷学園大学, リハビリテーション学部, 講師 (50353008)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リハビリテーション医学 / 小脳 / BDNF / プロモーター / 運動失調 / 神経栄養因子 / エピジェネティックス / 可塑性 / TrkB |
|---|
| Research Abstract |
We investigated the restorative processes after the chronic and acute cerebellar damages. Firstly, the restorations after chronic cerebellar damages were assessed in the cerebellar neurodegenerative mutant mice. We found that neurodegeneration of cerebellar cells was partially prevented by inhibition of inflammation, using an antibiotic, minocycline. Secondly, the restoration after acute cerebellar damage was examined by ablation of unilateral cerebellar hemisphere in mice and rats. Acute cerebellar damage resulted in severe ataxia just after the lesion. However, prominent functional recoveries were observed within two weeks after the lesion. During the recovery period, marked upregulation of brain-derived neurotrophic factor (BDNF) was observed in motor cortex and remaining cerebellar hemisphere. Blocking the BDNF neurotransmission delayed the functional recoveries. Since it is generally accepted that BDNF is upregulated after rehabilitation (exercise) in the brain, BDNF expression in the cerebellum and motor cortex facilitated by some appropriate rehabilitations may promote the recoveries from the cerebellar damages.
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