| Project/Area Number |
19500679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Tokyo Gakugei University |
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Principal Investigator |
MINAMI Michiko Tokyo Gakugei University, 教育学部, 教授 (70272432)
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| Co-Investigator(Kenkyū-buntansha) |
中井 雄治 東京大学, 大学院・農学生命科学研究科, 特任准教授 (10321788)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAI Yuji 東京大学, 大学院・農学生命研究科, 特任准教授 (10321788)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 食物繊維 / DNAマイクロアレイ / 遺伝子発現 / 老年期 / 遺伝子 / 栄養学 / マイクロアレイ / 発現変化 / 栄誉学 |
|---|
| Research Abstract |
To determine the physiological role of dietary fiber, 10% and 2% cellulose diet were served 40 weeks male Wister rat for a week. The composition of 12 fecal microflora was analysed by T-RFLP profile derived from the digestion of the fecal 16S rRNA gene by HhaI digestion. The fecal microflora was divided into 2 clusters. Serum PAI-1 is significantly different from 10% and 2% cellulose diet group. The effect of dietary fiber on the gene expression profiles in liver by using DNA microarray analysis.
A gene ontology analysis revealed that lipid metabolic-related genes had been markedly up-regulated.
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