| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
Skeletal muscle is an important tissue for glucose homeostasis. Although there are numerous physiological and pharmacological perturbations can increase glucose transport in skeletal muscle, the signaling mechanisms that lead to transport activations are still poorly defined. In the current study, we determined the effects of acute exposure of skeletal muscle to pharmacological agents that produce reactive oxygen spices (ROS) and then assessed potential signaling mechanisms that might mediate the effects of these agents on glucose transport. We found that the acute exposure of muscle to ROS is a potent stimulator of skeletal muscle glucose uptake, and that this occurs though the phosphorylation of AktThr^<308>.
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