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Survey and experimental verification of adverse effects of dietary habits on reproductive functions in post-adolescence women

Research Project

Project/Area Number 19500707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionAshiya College

Principal Investigator

FUJIWARA Tomoko  Ashiya College, その他, 教授 (60310744)

Co-Investigator(Kenkyū-buntansha) NAKATA Rieko  奈良女子大学, 生活環境学部, 講師 (90198119)
FUJIWARA Hiroshi  京都大学, 医学研究科, 講師 (30252456)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords女子大学生 / 婦人科疾患 / 食習慣 / ラット実験モデル / 食育プログラム
Research Abstract

性成熟過程にある女性の食生活は以後の母性を担う時期の女性のQOLに重要な影響を与えるという新しい着想から、悪影響を及ぼす可能性のある食生活習慣の因子を抽出することを目的として、18-20歳の女子学生を対象に食事習慣を含む基本的な生活習慣、体型認識やダイエット行動の実態、婦人科愁訴をふくむ身体症状についてのアンケート調査を平成19年度に引き続いて行った。また奈良女子大学の倫理委員会に諮り、承認を得た上でボランティア学生を募って3ヶ月に及ぶ食事調査を実施し、合わせて基礎体温や婦人科愁訴などのデータも収集した。食事内容についてはデジタルカメラで撮影した記録をもとに詳細な栄養分析を行い、朝食の欠食とともに生殖機能に障害をもたらす可能性のある食習慣について調査した。その結果、女子学生の食生活上の問題点として新たに、ファストフードやコンビニエンスストアで売られている加工食品を多用するといった他の有害な食習慣を有していることが示された。ファストフードや加工食品の摂取頻度の多いグループにおいても月経痛の程度が強いことが観察され、食習慣が将来の婦人科疾患の誘因になる可能性を支持する結果が示された。一方、朝食欠食についても月経周期の異常すなわち性機能に機能的に悪影響を及ぼす可能性が示されたが、さらにファストフードや加工食品の多用者に比べ朝食を欠食している学生に体調不良を訴える者が多いことが明らかとなった。以上の知見より一日の活動の最初の段階での飢餓状態を生じる朝食の欠食は女子学生のQOLに影響を及ぼすもっとも重要な因子のひとつである可能性が示唆された。本研究にて得られた結果は性成熟完成期女性に対してより効果的な教育プログラムの開発を進める上で意義ある知見といえる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (41 results)

All 2009 2008 2007

All Journal Article (30 results) (of which Peer Reviewed: 19 results) Presentation (7 results) Book (4 results)

  • [Journal Article] Skipping breakfast adversely affects menstrual disorders in young college students2009

    • Author(s)
      Fujiwara T, Sato N, Awaji H, Sakamoto H, Nakata R
    • Journal Title

      Int J Food Sci Nutr (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 免疫細胞を用いた着床率の向上2009

    • Author(s)
      藤原浩、高尾由美、小西郁生
    • Journal Title

      産婦人科治療 98巻

      Pages: 140-146

    • Related Report
      2008 Final Research Report
  • [Journal Article] 血液細胞を介した新しい胚-母体間の相互応答機構とそれを応用した着床不全患者に対する治療法の開発2009

    • Author(s)
      藤原浩
    • Journal Title

      日本産科婦人科・新生児血液学会誌 18巻

      Pages: 2-2

    • NAID

      10026709998

    • Related Report
      2008 Final Research Report
  • [Journal Article] Do circulating blood cells contribute to maternal tissue remodeling and embryo-maternal cross-talk around the implantation period?2009

    • Author(s)
      Fujiwara H
    • Journal Title

      Mol Hum Reprod (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is the zona pellucida an intrinsic source of signals activating maternal recognition of the developing mammalian embryo?2009

    • Author(s)
      Fujiwara H, Araki Y, Toshimori K
    • Journal Title

      J Reprod Immunol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Administration of bovine peripheral blood mononuclear cells into the uterine horn improve pregnancy rate following embryo transplantation2009

    • Author(s)
      Ideta A, Sakai S, Nakamura Y, Urakawa M, Hayama K, Tsuchiya K, Fujiwara H, Aoyagi Y
    • Journal Title

      Ani Reprod Sci (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Skipping Breakfast Adversely Affects Menstrual Disorders in Young college students.2009

    • Author(s)
      Fujiwara T, Nakata R
    • Journal Title

      International Journal of Food Sciences and Nutrition (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不適切なダイエットか若年女性の月経周期に及ぼす悪影響の実態調査と実験的検証2009

    • Author(s)
      藤原智子
    • Journal Title

      芦屋女子短期大学研究紀要 33

      Pages: 1-13

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 食生活に対する意識改善を目指した効果的な教育プログラム構築の試み2008

    • Author(s)
      藤原智子, 1番目, その他4名
    • Journal Title

      研究紀要<芦屋女子短期大学> 31

      Pages: 69-78

    • NAID

      40016092560

    • Related Report
      2008 Final Research Report
  • [Journal Article] 誘導型シクロオキシゲナーゼ発現抑制を指標とした植物油の機能性評価2008

    • Author(s)
      堀田真理子、中田理恵子、井上裕康
    • Journal Title

      日本家政学会誌 59

      Pages: 373-378

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 葉酸欠乏が脂質代謝関連酵素の遺伝子発現に及ぼす影響2008

    • Author(s)
      中田理恵子, 1番目,その他3名
    • Journal Title

      脂質生化学研究 50

      Pages: 300-303

    • NAID

      10024355941

    • Related Report
      2008 Final Research Report
  • [Journal Article] Monoamine oxidase A is highly expressed by the human corpus luteum of pregnancy2008

    • Author(s)
      Takao Y, Fujiwara H, Yoshioka S, Fujii S, Ueda M
    • Journal Title

      Reproduction 136

      Pages: 367-375

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Emergence of highly neurofilamentimmunoreactive zipper-like axon segments at the transection site in scalpel-cordotomized adult rats2008

    • Author(s)
      Nishio K, Kawaguchi S, Fujiwara H
    • Journal Title

      Neuroscience 155

      Pages: 90-103

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 免疫細胞を用いた着床率向上の試み2008

    • Author(s)
      藤原浩
    • Journal Title

      日本産科婦人科学会雑誌, (N399-402) 60巻

    • NAID

      110006943999

    • Related Report
      2008 Final Research Report
  • [Journal Article] 女子学生における米食に対する意識調査とそれに基づく食育の試み「ごはんを食べようレスキュー隊」実施報告2007

    • Author(s)
      藤原智子, 1番目, その他6名
    • Journal Title

      研究紀要<芦屋女子短期大学> 29

      Pages: 83-90

    • NAID

      40016092546

    • Related Report
      2008 Final Research Report
  • [Journal Article] Diet during adolescence is a trigger for subsequent development of dysmenorrhea in young women2007

    • Author(s)
      Fujiwara T
    • Journal Title

      Int J Food Sci Nutr 58

      Pages: 437-444

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Young Japanese college students with dysmenorrhea have high frequency of irregular menstruation and premenstrual symptoms2007

    • Author(s)
      Fujiwara T, Nakata R
    • Journal Title

      The Open Medical Informatics Journal 1

      Pages: 8-11

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adverse effects of dietary habits on menstrual disorders in young women2007

    • Author(s)
      Fujiwara T, Sato N, Awaji H, Nakata R
    • Journal Title

      The Open Food Science Journal 1

      Pages: 24-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The relationship among food habits, sleeping habits and general conditions inyoung female students in Japan2007

    • Author(s)
      Fujiwara T
    • Journal Title

      Bulletin of Ashiya College 29

      Pages: 75-82

    • Related Report
      2008 Final Research Report
  • [Journal Article] Normal range of periodicity of young women with regular menstrual cycle in Japan2007

    • Author(s)
      Fujiwara T
    • Journal Title

      Bulletin of Ashiya College 30

      Pages: 21-27

    • NAID

      40016092549

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Journal Article] Platelet is a novel regulator for neovascularization and luteinization during human corpus luteum formation2007

    • Author(s)
      Furukawa K, Fujiwara H, Sato Y, Zeng BX, Fujii H, Yoshioka S, Nishi E, Nishio T
    • Journal Title

      Endocrinology 148

      Pages: 3056-3064

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor production by circulating immune cells is elevated in ovarian hyperstimulation syndrome2007

    • Author(s)
      Kosaka K, Fujiwara H, Yoshioka S, Fujii S
    • Journal Title

      Hum Reprod 22

      Pages: 647-1651

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrin a5 is involved in fibronectin-induced human extravillous trophoblast invasion2007

    • Author(s)
      Zeng BX, Fujiwara H, Sato Y, Nishioka Y, Yamada S, Yoshioka S, Ueda M, Higuchi T, Fujii S
    • Journal Title

      J Reprod Immunol 73

      Pages: 1-10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-bound peptidases regulate human extravillous trophoblast invasion2007

    • Author(s)
      Fujiwara H
    • Journal Title

      Trophoblast Res, (S70-S75) 21

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laeverin/aminopeptidase Q, a novel bestatinsensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases2007

    • Author(s)
      Maruyama M, Hattori A, Goto Y, Ueda M, Maeda M, Fujiwara H, Tsujimoto M
    • Journal Title

      J Biol Chem 282

      Pages: 20088-20096

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胚着床による制御機構; 細胞間に反発力を誘導する Eph-ephrin シグナルの関与2007

    • Author(s)
      藤井治子、 藤原浩
    • Journal Title

      Hormone Frontier in Gynecology 14

      Pages: 2-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] Diet during adolescence is a trigger for subsequent development of dysmenorrhea in young women2007

    • Author(s)
      Fujiwara T
    • Journal Title

      International Journal of Food Sciences and Nutrition 58

      Pages: 437-444

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adverse effects of dietary habits on menstrual disorders in young women2007

    • Author(s)
      Fujiwara T, et. al.
    • Journal Title

      The Open Food Science Journal 1

      Pages: 24-30

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Young Japanese college students with dysmenorrhea hava high frequency of irregular menstruation and premenstrual symptoms2007

    • Author(s)
      Fujiwara T, Nakata R
    • Journal Title

      The Open Medical Informatics Journal

      Pages: 8-11

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship among food habits,sleeping habits and general conditions in young female students in Japan2007

    • Author(s)
      Fujiwara T
    • Journal Title

      Bulletin of Ashiya College 29

      Pages: 75-82

    • NAID

      40016092545

    • Related Report
      2007 Annual Research Report
  • [Presentation] 難治性着床不全、不育症に対する治療の試み2008

    • Author(s)
      藤原浩
    • Organizer
      自己血液細胞の応用日本生殖免疫学会第23回学術集会
    • Place of Presentation
      富山
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Immune cell contribution to systemic crosstalk between mother and embryo around implantation period2008

    • Author(s)
      Fujiwara H
    • Organizer
      The 1st International workshop on Reproductive Biology : "Recent Progresses in Reproductive Biology" SKLAB 2008
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-10-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 周産期免疫、常態と病態、着床誘導機構について2008

    • Author(s)
      藤原浩
    • Organizer
      日本産婦人科・新生児血液学会第18回学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-06-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 免疫細胞を用いた着床率向上の試み2008

    • Author(s)
      藤原浩
    • Organizer
      第60回日本産科婦人科学学会学術集会卒後研修プログラム3. ARTの最近の話題
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 着床機構に関するOverview2008

    • Author(s)
      藤原浩
    • Organizer
      第3回生殖再生医学会シンポジウム, 着床に関する理論と実践
    • Place of Presentation
      東京
    • Year and Date
      2008-03-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞膜結合型ペプチダーゼによるヒト絨毛外栄養膜細胞浸潤の制御機構2007

    • Author(s)
      藤原浩
    • Organizer
      第12回病態と治療におけるプロテアーゼとインヒビター学会学術講演会シンポジウム
    • Place of Presentation
      大阪千里
    • Year and Date
      2007-08-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Systemic crosstalk between mother and embryo around implantation period by immune and endocrine systems2007

    • Author(s)
      Fujiwara H
    • Organizer
      The 112nd Annual Meeting of The Japanese Association of Anatomists, (日米合同シンポジウム)
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-27
    • Related Report
      2008 Final Research Report
  • [Book] 小児の発育と食生活 小児栄養,(岡佐智子、小川雄二編)(分担執筆)2009

    • Author(s)
      藤原智子
    • Publisher
      ミネルヴァ書房
    • Related Report
      2008 Final Research Report
  • [Book] 妊娠・授乳期の食生活 小児栄養, (岡佐智子、小川雄二編)(分担執筆)2009

    • Author(s)
      藤原智子
    • Publisher
      ミネルヴァ書房
    • Related Report
      2008 Final Research Report
  • [Book] 排卵・月経の機序 産婦人科学テキスト,(倉智博久、吉村泰典編)(分担執筆)2007

    • Author(s)
      藤原浩
    • Publisher
      中外医学社
    • Related Report
      2008 Final Research Report
  • [Book] 月経困難症の取り扱い、スーパーローテート・マニュアル, (朝倉啓文、小西郁生、末岡浩、田中忠夫、堤治編)(分担執筆)2007

    • Author(s)
      藤原浩
    • Publisher
      金原出版
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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