Regulatory mechanism of hesperidin, a citrus flavonoid, in bone metabolism and prevention of osteoporosis
| Project/Area Number |
19500610
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Josai University |
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Principal Investigator |
CHIBA Hiroshige Josai University, 薬学部・医療栄養学科, 助教 (30337779)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨粗鬆症 / フラボノイド / ヘスペリジン / 骨密度 / 骨吸収 |
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| Research Abstract |
Among the naturally occurring citrus flavonoids, hesperidin, a flavanon glycoside, also regulates hepatic cholesterol synthesis by inhibiting the activity of 3-hydroxy-3-methylglutanyl coenzyme A (HMG-CoA) reductase. On the other hand, Mundy et al. reported that statins, cholesterol lowering agents, induce bone formation and inhibit bone resorption both in vitro and in vivo. I examined the effects of hesperidin on bone metabolism in ovariectomized mice, animal models of osteoporosis. The results of my experiment suggest that hesperidin may act on bone by the same mechanism as that of statins, and hesperidin effects on bone metabolism which inhibit activation of Rho-A by mevalonate-GG-PP metabolic pathways.
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Report
(4 results)
Research Products
(16 results)
