Role of lipoprotein receptors in the development of metabolic syndrome
| Project/Area Number |
19500684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Osaka City University |
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Principal Investigator |
KIM Dongho Osaka City University, 大学院・生活科学研究科, 講師 (70326271)
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| Co-Investigator(Kenkyū-buntansha) |
SAEKI Shigeru 大阪市立大学, 大学院・生活科学研究科, 准教授 (60211926)
HOSODA Akemi 東京医療保健大学, 医療保健学部, 助手 (40449418)
YAMAGHISI Azumi 山形大学, 地域教育文化学部, 助教 (00400531)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 食と栄養 / メタボリック症候群 / 食品因子 / リポ蛋白質 / 受容体 / リポ蛋白質受容体 |
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| Research Abstract |
Wnt signaling pathways play fundamental roles in the differentiation, proliferation and functions of many cells as well as developmental, growth, and homeostatic processes in animals. We demonstrate that LRP10, belonging the LDLR gene family, inhibits Wnt/β-catenin signaling pathway in HEK293 cells. The present studies suggest that LRP10 may interfere with the formation of the β-catenin/TCF complex and/or its binding to target DNA in the nucleus, and that the extracellular domain of LRP10 is critical for inhibition of the canonical Wnt/β-catenin signaling pathway.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/β-catenin signaling pathway2010
Author(s)
Jeong YH, Sekiya M, Hirata M, Ye M, Yamagishi A, Lee SM, Kang MJ, Hosoda A, Fukumura T, Kim DH, Saeki S
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Journal Title
Biochemical and Biophysical Research Communications 392
Pages: 495-499
Related Report
Peer Reviewed
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[Journal Article] Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family2010
Author(s)
Jeong YH, Ishikawa K, Someya Y, Hosoda A, Yoshimi T, Yokoyama C, Kiryu-Seo S, Kang MJ, Tachibana T, Kiyama H, Fukumura T, Kim DH, Saeki S
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Journal Title
Biochemical and Biophysical Research Communications 391
Pages: 1110-1115
Related Report
Peer Reviewed
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[Journal Article] Presenilin enhancer-2 (PSENEN), a component of the gamma-secretase complex, is involved in adipocyte differentiation2009
Author(s)
Lee SM, Jeong YH, Kim HM, Park HY, Yoon D, Kim DH, Saeki S, Moon SJ, Kang MJ
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Journal Title
Domestic Animal Endocrinology 37
Pages: 170-180
Related Report
Peer Reviewed
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[Journal Article] Cloning, expression, and regulation of bovine cellular retinoicacid-binding protein-II (CRABP-II) during adipogenesis2008
Author(s)
Jeong YH, Lee SM, Kim HM, Park HY, Yoon D, Moon SJ, Hosoda A, Kim DH, Saeki S, Kang MJ
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Journal Title
American Journal of Animal Science 21(11)
Pages: 1551-1588
Related Report
Peer Reviewed
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