| Project/Area Number |
19500605
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
IMAI Saeko 大阪府立大学, 総合リハビリテーション学部, 准教授 (00438235)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUI Michiaki 京都府立医科大学, 大学院・医学研究科・内分泌・代謝内科学, 講師 (30247829)
HASEGAWA Goji 京都府立医科大学, 大学院・医学研究科・内分泌・代謝内科学, 講師 (00295643)
KOZAI Hana 大阪府立大学, 総合リハビリテーション学部, 講師 (00382242)
MIYATANI Syuichi 大阪府立大学, 総合リハビリテーション学部, 教授 (50137311)
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| Co-Investigator(Renkei-kenkyūsha) |
KAJIYAMA Shizuo 京都府立医科大学, 大学院・医学研究科・内分泌・代謝内科学, 客員講師
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| Research Collaborator |
MSTSUDA Mikuko 梶山内科クリニック, 管理栄養士
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 糖尿病 / 栄養指導 / 遺伝子多型 / テーラーメイド栄養指導 / β3AR / UCP1 / MTHFR / AGT / 食事療法 / β3-AR / 遺伝子検査 / 宅配食 |
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| Research Abstract |
We investigated to determine the effects of tailor-made dietary intervention by using single nucleotide polymorphisms(SNPs) ofβ3AR(Trp64Arg), UCP1(-3826 A/G), AGT(M235T), and MTHFR(C677T) on clinical data in Japanese patients with type 2 diabetes mellitus(T2DM). The glycemic control, blood pressure and serum lipids levels were improved after the intervention. Since the majority of the patients had the SNPs ofβ3AR(Trp64Arg) and/or UCP1(-3826A/G) and/or AGT(M235T), the tailor-made dietary intervention should be considered thrifty genes and salt sensitive genes in Japanese patients with T2DM. However, these results suggest that important factors are not only SNPs but also smoking and dietary habits for dietary education in patients with T2DM.
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