Immunostimulating effects of health foods on murine macrophage cell line

• Project/Area Number: 19500700
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kobe Women's University
• Principal Investigator: SATO Katsumasa Kobe Women's University, 家政学部, 教授 (00142331)
• Co-Investigator(Kenkyū-buntansha): 瀬口 春道 神戸女子大学, 家政学部, 教授 (90030866) ; 岩阪 由位子 神戸女子大学, 家政学部, 助手 (90299082) ; 八木 真知子 神戸女子大学, 家政学部, 助手 (50388782)
• Co-Investigator(Renkei-kenkyūsha): SEGUCHI Harumichi 神戸女子大学, 健康福祉学部, 教授 (90030866) ; IWASAKA Yumiko 神戸女子大学, 家政学部, 助手 (90299082) ; YAGI Machiko 神戸女子大学, 家政学部, 助手 (50388782)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 食と栄養 / 栄養学 / 感染症 / 細菌 / 食品 / 生理活性

Research Abstract

Immunostimulating effects of various health foods were studied using murine macrophage cell line. These foods were added to the culture medium of the cell line, and, as an index of the effects, morphological changes of the cell were searched under the microscope. As a result, among the health foods tested, immunostimulating effects could be expected in agaricus and extracts from Lentinula edodes mycelia (LEM). Next, anti-Listeria monocytogenes activities of these foods were examined. The agaricus-treated cells had increased anti-Listeria activity than the non-treated cells, which was suggested to derive from active oxygen dependence.

Research Products

• [Journal Article] In vitro drug susceptibility of Mycobacterium bovis BCG Connaught and Tokyo strains (2010)
  • Author(s): Shimizu T, Yasumoto K, Tatano Y, Tomioka H, Sato K, Sano C, Kumon H, Monden K
  • Journal Title: Journal of Infection 60 Pages: 248-251
  • Peer Reviewed
• [Journal Article] ある妊婦の217日間にわたる栄養摂取量-2010年版食事摂取基準との比較- (2010)
  • Author(s): 三原純子, 佐藤誓子, 清水典子, 佐藤勝昌
  • Journal Title: 神戸女子大学家政学部紀要 43 Pages: 21-30
  • Peer Reviewed
• [Journal Article] Experimental and clinical studies on Rifacinna-The new effective antituberculous drug (Review) (2010)
  • Author(s): Dimova V, Atanasova I, Tomioka H, Sato K, Reddy V, Nadadhur G, Daneluzzi D, Gangadharam PR, Kantardjiev T, Dhople A, Feshchenko Y, Yashino L, Toumanov A, hivkova Zv
  • Journal Title: Recent Patents on Anti-infective Drug Discovery 5 Pages: 76-90
  • Peer Reviewed
• [Journal Article] Comparative study for the virulence of Mycobacterium avium isolates from patients with nodularbronchiectasis-and cavitarytype diseases (2010)
  • Author(s): Tatano Y, Yasumoto K, Shimizu T, Sano C, Sato K, Yano S, Takeyama H, Tomioka H
  • Journal Title: Eur J Clin Microbiol Infect Dis (in press)
• [Journal Article] 食物アレルギーに対する保育所の給食対応-除去食・代替食提供時の工夫と配慮のあり方を中心として- (2010)
  • Author(s): 佐藤誓子, 佐藤勝昌, 増澤康男
  • Journal Title: 栄養学雑誌 (in press) Pages: 68-68